The flow around the ship bow involves complex three-dimensional flow separation,leading to the generation of a large number of bubbles.These bubbles have a significant impact on acoustic instrumentation,and mitigating...The flow around the ship bow involves complex three-dimensional flow separation,leading to the generation of a large number of bubbles.These bubbles have a significant impact on acoustic instrumentation,and mitigating their effects has become a key focus in the field.Central to this issue is understanding the bubble generation mechanism near the bow.This study investigates the generation of bubbles in the bow region through a com-bination of physical experiments and numerical simulations.Experiments were conducted in a wind-wavecurrent circulating flume under controlled laboratory conditions.Qualitative observations of bubble phenom-ena near the bow were carried out,complemented by numerical simulations to examine the statistical charac-teristics of bubble distribution.Two distinct types of bubble generation were identified in the experiments:air entrainment due to vortex formation and bubble clouds caused by wave breaking.The former is primarily influenced by hull geometry and the turbulence intensity of the incoming flow,whereas the latter is strongly affected by wave parameters and hull motion.Numerical simulations successfully reproduced bubble generation around the hull,revealing vortex entrainment and wave-breaking-induced bubble clouds.The bubble size-density distribution follows a power-law behavior,with the slope of the bubble density versus diameter distribution found to be-3.3.展开更多
Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role...Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear.展开更多
基金supported by Postdoctoral Innovation Fund of the Northwestern Polytechnical University Taicang Yangtze River Delta Research Institute(14005-5140250014,14005-5140250013)the Fundamental Research Funds for the Central Universities(D5000240079,D5000250321).
文摘The flow around the ship bow involves complex three-dimensional flow separation,leading to the generation of a large number of bubbles.These bubbles have a significant impact on acoustic instrumentation,and mitigating their effects has become a key focus in the field.Central to this issue is understanding the bubble generation mechanism near the bow.This study investigates the generation of bubbles in the bow region through a com-bination of physical experiments and numerical simulations.Experiments were conducted in a wind-wavecurrent circulating flume under controlled laboratory conditions.Qualitative observations of bubble phenom-ena near the bow were carried out,complemented by numerical simulations to examine the statistical charac-teristics of bubble distribution.Two distinct types of bubble generation were identified in the experiments:air entrainment due to vortex formation and bubble clouds caused by wave breaking.The former is primarily influenced by hull geometry and the turbulence intensity of the incoming flow,whereas the latter is strongly affected by wave parameters and hull motion.Numerical simulations successfully reproduced bubble generation around the hull,revealing vortex entrainment and wave-breaking-induced bubble clouds.The bubble size-density distribution follows a power-law behavior,with the slope of the bubble density versus diameter distribution found to be-3.3.
基金This work was supported by the National Natural Science Foundation(81972146 to Chengqi He)the Department of Science and Technology of Sichuan Province(20YYJC3320,2020YJ0210 to Chengqi He)+1 种基金West China Hospital of Sichuan University(ZYGD18018 and HX-20l9-nCoV-011to Chengqi He)West China Nursing Discipline Development Special Fund Project,Sichuan University(HXHL20001 to Chengqi He).
文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear.
