Apurine/pyrimidine-free endonuclease 1(APEX1)is a multifunctional enzyme that contributes to oxidization-mediated DNA-cleaved base excision repair and redox activation of transcription factors.However,the role of APEX...Apurine/pyrimidine-free endonuclease 1(APEX1)is a multifunctional enzyme that contributes to oxidization-mediated DNA-cleaved base excision repair and redox activation of transcription factors.However,the role of APEX1 during cardiomyocyte oxidative stress injury is not completely understood.In the present study,whether APEX1 protects oxidative damage-induced cardiomyocytes was investigated.mRNA and protein expression levels of APEX1 were downregulated in the mouse model of cardiac ischemia-reperfusion injury.Furthermore,the expression of APEX1 in hydrogen peroxide(H 2 O 2)-treated neonatal mice cardiomyocytes was also decreased.APEX1 knockdown aggravated H 2 O 2-treated cardiomyocyte apoptosis indexes.By contrast,APEX1 overexpression reversed H 2 O 2-induced oxidative damage,as demonstrated by decreased caspase 3 and Bax expression levels.Moreover,homeobox A5 upregulated APEX1.The results of the present study indicated that APEX1 displayed protective effects against oxidative damage,suggesting that APEX1 may serve as a unique protective strategy for cardiac ischemia-reperfusion injury.展开更多
The most abundant rare earth metals in the Earth’s crust have received considerable recent attention as efficient electrocatalysts for full water splitting,but it is highly desired to explore a new strategy to improv...The most abundant rare earth metals in the Earth’s crust have received considerable recent attention as efficient electrocatalysts for full water splitting,but it is highly desired to explore a new strategy to improve their catalytic activity.In this communication,we report the development of nanoporous CeO_(2) nanowire array on Ti mesh(np-CeO_(2)/TM)derived from MnO_(2)–CeO_(2)/TM via an acid etching strategy,and MnO_(2) acts as a pore-forming agent through selective etching with oxalic acid.As a rare earth metal catalyst,np-CeO_(2)/TM needs an overpotential of 91 mV for the hydrogen evolution reaction(HER)and 279 mV for the oxygen evolution reaction(OER)to drive a current density of 10 mV cm^(−2) in 1.0 M KOH,93 mV and 101 mV less than that needed by MnO_(2)–CeO_(2)/TM,respectively.We also demonstrate the use of np-CeO_(2)/TM to make a two-electrode electrolyzer capable of driving 10 mV cm^(−2) at a cell voltage of 1.57 V.展开更多
Traditional NH_(3) production based on the Haber–Bosch process is usually accompanied by high energy consumption and a large amount of carbon dioxide emission,which are not conducive to the realization of global carb...Traditional NH_(3) production based on the Haber–Bosch process is usually accompanied by high energy consumption and a large amount of carbon dioxide emission,which are not conducive to the realization of global carbon neutralization.Electrochemical N_(2) reduction is regarded as a clean strategy to deal with this problem.In this work,porous LiFe_(5)O_(8) nanoparticle–reduced graphene oxide (rGO) is proposed as an efficient electrocatalyst for artificial N_(2)-to-NH_(3) fixation with excellent selectivity under ambient conditions.Electrochemical tests in 0.1 M HCl show that such a hybrid achieves a high NH_(3) yield of 36.025 mg h^(-1) mg_(cat.)^(-1) and a high faradaic efficiency of 13.08% at −0.2 V vs.the reversible hydrogen electrode.Furthermore,it also exhibits structural stability.Theoretical calculations reveal that LiFe_(5)O_(8)–rGO can efficiently catalyze NH_(3) synthesis with a low energy barrier.展开更多
The Haber Bosch industrial NH_(3) production process has high energy consumption and severe CO_(2) emission.Electrochemical N_(2) reduction is an attractive method for the synthesis of carbon-neutral NH_(3).However,si...The Haber Bosch industrial NH_(3) production process has high energy consumption and severe CO_(2) emission.Electrochemical N_(2) reduction is an attractive method for the synthesis of carbon-neutral NH_(3).However,since an efficient electrocatalyst is required to perform the N_(2) reduction reaction (NRR) at room temperature,N_(2) activation is a severe challenge.Herein,we report a CeP nanoparticle–reduced graphene oxide (CeP–rGO) hybrid as an effective electrocatalyst for NH_(3) synthesis.In 0.1 M HCl,CeP–rGO achieves a large NH_(3) yield of 28.69 μg h^(−1) mg_(cat.)^(−1) and a high faradaic efficiency of 9.6% at −0.40 V,and it also shows high electrochemical and structural stability.Density functional theory (DFT) calculations show that CeP can efficiently catalyze the synthesis of NH_(3).展开更多
It is highly attractive but still remains a great challenge to develop an efficient electrocatalyst for oxygen evolution reaction under nearly neutral conditions. In this work, we report the transformation of Ni3S2 na...It is highly attractive but still remains a great challenge to develop an efficient electrocatalyst for oxygen evolution reaction under nearly neutral conditions. In this work, we report the transformation of Ni3S2 nanowire array on nickel foam into the amorphous nickel carbonate nanowire array on nickel foam （NiCO3/NF）. The resulting NiCO3/NF shows high electrocatalytic activity towards water oxidation and affords current density of 50 mA. cm-2 at overpotential of 395 mV in 1.0 mol·L^-1 KHCO3. Moreover, this NiCO3/NF is also durable with a long-term electrochemical durability of 60 h. This catalyst electrode achieves a high turnover frequency of 0.21 mol O2·s^-1 at the overpotential of 500 mV.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.81900245 and 81770395).
文摘Apurine/pyrimidine-free endonuclease 1(APEX1)is a multifunctional enzyme that contributes to oxidization-mediated DNA-cleaved base excision repair and redox activation of transcription factors.However,the role of APEX1 during cardiomyocyte oxidative stress injury is not completely understood.In the present study,whether APEX1 protects oxidative damage-induced cardiomyocytes was investigated.mRNA and protein expression levels of APEX1 were downregulated in the mouse model of cardiac ischemia-reperfusion injury.Furthermore,the expression of APEX1 in hydrogen peroxide(H 2 O 2)-treated neonatal mice cardiomyocytes was also decreased.APEX1 knockdown aggravated H 2 O 2-treated cardiomyocyte apoptosis indexes.By contrast,APEX1 overexpression reversed H 2 O 2-induced oxidative damage,as demonstrated by decreased caspase 3 and Bax expression levels.Moreover,homeobox A5 upregulated APEX1.The results of the present study indicated that APEX1 displayed protective effects against oxidative damage,suggesting that APEX1 may serve as a unique protective strategy for cardiac ischemia-reperfusion injury.
基金supported by the National Natural Science Foundation of China(no.21575137).
文摘The most abundant rare earth metals in the Earth’s crust have received considerable recent attention as efficient electrocatalysts for full water splitting,but it is highly desired to explore a new strategy to improve their catalytic activity.In this communication,we report the development of nanoporous CeO_(2) nanowire array on Ti mesh(np-CeO_(2)/TM)derived from MnO_(2)–CeO_(2)/TM via an acid etching strategy,and MnO_(2) acts as a pore-forming agent through selective etching with oxalic acid.As a rare earth metal catalyst,np-CeO_(2)/TM needs an overpotential of 91 mV for the hydrogen evolution reaction(HER)and 279 mV for the oxygen evolution reaction(OER)to drive a current density of 10 mV cm^(−2) in 1.0 M KOH,93 mV and 101 mV less than that needed by MnO_(2)–CeO_(2)/TM,respectively.We also demonstrate the use of np-CeO_(2)/TM to make a two-electrode electrolyzer capable of driving 10 mV cm^(−2) at a cell voltage of 1.57 V.
基金supported by the National Natural Science Foundation of China(No.21575137).
文摘Traditional NH_(3) production based on the Haber–Bosch process is usually accompanied by high energy consumption and a large amount of carbon dioxide emission,which are not conducive to the realization of global carbon neutralization.Electrochemical N_(2) reduction is regarded as a clean strategy to deal with this problem.In this work,porous LiFe_(5)O_(8) nanoparticle–reduced graphene oxide (rGO) is proposed as an efficient electrocatalyst for artificial N_(2)-to-NH_(3) fixation with excellent selectivity under ambient conditions.Electrochemical tests in 0.1 M HCl show that such a hybrid achieves a high NH_(3) yield of 36.025 mg h^(-1) mg_(cat.)^(-1) and a high faradaic efficiency of 13.08% at −0.2 V vs.the reversible hydrogen electrode.Furthermore,it also exhibits structural stability.Theoretical calculations reveal that LiFe_(5)O_(8)–rGO can efficiently catalyze NH_(3) synthesis with a low energy barrier.
基金supported by the National Natural Science Foundation of China(No.21575137).
文摘The Haber Bosch industrial NH_(3) production process has high energy consumption and severe CO_(2) emission.Electrochemical N_(2) reduction is an attractive method for the synthesis of carbon-neutral NH_(3).However,since an efficient electrocatalyst is required to perform the N_(2) reduction reaction (NRR) at room temperature,N_(2) activation is a severe challenge.Herein,we report a CeP nanoparticle–reduced graphene oxide (CeP–rGO) hybrid as an effective electrocatalyst for NH_(3) synthesis.In 0.1 M HCl,CeP–rGO achieves a large NH_(3) yield of 28.69 μg h^(−1) mg_(cat.)^(−1) and a high faradaic efficiency of 9.6% at −0.40 V,and it also shows high electrochemical and structural stability.Density functional theory (DFT) calculations show that CeP can efficiently catalyze the synthesis of NH_(3).
文摘It is highly attractive but still remains a great challenge to develop an efficient electrocatalyst for oxygen evolution reaction under nearly neutral conditions. In this work, we report the transformation of Ni3S2 nanowire array on nickel foam into the amorphous nickel carbonate nanowire array on nickel foam （NiCO3/NF）. The resulting NiCO3/NF shows high electrocatalytic activity towards water oxidation and affords current density of 50 mA. cm-2 at overpotential of 395 mV in 1.0 mol·L^-1 KHCO3. Moreover, this NiCO3/NF is also durable with a long-term electrochemical durability of 60 h. This catalyst electrode achieves a high turnover frequency of 0.21 mol O2·s^-1 at the overpotential of 500 mV.
