What is known about this topic?Global human cases of zoonotic influenza A(H5N6)have increased significantly in recent years,primarily due to widespread circulation of clade 2.3.4.4b virus since 2020.Concurrent with th...What is known about this topic?Global human cases of zoonotic influenza A(H5N6)have increased significantly in recent years,primarily due to widespread circulation of clade 2.3.4.4b virus since 2020.Concurrent with this trend,sporadic human infections with clade 2.3.4.4h H5N6 avian influenza virus continue to occur.The high mortality rate associated with H5N6 virus infections has emerged as a critical public health concern.What is added by this report?Through comprehensive field epidemiological investigations and laboratory analyses,we identified the infection sources for these cases and conclusively ruled out human-to-human transmission.Genetic analyses revealed that while the virus maintains its avian host tropism,it has acquired mutations that may enhance human receptor binding affinity,viral replication capacity,pathogenicity,and neuraminidase inhibitor resistance.What are the implications for public health practice?The ongoing viral mutations increase the potential for H5 subtype avian influenza viruses to overcome species barriers and cause human epidemics.Enhanced surveillance strategies incorporating advanced technologies,such as metagenomic sequencing,are essential for early risk detection and management.Special attention should be directed toward cancer patients and immunocompromised individuals,who demonstrate increased susceptibility to avian influenza virus infections and require targeted prevention and control measures.展开更多
Dengue fever(DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF...Dengue fever(DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004–2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612(83.5%) occurred during the peak period from August to October. Additionally, 76%(190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes(I, IV, V) of DENV1, and one genotype each of DENV2(cosmopolitan) and DENV3(I) circulated in Fujian during 2004–2014. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian.展开更多
基金Supported by the Fujian Natural Science Foundation(2021J01351)the Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province,China(Grant No.2021ZQNZD006).
文摘What is known about this topic?Global human cases of zoonotic influenza A(H5N6)have increased significantly in recent years,primarily due to widespread circulation of clade 2.3.4.4b virus since 2020.Concurrent with this trend,sporadic human infections with clade 2.3.4.4h H5N6 avian influenza virus continue to occur.The high mortality rate associated with H5N6 virus infections has emerged as a critical public health concern.What is added by this report?Through comprehensive field epidemiological investigations and laboratory analyses,we identified the infection sources for these cases and conclusively ruled out human-to-human transmission.Genetic analyses revealed that while the virus maintains its avian host tropism,it has acquired mutations that may enhance human receptor binding affinity,viral replication capacity,pathogenicity,and neuraminidase inhibitor resistance.What are the implications for public health practice?The ongoing viral mutations increase the potential for H5 subtype avian influenza viruses to overcome species barriers and cause human epidemics.Enhanced surveillance strategies incorporating advanced technologies,such as metagenomic sequencing,are essential for early risk detection and management.Special attention should be directed toward cancer patients and immunocompromised individuals,who demonstrate increased susceptibility to avian influenza virus infections and require targeted prevention and control measures.
基金supported by Chinese National Hi-Tech research development plan (2011AA02A114)Chinese National Major Science & technology project (2012ZA10004-210)Fujian provincial medical innovation project (2015-CXB-13)
文摘Dengue fever(DF) is a vector-borne disease and a tremendous socioeconomic burden on tropical and subtropical countries worldwide. To explore the characteristics of DF epidemic in the Fujian province, information of DF cases in Fujian during 2004–2014 was collected and analyzed. The complete E genes of 48 viral isolates were amplified and sequenced for phylogenetic analysis. A total of 733 cases was reported, of which 612(83.5%) occurred during the peak period from August to October. Additionally, 76%(190/250) of imported cases originated from Southeast Asia countries, by the epidemiological investigation. Phylogenetic analysis of the 48 viral isolates revealed that three genotypes(I, IV, V) of DENV1, and one genotype each of DENV2(cosmopolitan) and DENV3(I) circulated in Fujian during 2004–2014. Similar to the results of the epidemiological investigations, the source of most of the viral isolates, including imported and indigenous cases, may be Southeast Asia countries; however, importation from adjacent provinces was also observed in recent years. Overall, DF is considered an imported epidemic disease in Fujian. Increasing diversity of the viral source and geographic expansion of the area affected by DF in recent years highlights the necessity for strengthening surveillance of the DF epidemic and developing strategies for DF prevention and control in Fujian.
