Recent years have witnessed the wide contributions made by transition metal dichalcogenides(TMDCs)to various fields, including the biomedical field. Here, to identify and further promote the development of biomedical ...Recent years have witnessed the wide contributions made by transition metal dichalcogenides(TMDCs)to various fields, including the biomedical field. Here, to identify and further promote the development of biomedical TMDCs, we provide a bibliometric analysis of literature regarding TMDCs for biomedical applications. Firstly, general bibliometric distributions of the dataset by year, country, institute, Web of Science category and referenced source are recognized. Following, we carefully explore the research hotspots of the TMDC-related biomedical field, among which biosensing, bioelectronics, cancer theranostics, antibacterial and tissue engineering are identified. The functions of TMDCs in each biomedical scenario, the related properties and research challenges are highlighted. Finally, future prospects are proposed to shed light on the design of novel TMDC-related biomaterials, potential new biomedical applications, as well as their clinical translation.展开更多
Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the...Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.展开更多
Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white(i.e.,correlated color temperature,4000 K)with good color rendition(i.e.,color rendering index.80).However,no single-phosphor...Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white(i.e.,correlated color temperature,4000 K)with good color rendition(i.e.,color rendering index.80).However,no single-phosphor,single-emitting-center-converted white light-emitting diodes can simultaneously satisfy the color temperature and rendition requirements due to the lack of sufficient red spectral component in the phosphors’emission spectrum.Here,we report a new yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor that has a new orthorhombic lattice structure and exhibits a broad yellow photoluminescence band with sufficient red spectral component.Warm-white emissions with correlated color temperature,4000 K and color rendering index.80 were readily achieved when combining the Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor with a blue light-emitting diode(440–470 nm).This study demonstrates that warm-white light-emitting diodes with high color rendition(i.e.,color rendering index.80)can be achieved based on single-phosphor,single-emitting-center conversion.展开更多
Manufactured nanomaterials with unique properties have been extensively applied in various indus-trial,agricultural or medical fields.However,some of the properties have been identified to be closely related to nanoma...Manufactured nanomaterials with unique properties have been extensively applied in various indus-trial,agricultural or medical fields.However,some of the properties have been identified to be closely related to nanomaterial toxicity.The"nano-paradox"has aroused concerns over the use and develop-ment of nanotechnology,which makes it difficult for regulatory agencies to regulate nanomaterials.The key to fulfilling proper nanomaterial regulation lies in the adequate understanding of the impact of nanomaterial properties on nano-bio interactions.To this end,we start the present work with a brief intro-duction to nano-bio interactions at different levels.Based on that,how key toxicity-associated properties of manufactured nanomaterials(i.e.,size,shape,chemical composition,surface properties,biocorona formation,agglomeration and/or aggregation state,and biodegradability)impact their toxicokinetics,cel-lular uptake,trafficking and responses,and toxicity mechanisms is deeply explored.Moreover,advanced analytical methods for studying nano-bio interactions are introduced.Furthermore,the current reg-ulatory and legislative frameworks for nanomaterial-containing products in different regions and/or countries are presented.Finally,we propose several challenges facing the nanotoxicology field and their possible solutions to shed light on the safety evaluation of nanomaterials.展开更多
An upconversion nanocomposite containing photothermal material that can be served as an ideal probe to real-time monitor microscopic temperature during photothermal therapy(PTT)in biological system was described in a ...An upconversion nanocomposite containing photothermal material that can be served as an ideal probe to real-time monitor microscopic temperature during photothermal therapy(PTT)in biological system was described in a paper on Nature Communications[1].This temperature-feedback upconversion nanocomposite is shown to be able to reach high temperature at microscopic scale as to implement PTT for cancer treatment while keeping the temperature of lesion at low level to prevent damage to normal tissue in real biosystems.展开更多
Scintillating materials, which can convert high energy X-ray radiation into visible luminescence [1], are crucial parts of Xray imaging technology. Since the discovery of X-ray in 1895, scintillating materials have wi...Scintillating materials, which can convert high energy X-ray radiation into visible luminescence [1], are crucial parts of Xray imaging technology. Since the discovery of X-ray in 1895, scintillating materials have witnessed wild applications in various fields, including security inspection, space exploration, nondestructive detection, and medical diagnostics [2,3]- Conventional scintillators are generally large inorganic crystals and can only be grown at high temperature, which significantly increases the manufacturing difficulty and cost. The luminescence of current crystal scintillators is usually limited by lowefficiency or afterglow effects, and is difficult to be tuned cross the visible spectrum. As traditional scintillators have reached their performance limits, exploration of new scintillators has become a crucial topic considering the increased demands of X-ray imaging and detection technology [4-6].展开更多
Near infrared(NIR) light-driven nitric oxide(NO) release nano-platform based on upconversion nanoparticles(UCNPs) and light sensitive NO precursor Roussin's black salt(RBS) was fabricated to generate NO upon 808 n...Near infrared(NIR) light-driven nitric oxide(NO) release nano-platform based on upconversion nanoparticles(UCNPs) and light sensitive NO precursor Roussin's black salt(RBS) was fabricated to generate NO upon 808 nm irradiation. The application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. The combination of UCNPs and RBS could realize the on-demand release of NO at desired time and location by simply controlling the output of NIR laser.Cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells(CSCs)rather than non-CSCs. Therefore, a synergistic cancer therapy strategy to eradicate both CSCs and nonCSCs simultaneously was developed. Traditional chemo-drug could inhibit non-CSCs but has low killing efficiency in CSCs. However, we found that the combination of NO and chemotherapy could efficiently inhibit CSCs in bulk cells, including inhibiting mammosphere formation ability, decreasing CD44^+/CD24^- subpopulation and reducing tumorigenic ability. The mechanism studies confirmed that NO could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in CSCs. This UCNPsbased platform may provide a new combinatorial strategy of NO and chemotherapy to improve cancer treatment.展开更多
The human cornea is exposed directly to particulate matter （PM） in polluted air. This exposure can cause eye discomfort and corneal injury. Ultrafine PM （diameter ~100 nm） is thought to be particularly harmful to ...The human cornea is exposed directly to particulate matter （PM） in polluted air. This exposure can cause eye discomfort and corneal injury. Ultrafine PM （diameter ~100 nm） is thought to be particularly harmful to health, but there is limited research investigating its toxicity to the eye. In this study, we evaluated toxiciW differences among 30-, 40-, 100- and 150-nm silicon dioxide nanoparticles （Si02 NPs） on the cornea. A 24-hour in vitro exposure of primary human corneal epithelial cells （hCECs） to ultrafine （30 and 40 nm） SiO2 NPs produced toxicity, as evidenced by cell membrane damage, reduced cell viability, increased cell death and mitochondrial dysfunction. In vivo exposure to the same nanoparticles produced observable corneal injury. These effects were more severe with ultrafine than with fine （100 and 150 nm） Si02 NPs. Common antioxidant compounds, e.g., glutathione, did not protect the cornea from SiO2 NP-induced damage. However, foetal bovine serum （FBS） did significantly reduce toxicity, likely by forming a protective protein corona around the nanoparticles. This finding suggests that FBS （or its derivatives） may be a useful clinical therapy for corneal toxicity caused by ultrafine particulates.展开更多
A method to enhance the limitation of synergistic chemodrugs based on nanomedicine delivering to tumors was proposed in a recent paper published in Nature Nanotechnology[1].This research not only improves current fron...A method to enhance the limitation of synergistic chemodrugs based on nanomedicine delivering to tumors was proposed in a recent paper published in Nature Nanotechnology[1].This research not only improves current front-line combination therapies for multiple myeloma(MM),but also offers a novel design idea for nanomedicine of other diseases.展开更多
Long-term pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) may promote breast cancer metastasis and rapid colonization in the lungs and other organs according to recent research conducted by Prof.Chunying ...Long-term pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) may promote breast cancer metastasis and rapid colonization in the lungs and other organs according to recent research conducted by Prof.Chunying Chen,Prof.Tao Zhu and their colleagues,published in Nature Nanotechnology [1].展开更多
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences (No. XDB36000000)the National Basic Research Program of China (Nos. 2020YFA0710702 and 2016YFA2021600)+2 种基金the National Natural Science Foundation of China (Nos. 51822207, 51772292 and 11621505)Chinese Academy of Sciences Youth Innovation Promotion Association (No. 2013007)CAS-Iranian Vice Presidency for Science and Technology Joint Research Project (No. 113111KYSB20190067)。
文摘Recent years have witnessed the wide contributions made by transition metal dichalcogenides(TMDCs)to various fields, including the biomedical field. Here, to identify and further promote the development of biomedical TMDCs, we provide a bibliometric analysis of literature regarding TMDCs for biomedical applications. Firstly, general bibliometric distributions of the dataset by year, country, institute, Web of Science category and referenced source are recognized. Following, we carefully explore the research hotspots of the TMDC-related biomedical field, among which biosensing, bioelectronics, cancer theranostics, antibacterial and tissue engineering are identified. The functions of TMDCs in each biomedical scenario, the related properties and research challenges are highlighted. Finally, future prospects are proposed to shed light on the design of novel TMDC-related biomaterials, potential new biomedical applications, as well as their clinical translation.
基金supported by the National Natural Science Foundation of China (11621505, 11435002, 31671016)
文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.
基金ZWP acknowledges funding by the US National Science Foundation(CAREER DMR-0955908)ZJG acknowledges support by the National Basic Research Programs of China(973 program,No.2012CB932504)+4 种基金JDB was supported by the Materials Sciences and Engineering Division,Office of Basic Energy Sciences(BES),US Department of Energy(DOE).Use of the APS beamline 11-BM-B for synchrotron X-ray powder diffractionbeamline 34-ID-E for polychromatic Laue microdiffraction was supported by the Scientific User Facilities Division of BES,US DOE.Use of the APS beamline 20-BM-B for X-ray absorption near edge structure measurement by CJS was supported by US DOE under Contract no.DE-AC02-06CH11357 with Argonne National Laboratory.The TEM characterization was sponsored by Oak Ridge National Laboratory’s Shared Research Equipment(ShaRE)User program,which is sponsored by the Division of Scientific User Facilities of BES,US DOE.
文摘Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white(i.e.,correlated color temperature,4000 K)with good color rendition(i.e.,color rendering index.80).However,no single-phosphor,single-emitting-center-converted white light-emitting diodes can simultaneously satisfy the color temperature and rendition requirements due to the lack of sufficient red spectral component in the phosphors’emission spectrum.Here,we report a new yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor that has a new orthorhombic lattice structure and exhibits a broad yellow photoluminescence band with sufficient red spectral component.Warm-white emissions with correlated color temperature,4000 K and color rendering index.80 were readily achieved when combining the Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor with a blue light-emitting diode(440–470 nm).This study demonstrates that warm-white light-emitting diodes with high color rendition(i.e.,color rendering index.80)can be achieved based on single-phosphor,single-emitting-center conversion.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(grant No.XDB36000000)the National Basic Research Program of China(grant No.2020YFA0710702)the National Natural Science Foundation of China(grant Nos.51822207 and 51772292).
文摘Manufactured nanomaterials with unique properties have been extensively applied in various indus-trial,agricultural or medical fields.However,some of the properties have been identified to be closely related to nanomaterial toxicity.The"nano-paradox"has aroused concerns over the use and develop-ment of nanotechnology,which makes it difficult for regulatory agencies to regulate nanomaterials.The key to fulfilling proper nanomaterial regulation lies in the adequate understanding of the impact of nanomaterial properties on nano-bio interactions.To this end,we start the present work with a brief intro-duction to nano-bio interactions at different levels.Based on that,how key toxicity-associated properties of manufactured nanomaterials(i.e.,size,shape,chemical composition,surface properties,biocorona formation,agglomeration and/or aggregation state,and biodegradability)impact their toxicokinetics,cel-lular uptake,trafficking and responses,and toxicity mechanisms is deeply explored.Moreover,advanced analytical methods for studying nano-bio interactions are introduced.Furthermore,the current reg-ulatory and legislative frameworks for nanomaterial-containing products in different regions and/or countries are presented.Finally,we propose several challenges facing the nanotoxicology field and their possible solutions to shed light on the safety evaluation of nanomaterials.
文摘An upconversion nanocomposite containing photothermal material that can be served as an ideal probe to real-time monitor microscopic temperature during photothermal therapy(PTT)in biological system was described in a paper on Nature Communications[1].This temperature-feedback upconversion nanocomposite is shown to be able to reach high temperature at microscopic scale as to implement PTT for cancer treatment while keeping the temperature of lesion at low level to prevent damage to normal tissue in real biosystems.
文摘Scintillating materials, which can convert high energy X-ray radiation into visible luminescence [1], are crucial parts of Xray imaging technology. Since the discovery of X-ray in 1895, scintillating materials have witnessed wild applications in various fields, including security inspection, space exploration, nondestructive detection, and medical diagnostics [2,3]- Conventional scintillators are generally large inorganic crystals and can only be grown at high temperature, which significantly increases the manufacturing difficulty and cost. The luminescence of current crystal scintillators is usually limited by lowefficiency or afterglow effects, and is difficult to be tuned cross the visible spectrum. As traditional scintillators have reached their performance limits, exploration of new scintillators has become a crucial topic considering the increased demands of X-ray imaging and detection technology [4-6].
基金supported by the National Basic Research Program of China(2016YFA2021600,2016YFA0202104,and2015CB932104)the National Natural Science Foundation of China(31571015,11621505,and 21320102003)Chinese Academy of Sciences Youth Innovation Promotion Association(2013007)
文摘Near infrared(NIR) light-driven nitric oxide(NO) release nano-platform based on upconversion nanoparticles(UCNPs) and light sensitive NO precursor Roussin's black salt(RBS) was fabricated to generate NO upon 808 nm irradiation. The application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. The combination of UCNPs and RBS could realize the on-demand release of NO at desired time and location by simply controlling the output of NIR laser.Cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells(CSCs)rather than non-CSCs. Therefore, a synergistic cancer therapy strategy to eradicate both CSCs and nonCSCs simultaneously was developed. Traditional chemo-drug could inhibit non-CSCs but has low killing efficiency in CSCs. However, we found that the combination of NO and chemotherapy could efficiently inhibit CSCs in bulk cells, including inhibiting mammosphere formation ability, decreasing CD44^+/CD24^- subpopulation and reducing tumorigenic ability. The mechanism studies confirmed that NO could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in CSCs. This UCNPsbased platform may provide a new combinatorial strategy of NO and chemotherapy to improve cancer treatment.
基金supported by the National Key R&D program of China(2018YFA0107302,2016YFA0201600)the National Natural Science Foundation of China(81570890)the Foundation of Southwest Hospital(SWH2016LHYS-03)
文摘The human cornea is exposed directly to particulate matter （PM） in polluted air. This exposure can cause eye discomfort and corneal injury. Ultrafine PM （diameter ~100 nm） is thought to be particularly harmful to health, but there is limited research investigating its toxicity to the eye. In this study, we evaluated toxiciW differences among 30-, 40-, 100- and 150-nm silicon dioxide nanoparticles （Si02 NPs） on the cornea. A 24-hour in vitro exposure of primary human corneal epithelial cells （hCECs） to ultrafine （30 and 40 nm） SiO2 NPs produced toxicity, as evidenced by cell membrane damage, reduced cell viability, increased cell death and mitochondrial dysfunction. In vivo exposure to the same nanoparticles produced observable corneal injury. These effects were more severe with ultrafine than with fine （100 and 150 nm） Si02 NPs. Common antioxidant compounds, e.g., glutathione, did not protect the cornea from SiO2 NP-induced damage. However, foetal bovine serum （FBS） did significantly reduce toxicity, likely by forming a protective protein corona around the nanoparticles. This finding suggests that FBS （or its derivatives） may be a useful clinical therapy for corneal toxicity caused by ultrafine particulates.
文摘A method to enhance the limitation of synergistic chemodrugs based on nanomedicine delivering to tumors was proposed in a recent paper published in Nature Nanotechnology[1].This research not only improves current front-line combination therapies for multiple myeloma(MM),but also offers a novel design idea for nanomedicine of other diseases.
文摘Long-term pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) may promote breast cancer metastasis and rapid colonization in the lungs and other organs according to recent research conducted by Prof.Chunying Chen,Prof.Tao Zhu and their colleagues,published in Nature Nanotechnology [1].
