Background The Dextroscope system by Volume Interactions （Singapore） had been applied to minimally invasive neurosurgery in many units. This system enables the neurosurgeon to interact intuitively with the three-dim...Background The Dextroscope system by Volume Interactions （Singapore） had been applied to minimally invasive neurosurgery in many units. This system enables the neurosurgeon to interact intuitively with the three-dimensional graphics in a direct manner resembling the way one communicates with the real objects. In the paper, we explored its values in pre-operation surgical planning for intracranial meningiomas resection. Methods Brain computed tomography （CT）, magnetic resonance imaging （MRI）, and magnetic resonance venography （MRV） were performed on 10 patients with parasagittal and falcine meningiomas located on central groove area; brain CT, MRI and magnetic resonance angiography （MIRA） were performed on 10 patients with anterior skull base meningiomas and 10 patients with sphenoid ridge meningiomas. All these data were transferred to Dextroscope virtual reality system, and reconstructed. Then meningiomas, skull base, brain tissue, drainage vein and cerebral arteries were displayed within the system, and their anatomic relationships were evaluated. Also, the simulation operations were performed. Results For parasagittal and falcine meningiomas, the relationships of tumor with drainage vein and superior sagittal sinus were clearly displayed in the Dextroscope system. For anterior skull base and sphenoid ridge meningiomas, the relationships of tumor with bilateral internal carotid arteries, anterior cerebral arteries, middle cerebral arteries and skull base were vividly displayed within the virtual reality system. Surgical planning and simulation operation of all cases were performed as well. The real operations of all patients were conducted according to the simulation with well outcomes. Conclusions According to the virtual reality planning, neurosurgeons could get more anatomic information about meningioma and its surrounding structures, especially important vessels, and choose the best approach for tumor resection, which would lead to better prognosis for patients.展开更多
Chordoid meningioma （CM）, characterized by its resemblance to chordoma, was first described by Kepes et al＇ in 1988, and classified histologically as a WHO grade II neoplasm in the 2000 revision of the WHO grading ...Chordoid meningioma （CM）, characterized by its resemblance to chordoma, was first described by Kepes et al＇ in 1988, and classified histologically as a WHO grade II neoplasm in the 2000 revision of the WHO grading system, featured by its aggressive clinical course, great risk of recurrence, and infrequent association with hematological conditions.2 This article describes the clinical course, radiological characteristics, postoperative treatment, and prognosis of 17 patients with CM who underwent surgical treatment at our hospital.展开更多
Background Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospec...Background Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospective analysis of the characteristics of meningioma cases consecutively operated on at a single institution in China from 2001 to 2010. Methods This study investigated the demographic background of 7084 meningioma cases, and the subtypes and locations of the tumors. Sex and age distributions were analyzed, and the pathological subtypes were classified according to the World Health Organization （WHO） classification. The location of the meningiomas was also categorized. Results The female：male ratio of the 7084 cases was 2.34：1. The mean age was 51.4 years （range, 11 months-86 years）. The mean age of cases of WHO grade I meningioma was significantly older than that of grade II or III meningiomas （P 〈0.001, Fisher＇s Least Significant Digit test）. There was a significantly higher female：male ratio in WHO grade I meningiomas than in grade II or grade III meningiomas （2.57, 1.03 and 0.76, respectively; P 〈0.001, X^2 test）. Meningothelial （n=2061） and fibrous meningiomas （n=3556） were the most common subtypes, comprising 79.3% of all meningiomas. All meningioma cases were classified into 23 locations in this study, with the cerebral convexity the most common site （38.33%, n=2722）. Cases with uncommon locations such as extra-cranial and sylvian fissure meningiomas were also present in this series. Conclusions Female predominance was found for benign meningiomas, while malignant subtypes showed male predominance. The mean age of patients with WHO grade Ⅰ meningiomas was older than that of patients with higher-grade tumors. Meningothelial and fibrous meningiomas were the most common subtypes. The cerebral convexity was the most common menin.qioma location.展开更多
目的探讨脑出血后锌指蛋白A20(A20)在脑和肺组织的表达以及在急性肺损伤中的作用。方法通过自体血尾状核注入法构建脑出血大鼠模型。雄性SD大鼠随机分为假手术对照组(n=12)和脑出血组(n=72),脑出血组再按时间点分为3、6、24、48、72和16...目的探讨脑出血后锌指蛋白A20(A20)在脑和肺组织的表达以及在急性肺损伤中的作用。方法通过自体血尾状核注入法构建脑出血大鼠模型。雄性SD大鼠随机分为假手术对照组(n=12)和脑出血组(n=72),脑出血组再按时间点分为3、6、24、48、72和168 h6个亚组(均n=12)o测定肺水肿、支气管肺泡灌洗液(BALF)总蛋白浓度,苏木精-伊红染色观察脑出血后脑组织和肺组织的周围炎症反应情况,免疫组化‘Western blot检测脑、肺组织中A20、核转录因子-kB(NF-kB)的表达。结果脑岀血后3 h出现肺水肿、BALF总蛋白浓度增加,48 h达到高峰(P<0.05);脑血肿周围组织72 h A20、NF-kB表达量达高峰(P<0.05);肺组织48 h A20、NF-kB表达量达高峰(P<0.05)o结论A20在脑出血后脑组织和肺组织中表达均有升高,提示A20可能在脑出血后急性肺损伤的发生发展过程中发挥作用。展开更多
基金This study was supported by grants from the National Natural Science Foundation of China （No. 30872675 and No. 30901549）, Shanghai Committee of Science and Technology （No. 08411965100）, and 2011 Shanghai Medical College Young Scientist Fund of Fudan University （No. 11L-24）.
文摘Background The Dextroscope system by Volume Interactions （Singapore） had been applied to minimally invasive neurosurgery in many units. This system enables the neurosurgeon to interact intuitively with the three-dimensional graphics in a direct manner resembling the way one communicates with the real objects. In the paper, we explored its values in pre-operation surgical planning for intracranial meningiomas resection. Methods Brain computed tomography （CT）, magnetic resonance imaging （MRI）, and magnetic resonance venography （MRV） were performed on 10 patients with parasagittal and falcine meningiomas located on central groove area; brain CT, MRI and magnetic resonance angiography （MIRA） were performed on 10 patients with anterior skull base meningiomas and 10 patients with sphenoid ridge meningiomas. All these data were transferred to Dextroscope virtual reality system, and reconstructed. Then meningiomas, skull base, brain tissue, drainage vein and cerebral arteries were displayed within the system, and their anatomic relationships were evaluated. Also, the simulation operations were performed. Results For parasagittal and falcine meningiomas, the relationships of tumor with drainage vein and superior sagittal sinus were clearly displayed in the Dextroscope system. For anterior skull base and sphenoid ridge meningiomas, the relationships of tumor with bilateral internal carotid arteries, anterior cerebral arteries, middle cerebral arteries and skull base were vividly displayed within the virtual reality system. Surgical planning and simulation operation of all cases were performed as well. The real operations of all patients were conducted according to the simulation with well outcomes. Conclusions According to the virtual reality planning, neurosurgeons could get more anatomic information about meningioma and its surrounding structures, especially important vessels, and choose the best approach for tumor resection, which would lead to better prognosis for patients.
基金This study was supported by-grants from the National Natural Science Foundation of China （No. 30872675 and No. 30901549）, and Science and Technology Commission of Shanghai Municipality （No. 08411965100 and No. 12JC1401800）. There is no conflict of interest in this manuscript and we strictly follow the protocols of ethical board and clinical practice in China.
文摘Chordoid meningioma （CM）, characterized by its resemblance to chordoma, was first described by Kepes et al＇ in 1988, and classified histologically as a WHO grade II neoplasm in the 2000 revision of the WHO grading system, featured by its aggressive clinical course, great risk of recurrence, and infrequent association with hematological conditions.2 This article describes the clinical course, radiological characteristics, postoperative treatment, and prognosis of 17 patients with CM who underwent surgical treatment at our hospital.
基金This work was supported by grants from the National Natural Science Foundation of China （No. 30872675 and No. 30901549）, and Science and Technology Commission of Shanghai Municipality （No. 08411965100 and No. 12JC 1401800）. Conflict of interest： none.
文摘Background Meningioma is one of the most common primary tumors of the central nervous system, but there are not many detailed studies on the sex, age, subtypes and locations of large series. This study was a retrospective analysis of the characteristics of meningioma cases consecutively operated on at a single institution in China from 2001 to 2010. Methods This study investigated the demographic background of 7084 meningioma cases, and the subtypes and locations of the tumors. Sex and age distributions were analyzed, and the pathological subtypes were classified according to the World Health Organization （WHO） classification. The location of the meningiomas was also categorized. Results The female：male ratio of the 7084 cases was 2.34：1. The mean age was 51.4 years （range, 11 months-86 years）. The mean age of cases of WHO grade I meningioma was significantly older than that of grade II or III meningiomas （P 〈0.001, Fisher＇s Least Significant Digit test）. There was a significantly higher female：male ratio in WHO grade I meningiomas than in grade II or grade III meningiomas （2.57, 1.03 and 0.76, respectively; P 〈0.001, X^2 test）. Meningothelial （n=2061） and fibrous meningiomas （n=3556） were the most common subtypes, comprising 79.3% of all meningiomas. All meningioma cases were classified into 23 locations in this study, with the cerebral convexity the most common site （38.33%, n=2722）. Cases with uncommon locations such as extra-cranial and sylvian fissure meningiomas were also present in this series. Conclusions Female predominance was found for benign meningiomas, while malignant subtypes showed male predominance. The mean age of patients with WHO grade Ⅰ meningiomas was older than that of patients with higher-grade tumors. Meningothelial and fibrous meningiomas were the most common subtypes. The cerebral convexity was the most common menin.qioma location.
文摘目的探讨脑出血后锌指蛋白A20(A20)在脑和肺组织的表达以及在急性肺损伤中的作用。方法通过自体血尾状核注入法构建脑出血大鼠模型。雄性SD大鼠随机分为假手术对照组(n=12)和脑出血组(n=72),脑出血组再按时间点分为3、6、24、48、72和168 h6个亚组(均n=12)o测定肺水肿、支气管肺泡灌洗液(BALF)总蛋白浓度,苏木精-伊红染色观察脑出血后脑组织和肺组织的周围炎症反应情况,免疫组化‘Western blot检测脑、肺组织中A20、核转录因子-kB(NF-kB)的表达。结果脑岀血后3 h出现肺水肿、BALF总蛋白浓度增加,48 h达到高峰(P<0.05);脑血肿周围组织72 h A20、NF-kB表达量达高峰(P<0.05);肺组织48 h A20、NF-kB表达量达高峰(P<0.05)o结论A20在脑出血后脑组织和肺组织中表达均有升高,提示A20可能在脑出血后急性肺损伤的发生发展过程中发挥作用。
