人偏肺病毒(human metapneumovirus,hMPV)作为一种感染性病毒病原体,可导致严重的呼吸道感染,被世界卫生组织列为重要病原体之一。尽管疫苗在疾病预防与传播控制中发挥了重要作用,但由于hMPV的结构蛋白具有相对较高的突变率,野生型病毒...人偏肺病毒(human metapneumovirus,hMPV)作为一种感染性病毒病原体,可导致严重的呼吸道感染,被世界卫生组织列为重要病原体之一。尽管疫苗在疾病预防与传播控制中发挥了重要作用,但由于hMPV的结构蛋白具有相对较高的突变率,野生型病毒通常易于发生免疫逃逸。因此,设计能针对多种病毒变异株并为人体提供广泛保护的广谱hMPV疫苗具有重要意义。本研究基于共识序列方法,设计了一种广谱T细胞表位疫苗,该疫苗由478个氨基酸残基组成,涵盖来自病毒融合蛋白、附着糖蛋白、基质蛋白及小疏水性蛋白的10个细胞毒性T细胞(cytotoxic T lymphocyte,CTL)表位和11个辅助性T细胞(helper T lymphocyte,HTL)表位。进一步的分析表明,该多表位疫苗无致敏性,且具有高人群覆盖率、强抗原性和免疫原性,以及适宜的物理化学特性和较高的溶解性。同时,疫苗的结构与天然病毒高度相似。结构生物学分析表明,构建的疫苗在结构紧凑性和结合稳定性方面表现出较强的性能。计算机模拟的免疫学分析表明,该疫苗能激发人体的免疫应答。综上所述,本研究设计的广谱hMPV疫苗可作为一种用于预防hMPV感染的优秀候选疫苗;研究采用的预测流程可用于高效筛选其他病原体的免疫表位。展开更多
Under the background of“artificial intelligence+X”,the development of landscape architecture industry ushers in new opportunities,and professional talents need to be updated to meet the social demand.This paper anal...Under the background of“artificial intelligence+X”,the development of landscape architecture industry ushers in new opportunities,and professional talents need to be updated to meet the social demand.This paper analyzes the cultivation demand of landscape architecture graduate students in the context of the new era,and identifies the problems by comparing the original professional graduate training mode.The new cultivation mode of graduate students in landscape architecture is proposed,including updating the target orientation of the discipline,optimizing the teaching system,building a“dualteacher”tutor team,and improving the“industry-university-research-utilization”integrated cultivation,so as to cultivate high-quality compound talents with disciplinary characteristics.展开更多
为全面了解国内外镉污染土壤修复领域的研究现状及前沿动态,以Web of Science数据库及中国知网的文献资料(截至2024年5月13日)为数据源,利用CiteSpace文献计量工具进行可视化分析。结果表明:国内学者发表的文献数量增长迅速,且明显多于...为全面了解国内外镉污染土壤修复领域的研究现状及前沿动态,以Web of Science数据库及中国知网的文献资料(截至2024年5月13日)为数据源,利用CiteSpace文献计量工具进行可视化分析。结果表明:国内学者发表的文献数量增长迅速,且明显多于国外。国内文献发文量呈现先慢后快的趋势,尤其在2014年后增速显著。国内外文献作者和研究机构联系均较弱,其中国外文献作者和机构形成了以法国、印度为中心的合作网络关系,发文作者群体分布离散;国内则以各大高校和部分研究所为主导力量,呈多中心、分散式的结构模式。关键词可视化结果表明,国内外研究同步性较强,均以土壤镉污染的健康影响和解决策略为基础。植物修复、生物修复和健康风险评估是目前国外研究热点,国内则以植物修复、联合修复以及钝化材料筛选与应用为研究热点。研究发展脉络从最初的镉污染源解析到土壤镉的累积特征发展到现在的修复技术与材料的研发及健康风险评估。深入探究联合修复技术、研发和应用绿色无污染和安全可持续修复材料是未来镉污染土壤修复领域研究的重点,健康风险评估模型构建也迫在眉睫。展开更多
As a key carrier supporting urban ecological health and living environment quality,urban ecological network is a key focus of current urban green space research.Jingzhou City of Hubei Province is taken as the research...As a key carrier supporting urban ecological health and living environment quality,urban ecological network is a key focus of current urban green space research.Jingzhou City of Hubei Province is taken as the research object.Relying on GIS technology platform,MSPA method is used to analyze the landscape pattern of Jingzhou City.On this basis,the landscape connectivity evaluation method is used to accurately identify and extract the source areas with important ecological value in Jingzhou City.Then,the normalization method and weighting method are combined to create a resistance factor evaluation system to construct the resistance surface.Based on the MCR model,the ecological network of Jingzhou City is successfully constructed,and targeted spatial optimization strategies and development suggestions are proposed.展开更多
By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly...By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly parks,so as to provide a practical basis for the construction of child-friendly cities.展开更多
Under the macro background of rapid urbanization and social transformation in China,campus space renewal has become an important practice and carrier for the sustainable development of schools.The study on campus spac...Under the macro background of rapid urbanization and social transformation in China,campus space renewal has become an important practice and carrier for the sustainable development of schools.The study on campus space by big data and quantitative reflection of spatial distribution of applicable people in different areas of the campus can provide a certain scientific basis for campus space updating.West campus of Yangtze University is taken as research object.Based on cognitive map method,questionnaire survey method,behavior trajectory and correlation analysis method,the types and characteristics of campus space composition,campus satisfaction,usage and its relevance are analyzed.Research results show that ①the overall imageability of campus space is higher,which has a significantly positive correlation with the satisfaction of campus environment,and has no correlation with users’ behavior activities.The use frequency of non teaching areas varies greatly in different periods of time.②The correlation between the surrounding green vegetation and the image degree of campus landmarks is the most significant,and the coefficient is 0.886.③The correlation between spatial size suitability and regional image degree is the most significant,and the coefficient is 0.937.④The correlation between public activity facilities in the region and node image degree is the most significant,and the coefficient is 0.995.According to the research results,the corresponding solutions are put forward to provide scientific and quantitative reference suggestions for the renewal and transformation of the campus.展开更多
With the rapid development of urbanization,traditional old industrial areas can not cope with the impact of the new wave of urbanization and have been abandoned,demolished and remodeled.Solving the pollution problem o...With the rapid development of urbanization,traditional old industrial areas can not cope with the impact of the new wave of urbanization and have been abandoned,demolished and remodeled.Solving the pollution problem of industrial wasteland has become an important part of urban renewal research.Based on the development of industrial sites,the paper discusses the design principles and methods of industrial sites.Through the case analysis of the industrial site of Guangzhou Zilintang Art Town,the paper excavates the deep cultural deposits in the post-industrial era and analyzes the renewal,utilization,transformation and regeneration of the landscape space of industrial sites.展开更多
文摘人偏肺病毒(human metapneumovirus,hMPV)作为一种感染性病毒病原体,可导致严重的呼吸道感染,被世界卫生组织列为重要病原体之一。尽管疫苗在疾病预防与传播控制中发挥了重要作用,但由于hMPV的结构蛋白具有相对较高的突变率,野生型病毒通常易于发生免疫逃逸。因此,设计能针对多种病毒变异株并为人体提供广泛保护的广谱hMPV疫苗具有重要意义。本研究基于共识序列方法,设计了一种广谱T细胞表位疫苗,该疫苗由478个氨基酸残基组成,涵盖来自病毒融合蛋白、附着糖蛋白、基质蛋白及小疏水性蛋白的10个细胞毒性T细胞(cytotoxic T lymphocyte,CTL)表位和11个辅助性T细胞(helper T lymphocyte,HTL)表位。进一步的分析表明,该多表位疫苗无致敏性,且具有高人群覆盖率、强抗原性和免疫原性,以及适宜的物理化学特性和较高的溶解性。同时,疫苗的结构与天然病毒高度相似。结构生物学分析表明,构建的疫苗在结构紧凑性和结合稳定性方面表现出较强的性能。计算机模拟的免疫学分析表明,该疫苗能激发人体的免疫应答。综上所述,本研究设计的广谱hMPV疫苗可作为一种用于预防hMPV感染的优秀候选疫苗;研究采用的预测流程可用于高效筛选其他病原体的免疫表位。
基金University-level Graduate Education Reform Project of Yangtze University(YJY202329).
文摘Under the background of“artificial intelligence+X”,the development of landscape architecture industry ushers in new opportunities,and professional talents need to be updated to meet the social demand.This paper analyzes the cultivation demand of landscape architecture graduate students in the context of the new era,and identifies the problems by comparing the original professional graduate training mode.The new cultivation mode of graduate students in landscape architecture is proposed,including updating the target orientation of the discipline,optimizing the teaching system,building a“dualteacher”tutor team,and improving the“industry-university-research-utilization”integrated cultivation,so as to cultivate high-quality compound talents with disciplinary characteristics.
文摘为全面了解国内外镉污染土壤修复领域的研究现状及前沿动态,以Web of Science数据库及中国知网的文献资料(截至2024年5月13日)为数据源,利用CiteSpace文献计量工具进行可视化分析。结果表明:国内学者发表的文献数量增长迅速,且明显多于国外。国内文献发文量呈现先慢后快的趋势,尤其在2014年后增速显著。国内外文献作者和研究机构联系均较弱,其中国外文献作者和机构形成了以法国、印度为中心的合作网络关系,发文作者群体分布离散;国内则以各大高校和部分研究所为主导力量,呈多中心、分散式的结构模式。关键词可视化结果表明,国内外研究同步性较强,均以土壤镉污染的健康影响和解决策略为基础。植物修复、生物修复和健康风险评估是目前国外研究热点,国内则以植物修复、联合修复以及钝化材料筛选与应用为研究热点。研究发展脉络从最初的镉污染源解析到土壤镉的累积特征发展到现在的修复技术与材料的研发及健康风险评估。深入探究联合修复技术、研发和应用绿色无污染和安全可持续修复材料是未来镉污染土壤修复领域研究的重点,健康风险评估模型构建也迫在眉睫。
基金by Jingzhou Science and Technology Program(2023EC45).
文摘As a key carrier supporting urban ecological health and living environment quality,urban ecological network is a key focus of current urban green space research.Jingzhou City of Hubei Province is taken as the research object.Relying on GIS technology platform,MSPA method is used to analyze the landscape pattern of Jingzhou City.On this basis,the landscape connectivity evaluation method is used to accurately identify and extract the source areas with important ecological value in Jingzhou City.Then,the normalization method and weighting method are combined to create a resistance factor evaluation system to construct the resistance surface.Based on the MCR model,the ecological network of Jingzhou City is successfully constructed,and targeted spatial optimization strategies and development suggestions are proposed.
文摘By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly parks,so as to provide a practical basis for the construction of child-friendly cities.
文摘Under the macro background of rapid urbanization and social transformation in China,campus space renewal has become an important practice and carrier for the sustainable development of schools.The study on campus space by big data and quantitative reflection of spatial distribution of applicable people in different areas of the campus can provide a certain scientific basis for campus space updating.West campus of Yangtze University is taken as research object.Based on cognitive map method,questionnaire survey method,behavior trajectory and correlation analysis method,the types and characteristics of campus space composition,campus satisfaction,usage and its relevance are analyzed.Research results show that ①the overall imageability of campus space is higher,which has a significantly positive correlation with the satisfaction of campus environment,and has no correlation with users’ behavior activities.The use frequency of non teaching areas varies greatly in different periods of time.②The correlation between the surrounding green vegetation and the image degree of campus landmarks is the most significant,and the coefficient is 0.886.③The correlation between spatial size suitability and regional image degree is the most significant,and the coefficient is 0.937.④The correlation between public activity facilities in the region and node image degree is the most significant,and the coefficient is 0.995.According to the research results,the corresponding solutions are put forward to provide scientific and quantitative reference suggestions for the renewal and transformation of the campus.
文摘With the rapid development of urbanization,traditional old industrial areas can not cope with the impact of the new wave of urbanization and have been abandoned,demolished and remodeled.Solving the pollution problem of industrial wasteland has become an important part of urban renewal research.Based on the development of industrial sites,the paper discusses the design principles and methods of industrial sites.Through the case analysis of the industrial site of Guangzhou Zilintang Art Town,the paper excavates the deep cultural deposits in the post-industrial era and analyzes the renewal,utilization,transformation and regeneration of the landscape space of industrial sites.
