Objective:To conduct a scoping review on the application status of the Functional Activity Score(FAS)in postoperative active pain management in China,providing a reference for its standardized and normative promotion....Objective:To conduct a scoping review on the application status of the Functional Activity Score(FAS)in postoperative active pain management in China,providing a reference for its standardized and normative promotion.Methods:Computerized searches of Chinese and English databases were performed to collect studies published by Chinese scholars from 2005 to July 2025 on the application of FAS in postoperative active pain management.After strict screening,the basic characteristics,application fields,assessment models,evaluation timing,types of functional activities,and clinical outcomes of the included literature were systematically analyzed.Results:A total of 18 studies were included,involving surgical types such as thoracic surgery,general surgery,and orthopedics.All studies adopted FAS combined with the Numeric Rating Scale(NRS)for assessment,with evaluation timing mostly concentrated within 72 hours postoperatively.The selected functional activities primarily included respiration-related and limb movements.Evaluation indicators covered pain control,functional recovery,complications,adverse events,patient experience,and tool assessment,with most studies reporting positive outcomes.Conclusion:FAS can effectively enhance pain control and promote functional recovery in postoperative active pain management in China,demonstrating high clinical value.However,existing studies exhibit inconsistencies in assessment criteria,selection of activity types,and research quality.展开更多
Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The...Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.展开更多
Band offset in semiconductors is a fundamental physical quantity that determines the performance of optoelectronic devices.However,the current method of calculating band offset is difficult to apply directly to the la...Band offset in semiconductors is a fundamental physical quantity that determines the performance of optoelectronic devices.However,the current method of calculating band offset is difficult to apply directly to the large-lattice-mismatched and heterovalent semiconductors because of the existing electric field and large strain at the interfaces.Here,we proposed a modified method to calculate band offsets for such systems,in which the core energy level shifts caused by heterovalent effects and lattice mismatch are estimated by interface reconstruction and the insertion of unidirectional strain structures as transitions,respectively.Taking the Si and III-V systems as examples,the results have the same accuracy as what is a widely used method for small-lattice-mismatched systems,and are much closer to the experimental values for the large-lattice-mismatched and heterovalent systems.Furthermore,by systematically studying the heterojunctions of Si and III-V semiconductors along different directions,it is found that the band offsets of Si/InAs and Si/InSb systems in[100],[110]and[111]directions belong to the type I,and could be beneficial for silicon-based luminescence performance.Our study offers a more reliable and direct method for calculating band offsets of large-lattice-mismatched and heterovalent semiconductors,and could provide theoretical support for the design of the high-performance silicon-based light sources.展开更多
Most transcriptional activities are silent during mitosis and reactivated upon mitotic exit;however,the underlying detailed mechanisms are still largely unknown.We revealed that the cell cycle regulatory machinery ana...Most transcriptional activities are silent during mitosis and reactivated upon mitotic exit;however,the underlying detailed mechanisms are still largely unknown.We revealed that the cell cycle regulatory machinery anaphase-promoting complex/cyclosome(APC/C)and mitotic checkpoint complex(MCC)are coupled with transcription termination to modulate cell cycle progression via the transcription termination factor TTF2.The protein level of TTF2 oscillated during cell cycle progression,and increased in the S and G2/M phases while maintaining a low level in late mitosis and the G1 phase.Knockdown of TTF2 induced G2/M arrest,while overexpression of TTF2 accelerated the M/G1 transition and promoted cell proliferation.Mechanistic studies revealed that TTF2 was ubiquitinated by APC/CCDH1 and targeted for proteasomal degradation.Interestingly,TTF2 bound to CDC20 and prevented MCC formation during normal mitosis.However,TTF2 was degraded by APC/CCDH1 when the cell encountered persistent G2/M arrest,which would release CDC20 and promote the assembly of MCC.Additionally,TTF2 was overexpressed in almost all solid tumors and correlated with poor survival in patients with several kinds of solid tumors.Thus,these findings establish a link between transcription termination and cell cycle regulation,revealing an unexpected mechanism by which TTF2 plays dual roles in mitosis by binding to CDH1 and CDC20 to balance the activation of APC/C and MCC.展开更多
基金School-level Educational Reform Project of Hangzhou Normal University(Project No.:HLXYJG202304)。
文摘Objective:To conduct a scoping review on the application status of the Functional Activity Score(FAS)in postoperative active pain management in China,providing a reference for its standardized and normative promotion.Methods:Computerized searches of Chinese and English databases were performed to collect studies published by Chinese scholars from 2005 to July 2025 on the application of FAS in postoperative active pain management.After strict screening,the basic characteristics,application fields,assessment models,evaluation timing,types of functional activities,and clinical outcomes of the included literature were systematically analyzed.Results:A total of 18 studies were included,involving surgical types such as thoracic surgery,general surgery,and orthopedics.All studies adopted FAS combined with the Numeric Rating Scale(NRS)for assessment,with evaluation timing mostly concentrated within 72 hours postoperatively.The selected functional activities primarily included respiration-related and limb movements.Evaluation indicators covered pain control,functional recovery,complications,adverse events,patient experience,and tool assessment,with most studies reporting positive outcomes.Conclusion:FAS can effectively enhance pain control and promote functional recovery in postoperative active pain management in China,demonstrating high clinical value.However,existing studies exhibit inconsistencies in assessment criteria,selection of activity types,and research quality.
基金supported by the National Natural Science Foundation of China(Grant No.:82374033,21901067)Ministry of Science and Technology of China(Grant No.:2023YFC3504100)Starting Grant from the Ministry of Human Resource and Social Security of China(Quan Li).
文摘Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,aggregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and assembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.
基金This work was supported by the National Key Research and Development Program of China(Grant No.2018YFB2200100)the Key Research Program of the Chinese Academy of Sciences(Grant No.XDPB22)+1 种基金the National Natural Science Foundation of China(Grant No.118764347,11614003,11804333)H.X.D.was also supported by the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2017154).
文摘Band offset in semiconductors is a fundamental physical quantity that determines the performance of optoelectronic devices.However,the current method of calculating band offset is difficult to apply directly to the large-lattice-mismatched and heterovalent semiconductors because of the existing electric field and large strain at the interfaces.Here,we proposed a modified method to calculate band offsets for such systems,in which the core energy level shifts caused by heterovalent effects and lattice mismatch are estimated by interface reconstruction and the insertion of unidirectional strain structures as transitions,respectively.Taking the Si and III-V systems as examples,the results have the same accuracy as what is a widely used method for small-lattice-mismatched systems,and are much closer to the experimental values for the large-lattice-mismatched and heterovalent systems.Furthermore,by systematically studying the heterojunctions of Si and III-V semiconductors along different directions,it is found that the band offsets of Si/InAs and Si/InSb systems in[100],[110]and[111]directions belong to the type I,and could be beneficial for silicon-based luminescence performance.Our study offers a more reliable and direct method for calculating band offsets of large-lattice-mismatched and heterovalent semiconductors,and could provide theoretical support for the design of the high-performance silicon-based light sources.
基金supported by the National Natural Science Foundation of China(81988101,82172930,81830086)the National Key Research and Development Program of China(2022YFC3401002)+6 种基金the Beijing Municipal Commission of Health and Family Planning Project(PXM2018_026279_000005)the Beijing Nova Program(Z191100001119038)the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-081)the Funding by Major Program of Shenzhen Bay Laboratory(S201101004)the Guangdong Basic and Applied Basic Research Foundation(2019B030302012)the Fund of“San-ming”Project of Medicine in Shenzhen(SZSM201812088)the Beijing Hospitals Authority Youth Programme(QML20191104)。
文摘Most transcriptional activities are silent during mitosis and reactivated upon mitotic exit;however,the underlying detailed mechanisms are still largely unknown.We revealed that the cell cycle regulatory machinery anaphase-promoting complex/cyclosome(APC/C)and mitotic checkpoint complex(MCC)are coupled with transcription termination to modulate cell cycle progression via the transcription termination factor TTF2.The protein level of TTF2 oscillated during cell cycle progression,and increased in the S and G2/M phases while maintaining a low level in late mitosis and the G1 phase.Knockdown of TTF2 induced G2/M arrest,while overexpression of TTF2 accelerated the M/G1 transition and promoted cell proliferation.Mechanistic studies revealed that TTF2 was ubiquitinated by APC/CCDH1 and targeted for proteasomal degradation.Interestingly,TTF2 bound to CDC20 and prevented MCC formation during normal mitosis.However,TTF2 was degraded by APC/CCDH1 when the cell encountered persistent G2/M arrest,which would release CDC20 and promote the assembly of MCC.Additionally,TTF2 was overexpressed in almost all solid tumors and correlated with poor survival in patients with several kinds of solid tumors.Thus,these findings establish a link between transcription termination and cell cycle regulation,revealing an unexpected mechanism by which TTF2 plays dual roles in mitosis by binding to CDH1 and CDC20 to balance the activation of APC/C and MCC.
