目的通过分析2000至2025年中国知网(CNKI)和Web of Science数据库中关于高血压与睡眠质量的文献,探讨该领域的研究现状、热点及发展趋势,为优化高血压患者睡眠管理及未来研究提供科学依据。方法采用CiteSpace(6.3.R1)软件对检索到的414...目的通过分析2000至2025年中国知网(CNKI)和Web of Science数据库中关于高血压与睡眠质量的文献,探讨该领域的研究现状、热点及发展趋势,为优化高血压患者睡眠管理及未来研究提供科学依据。方法采用CiteSpace(6.3.R1)软件对检索到的4146篇文献(中文1808篇,英文2338篇)进行文献计量学与可视化分析。结果美国是英文文献发文量最高的国家(645篇),中国位列第2名(406篇)。哈佛大学医学院(93篇)为国外发文量最高的机构,北京中医药大学(37篇)为国内核心研究机构。新疆维吾尔自治区人民医院高血压中心的Li Nanfang以及法国格勒诺布尔大学医院的Pepin Jean-Louis发文量最多(8篇)。英文文献聚焦睡眠质量、危险因素及血压水平,中文研究则侧重于护理干预与危险因素分析。时间线分析结果显示,2009年后关于高血压与睡眠质量的研究进入快速增长期,2020年后“不良情绪”和“血压水平”成为新兴突现词。结论关于高血压患者睡眠质量研究呈现多学科交叉趋势,美国在该领域处于领先地位,研究重点已从基础睡眠监测转向心理社会因素及个性化干预。可穿戴设备结合人工智能的睡眠评估应用、肠道菌群-脑-血压轴机制是该领域两大前沿方向,但跨区域合作网络尚未完善,仍需强化。建议深化临床与公共卫生领域的协同研究,进而构建睡眠-血压综合管理模式。展开更多
OBJECTIVE:To investigate the key targets and mechanisms of the Wenyang Huayin decoction(WYHYD,温阳化饮方)in treating bronchial asthma with cold fluid retention syndrome using network pharmacology and animal experiment...OBJECTIVE:To investigate the key targets and mechanisms of the Wenyang Huayin decoction(WYHYD,温阳化饮方)in treating bronchial asthma with cold fluid retention syndrome using network pharmacology and animal experiments.METHODS:On the one hand,we used network pharmacology method to explored the chemical components of the WYHYD and the main targets of bronchial asthma were acquired.Besides,a protein interaction network was built after protein interaction analysis to find potential protein functional modules.Then,we constructed the"WYHYD component-bronchial asthma target-pathway"network.On the other hand,the experimental intervention was as follows:first,we formed a rat model of bronchial asthma.Thereafter,we used the WYHYD to treat the disease while observing autophagyrelated indicators as the core target of network pharmacology.RESULTS:The network pharmacology revealed that there are 122 potential therapeutic targets in treating bronchial asthma with WYHYD.The biological processes mainly involved in the WYHYD included Gene Ontology:0110032:positive regulation of G2/MI transition of the medical cell cycle etc.and four major signaling pathways were involved.During laboratory investigations,various signs and clinical manifestations of the rat model group were the same.After administering the WYHYD,lung function,pathological sections,inflammatory factors,and other microscopic indicators improved to varying degrees,providing evidence for the study results.Meanwhile,we verified that the core targets of WYHYD in treating asthma through the intervention of autophagy are tumor necrosis factor,caspase 8,interleukin 1 beta,sirtuin 1,phosphatidylinositol 3-kinase catalytic subunit type 3,C-C chemokine receptor type 7,L/YN kinase,and protein tyrosine kinase 2.CONCLUSION:This preliminary study revealed the treatment process of bronchial asthma with multicomponent,multi-target,and multi-pathway mechanisms of the WYHYD.展开更多
为研究真空等离子喷涂Si/Yb_(2)Si_(2)O_(7)/Yb_(2)SiO_(5)环境障涂层试样在涂层受压、涂层受拉时的室温弯曲强度及失效原因,采用超景深三维显微镜、SEM(Scanning Electron Microscope)等方法对喷涂后的试样进行了表征,并测量了涂层孔隙...为研究真空等离子喷涂Si/Yb_(2)Si_(2)O_(7)/Yb_(2)SiO_(5)环境障涂层试样在涂层受压、涂层受拉时的室温弯曲强度及失效原因,采用超景深三维显微镜、SEM(Scanning Electron Microscope)等方法对喷涂后的试样进行了表征,并测量了涂层孔隙率;采用拉伸法测试了涂层的结合强度,并采用三点弯曲试验测试了裸材、涂层受压和涂层受拉时的室温弯曲强度。结果表明:Si/Yb_(2)Si_(2)O_(7)/Yb_(2)SiO_(5)涂层与SiC_(f)/SiC复合材料的结合强度为10.13 MPa,拉伸断裂主要在复材表层发生。计算涂层厚度时,涂层受压样的弯曲强度(503.21 MPa)与裸材(506.79 MPa)基本一致;不计算涂层厚度时,涂层受拉样的弯曲强度(499.77 MPa)与裸材一致;EBC涂层整体具有一定的压缩强度,其整体抗拉强度比复材自身抗拉强度小很多。压涂层时,在载荷增加至接近最大载荷时,复材层间发生破坏,并逐步失效,随后涂层发生飞崩,载荷迅速下降,试验停止;拉涂层时,在载荷很小时(约64 N)涂层就被拉开,随着载荷增加,直至接近最大载荷时,层间发生破坏并逐步失效。弯曲试验时复材的主要失效模式是SiC纤维断裂、复材的SiC基体开裂和复材层间撕裂,复材受拉面产生复材厚度方向的纵向裂纹;复材表层沉积的SiC膜层失效模式主要是开裂和剥落;EBC涂层在受压时的主要失效模式是整体飞崩和开裂,在受拉时,涂层在最大应力处断裂为2部分。本研究对含EBC涂层的SiC_(f)/SiC复材的最大弯曲载荷设计具有参考意义.展开更多
文摘目的通过分析2000至2025年中国知网(CNKI)和Web of Science数据库中关于高血压与睡眠质量的文献,探讨该领域的研究现状、热点及发展趋势,为优化高血压患者睡眠管理及未来研究提供科学依据。方法采用CiteSpace(6.3.R1)软件对检索到的4146篇文献(中文1808篇,英文2338篇)进行文献计量学与可视化分析。结果美国是英文文献发文量最高的国家(645篇),中国位列第2名(406篇)。哈佛大学医学院(93篇)为国外发文量最高的机构,北京中医药大学(37篇)为国内核心研究机构。新疆维吾尔自治区人民医院高血压中心的Li Nanfang以及法国格勒诺布尔大学医院的Pepin Jean-Louis发文量最多(8篇)。英文文献聚焦睡眠质量、危险因素及血压水平,中文研究则侧重于护理干预与危险因素分析。时间线分析结果显示,2009年后关于高血压与睡眠质量的研究进入快速增长期,2020年后“不良情绪”和“血压水平”成为新兴突现词。结论关于高血压患者睡眠质量研究呈现多学科交叉趋势,美国在该领域处于领先地位,研究重点已从基础睡眠监测转向心理社会因素及个性化干预。可穿戴设备结合人工智能的睡眠评估应用、肠道菌群-脑-血压轴机制是该领域两大前沿方向,但跨区域合作网络尚未完善,仍需强化。建议深化临床与公共卫生领域的协同研究,进而构建睡眠-血压综合管理模式。
基金Supported by National Natural Science Foundation of China:Study on the Mechanism of Airway Inflammation in Rats with Bronchial Asthma Cold Drink Lung Syndrome Treated with Metastasis Associated Lung Adenocarcinoma Transcript 1 Regulated Autophagy(No.82004233)the Shandong Province Traditional Chinese Medicine Science and Technology Project:Exploring the Mechanism of Xiaoqinglong Tang's Intervention in Bronchial Asthma Cold Drink Lung Syndrome through the"Temperature Sensing Channel Transient Receptor Potential Mitochondrial Autophagy"Pathway based on Transcriptomics Combined with Proteomics(No.MR20241737)+3 种基金Shandong Province Traditional Chinese Medicine Science and Technology Project:Optimization of Ultrasonic Extraction Process and Study on Structure and Activity of Asarum Polysaccharides(No.Q-2023042)Shandong Province Traditional Chinese Medicine Science and Technology Project:Study on the Mechanism of Ma Gui Synergistic Intervention on Airway Inflammatory Response in Rats with Asthma Cold Drink and Lung Accumulation Syndrome(No.Q-2023122)2023 Qilu Biancang Traditional Chinese Medicine Talent Cultivation ProjectShandong Province Medical and Health Science and Technology Development Plan Project:Study on the Mechanism of Airway Epithelial Cell Inflammation Induced by Cellular Autophagy Regulation lnc RNA Metastasis Associated Lung Adenocarcinoma Transcript 1 Antagonism Against Ovalbumin Intervention(No.202203020866)。
文摘OBJECTIVE:To investigate the key targets and mechanisms of the Wenyang Huayin decoction(WYHYD,温阳化饮方)in treating bronchial asthma with cold fluid retention syndrome using network pharmacology and animal experiments.METHODS:On the one hand,we used network pharmacology method to explored the chemical components of the WYHYD and the main targets of bronchial asthma were acquired.Besides,a protein interaction network was built after protein interaction analysis to find potential protein functional modules.Then,we constructed the"WYHYD component-bronchial asthma target-pathway"network.On the other hand,the experimental intervention was as follows:first,we formed a rat model of bronchial asthma.Thereafter,we used the WYHYD to treat the disease while observing autophagyrelated indicators as the core target of network pharmacology.RESULTS:The network pharmacology revealed that there are 122 potential therapeutic targets in treating bronchial asthma with WYHYD.The biological processes mainly involved in the WYHYD included Gene Ontology:0110032:positive regulation of G2/MI transition of the medical cell cycle etc.and four major signaling pathways were involved.During laboratory investigations,various signs and clinical manifestations of the rat model group were the same.After administering the WYHYD,lung function,pathological sections,inflammatory factors,and other microscopic indicators improved to varying degrees,providing evidence for the study results.Meanwhile,we verified that the core targets of WYHYD in treating asthma through the intervention of autophagy are tumor necrosis factor,caspase 8,interleukin 1 beta,sirtuin 1,phosphatidylinositol 3-kinase catalytic subunit type 3,C-C chemokine receptor type 7,L/YN kinase,and protein tyrosine kinase 2.CONCLUSION:This preliminary study revealed the treatment process of bronchial asthma with multicomponent,multi-target,and multi-pathway mechanisms of the WYHYD.
