A 20 cm focal length normal incidence vacuum ultraviolet （VUV_20 cm） monochromator with a fast time response has been developed for measuring edge impurity line emission in the wavelength range of 300-2000 A on an H...A 20 cm focal length normal incidence vacuum ultraviolet （VUV_20 cm） monochromator with a fast time response has been developed for measuring edge impurity line emission in the wavelength range of 300-2000 A on an HL-2A tokamak. An aberration corrected concave holographic grating with 1200 grooves/mm is adopted in the monochromator, which provides a wavelength dispersion of 40 A mm-1. The aperture is f/4.5. A channel electron multiplier is used as a detector. The time resolution of the system is 17 μs. Wavelength calibration of the system has been done by using a hollow cathode light source in the laboratory with helium and argon gases. The obtained signals of helium and argon spectra are very strong since the inner surface of the monochromator vacuum chamber is blackened and the stray light level is then significantly reduced. The optical property of the system has been examined by scanning the width of the entrance and exit slits. The system is then installed at the mid-port of the HL-2A tokamak and typical line emissions from the HL-2A plasma are measured. Time behaviors of edge impurity line emissions are observed with the fast time response system in different plasma confinement regimes, especially in the H-mode discharges. The result shows that the VUV_20 cm system works very well to measure the edge impurity line emissions in the edge localized modes phase of H-mode discharges.展开更多
Branched-chain fatty acids(BCFAs)are new bioactive fatty acids with anti-inflammatory properties.However,the role of BCFAs in alleviating ulcerative colitis has not been clarified.Herein,we evaluated the protective ef...Branched-chain fatty acids(BCFAs)are new bioactive fatty acids with anti-inflammatory properties.However,the role of BCFAs in alleviating ulcerative colitis has not been clarified.Herein,we evaluated the protective effect of BCFAs from goat milk in mice with colitis induced using dextran sodium sulfate(DSS)and explored the corresponding mechanism.These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice,and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response.These data also show that BCFAs can down-regulate the gene and protein expression of the toll-like receptor 4(TLR4)/nuclear factorκB p65(NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,and at the same time significantly reduce the expression of pro-inflammatory factors tumor necrosis factorα(TNF-α),interleukin 1β(IL-1β),and IL-18 in colon tissue,and significantly increase the expression of the anti-inflammatory factor IL-10.In conclusion,these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate DSS-induced ulcerative colitis.This study provides evidence for the potential of BCFAs as bioactive fatty acids in food products and to ameliorate ulcerative colitis development in mice.展开更多
A cylindrical carbon pellet with a size of 1.2L x 1.2φ mm to 1.8L x 1.8φ mm and a velocity of 100 m/s to 300 m/s was injected into large helical device （LHD） for an efficient fueling based on its deeper deposition...A cylindrical carbon pellet with a size of 1.2L x 1.2φ mm to 1.8L x 1.8φ mm and a velocity of 100 m/s to 300 m/s was injected into large helical device （LHD） for an efficient fueling based on its deeper deposition instead of hydrogen gas puffing and ice pellet injection. Electron density increment of Ane = 10^14 cm^-3 is successfully obtained by single carbon pellet injection without plasma collapse. Typical density and temperature of the ablation plasma of the carbon pellet, e.g., 6.5× 10^16 cm^-3 and 2.5 eV for CII, are examined respectively by spectroscopic method. A confinement improvement up to 50% compared to ISS-95 stellarator scaling is clearly observed in a relatively low-density regime of ne = 2 × 10^13 cm^-3 to 4×10^13 cm^-3, and high ion temperature Ti（0） of about 6 keV is also observed with an internal transport barrier at ne = 1.2 × 10^13 cm^-3. In particular, the improvement in the ion temperature largely exceeds that observed in hydrogen gas-puffed discharges, which typically ranges below 3 keV.展开更多
基金partly supported by National Natural Science Foundation of China (Nos. 11375057 and 11505051)the National Magnetic Confinement Fusion Program of China (Nos. 2014GB108003 and 2015GB104003)
文摘A 20 cm focal length normal incidence vacuum ultraviolet （VUV_20 cm） monochromator with a fast time response has been developed for measuring edge impurity line emission in the wavelength range of 300-2000 A on an HL-2A tokamak. An aberration corrected concave holographic grating with 1200 grooves/mm is adopted in the monochromator, which provides a wavelength dispersion of 40 A mm-1. The aperture is f/4.5. A channel electron multiplier is used as a detector. The time resolution of the system is 17 μs. Wavelength calibration of the system has been done by using a hollow cathode light source in the laboratory with helium and argon gases. The obtained signals of helium and argon spectra are very strong since the inner surface of the monochromator vacuum chamber is blackened and the stray light level is then significantly reduced. The optical property of the system has been examined by scanning the width of the entrance and exit slits. The system is then installed at the mid-port of the HL-2A tokamak and typical line emissions from the HL-2A plasma are measured. Time behaviors of edge impurity line emissions are observed with the fast time response system in different plasma confinement regimes, especially in the H-mode discharges. The result shows that the VUV_20 cm system works very well to measure the edge impurity line emissions in the edge localized modes phase of H-mode discharges.
基金financially supported by the 2021 Kabrita Nutrition Grant.
文摘Branched-chain fatty acids(BCFAs)are new bioactive fatty acids with anti-inflammatory properties.However,the role of BCFAs in alleviating ulcerative colitis has not been clarified.Herein,we evaluated the protective effect of BCFAs from goat milk in mice with colitis induced using dextran sodium sulfate(DSS)and explored the corresponding mechanism.These results show that BCFAs extracted from goat milk can significantly alleviate weight loss in mice,and reduce the disease activity index and the activity of myeloperoxidase while increasing the content of antioxidant enzymes in colon tissue and reducing the oxidation stress response.These data also show that BCFAs can down-regulate the gene and protein expression of the toll-like receptor 4(TLR4)/nuclear factorκB p65(NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)signaling pathway,and at the same time significantly reduce the expression of pro-inflammatory factors tumor necrosis factorα(TNF-α),interleukin 1β(IL-1β),and IL-18 in colon tissue,and significantly increase the expression of the anti-inflammatory factor IL-10.In conclusion,these results demonstrated that BCFAs in goat milk exerted effects on colitis-related inflammatory cytokines and inhibited inflammation by inducing the TLR4/NF-κB/NLRP3 pathway to alleviate DSS-induced ulcerative colitis.This study provides evidence for the potential of BCFAs as bioactive fatty acids in food products and to ameliorate ulcerative colitis development in mice.
文摘A cylindrical carbon pellet with a size of 1.2L x 1.2φ mm to 1.8L x 1.8φ mm and a velocity of 100 m/s to 300 m/s was injected into large helical device （LHD） for an efficient fueling based on its deeper deposition instead of hydrogen gas puffing and ice pellet injection. Electron density increment of Ane = 10^14 cm^-3 is successfully obtained by single carbon pellet injection without plasma collapse. Typical density and temperature of the ablation plasma of the carbon pellet, e.g., 6.5× 10^16 cm^-3 and 2.5 eV for CII, are examined respectively by spectroscopic method. A confinement improvement up to 50% compared to ISS-95 stellarator scaling is clearly observed in a relatively low-density regime of ne = 2 × 10^13 cm^-3 to 4×10^13 cm^-3, and high ion temperature Ti（0） of about 6 keV is also observed with an internal transport barrier at ne = 1.2 × 10^13 cm^-3. In particular, the improvement in the ion temperature largely exceeds that observed in hydrogen gas-puffed discharges, which typically ranges below 3 keV.
