OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a mor...OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.展开更多
目的研究去甲肾上腺素联合重症超声(critical care ultrasound,CCUS)指导下液体复苏在老年脓毒性休克患者中的治疗效果及对血流动力学、预后的影响。方法非随机选取四川省自贡市第四人民医院于2022年5月—2023年8月收治的90例脓毒性休...目的研究去甲肾上腺素联合重症超声(critical care ultrasound,CCUS)指导下液体复苏在老年脓毒性休克患者中的治疗效果及对血流动力学、预后的影响。方法非随机选取四川省自贡市第四人民医院于2022年5月—2023年8月收治的90例脓毒性休克老年患者为研究对象。根据治疗方法不同分为对照组与研究组,各45例。对照组在去甲肾上腺素治疗基础上给予早期目标导向治疗(early goal-directed therapy,EGDT),研究组在去甲肾上腺素治疗基础上给予CCUS指导下液体复苏治疗。对比两组临床疗效、血流动力学指标及预后情况。结果研究组治疗总有效率为95.56%(43/45),高于对照组的71.11%(32/45),差异有统计学意义(χ^(2)=9.680,P<0.05)。研究组平均动脉压及中心动脉压均高于对照组,心率、序贯器官衰竭估计评分与急性生理与慢性健康评分低于对照组患者,差异有统计学意义(P均<0.05)。结论在脓毒性休克老年患者的治疗中应用CCUS指导下液体复苏治疗,相较于应用目标导向治疗有更好的临床疗效,能够改善患者血流动力学及预后。展开更多
基金National Key Research and Development Project:Clinical Evaluation of the Interventional Techniques for Abdominal Obesity(No.2019YFC1710102)。
文摘OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.
文摘目的研究去甲肾上腺素联合重症超声(critical care ultrasound,CCUS)指导下液体复苏在老年脓毒性休克患者中的治疗效果及对血流动力学、预后的影响。方法非随机选取四川省自贡市第四人民医院于2022年5月—2023年8月收治的90例脓毒性休克老年患者为研究对象。根据治疗方法不同分为对照组与研究组,各45例。对照组在去甲肾上腺素治疗基础上给予早期目标导向治疗(early goal-directed therapy,EGDT),研究组在去甲肾上腺素治疗基础上给予CCUS指导下液体复苏治疗。对比两组临床疗效、血流动力学指标及预后情况。结果研究组治疗总有效率为95.56%(43/45),高于对照组的71.11%(32/45),差异有统计学意义(χ^(2)=9.680,P<0.05)。研究组平均动脉压及中心动脉压均高于对照组,心率、序贯器官衰竭估计评分与急性生理与慢性健康评分低于对照组患者,差异有统计学意义(P均<0.05)。结论在脓毒性休克老年患者的治疗中应用CCUS指导下液体复苏治疗,相较于应用目标导向治疗有更好的临床疗效,能够改善患者血流动力学及预后。
