Effects of -carboxyethylgermanium sesquioxide (Ge-132) on the function of antioxidative system of cow and the relationship among autioxidative elements Ge, selenium (Se), copper(Cu) and zinc(Zn) were studied for thre...Effects of -carboxyethylgermanium sesquioxide (Ge-132) on the function of antioxidative system of cow and the relationship among autioxidative elements Ge, selenium (Se), copper(Cu) and zinc(Zn) were studied for three months. 25 cow fed on the same basal diet were randomly divided into 5 groups, 5 for each group. Group was used as the control. Investigated elements were administered to the following animals, group : Ge132;Group :Ge-132 and Se; Group : Ge-132, Se and Zn; Group : Ge-132, Se,Zn and Cu. Blood samples were collected at regular intervals to examine the activities of serum GSH-Px,CuZn-SOD, and the contents of serum MDA, and Ge, Se, Zn, Cu in whole blood. The results indicated that the activities of serum GSH-Px and CuZn-SOD in group , , were significantly higher than those in group (P< 001),but the content of serum MDA significantly lower( P <001). There was a significantly positive correlation between the content of blood Ge and the activities of serum GSH-Px, Cu Zn-SOD(r=04997 and r=02502), but a negative correlation between the content of blood Ge and serum MDA(r=02996). The activity of serum GSH-Px in group was significantly higher than that in group . There was a significantly positive correlation be tween the content of blood Ge and Se. It can be concluded that Ge-132 and Se synergically played an important role in resisting peroxidation and scanvenging free radicals in cow.展开更多
文摘Effects of -carboxyethylgermanium sesquioxide (Ge-132) on the function of antioxidative system of cow and the relationship among autioxidative elements Ge, selenium (Se), copper(Cu) and zinc(Zn) were studied for three months. 25 cow fed on the same basal diet were randomly divided into 5 groups, 5 for each group. Group was used as the control. Investigated elements were administered to the following animals, group : Ge132;Group :Ge-132 and Se; Group : Ge-132, Se and Zn; Group : Ge-132, Se,Zn and Cu. Blood samples were collected at regular intervals to examine the activities of serum GSH-Px,CuZn-SOD, and the contents of serum MDA, and Ge, Se, Zn, Cu in whole blood. The results indicated that the activities of serum GSH-Px and CuZn-SOD in group , , were significantly higher than those in group (P< 001),but the content of serum MDA significantly lower( P <001). There was a significantly positive correlation between the content of blood Ge and the activities of serum GSH-Px, Cu Zn-SOD(r=04997 and r=02502), but a negative correlation between the content of blood Ge and serum MDA(r=02996). The activity of serum GSH-Px in group was significantly higher than that in group . There was a significantly positive correlation be tween the content of blood Ge and Se. It can be concluded that Ge-132 and Se synergically played an important role in resisting peroxidation and scanvenging free radicals in cow.
