In this paper we evaluate typical values of magnetic energy and electromagnetic angular momentum of atomic nuclei with very simple scenarios,for the first time.We point out possible situations in which magnetic energy...In this paper we evaluate typical values of magnetic energy and electromagnetic angular momentum of atomic nuclei with very simple scenarios,for the first time.We point out possible situations in which magnetic energy and angular momentum might play essential roles in nuclear physics.展开更多
OBJECTIVE:To explore the clinical efficacy and potential mechanisms of Huoxue Jiedu prescription(活血解毒方)in the treatment of polycythemia vera and provide objective basis for the treatment of polycythemia vera by u...OBJECTIVE:To explore the clinical efficacy and potential mechanisms of Huoxue Jiedu prescription(活血解毒方)in the treatment of polycythemia vera and provide objective basis for the treatment of polycythemia vera by using network pharmacology,molecular docking technology,and clinical trials.METHODS:First,network pharmacology and molecular docking analysis methods were used to screen the main targets of Huoxue Jiedu prescription in the treatment of polycythemia vera.Patients who were first diagnosed with polycythemia vera in the Hematology Department of Langfang Hospital of Traditional Chinese Medicine from September 2022 to January 2024 were enrolled,and a clinical randomized controlled study was conducted.Sixty patients with primary polycythemia who met the inclusion criteria were randomly divided into the treatment group and the control group,with 30 cases in each group.The control group received oral Western Medicine treatment,whereas the treatment group received oral Western Medicine combined with Huoxue Jiedu prescription treatment,and three courses were observed.The differences in the efficacy of Traditional Chinese and Western Medicine,hematological indicators,coagulation function,and expression of related targets before and after treatment were observed between the two groups.SPSS 26.0 statistical software was used for data analysis,and the treatment results of the two groups were compared to observe their clinical efficacy and mechanisms.RESULTS:Network pharmacology results identified the phosphatidyqinositol-3 kinase(PI3K-Akt)pathway as an important pathway of Huoxue Jiedu prescription in the treatment of polycythemia vera PV,which was closely related to thrombosis.Clinical trial results showed that Huoxue Jiedu prescription improved efficacy and hematological indicators,reduced patients'coagulation indicators such as D-dimer and fibrinogen,reduced activated partial thromboplastin time and prothrombin time,and decreased the expression of PI3K and Serine/threonine-protein kinase AKT1(AKT1)m RNA in peripheral blood.CONCLUSION:Network pharmacology predicted the corresponding targets of traditional Chinese medicine to a certain extent.Huoxue Jiedu prescription could enhance clinical efficacy,improve hematological indicators,and reduce coagulation indicators through antithrombotic effect by inhibiting the expression of PI3K and AKT1.展开更多
文摘In this paper we evaluate typical values of magnetic energy and electromagnetic angular momentum of atomic nuclei with very simple scenarios,for the first time.We point out possible situations in which magnetic energy and angular momentum might play essential roles in nuclear physics.
基金Scientific Research Project of the Chinese Society of Ethnographic Medicine:A Feasibility Study on the Treatment of Polycythemia Vera with Stasis-Expelling Decoctions Based on the Theory of Activating Blood and Resolving Stasis(2020,2020ZY175-440801)Scientific Research Project of the Chinese Society of Traditional Chinese Medicine:a Real-World Prospective Study on the Use of Stasis-Expelling Decoctions in Treating Polycythemia Vera(2021,202169-003)+2 种基金National Administration of Traditional Chinese Medicine Yang Shulian’s National Famous Traditional Chinese Medicine Expert Inheritance Studio Construction Project(State Administration of Traditional Chinese Medicine Jiaohan[2022]No.75)Hebei Province Graduate Innovation Funding Project(2023,PX-19221895)Beijing-Tianjin-Hebei Traditional Chinese Medicine Collaborative Specialty Alliance(Hebei Traditional Chinese Medicine[2024]No.11)。
文摘OBJECTIVE:To explore the clinical efficacy and potential mechanisms of Huoxue Jiedu prescription(活血解毒方)in the treatment of polycythemia vera and provide objective basis for the treatment of polycythemia vera by using network pharmacology,molecular docking technology,and clinical trials.METHODS:First,network pharmacology and molecular docking analysis methods were used to screen the main targets of Huoxue Jiedu prescription in the treatment of polycythemia vera.Patients who were first diagnosed with polycythemia vera in the Hematology Department of Langfang Hospital of Traditional Chinese Medicine from September 2022 to January 2024 were enrolled,and a clinical randomized controlled study was conducted.Sixty patients with primary polycythemia who met the inclusion criteria were randomly divided into the treatment group and the control group,with 30 cases in each group.The control group received oral Western Medicine treatment,whereas the treatment group received oral Western Medicine combined with Huoxue Jiedu prescription treatment,and three courses were observed.The differences in the efficacy of Traditional Chinese and Western Medicine,hematological indicators,coagulation function,and expression of related targets before and after treatment were observed between the two groups.SPSS 26.0 statistical software was used for data analysis,and the treatment results of the two groups were compared to observe their clinical efficacy and mechanisms.RESULTS:Network pharmacology results identified the phosphatidyqinositol-3 kinase(PI3K-Akt)pathway as an important pathway of Huoxue Jiedu prescription in the treatment of polycythemia vera PV,which was closely related to thrombosis.Clinical trial results showed that Huoxue Jiedu prescription improved efficacy and hematological indicators,reduced patients'coagulation indicators such as D-dimer and fibrinogen,reduced activated partial thromboplastin time and prothrombin time,and decreased the expression of PI3K and Serine/threonine-protein kinase AKT1(AKT1)m RNA in peripheral blood.CONCLUSION:Network pharmacology predicted the corresponding targets of traditional Chinese medicine to a certain extent.Huoxue Jiedu prescription could enhance clinical efficacy,improve hematological indicators,and reduce coagulation indicators through antithrombotic effect by inhibiting the expression of PI3K and AKT1.
