BACKGROUND Percutaneous transhepatic cholangiodrainage(PTCD)and endoscopic retrograde cholangiopancreatography/endoscopic nasobiliary drainage are the most common clinical procedures for jaundice control in patients w...BACKGROUND Percutaneous transhepatic cholangiodrainage(PTCD)and endoscopic retrograde cholangiopancreatography/endoscopic nasobiliary drainage are the most common clinical procedures for jaundice control in patients with unresectable malignant obstructive jaundice,yet the safety and effect of endobiliary radiofrequency ablation(EB-RFA)combined PTCD is rarely reported,in this article,we report our experience of EB-RFA combined PTCD in such patients.AIM To retrospectively study the efficacy and safety of EB-RFA combined PTCD in patients with unresectable malignant obstructive jaundice.METHODS Patients with unresectable malignant obstructive jaundice treated with EB-RFA under PTCD were selected,the bile ducts of the right posterior lobe was selected as the target bile ducts in all cases.The general conditions of all patients,preoperative tumour markers,total bilirubin(TBIL),direct bilirubin(DBIL),albumin(ALB),alkaline phosphatase(ALP),and glutamyl transferase(GGT)before and on the 7th day after the procedure,as well as perioperative complications,stent patency time and patient survival were recorded.RESULTS All patients successfully completed the operation,TBIL and DBIL decreased significantly in all patients at the 7th postoperative day(P=0.009 and 0.006,respectively);the values of ALB,ALP and GGT also decreased compared with the preoperative period,but the difference was not statistically significant.Perioperative biliary bleeding occurred in 2 patients,which was improved after transfusion of blood and other conservative treatments,pancreatitis appeared in 1 patient after the operation,no serious complication and death happened after operation.Except for 3 patients with loss of visits,the stent patency rate of the remaining 14 patients was 100%71%and 29%at the 1^(st),3^(rd),and 6^(th)postoperative months respectively,with a median survival of 4 months.CONCLUSION EB-RFA under PTCD in patients with unresectable malignant obstructive jaundice has a satisfactory therapeutic effect and high safety,which is worthy of further clinical practice.展开更多
Floquet engineering has attracted considerable attention as a promising approach for tuning topological phase transitions.We investigate the effects of high-frequency time-periodic driving in a four-dimensional(4D)top...Floquet engineering has attracted considerable attention as a promising approach for tuning topological phase transitions.We investigate the effects of high-frequency time-periodic driving in a four-dimensional(4D)topological insulator,focusing on topological phase transitions at the off-resonant quasienergy gap.The 4D topological insulator hosts gapless three-dimensional boundary states,characterized by the second Chern number C_(2).We demonstrate that the second Chern number of 4D topological insulators can be modulated by tuning the amplitude of time-periodic driving.This includes transitions from a topological phase with C_(2)=±3 to another topological phase with C_(2)=±1,or to a topological phase with an even second Chern number C_(2)=±2,which is absent in the 4D static system.Finally,the approximation theory in the high-frequency limit further confirms the numerical conclusions.展开更多
Disorder effects on topological materials in integer dimensions have been extensively explored in recent years. However, its influence on topological systems in fractional dimensions remains unclear. Here, we investig...Disorder effects on topological materials in integer dimensions have been extensively explored in recent years. However, its influence on topological systems in fractional dimensions remains unclear. Here, we investigate the disorder effects on a fractal system constructed on the Sierpiński lattice in fractional dimensions. The system supports the second-order topological insulator phase characterized by a quantized quadrupole moment and the normal insulator phase. We find that the second-order topological insulator phase on the Sierpiński lattice is robust against weak disorder but suppressed by strong disorder. Most interestingly, we find that disorder can transform the normal insulator phase to the second-order topological insulator phase with an emergent quantized quadrupole moment. Finally, the disorder-induced phase is further confirmed by calculating the energy spectrum and the corresponding probability distributions.展开更多
BACKGROUND Post-hepatectomy liver failure(PHLF)is a serious complication and a leading cause of death after hepatectomy,an accurate prediction of PHLF is important for improvement of prognosis after hepatectomy.AIM To...BACKGROUND Post-hepatectomy liver failure(PHLF)is a serious complication and a leading cause of death after hepatectomy,an accurate prediction of PHLF is important for improvement of prognosis after hepatectomy.AIM To retrospectively analyze the risk factors for postoperative liver failure in patients undergoing hepatectomy for liver tumors.METHODS The clinical data of 80 patients undergoing hepatectomy in our hospital from June 2018 to January 2020 were collected.With laboratory examination as well as preand post-operative abdominal three-dimensional reconstructive computed tomography,the demographic data,surgical data,biochemical indicators,coagulation index,routine blood tests,spleen and liver volumes,relative remnant liver volume,and other related indicators were obtained and compared between patients with PHLF and those without PHLF.RESULTS PHLF occurred in 19(23.75%)patients.Univariate logistic regression analysis showed that gender,history of hepatitis/cirrhosis,and preoperative bilirubin,albumin,coagulation function,albumin-bilirubin ratio,aspartate aminotransferase-to-platelet ratio index(APRI),Model for End-Stage Liver Disease score,spleen volume(SV),spleen volume/liver volume ratio(SV/LV),and relative remnant liver volume were statistically associated with the occurrence of PHLF(all P<0.05).Multivariate regression analysis showed that preoperative total bilirubin,platelets(PLT),APRI,and SV/LV were independent risk factors for PHLF(all P<0.05).The area under the curve and cut-off values were 0.787 and 18.6 mmol/L for total bilirubin,0.893 and 146×1012/L for PLT,0.907 and 0.416 for APRI,and 0.752 and 20.84%for SV/LV,respectively.CONCLUSION For patients undergoing liver resection,preoperative total bilirubin,PLT,APRI,and SV/LV are independent risk factors for PHLF.These findings may provide guidance to safely perform liver surgery in such patients.展开更多
Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a,VEGF-b,VEGF-c and the VEGF receptor,Flk-1,were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley(SD)rats were random...Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a,VEGF-b,VEGF-c and the VEGF receptor,Flk-1,were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley(SD)rats were randomized into Groups A(blank),B(model),C(Shuang Dan Ming Mu)and D(positive control)group,with each group containing10rats and20eyes.Rats from groups B,C and D were administered one dose of50mg/kg streptozotocin(STZ)by tail vein injection to establish a diabetic rat model.One week after model preparation,medication was continuously administered by gavage.After gavage for8weeks,the animals were sacrificed and retinal expression of VEGF-a,VEGF-b,VEGF-c and Flk-1was quantified by immunohistochemical analysis.Results At week8of drug administration after model preparation,the average protein expression grayscale values for VEGF-a,VEGF-b,VEGF-c and Flk-1in the rats model,Shuang Dan Ming Mu and positive control groups were all lower than those in the normal group,while the mean optical density values were higher than those in the normal group.When the model group was compared to the normal group,the difference was extremely significant(P<0.01).The mean grayscale values of VEGF-a,VEGF-b,VEGF-c and Flk-1in the Shuang Dan Ming Mu and positive control groups were all higher than those in the model group,while the mean optical density values were lower than those in the model group(P<0.05or0.01).Conclusion Shuang Dan Ming Mu capsule can significantly decrease the expression of VEGF-a,VEGF-b,VEGF-c and Flk-1in the retinas of diabetic model rats and exhibit some protective effects in their retinas.展开更多
文摘BACKGROUND Percutaneous transhepatic cholangiodrainage(PTCD)and endoscopic retrograde cholangiopancreatography/endoscopic nasobiliary drainage are the most common clinical procedures for jaundice control in patients with unresectable malignant obstructive jaundice,yet the safety and effect of endobiliary radiofrequency ablation(EB-RFA)combined PTCD is rarely reported,in this article,we report our experience of EB-RFA combined PTCD in such patients.AIM To retrospectively study the efficacy and safety of EB-RFA combined PTCD in patients with unresectable malignant obstructive jaundice.METHODS Patients with unresectable malignant obstructive jaundice treated with EB-RFA under PTCD were selected,the bile ducts of the right posterior lobe was selected as the target bile ducts in all cases.The general conditions of all patients,preoperative tumour markers,total bilirubin(TBIL),direct bilirubin(DBIL),albumin(ALB),alkaline phosphatase(ALP),and glutamyl transferase(GGT)before and on the 7th day after the procedure,as well as perioperative complications,stent patency time and patient survival were recorded.RESULTS All patients successfully completed the operation,TBIL and DBIL decreased significantly in all patients at the 7th postoperative day(P=0.009 and 0.006,respectively);the values of ALB,ALP and GGT also decreased compared with the preoperative period,but the difference was not statistically significant.Perioperative biliary bleeding occurred in 2 patients,which was improved after transfusion of blood and other conservative treatments,pancreatitis appeared in 1 patient after the operation,no serious complication and death happened after operation.Except for 3 patients with loss of visits,the stent patency rate of the remaining 14 patients was 100%71%and 29%at the 1^(st),3^(rd),and 6^(th)postoperative months respectively,with a median survival of 4 months.CONCLUSION EB-RFA under PTCD in patients with unresectable malignant obstructive jaundice has a satisfactory therapeutic effect and high safety,which is worthy of further clinical practice.
基金supported by the National Natural Science Foundation of China(Grant Nos.12074107 and 12304195)the Program of Outstanding Young and Middle-Aged Scientific and Technological Innovation Team of Colleges and Universities in Hubei Province(Grant No.T2020001)+2 种基金the Innovation Group Project of the Natural Science Foundation of Hubei Province of China(Grant No.2022CFA012)the Chutian Scholars Program in Hubei Province,the Postdoctoral Fellowship Program of CPSF(Grant No.GZC20230751)the Postdoctoral Innovation Research Program in Hubei Province(Grant No.351342)。
文摘Floquet engineering has attracted considerable attention as a promising approach for tuning topological phase transitions.We investigate the effects of high-frequency time-periodic driving in a four-dimensional(4D)topological insulator,focusing on topological phase transitions at the off-resonant quasienergy gap.The 4D topological insulator hosts gapless three-dimensional boundary states,characterized by the second Chern number C_(2).We demonstrate that the second Chern number of 4D topological insulators can be modulated by tuning the amplitude of time-periodic driving.This includes transitions from a topological phase with C_(2)=±3 to another topological phase with C_(2)=±1,or to a topological phase with an even second Chern number C_(2)=±2,which is absent in the 4D static system.Finally,the approximation theory in the high-frequency limit further confirms the numerical conclusions.
基金the support of the National Natural Science Foundation of China (Grant No.12304195)the Chutian Scholars Program in Hubei Province+3 种基金supported by the National Natural Science Foundation of China (Grant No.12074107)the program of outstanding young and middle-aged scientific and technological innovation team of colleges and universities in Hubei Province (Grant No.T2020001)the innovation group project of the Natural Science Foundation of Hubei Province of China (Grant No.2022CFA012)supported by the Postdoctoral Innovation Research Program in Hubei Province (Grant No.351342)。
文摘Disorder effects on topological materials in integer dimensions have been extensively explored in recent years. However, its influence on topological systems in fractional dimensions remains unclear. Here, we investigate the disorder effects on a fractal system constructed on the Sierpiński lattice in fractional dimensions. The system supports the second-order topological insulator phase characterized by a quantized quadrupole moment and the normal insulator phase. We find that the second-order topological insulator phase on the Sierpiński lattice is robust against weak disorder but suppressed by strong disorder. Most interestingly, we find that disorder can transform the normal insulator phase to the second-order topological insulator phase with an emergent quantized quadrupole moment. Finally, the disorder-induced phase is further confirmed by calculating the energy spectrum and the corresponding probability distributions.
基金The study was reviewed and approved by the Ethics Committee Approval Document of Tiantan Hospital,Institutional Review Board Approval No.KYSQ 2020-177-01.
文摘BACKGROUND Post-hepatectomy liver failure(PHLF)is a serious complication and a leading cause of death after hepatectomy,an accurate prediction of PHLF is important for improvement of prognosis after hepatectomy.AIM To retrospectively analyze the risk factors for postoperative liver failure in patients undergoing hepatectomy for liver tumors.METHODS The clinical data of 80 patients undergoing hepatectomy in our hospital from June 2018 to January 2020 were collected.With laboratory examination as well as preand post-operative abdominal three-dimensional reconstructive computed tomography,the demographic data,surgical data,biochemical indicators,coagulation index,routine blood tests,spleen and liver volumes,relative remnant liver volume,and other related indicators were obtained and compared between patients with PHLF and those without PHLF.RESULTS PHLF occurred in 19(23.75%)patients.Univariate logistic regression analysis showed that gender,history of hepatitis/cirrhosis,and preoperative bilirubin,albumin,coagulation function,albumin-bilirubin ratio,aspartate aminotransferase-to-platelet ratio index(APRI),Model for End-Stage Liver Disease score,spleen volume(SV),spleen volume/liver volume ratio(SV/LV),and relative remnant liver volume were statistically associated with the occurrence of PHLF(all P<0.05).Multivariate regression analysis showed that preoperative total bilirubin,platelets(PLT),APRI,and SV/LV were independent risk factors for PHLF(all P<0.05).The area under the curve and cut-off values were 0.787 and 18.6 mmol/L for total bilirubin,0.893 and 146×1012/L for PLT,0.907 and 0.416 for APRI,and 0.752 and 20.84%for SV/LV,respectively.CONCLUSION For patients undergoing liver resection,preoperative total bilirubin,PLT,APRI,and SV/LV are independent risk factors for PHLF.These findings may provide guidance to safely perform liver surgery in such patients.
基金funding support from the National Natural Science Foundation General Program (No. 814737370)Hunan Province Graduate Student Research Innovation Program (No. CX2016B377 and No. CX2017B432)+4 种基金Traditional Chinese Medicine Prevention and Treatment of Facial Feature Disease Hunan Province Key Laboratory Construction Program (No. 2017TP1018)Changsha City Science and Technology Program (No. kc1704005)Central Finance Supported Local High School Construction ProjectState Administration of Traditional Chinese Medicine Ophthalmology Key Discipline Construction ProjectHunan Province Traditional Chinese Medicine Facial Feature Key Discipline Construction Project
文摘Objective The effects of Shuang Dan Ming Mu capsule on expression of VEGF-a,VEGF-b,VEGF-c and the VEGF receptor,Flk-1,were examined in a diabetic retinopathy rats model.Methods Forty Sprague-Dawley(SD)rats were randomized into Groups A(blank),B(model),C(Shuang Dan Ming Mu)and D(positive control)group,with each group containing10rats and20eyes.Rats from groups B,C and D were administered one dose of50mg/kg streptozotocin(STZ)by tail vein injection to establish a diabetic rat model.One week after model preparation,medication was continuously administered by gavage.After gavage for8weeks,the animals were sacrificed and retinal expression of VEGF-a,VEGF-b,VEGF-c and Flk-1was quantified by immunohistochemical analysis.Results At week8of drug administration after model preparation,the average protein expression grayscale values for VEGF-a,VEGF-b,VEGF-c and Flk-1in the rats model,Shuang Dan Ming Mu and positive control groups were all lower than those in the normal group,while the mean optical density values were higher than those in the normal group.When the model group was compared to the normal group,the difference was extremely significant(P<0.01).The mean grayscale values of VEGF-a,VEGF-b,VEGF-c and Flk-1in the Shuang Dan Ming Mu and positive control groups were all higher than those in the model group,while the mean optical density values were lower than those in the model group(P<0.05or0.01).Conclusion Shuang Dan Ming Mu capsule can significantly decrease the expression of VEGF-a,VEGF-b,VEGF-c and Flk-1in the retinas of diabetic model rats and exhibit some protective effects in their retinas.
