目的分析微交联透明质酸水光治疗联合强脉冲光(intense pulsed light,IPL)改善面部光老化症状的疗效及安全性。方法收集杭州整形医院2021年1月至2023年2月伴有不同程度光老化症状的受试者。按接受治疗方法的不同分为三组:一组单纯采用...目的分析微交联透明质酸水光治疗联合强脉冲光(intense pulsed light,IPL)改善面部光老化症状的疗效及安全性。方法收集杭州整形医院2021年1月至2023年2月伴有不同程度光老化症状的受试者。按接受治疗方法的不同分为三组:一组单纯采用微交联透明质酸钠水光治疗(水光治疗组),一组单纯采用IPL治疗[宽带光(broad band light,BBL)治疗组],一组采用IPL联合微交联透明质酸水光治疗(联合治疗组),并于3次治疗完成后的3个月进行随访。采用光老化整体评分(global scores for photoaging,GSP)对受试者治疗前后皮肤老化进行整体评价,采用全球美学改善量表(global aesthetic improvement scale,GAIS)对受试者治疗后整体外观改善情况进行评估,使用VISIA皮肤检测仪采集受试者治疗前后毛孔、纹理、细纹、棕色斑及红色区数据,采用视觉模拟评分(visual analog scale,VAS)法对疼痛进行评价,治疗及随访过程中记录不良反应。结果治疗后联合治疗组受试者的GSP评分低于水光治疗组和BBL治疗组(P<0.05);皱纹和纹理GAIS改善评分高于水光治疗组和BBL治疗组(P<0.05);毛孔GAIS改善评分高于BBL治疗组(P<0.05);VISIA皮肤检测中皱纹和棕色斑数值低于水光治疗组和BBL治疗组(P<0.05)。VISIA皮肤检测中红色区数值低于水光治疗组(P<0.05)。联合治疗组受试者的皱纹、纹理、毛孔有效率分别为88.2%、94.1%、94.1%,高于水光治疗组和BBL治疗组,并发症主要为立即出现红斑、针刺反应、丘疹,且数小时内可缓解。结论微交联透明质酸水光疗法联合强脉冲光是面部光老化皮肤有效且安全的改善方法。展开更多
Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to asse...Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.展开更多
文摘目的分析微交联透明质酸水光治疗联合强脉冲光(intense pulsed light,IPL)改善面部光老化症状的疗效及安全性。方法收集杭州整形医院2021年1月至2023年2月伴有不同程度光老化症状的受试者。按接受治疗方法的不同分为三组:一组单纯采用微交联透明质酸钠水光治疗(水光治疗组),一组单纯采用IPL治疗[宽带光(broad band light,BBL)治疗组],一组采用IPL联合微交联透明质酸水光治疗(联合治疗组),并于3次治疗完成后的3个月进行随访。采用光老化整体评分(global scores for photoaging,GSP)对受试者治疗前后皮肤老化进行整体评价,采用全球美学改善量表(global aesthetic improvement scale,GAIS)对受试者治疗后整体外观改善情况进行评估,使用VISIA皮肤检测仪采集受试者治疗前后毛孔、纹理、细纹、棕色斑及红色区数据,采用视觉模拟评分(visual analog scale,VAS)法对疼痛进行评价,治疗及随访过程中记录不良反应。结果治疗后联合治疗组受试者的GSP评分低于水光治疗组和BBL治疗组(P<0.05);皱纹和纹理GAIS改善评分高于水光治疗组和BBL治疗组(P<0.05);毛孔GAIS改善评分高于BBL治疗组(P<0.05);VISIA皮肤检测中皱纹和棕色斑数值低于水光治疗组和BBL治疗组(P<0.05)。VISIA皮肤检测中红色区数值低于水光治疗组(P<0.05)。联合治疗组受试者的皱纹、纹理、毛孔有效率分别为88.2%、94.1%、94.1%,高于水光治疗组和BBL治疗组,并发症主要为立即出现红斑、针刺反应、丘疹,且数小时内可缓解。结论微交联透明质酸水光疗法联合强脉冲光是面部光老化皮肤有效且安全的改善方法。
文摘Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.
