IN photodynamic therapy, the damage of protein results from the photooxidation of one ormore of only five amino acid residues (tryptophanyl, tyrosyl, histidyl, methionyl and cys-teinyl). These five amino acids are als...IN photodynamic therapy, the damage of protein results from the photooxidation of one ormore of only five amino acid residues (tryptophanyl, tyrosyl, histidyl, methionyl and cys-teinyl). These five amino acids are also readily photooxidized in their monomeric states. How-ever, the reaction kinetics and mechanisms of free amino acids and bound amino acid residuesin proteins are somewhat different. For example, Tassin found that the incorporation of tryp-tophan into a peptide linkage dramatically altered its susceptibility to photooxidation as well展开更多
文摘IN photodynamic therapy, the damage of protein results from the photooxidation of one ormore of only five amino acid residues (tryptophanyl, tyrosyl, histidyl, methionyl and cys-teinyl). These five amino acids are also readily photooxidized in their monomeric states. How-ever, the reaction kinetics and mechanisms of free amino acids and bound amino acid residuesin proteins are somewhat different. For example, Tassin found that the incorporation of tryp-tophan into a peptide linkage dramatically altered its susceptibility to photooxidation as well
