目的比较观察支架取栓与动静脉联合溶栓对急性脑梗死患者神经功能及预后的影响。方法选取2015-08-2018-08福建龙岩市第二医院收治的52例急性脑梗死患者为研究对象,按照随机数表法分为研究组(26例)与对照组(26例),研究组采用支架取栓予...目的比较观察支架取栓与动静脉联合溶栓对急性脑梗死患者神经功能及预后的影响。方法选取2015-08-2018-08福建龙岩市第二医院收治的52例急性脑梗死患者为研究对象,按照随机数表法分为研究组(26例)与对照组(26例),研究组采用支架取栓予以治疗,对照组采用动静脉联合溶栓治疗,比较2组术前及术后第1、7天时的简明精神状态量表(mini-mental state examination,MMSE)评分,术前及术后3、6个月的改良Rankin量表(modified rankin scale,mRS)评分。结果术后第1、7天,研究组MMSE评分均明显高于对照组,2组比较差异有统计学意义(P<0.05);术后3、6个月,研究组mRS评分均明显低于对照组,2组比较差异有统计学意义(P<0.05)。结论支架取栓可有效恢复急性脑梗死患者的神经功能,提高患者预后,效果明显优于动静脉联合溶栓治疗,具有较高的临床应用价值。展开更多
Different cell types make up tissues and organs hierarchically and communicate within a complex, three-dimensional (3D) en- vironment. The in vitro recapitulation of tissue-like structures is meaningful, not only for ...Different cell types make up tissues and organs hierarchically and communicate within a complex, three-dimensional (3D) en- vironment. The in vitro recapitulation of tissue-like structures is meaningful, not only for fundamental cell biology research, but also for tissue engineering (TE). Currently, TE research adopts either the top-down or bottom-up approach. The top-down approach involves defining the macroscopic tissue features using biomaterial scaffolds and seeding cells into these scaffolds. Conversely, the bottom-up approach aims at crafting small tissue building blocks with precision-engineered structural and functional microscale features, using physical and/or chemical approaches. The bottom-up strategy takes advantage of the repeating structural and functional units that facilitate cell-cell interactions and cultures multiple cells together as a functional unit of tissue. In this review, we focus on currently available microscale methods that can control mammalian cells to assemble into 3D tissue-like structures.展开更多
Microfluidic technology provides opportunities to create in vitro models with physiological microenvironment for cell study.Introducing the identified key aspects,including tissue-tissue interfaces,spatiotemporal chem...Microfluidic technology provides opportunities to create in vitro models with physiological microenvironment for cell study.Introducing the identified key aspects,including tissue-tissue interfaces,spatiotemporal chemical gradients,and dynamic mechanical forces,of living organs into the microfluidic system,"organs-on-chips"display an unprecedented application potential in a lot of biological fields such as fundamental physiological and pathophysiological research,drug efficacy and toxicity testing,and clinical diagnosis.Here,we review the recent development of organs-on-chips and briefly discuss their future challenges.展开更多
文摘目的比较观察支架取栓与动静脉联合溶栓对急性脑梗死患者神经功能及预后的影响。方法选取2015-08-2018-08福建龙岩市第二医院收治的52例急性脑梗死患者为研究对象,按照随机数表法分为研究组(26例)与对照组(26例),研究组采用支架取栓予以治疗,对照组采用动静脉联合溶栓治疗,比较2组术前及术后第1、7天时的简明精神状态量表(mini-mental state examination,MMSE)评分,术前及术后3、6个月的改良Rankin量表(modified rankin scale,mRS)评分。结果术后第1、7天,研究组MMSE评分均明显高于对照组,2组比较差异有统计学意义(P<0.05);术后3、6个月,研究组mRS评分均明显低于对照组,2组比较差异有统计学意义(P<0.05)。结论支架取栓可有效恢复急性脑梗死患者的神经功能,提高患者预后,效果明显优于动静脉联合溶栓治疗,具有较高的临床应用价值。
基金supported by Ministry of Science and Technology of China(Grant Nos.2009CB930001 and 2011CB933201)Chinese Academy ofSciences(Grant No.KJCX2-YW-M15)the National Natural ScienceFoundation of China(Grant Nos.20890020,90813032,21025520 and 51073045)
文摘Different cell types make up tissues and organs hierarchically and communicate within a complex, three-dimensional (3D) en- vironment. The in vitro recapitulation of tissue-like structures is meaningful, not only for fundamental cell biology research, but also for tissue engineering (TE). Currently, TE research adopts either the top-down or bottom-up approach. The top-down approach involves defining the macroscopic tissue features using biomaterial scaffolds and seeding cells into these scaffolds. Conversely, the bottom-up approach aims at crafting small tissue building blocks with precision-engineered structural and functional microscale features, using physical and/or chemical approaches. The bottom-up strategy takes advantage of the repeating structural and functional units that facilitate cell-cell interactions and cultures multiple cells together as a functional unit of tissue. In this review, we focus on currently available microscale methods that can control mammalian cells to assemble into 3D tissue-like structures.
基金supported by the Ministry of Science and Technology(2012AA022703,2012AA030608,2011CB933201 and 2009CB930001)the National Natural Science Foundation of China(31170905,21025520,51073045,31170905,GZ 614 and 91213305)+1 种基金the Chinese Academy of Sciences(KJCX2-YW-M15)the State Major Scientific and Technological Project of China(2013ZX09507005)
文摘Microfluidic technology provides opportunities to create in vitro models with physiological microenvironment for cell study.Introducing the identified key aspects,including tissue-tissue interfaces,spatiotemporal chemical gradients,and dynamic mechanical forces,of living organs into the microfluidic system,"organs-on-chips"display an unprecedented application potential in a lot of biological fields such as fundamental physiological and pathophysiological research,drug efficacy and toxicity testing,and clinical diagnosis.Here,we review the recent development of organs-on-chips and briefly discuss their future challenges.
