为了系统梳理人参皂苷在肿瘤治疗领域的研究现状与发展趋势,本研究通过检索中国知网、万方、维普及Web of Science核心数据库,共纳入中英文文献1358篇,其中中文文献492篇、英文文献866篇;同时利用IncoPat专利数据库获取全球相关专利735...为了系统梳理人参皂苷在肿瘤治疗领域的研究现状与发展趋势,本研究通过检索中国知网、万方、维普及Web of Science核心数据库,共纳入中英文文献1358篇,其中中文文献492篇、英文文献866篇;同时利用IncoPat专利数据库获取全球相关专利735项,构建了涵盖2000年1月1日至2025年10月1日期间的相关文献与专利数据集。第一部分运用CiteSpace软件对发文趋势、国家、机构合作、作者网络、关键词共现与聚类等进行可视化分析;第二部分利用GraphPad Prism、Excel对专全球相关专利的申请趋势、地域分布、申请人、专利转化率与无效率分析进行计量分析本。数据集共生成14个Excel表与24张图,全面梳理了人参皂苷在肿瘤防治领域的研究全景与知识产权布局,为该领域的后续研究方向、专利战略优化及临床转化提供系统的数据支持与决策参考,从而推动该领域向更精准、高效的肿瘤防治策略发展。展开更多
AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA scree...AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA screening indicators to detect concurrent DR at an early stage.METHODS:A total of 200 patients who treated in the ophthalmology department of the Seventh Affiliated Hospital,Sun Yat-sen University from 2022 to 2023 were included,including 95 first-diagnosed DR patients and 105 patients without DR,and all patients underwent OCTA examination and a collection of demographics and renal function parameters.After a quality check,automated measurements of the foveal avascular zone area,vessel density(VD),and perfusion density(PD)of both 3 mm×3 mm and 6 mm×6 mm windows were obtained.RESULTS:Using random forest and multivariate Logistic regression methods,we developed a diagnostic model for DR based on 12 variables(age,FBG,SBP,DBP,HbA1c,ALT,ALP,urea/Scr,DM duration,HUA,DN,and CMT).Adding specific OCTA parameters enhanced the efficacy of the existing diagnostic model for DR(outer vessel density in 6 mm×6 mm window,AUC=0.837 vs 0.819,P=0.03).In the study of DN patients,the parameters in the 6 mm×6 mm window improved the diagnostic efficacy of DR(inner VD;outer VD;full VD;outer PD;full PD).CONCLUSION:The outer VD in the 6 mm×6 mm window can enhance the efficacy of the traditional DR diagnostic model.Meanwhile,compared with the 3 mm×3 mm window,the microvascular parameters in the 6 mm×6 mm window focusing on DN patients can be more sensitive to diagnosing the occurrence of DR.展开更多
文摘为了系统梳理人参皂苷在肿瘤治疗领域的研究现状与发展趋势,本研究通过检索中国知网、万方、维普及Web of Science核心数据库,共纳入中英文文献1358篇,其中中文文献492篇、英文文献866篇;同时利用IncoPat专利数据库获取全球相关专利735项,构建了涵盖2000年1月1日至2025年10月1日期间的相关文献与专利数据集。第一部分运用CiteSpace软件对发文趋势、国家、机构合作、作者网络、关键词共现与聚类等进行可视化分析;第二部分利用GraphPad Prism、Excel对专全球相关专利的申请趋势、地域分布、申请人、专利转化率与无效率分析进行计量分析本。数据集共生成14个Excel表与24张图,全面梳理了人参皂苷在肿瘤防治领域的研究全景与知识产权布局,为该领域的后续研究方向、专利战略优化及临床转化提供系统的数据支持与决策参考,从而推动该领域向更精准、高效的肿瘤防治策略发展。
文摘AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA screening indicators to detect concurrent DR at an early stage.METHODS:A total of 200 patients who treated in the ophthalmology department of the Seventh Affiliated Hospital,Sun Yat-sen University from 2022 to 2023 were included,including 95 first-diagnosed DR patients and 105 patients without DR,and all patients underwent OCTA examination and a collection of demographics and renal function parameters.After a quality check,automated measurements of the foveal avascular zone area,vessel density(VD),and perfusion density(PD)of both 3 mm×3 mm and 6 mm×6 mm windows were obtained.RESULTS:Using random forest and multivariate Logistic regression methods,we developed a diagnostic model for DR based on 12 variables(age,FBG,SBP,DBP,HbA1c,ALT,ALP,urea/Scr,DM duration,HUA,DN,and CMT).Adding specific OCTA parameters enhanced the efficacy of the existing diagnostic model for DR(outer vessel density in 6 mm×6 mm window,AUC=0.837 vs 0.819,P=0.03).In the study of DN patients,the parameters in the 6 mm×6 mm window improved the diagnostic efficacy of DR(inner VD;outer VD;full VD;outer PD;full PD).CONCLUSION:The outer VD in the 6 mm×6 mm window can enhance the efficacy of the traditional DR diagnostic model.Meanwhile,compared with the 3 mm×3 mm window,the microvascular parameters in the 6 mm×6 mm window focusing on DN patients can be more sensitive to diagnosing the occurrence of DR.
