A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis.However,there is still a limited u...A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis.However,there is still a limited understanding of the in vivo glucose uptake and distribution across the human skeleton.To address this issue,we aimed to elucidate the detailed profile of glucose uptake across the skeleton using a total-body positron emission tomography(PET)scanner.A total of 41 healthy participants were recruited.Two of them received a 1-hour dynamic total-body^(18)F-fluorodeoxyglucose(^(18)F-FDG)PET scan,and all of them received a10-minute static total-body^(18)F-FDG PET scan.The net influx rate(K_i)and standardized uptake value normalized by lean body mass(SUL)were calculated as indicators of glucose uptake from the dynamic and static PET data,respectively.The results showed that the vertebrae,hip bone and skull had relatively high Kiand SUL values compared with metabolic organs such as the liver.Both the K_(i) and SUL were higher in the epiphyseal,metaphyseal and cortical regions of long bones.Moreover,trends associated with age and overweight with glucose uptake(SUL_(max)and SUL_(mean))in bones were uncovered.Overall,these results indicate that the skeleton is a site with significant glucose uptake,and skeletal glucose uptake can be affected by age and dysregulated metabolism.展开更多
The cause of obstructive jaundice is usually complex which renders its differential diagnosis and lesion localization challenging in clinical practice.Integrated Positron Emission tomography/Magnetic Resonance(PET/MR)...The cause of obstructive jaundice is usually complex which renders its differential diagnosis and lesion localization challenging in clinical practice.Integrated Positron Emission tomography/Magnetic Resonance(PET/MR)offers complementary information from PET and MR in the diagnosis of obstructive jaundice and is becoming widely adopted in clinical setting.While preserving its diagnostic accuracy,it is important to standardize and streamline the clinical scan protocol of PET/MR in evaluating obstructive jaundice.Based on literature review and experience of large number of clinical cases from the author group,this article reports an expert consensus on imaging protocol optimization and case interpretation template standardization.展开更多
Background:Brain metastases are frequent complications for lung cancer patients.However,changes in the brain of lung cancer patients have received little attention.We aimed to explore whether alterations in brain gluc...Background:Brain metastases are frequent complications for lung cancer patients.However,changes in the brain of lung cancer patients have received little attention.We aimed to explore whether alterations in brain glucose uptake and brain texture occur in non-small cell lung cancer(NSCLC)patients and to investigate associations between brain alterations and NSCLC via the uEXPLORER positron emission tomography/computed tomography(PET/CT)system.Methods:In total,105 participants were enrolled,including 55 healthy con-trols and 50 NSCLC patients.Images were acquired using the PET/CT system.Standardized uptake values normalized by lean body mass were calculated as indicators of glucose uptake.Correlation analysis was conducted between aberrant brain glucose uptake,glucose uptake of cancer lesions,and con-centrations of serum lung cancer markers.Radiomics was used to investigate whether features extracted from regions with altered brain glucose uptake could serve as biomarkers of lung cancer progression.Results:Compared with healthy controls,NSCLC patients showed decreased standardized uptake values normalized by lean body mass in the left insula,medial frontal gyrus,and anterior cingulate.Correlation analysis demon-strated that glucose uptake of the anterior cingulate was negatively correlated with serum lung cancer marker concentrations.Radiomic features on PET/CT images of the above brain regions could classify NSCLC patients and healthy controls with an accuracy of 79%.Conclusions:NSCLC patients exhibited altered brain glucose uptake and changes in brain textures.These alterations may reflect alterations in behav-ioral domains in NSCLC and may be related to altered lung-brain interactions and potential brain metastasis of NSCLC.展开更多
Glucose uptake differs in organs and tissues across the human body.To date,however,there has been no single atlas providing detailed glucose uptake profiles across the entire human body.Therefore,we aimed to generate ...Glucose uptake differs in organs and tissues across the human body.To date,however,there has been no single atlas providing detailed glucose uptake profiles across the entire human body.Therefore,we aimed to generate a detailed profile of glucose uptake across the entire human body using the uEXPLORER positron emission tomography/computed tomography scanner,which offers the opportunity to collect glucose metabolic imaging quickly and simultaneously in all sites of the body.The standardized uptake value normalized by lean body mass(SUL)of 18F-fluorodeoxyglucose was used as a measure of glucose uptake.We developed a fingerprint of glucose uptake reflecting the mean SULs of major organs and parts across the entire human body in 15 healthy-weight and 18 overweight subjects.Using the segmentation of organs and body parts from the atlas,we uncovered the significant impacts of age,sex,and obesity on glucose uptake in organs and parts across the entire body.A difference was recognized between the right and left side of the body.Overall,we generated a total-body glucose uptake atlas that could be used as the reference for the diagnosis and evaluation of disordered states involving dysregulated glucose metabolism.展开更多
基金supported by the Science and Technology Funding from Jinan (grant number:2020GXRC018)the Academic Promotion Program of Shandong First Medical University (grant number:2019QL009)the Taishan Scholars Program of Shandong Province (grant number:TS201712065)。
文摘A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis.However,there is still a limited understanding of the in vivo glucose uptake and distribution across the human skeleton.To address this issue,we aimed to elucidate the detailed profile of glucose uptake across the skeleton using a total-body positron emission tomography(PET)scanner.A total of 41 healthy participants were recruited.Two of them received a 1-hour dynamic total-body^(18)F-fluorodeoxyglucose(^(18)F-FDG)PET scan,and all of them received a10-minute static total-body^(18)F-FDG PET scan.The net influx rate(K_i)and standardized uptake value normalized by lean body mass(SUL)were calculated as indicators of glucose uptake from the dynamic and static PET data,respectively.The results showed that the vertebrae,hip bone and skull had relatively high Kiand SUL values compared with metabolic organs such as the liver.Both the K_(i) and SUL were higher in the epiphyseal,metaphyseal and cortical regions of long bones.Moreover,trends associated with age and overweight with glucose uptake(SUL_(max)and SUL_(mean))in bones were uncovered.Overall,these results indicate that the skeleton is a site with significant glucose uptake,and skeletal glucose uptake can be affected by age and dysregulated metabolism.
基金supported by grants from the Shanghai Municipal Key Clinical Specialty Project(SHSLCZDZK03401)Shanghai Science and Technology Project(19DZ1930700)+1 种基金the Shanghai Science and Technology Committee Program(20DZ2201800)the Three-year Action Plan of Clinical Skills and Innovation of Shanghai Hospital Development Center(SHDC2020CR3079B).
文摘The cause of obstructive jaundice is usually complex which renders its differential diagnosis and lesion localization challenging in clinical practice.Integrated Positron Emission tomography/Magnetic Resonance(PET/MR)offers complementary information from PET and MR in the diagnosis of obstructive jaundice and is becoming widely adopted in clinical setting.While preserving its diagnostic accuracy,it is important to standardize and streamline the clinical scan protocol of PET/MR in evaluating obstructive jaundice.Based on literature review and experience of large number of clinical cases from the author group,this article reports an expert consensus on imaging protocol optimization and case interpretation template standardization.
基金Taishan Scholar Project of Shandong Province,Grant/Award Number:TS201712065Chinese Polar Environment Comprehensive Investigation and Assessment Programmes,Grant/Award Number:2021YFE0204600Science and Technology Development Plan of Shandong Province,Grant/Award。
文摘Background:Brain metastases are frequent complications for lung cancer patients.However,changes in the brain of lung cancer patients have received little attention.We aimed to explore whether alterations in brain glucose uptake and brain texture occur in non-small cell lung cancer(NSCLC)patients and to investigate associations between brain alterations and NSCLC via the uEXPLORER positron emission tomography/computed tomography(PET/CT)system.Methods:In total,105 participants were enrolled,including 55 healthy con-trols and 50 NSCLC patients.Images were acquired using the PET/CT system.Standardized uptake values normalized by lean body mass were calculated as indicators of glucose uptake.Correlation analysis was conducted between aberrant brain glucose uptake,glucose uptake of cancer lesions,and con-centrations of serum lung cancer markers.Radiomics was used to investigate whether features extracted from regions with altered brain glucose uptake could serve as biomarkers of lung cancer progression.Results:Compared with healthy controls,NSCLC patients showed decreased standardized uptake values normalized by lean body mass in the left insula,medial frontal gyrus,and anterior cingulate.Correlation analysis demon-strated that glucose uptake of the anterior cingulate was negatively correlated with serum lung cancer marker concentrations.Radiomic features on PET/CT images of the above brain regions could classify NSCLC patients and healthy controls with an accuracy of 79%.Conclusions:NSCLC patients exhibited altered brain glucose uptake and changes in brain textures.These alterations may reflect alterations in behav-ioral domains in NSCLC and may be related to altered lung-brain interactions and potential brain metastasis of NSCLC.
基金supported by the“Outstanding University Driven by Talents”Program and Academic Promotion Program of Shandong First Medical University(2020LJ002 and 2019QL009)the Taishan Scholars Program of Shandong Province(TS201712065).
文摘Glucose uptake differs in organs and tissues across the human body.To date,however,there has been no single atlas providing detailed glucose uptake profiles across the entire human body.Therefore,we aimed to generate a detailed profile of glucose uptake across the entire human body using the uEXPLORER positron emission tomography/computed tomography scanner,which offers the opportunity to collect glucose metabolic imaging quickly and simultaneously in all sites of the body.The standardized uptake value normalized by lean body mass(SUL)of 18F-fluorodeoxyglucose was used as a measure of glucose uptake.We developed a fingerprint of glucose uptake reflecting the mean SULs of major organs and parts across the entire human body in 15 healthy-weight and 18 overweight subjects.Using the segmentation of organs and body parts from the atlas,we uncovered the significant impacts of age,sex,and obesity on glucose uptake in organs and parts across the entire body.A difference was recognized between the right and left side of the body.Overall,we generated a total-body glucose uptake atlas that could be used as the reference for the diagnosis and evaluation of disordered states involving dysregulated glucose metabolism.
