Several 4'- and 5'-substituted 17-(2'-oxazolyl)-androsta-5,16-diene derivatives were designed and synthesized as inhibitors of 17α-hydroxylase/C17,20 -Lyase (P45017α) for the treatment of prostatic cance...Several 4'- and 5'-substituted 17-(2'-oxazolyl)-androsta-5,16-diene derivatives were designed and synthesized as inhibitors of 17α-hydroxylase/C17,20 -Lyase (P45017α) for the treatment of prostatic cancer, the results of the preliminary pharmacological screening showed that compound 6c, i.e. 17-(2'-oxazoly)-androsta-5,16-diene-3-ol was a strong inhibitor, comparable with that of the reference compound VN-85. The introduction ofmethyl or phenyl group at the 4' or 5' position of oxazole ring decreased the activity. The in vitro activities of 3- acetate 5a-c and 8 were lower than their 3-ol counterparts 6a-c and 9 as expected. The further pharmacological study of 6c is in progress.展开更多
Traditional Chinese medicine is an important medicine in our country, and internal medicine of traditional Chinese medicine is a basic subject of traditional Chinese medicine. Its teaching scope is wide and comprehens...Traditional Chinese medicine is an important medicine in our country, and internal medicine of traditional Chinese medicine is a basic subject of traditional Chinese medicine. Its teaching scope is wide and comprehensive, and its teaching is difficult and practical. At the same time, in the process of training and teaching Chinese medicine students, it is necessary to pay attention to the cultivation of students clinical thinking and enhance their clinical adaptability. The cultivation of clinical thinking in the teaching of internal medicine of traditional Chinese medicine belongs to the important teaching content of the teaching course, and the cultivation effect of clinical thinking becomes the teaching index. This study focuses on the significance of clinical thinking cultivation in the teaching of internal medicine of traditional Chinese medicine from various perspectives, hoping to provide valuable suggestions for clinical thinking cultivation in the teaching of internal medicine of traditional Chinese medicine.展开更多
Traditional Chinese medicine is an important medical content in China. When various universities carry out the teaching work of traditional Chinese medicine, they analyze and study the teaching methods of traditional ...Traditional Chinese medicine is an important medical content in China. When various universities carry out the teaching work of traditional Chinese medicine, they analyze and study the teaching methods of traditional Chinese medicine. TCM medicine teaching is the main course of TCM teaching, which affects students clinical thinking cultivation and practical operation ability. The reform progress of traditional Chinese medicine teaching is constantly promoted. At the present stage, the medical teaching of traditional Chinese medicine needs to be reformed, to adapt to the new teaching mode, to cultivate more TCM clinical students for China, and to promote the further development of traditional Chinese medicine. Therefore, the main research of this paper is the main points of the teaching reform of TCM internal medicine teaching. It is expected that the relevant suggestions can promote the better development of TCM internal medicine teaching and maintain the stable development of TCM education.展开更多
文摘Several 4'- and 5'-substituted 17-(2'-oxazolyl)-androsta-5,16-diene derivatives were designed and synthesized as inhibitors of 17α-hydroxylase/C17,20 -Lyase (P45017α) for the treatment of prostatic cancer, the results of the preliminary pharmacological screening showed that compound 6c, i.e. 17-(2'-oxazoly)-androsta-5,16-diene-3-ol was a strong inhibitor, comparable with that of the reference compound VN-85. The introduction ofmethyl or phenyl group at the 4' or 5' position of oxazole ring decreased the activity. The in vitro activities of 3- acetate 5a-c and 8 were lower than their 3-ol counterparts 6a-c and 9 as expected. The further pharmacological study of 6c is in progress.
文摘Traditional Chinese medicine is an important medicine in our country, and internal medicine of traditional Chinese medicine is a basic subject of traditional Chinese medicine. Its teaching scope is wide and comprehensive, and its teaching is difficult and practical. At the same time, in the process of training and teaching Chinese medicine students, it is necessary to pay attention to the cultivation of students clinical thinking and enhance their clinical adaptability. The cultivation of clinical thinking in the teaching of internal medicine of traditional Chinese medicine belongs to the important teaching content of the teaching course, and the cultivation effect of clinical thinking becomes the teaching index. This study focuses on the significance of clinical thinking cultivation in the teaching of internal medicine of traditional Chinese medicine from various perspectives, hoping to provide valuable suggestions for clinical thinking cultivation in the teaching of internal medicine of traditional Chinese medicine.
文摘Traditional Chinese medicine is an important medical content in China. When various universities carry out the teaching work of traditional Chinese medicine, they analyze and study the teaching methods of traditional Chinese medicine. TCM medicine teaching is the main course of TCM teaching, which affects students clinical thinking cultivation and practical operation ability. The reform progress of traditional Chinese medicine teaching is constantly promoted. At the present stage, the medical teaching of traditional Chinese medicine needs to be reformed, to adapt to the new teaching mode, to cultivate more TCM clinical students for China, and to promote the further development of traditional Chinese medicine. Therefore, the main research of this paper is the main points of the teaching reform of TCM internal medicine teaching. It is expected that the relevant suggestions can promote the better development of TCM internal medicine teaching and maintain the stable development of TCM education.
