Norfloxacin complexes Co（nor）2.8H2O （nor=norfloxaein） and [Co（nor）（phen）]NO3.2H2O （phen=1,10-phenanthroline） were synthesized and their biological activity on Tetrahymena and Escherichia coli （E.coli） was ...Norfloxacin complexes Co（nor）2.8H2O （nor=norfloxaein） and [Co（nor）（phen）]NO3.2H2O （phen=1,10-phenanthroline） were synthesized and their biological activity on Tetrahymena and Escherichia coli （E.coli） was assayed by means of microcalorimetry. Massive experimental parameters such as the growth constant k, inhibitory ratio I, half inhibition concentration IC5o and generation time TG were obtained. Data showed that with the increase of exposing complex concentration, both complexes exhibited strong inhibition during the growth of organisms. While toxic degrees were quite different on Tetrahymena and E.coli, due to various toxic mechanisms. And complex molecular volume and the ability of the complex penetrating into cells may be the keys.展开更多
基金Funded by the National Natural Science Foundation of China(No.51273155)the Fundamental Research Funds for the Central Universities(No.2012-Ia-022)
文摘Norfloxacin complexes Co（nor）2.8H2O （nor=norfloxaein） and [Co（nor）（phen）]NO3.2H2O （phen=1,10-phenanthroline） were synthesized and their biological activity on Tetrahymena and Escherichia coli （E.coli） was assayed by means of microcalorimetry. Massive experimental parameters such as the growth constant k, inhibitory ratio I, half inhibition concentration IC5o and generation time TG were obtained. Data showed that with the increase of exposing complex concentration, both complexes exhibited strong inhibition during the growth of organisms. While toxic degrees were quite different on Tetrahymena and E.coli, due to various toxic mechanisms. And complex molecular volume and the ability of the complex penetrating into cells may be the keys.
