BACKGROUND Pancreatic cancer(PC),ranking among the most aggressive solid malignancies,currently lacks validated prognostic biomarkers to guide survival stratification.With a 5-year survival rate under 10%,this maligna...BACKGROUND Pancreatic cancer(PC),ranking among the most aggressive solid malignancies,currently lacks validated prognostic biomarkers to guide survival stratification.With a 5-year survival rate under 10%,this malignancy urgently requires precision tools for outcome prediction to optimize therapeutic decision-making.AIM To analyze whether the advanced lung cancer inflammation index(ALI)is a prognostic indicator for PC.METHODS Patients who were diagnosed with PC and underwent radical resection were included from January 2007 to January 2023 in a clinical center from National Cancer Center of China.The patients were divided into low and high ALI groups according to an ALI cut-off of 34.0 calculated with software X-tile.Overall survival(OS)and surgical outcomes were calculated between the two groups.Follow-up was conducted through telephone interview.Kaplan-Meier analysis was performed to estimate OS,while the log-rank test was utilized to compare OS among different tumor stages.Cox regression was used to identify independent risk factors for OS.RESULTS This study included 611 patients who underwent radical PC surgery.Using an ALI cutoff of 34.0,the patients were categorized into a high ALI group(n=378)and a low ALI group(n=233).The low ALI group had significantly lower body mass index,serum albumin,lymphocyte count,and ALI(P<0.01),but higher neutrophil count,a higher proportion of head and neck PC,and longer operation time(P<0.01).As for prognosis,the low ALI group had worse OS in stage I patients(P<0.01),and low ALI(P=0.018,hazard ratio=0.784,95%confidence interval:0.641-0.960)independently conferred an increased risk for mortality.CONCLUSION Lower ALI is associated with worse OS for PC patients who underwent radical surgery.Patients demonstrating low ALI preoperatively require special attention from surgeons.展开更多
BACKGROUND Gastric cancer(GC)and colorectal cancer(CRC)are the fifth and third most common cancer worldwide,respectively.Nowadays,GC is reported to have a potential predictive value for CRC,especially for advanced CRC...BACKGROUND Gastric cancer(GC)and colorectal cancer(CRC)are the fifth and third most common cancer worldwide,respectively.Nowadays,GC is reported to have a potential predictive value for CRC,especially for advanced CRC.AIM To evaluate the necessity of colonoscopy for gastric neoplasm(GN)patients.METHODS Four databases,including PubMed,EMBASE,the Cochrane Library,and Ovid,were used to perform the search strategy on May 2,2023.The prevalence of colorectal neoplasms(CRN)and baseline characteristics were compared between the neoplasm group and the control group.Continuous variables are expressed as the mean difference and standard deviation.Relationships of categorical variables in the two groups are expressed as odds ratios(OR)and 95%confidence intervals(95%CIs).Subgroup analysis according to different kinds of GNs was conducted for more in-depth analysis.The results of this study are represented by forest plots.Publication bias was evaluated by a funnel plot.All data analyses were performed by STATA SE 16.0 software.RESULTS A total of 3018 patients with GNs and 3905 healthy controls(age and sex matched)were enrolled for analysis.After comparing the prevalence of CRNs between the two groups,CRNs were detected significantly more frequently in GN patients than in controls(OR=1.69,95%CI=1.28 to 2.23,I^(2)=85.12%,P=0.00),especially in patients with GC(OR=1.80,95%CI=1.49 to 2.18,I^(2)=25.55%,P<0.1).Moreover,other risk factors including age(OR=1.08,95%CI=1.00 to 1.17,I^(2)=90.13%,P=0.00)and male sex(OR=2.31,95%CI=1.26 to 4.22,I^(2)=87.35%,P=0.00),were related to the prevalence of CRNs.For patients in the GN group,body mass index(BMI,OR=0.88,95%CI=0.80 to 0.98,I^(2)=0.00%,P=0.92)and smoking(OR=1.03,95%CI=1.01 to 1.05,I^(2)=0.00%,P=0.57)were protective and risk factors for CRNs,respectively.CONCLUSION Patients are recommended to undergo colonoscopy when diagnosed with GNs,especially GC patients with a low BMI and a history of smoking.展开更多
基金Supported by Special Research Fund for Central Universities,Peking Union Medical College,No.3332023024Beijing Hope Run Special Fund of Cancer Foundation of China,No.LC2021B20.
文摘BACKGROUND Pancreatic cancer(PC),ranking among the most aggressive solid malignancies,currently lacks validated prognostic biomarkers to guide survival stratification.With a 5-year survival rate under 10%,this malignancy urgently requires precision tools for outcome prediction to optimize therapeutic decision-making.AIM To analyze whether the advanced lung cancer inflammation index(ALI)is a prognostic indicator for PC.METHODS Patients who were diagnosed with PC and underwent radical resection were included from January 2007 to January 2023 in a clinical center from National Cancer Center of China.The patients were divided into low and high ALI groups according to an ALI cut-off of 34.0 calculated with software X-tile.Overall survival(OS)and surgical outcomes were calculated between the two groups.Follow-up was conducted through telephone interview.Kaplan-Meier analysis was performed to estimate OS,while the log-rank test was utilized to compare OS among different tumor stages.Cox regression was used to identify independent risk factors for OS.RESULTS This study included 611 patients who underwent radical PC surgery.Using an ALI cutoff of 34.0,the patients were categorized into a high ALI group(n=378)and a low ALI group(n=233).The low ALI group had significantly lower body mass index,serum albumin,lymphocyte count,and ALI(P<0.01),but higher neutrophil count,a higher proportion of head and neck PC,and longer operation time(P<0.01).As for prognosis,the low ALI group had worse OS in stage I patients(P<0.01),and low ALI(P=0.018,hazard ratio=0.784,95%confidence interval:0.641-0.960)independently conferred an increased risk for mortality.CONCLUSION Lower ALI is associated with worse OS for PC patients who underwent radical surgery.Patients demonstrating low ALI preoperatively require special attention from surgeons.
基金Supported by CQMU Program for Youth Innovation in Future Medicine,No.W0190.
文摘BACKGROUND Gastric cancer(GC)and colorectal cancer(CRC)are the fifth and third most common cancer worldwide,respectively.Nowadays,GC is reported to have a potential predictive value for CRC,especially for advanced CRC.AIM To evaluate the necessity of colonoscopy for gastric neoplasm(GN)patients.METHODS Four databases,including PubMed,EMBASE,the Cochrane Library,and Ovid,were used to perform the search strategy on May 2,2023.The prevalence of colorectal neoplasms(CRN)and baseline characteristics were compared between the neoplasm group and the control group.Continuous variables are expressed as the mean difference and standard deviation.Relationships of categorical variables in the two groups are expressed as odds ratios(OR)and 95%confidence intervals(95%CIs).Subgroup analysis according to different kinds of GNs was conducted for more in-depth analysis.The results of this study are represented by forest plots.Publication bias was evaluated by a funnel plot.All data analyses were performed by STATA SE 16.0 software.RESULTS A total of 3018 patients with GNs and 3905 healthy controls(age and sex matched)were enrolled for analysis.After comparing the prevalence of CRNs between the two groups,CRNs were detected significantly more frequently in GN patients than in controls(OR=1.69,95%CI=1.28 to 2.23,I^(2)=85.12%,P=0.00),especially in patients with GC(OR=1.80,95%CI=1.49 to 2.18,I^(2)=25.55%,P<0.1).Moreover,other risk factors including age(OR=1.08,95%CI=1.00 to 1.17,I^(2)=90.13%,P=0.00)and male sex(OR=2.31,95%CI=1.26 to 4.22,I^(2)=87.35%,P=0.00),were related to the prevalence of CRNs.For patients in the GN group,body mass index(BMI,OR=0.88,95%CI=0.80 to 0.98,I^(2)=0.00%,P=0.92)and smoking(OR=1.03,95%CI=1.01 to 1.05,I^(2)=0.00%,P=0.57)were protective and risk factors for CRNs,respectively.CONCLUSION Patients are recommended to undergo colonoscopy when diagnosed with GNs,especially GC patients with a low BMI and a history of smoking.
