Objective: this study mainly discussed the relationship between the polymorphism of PuvⅡ and XbaⅠ gene of estrogen α receptor and benign paroxysmal positional vertigo (BPPV). Methods: polymerase chain reaction-rest...Objective: this study mainly discussed the relationship between the polymorphism of PuvⅡ and XbaⅠ gene of estrogen α receptor and benign paroxysmal positional vertigo (BPPV). Methods: polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the genotypes of 40 patients with benign positional vertigo and 40 healthy people, and the gene polypeptide of PvuⅡ (RS4986938) and XbaⅠ (RS9340799) was detected. SPSS13.0 statistical software was used to analyze the correlation between gene polypeptide of PvuⅡ and XbaⅠ and BPPV. Results: 1. There are three genotypes of PVU ⅱ, namely Pp, pp, PP, and the distribution frequency of genotypes between BPPV group and control group is statistically significant (28.498, p0.014). The frequency of P gene in PvuⅡ allele is statistically significant (29.452, p0.02). 2. There are three genotypes in the restriction site of XbaⅠ. There is no significant difference in the distribution frequency of Xba Ⅰ genotype between BPPV group and control group (21.953, P 0.377). There was no significant difference in the frequencies of P and P genes in XbaⅠ allele between BPPV group and control group (22.020, p0.155). 3. There are 9 combined genotypes of ERα PvuⅡ and XbaⅠ. There was no significant difference between the two groups (21.953 p0.377, P > 0.05).展开更多
文摘Objective: this study mainly discussed the relationship between the polymorphism of PuvⅡ and XbaⅠ gene of estrogen α receptor and benign paroxysmal positional vertigo (BPPV). Methods: polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the genotypes of 40 patients with benign positional vertigo and 40 healthy people, and the gene polypeptide of PvuⅡ (RS4986938) and XbaⅠ (RS9340799) was detected. SPSS13.0 statistical software was used to analyze the correlation between gene polypeptide of PvuⅡ and XbaⅠ and BPPV. Results: 1. There are three genotypes of PVU ⅱ, namely Pp, pp, PP, and the distribution frequency of genotypes between BPPV group and control group is statistically significant (28.498, p0.014). The frequency of P gene in PvuⅡ allele is statistically significant (29.452, p0.02). 2. There are three genotypes in the restriction site of XbaⅠ. There is no significant difference in the distribution frequency of Xba Ⅰ genotype between BPPV group and control group (21.953, P 0.377). There was no significant difference in the frequencies of P and P genes in XbaⅠ allele between BPPV group and control group (22.020, p0.155). 3. There are 9 combined genotypes of ERα PvuⅡ and XbaⅠ. There was no significant difference between the two groups (21.953 p0.377, P > 0.05).
