Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice ...Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions.展开更多
Due to the greenhouse effect caused by carbon dioxide(CO_(2))emission,much attention has been paid for the removal of CO_(2).Porous liquids(PLs),as new type of liquid materials,have obvious advantages in mass and heat...Due to the greenhouse effect caused by carbon dioxide(CO_(2))emission,much attention has been paid for the removal of CO_(2).Porous liquids(PLs),as new type of liquid materials,have obvious advantages in mass and heat transfer,which are widely used in gas adsorption and sep-aration.Metal–organic frameworks(MOFs)with merits like large surface area,inherent porous structure and adjustable topology have been considered as one of the best candidates for PLs construction.This review presents the state-of-the-art status on the fabrication strategy of MOFs-based PLs and their CO_(2) absorption and utilization performance,and the positive effects of porosity and functional modification on the absorption-desorption property,selectivity of target product,and regeneration ability are well summarized.Finally,the challenges and prospects for MOFs-based PLs in the optimization of preparation,the coupling of multiple removal techniques,the in situ characterization methods,the regeneration and cycle stability,the environmental impact as well as expansion of application are proposed.展开更多
Although the Mg-air battery with high theoretical energy density is desirable for the energy supply of marine engineering equipment,its applications remain limited due to the low actual discharge voltage and inferior ...Although the Mg-air battery with high theoretical energy density is desirable for the energy supply of marine engineering equipment,its applications remain limited due to the low actual discharge voltage and inferior Mg anode utilization rate.In addition to the microstructure of Mg alloy anodes,the properties of discharge product films are of great importance to the discharge performance.Herein,the discharge behaviors of Mg-Y-Zn alloys are first studied mainly from the perspective of film properties.Through contrastive analysis,it is found that the sufficient Y^(3+) produced during the discharge process can substitute Mg^(2+) in Mg(OH)_(2) to introduce effective cation vacancies.The Mg-Y-Zn anode with profuse cation vacancies in the product film shows a synergy of potential and efficiency,and this can be attributed to an increase in the migration pathway for Mg^(2+),reducing the diffusion over-potential caused by the protective product film.This study is expected to provide a new strategy from the perspective of cation vacancy design of discharge film for developing high-performance Mg-air batteries.展开更多
基金supported financially by the National Natural Science Foundation of China,No.82071272(to YZ).
文摘Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions.
基金supported by the Natural Science Foundation of China(22106007 and U23A20120)Beijing Natural Science Foundation(8244060)+2 种基金China Postdoctoral Science Foundation(2023M730143)R&D Program of BeijingMunicipal Education Commission(KZ202210005011)Natural Science Foundation of Hebei Province(B2021208033).
文摘Due to the greenhouse effect caused by carbon dioxide(CO_(2))emission,much attention has been paid for the removal of CO_(2).Porous liquids(PLs),as new type of liquid materials,have obvious advantages in mass and heat transfer,which are widely used in gas adsorption and sep-aration.Metal–organic frameworks(MOFs)with merits like large surface area,inherent porous structure and adjustable topology have been considered as one of the best candidates for PLs construction.This review presents the state-of-the-art status on the fabrication strategy of MOFs-based PLs and their CO_(2) absorption and utilization performance,and the positive effects of porosity and functional modification on the absorption-desorption property,selectivity of target product,and regeneration ability are well summarized.Finally,the challenges and prospects for MOFs-based PLs in the optimization of preparation,the coupling of multiple removal techniques,the in situ characterization methods,the regeneration and cycle stability,the environmental impact as well as expansion of application are proposed.
基金support of the Natural Science Foundation of Heilongjiang Province of China(No.LH2023E059)the National Natural Science Foundation of China(No.52071093)the Opening Project of Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology(No.ASMA202205).
文摘Although the Mg-air battery with high theoretical energy density is desirable for the energy supply of marine engineering equipment,its applications remain limited due to the low actual discharge voltage and inferior Mg anode utilization rate.In addition to the microstructure of Mg alloy anodes,the properties of discharge product films are of great importance to the discharge performance.Herein,the discharge behaviors of Mg-Y-Zn alloys are first studied mainly from the perspective of film properties.Through contrastive analysis,it is found that the sufficient Y^(3+) produced during the discharge process can substitute Mg^(2+) in Mg(OH)_(2) to introduce effective cation vacancies.The Mg-Y-Zn anode with profuse cation vacancies in the product film shows a synergy of potential and efficiency,and this can be attributed to an increase in the migration pathway for Mg^(2+),reducing the diffusion over-potential caused by the protective product film.This study is expected to provide a new strategy from the perspective of cation vacancy design of discharge film for developing high-performance Mg-air batteries.
