The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so far.However,there is no approved vaccine available for severe acute respiratory synd...The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so far.However,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative agent.Vaccine is the most effective approach to eradicate a pathogen.The tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human populations.Here we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human primates.Our data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested animals.In addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in mice.These results warranted positive outcomes in future clinical trials in humans.展开更多
Copper matrix composites(CMCs)offer promising applications by combining the functional characteristics of copper with composite phases.With the rapid advancement in aerospace,microelectronics,and intelligent terminal ...Copper matrix composites(CMCs)offer promising applications by combining the functional characteristics of copper with composite phases.With the rapid advancement in aerospace,microelectronics,and intelligent terminal engineering,the demand for CMCs with superior mechanical and electrical properties has become increasingly critical.This paper reviews the design principles,preparation methods,microstructures and properties of some typical CMCs.The existing form of composite phases in the Cu matrix and their effects on microstructure evolution and comprehensive properties are summarised.Key underlying mechanisms governing these enhancements are discussed.The results provide a systematic understanding of the relationship between reinforcement phases and properties,offering insights for the future development of CMCs aimed to achieve much better comprehensive properties.The paper concludes by outlining the development trends and future outlook for the application of CMCs.展开更多
Objective To determine whether co-administration of mixed steriod hormones can enhance the restoration of spermatogenesis damaged by gossypol acetic acid （GA）. Methods Adult male Wistar rats were treated daily for 8...Objective To determine whether co-administration of mixed steriod hormones can enhance the restoration of spermatogenesis damaged by gossypol acetic acid （GA）. Methods Adult male Wistar rats were treated daily for 8 weeks with GA at 50mg/kg plus testosterone undercanoate （100 mg/kg）/desogestrel （0.125 mg/kg）/mini-dose ethinylestradiol （0.025 mg/kg） （TU/DSG/EE）, followed by a period of 9 weeks for recovery. Control animals were administered the same dose of GA or TU/DSG/EE, and vehicle, respectively. Testis weight, testicular sperm head count and histological analysis were utilized to assess the spermatogenesis. Results At the end of the 9-week reovery period, in rats given GA alone, spermato- genesis steadily declined. However, when rats received combined hormone adminis- tration during GA treatment, this decline was prevented and an complete recovery of spermagenesis occurred. The haploid spermatids and spermatocytes was not to be protected but to be more aggravatedly damaged. The excellent recovery must have resulted from that the hormone treatment could protect the ability of stem spermatogonia to differentialte and evolve progressively into mature spermatozoa. In addition, the concentrations of serum LH, FSH and intratesticular testosteron （ITT） notably decreased after 2 or 8 weeks of treatment, then returned to control levels at the end of 9-week recovery period.Conclusion Steriod hormone treatment enhaces the recovery of spermatogenesis through preventing seminiferous epithelim from GA-induced destructive damage in rats. The enhanced recovery was closely associated with the marked suppression in intratesticular testosteron （ITT）.展开更多
Generating meaningful assert statements is one of the key challenges in automated test case generation,which requires understanding the intended functionality of the tested code.Recently,deep learning based models hav...Generating meaningful assert statements is one of the key challenges in automated test case generation,which requires understanding the intended functionality of the tested code.Recently,deep learning based models have shown promise in improving the performance of assert statement generation.However,the existing models only rely on the test prefixes along with their corresponding focal methods,yet ignore the developer-written summarization.Based on our observations,the summarization contents usually express the intended program behavior or contain parameters that will appear directly in the assert statement.Such information will help existing models address their current inability to accurately predict assert statements.This paper presents a summarization-guided approach for automatically generating assert statements.To derive generic representations for natural language(i.e.,summarization)and programming language(i.e.,test prefixes and focal methods),we leverage a pre-trained language model as the reference architecture and fine-tune it on the task of assert statement generation.To the best of our knowledge,the proposed approach makes the first attempt to leverage the summarization of focal methods as the guidance for making the generated assert statements more accurate.We demonstrate the effectiveness of our approach on two real-world datasets compared with state-of-the-art models.展开更多
This paper is devoted to the study of the proper setting of the boundary conditions for the boundary value problems of the hyperbolic-elliptic coupled systems of first order.The wellposedness of the corresponding boun...This paper is devoted to the study of the proper setting of the boundary conditions for the boundary value problems of the hyperbolic-elliptic coupled systems of first order.The wellposedness of the corresponding boundary value problems is also established.The Lopatinski conditions for the boundary value problems of the elliptic systems is then extended to the case for hyperbolic-elliptic coupled systems.The result in this paper can be applied to the Euler system in fluid dynamics,especially to give wellposed boundary value problems describing subsonic flow.展开更多
基金supported by the National Key R&D Program of China(2020YFC0842000 to Z.M.Yuan and 2020YFC0842100 to C.Shan)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29010101 to Z.L.Shi)+1 种基金the China Natural Science Foundation(82041013 to P.Zhou)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(CAS)(2019328 to X.L.Yang)。
文摘The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so far.However,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative agent.Vaccine is the most effective approach to eradicate a pathogen.The tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human populations.Here we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human primates.Our data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested animals.In addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in mice.These results warranted positive outcomes in future clinical trials in humans.
基金support by the Key-Area Research and Development Program of Guangdong Province,China(No.2024B0101080003)Hunan Provincial Natural Science Foundation of China(No.2024JJ2076)grants from the State Key Laboratory of Powder Metallurgy,Central South University,China.
文摘Copper matrix composites(CMCs)offer promising applications by combining the functional characteristics of copper with composite phases.With the rapid advancement in aerospace,microelectronics,and intelligent terminal engineering,the demand for CMCs with superior mechanical and electrical properties has become increasingly critical.This paper reviews the design principles,preparation methods,microstructures and properties of some typical CMCs.The existing form of composite phases in the Cu matrix and their effects on microstructure evolution and comprehensive properties are summarised.Key underlying mechanisms governing these enhancements are discussed.The results provide a systematic understanding of the relationship between reinforcement phases and properties,offering insights for the future development of CMCs aimed to achieve much better comprehensive properties.The paper concludes by outlining the development trends and future outlook for the application of CMCs.
基金supported by the National Natural Science Foundation of China (30760267)The grants under Inner Mongolia Health & Medical development foundation (2006-033)+1 种基金Colleges and Universities Scientific Research Projects of Inner Mongolia Education Department (NJ06015)Health and Medical Development Foundation of Baotou (20060-28)
文摘Objective To determine whether co-administration of mixed steriod hormones can enhance the restoration of spermatogenesis damaged by gossypol acetic acid （GA）. Methods Adult male Wistar rats were treated daily for 8 weeks with GA at 50mg/kg plus testosterone undercanoate （100 mg/kg）/desogestrel （0.125 mg/kg）/mini-dose ethinylestradiol （0.025 mg/kg） （TU/DSG/EE）, followed by a period of 9 weeks for recovery. Control animals were administered the same dose of GA or TU/DSG/EE, and vehicle, respectively. Testis weight, testicular sperm head count and histological analysis were utilized to assess the spermatogenesis. Results At the end of the 9-week reovery period, in rats given GA alone, spermato- genesis steadily declined. However, when rats received combined hormone adminis- tration during GA treatment, this decline was prevented and an complete recovery of spermagenesis occurred. The haploid spermatids and spermatocytes was not to be protected but to be more aggravatedly damaged. The excellent recovery must have resulted from that the hormone treatment could protect the ability of stem spermatogonia to differentialte and evolve progressively into mature spermatozoa. In addition, the concentrations of serum LH, FSH and intratesticular testosteron （ITT） notably decreased after 2 or 8 weeks of treatment, then returned to control levels at the end of 9-week recovery period.Conclusion Steriod hormone treatment enhaces the recovery of spermatogenesis through preventing seminiferous epithelim from GA-induced destructive damage in rats. The enhanced recovery was closely associated with the marked suppression in intratesticular testosteron （ITT）.
基金supported by the National Natural Science Foundation of China under Grant Nos.62072007,62192733,61832009,62192731,and 62192730.
文摘Generating meaningful assert statements is one of the key challenges in automated test case generation,which requires understanding the intended functionality of the tested code.Recently,deep learning based models have shown promise in improving the performance of assert statement generation.However,the existing models only rely on the test prefixes along with their corresponding focal methods,yet ignore the developer-written summarization.Based on our observations,the summarization contents usually express the intended program behavior or contain parameters that will appear directly in the assert statement.Such information will help existing models address their current inability to accurately predict assert statements.This paper presents a summarization-guided approach for automatically generating assert statements.To derive generic representations for natural language(i.e.,summarization)and programming language(i.e.,test prefixes and focal methods),we leverage a pre-trained language model as the reference architecture and fine-tune it on the task of assert statement generation.To the best of our knowledge,the proposed approach makes the first attempt to leverage the summarization of focal methods as the guidance for making the generated assert statements more accurate.We demonstrate the effectiveness of our approach on two real-world datasets compared with state-of-the-art models.
基金the National Natural Science Foundation of China(No.10531020)the National Basic Research Program of China 2006CB805902+1 种基金the Doctorial Foundation of National Educational Ministry 20050246001the 111 Project.
文摘This paper is devoted to the study of the proper setting of the boundary conditions for the boundary value problems of the hyperbolic-elliptic coupled systems of first order.The wellposedness of the corresponding boundary value problems is also established.The Lopatinski conditions for the boundary value problems of the elliptic systems is then extended to the case for hyperbolic-elliptic coupled systems.The result in this paper can be applied to the Euler system in fluid dynamics,especially to give wellposed boundary value problems describing subsonic flow.
