In this study,uniform diamond films with a diameter of 100 mm were deposited in a 15 kW/2.45 GHz ellipsoidal microwave plasma chemical vapour deposition system.A phenomenological model previously developed by our grou...In this study,uniform diamond films with a diameter of 100 mm were deposited in a 15 kW/2.45 GHz ellipsoidal microwave plasma chemical vapour deposition system.A phenomenological model previously developed by our group was used to simulate the distribution of the electric strength and electron density of plasma.Results indicate that the electric field in the cavity includes multiple modes,i.e.TM_(02) and TM_(03).When the gas pressure exceeds 10 kPa,the electron density of plasma increases and plasma volume decreases.A T-shaped substrate was developed to achieve uniform temperature,and the substrate was suspended in air fromφ70 to 100 mm,thus eliminating vertical heat dissipation.An edge electric field was added to the system after the introduction of the T-shaped substrate.Moreover,the plasma volume in this case was greater than that in the central electric field but smaller than that in the periphery electric field of the TM_(02) mode.This indicates that the electric field above and below the edge benefits the plasma volume rather than the periphery electric field of the TM_(02) mode.The quality,uniformity and surface morphology of the deposited diamond films were primarily investigated to maintain substrate temperature uniformity.When employing the improved substrate,the thickness unevenness of theφ100 mm diamond film decreased from 22%to 7%.展开更多
Current electronic technology based on silicon is approaching its physical and scientific limits. Carbon-based devices have numer- ous advantages for next generation electronics (e.g., fast speed, low power consumptio...Current electronic technology based on silicon is approaching its physical and scientific limits. Carbon-based devices have numer- ous advantages for next generation electronics (e.g., fast speed, low power consumption and simple process), that when combined with the unique nature of the versatile allotropes of carbon elements, are creating an electronics revolution. Carbon electronics are greatly advancing with new preparations and sophisticated designs. In this perspective, representatives with various dimensions, e.g., carbon nanotubes, graphene, bulk diamond, and their extraordinary performance, are reviewed. The associated state-of-the-art devices and composite hybrid all-carbon structures are also emphasized to reveal their potential in the electronics field. Advances in commercial production have improved the cost effi-ciency, material quality, and device design, accelerating the promise of carbon materials.展开更多
Electrically-excited flux-switching machines are advantageous in simple and reliable structure,good speed control performance,low cost,etc.,so they have arouse wide concerns from new energy field.However,they have muc...Electrically-excited flux-switching machines are advantageous in simple and reliable structure,good speed control performance,low cost,etc.,so they have arouse wide concerns from new energy field.However,they have much lower torque density/thrust density compared with the same type PM machines.To overcome this challenge,electromagnetic-thermal coupled analysis is carried out with respect to water-cooled electrically-excited flux-switching linear machines(EEFSLM).The simulation results indicate that the conventional fixed copper loss method(FCLM)is no longer suitable for high thrust density design,since it is unable to consider the strong coupling between the electromagnetic and thermal performance.Hence,a multi-step electromagnetic-thermal joint optimisation method is proposed,which first ensures the consistency between the electromagnetic and thermal modelling and then considers the effect of different field/armature coil sizes.By using the proposed joint optimisation method,it is found that the combination of relatively large size of field coil and relatively low field copper loss is favourable for achieving high thrust force for the current EEFSLM design.Moreover,the thrust force is raised by 13-15%compared with using the FCLM.The electromagnetic and thermal performance of the EEFSLM is validated by the prototype test.展开更多
Two novel koninginin derivatives,koningipyridines A and B(1 and 2),along with four known compounds(3-6)were isolated from the EtOAc extract of the endophytic fungus Trichoderma koningiopsis SC-5.Among them,koningipyri...Two novel koninginin derivatives,koningipyridines A and B(1 and 2),along with four known compounds(3-6)were isolated from the EtOAc extract of the endophytic fungus Trichoderma koningiopsis SC-5.Among them,koningipyridine A featured an unprecedented pentacyclic ketal skeleton with the formation of a fascinating 6/6/5/6/5 fused ring system and shared a characteristic pyridine core,which represents the first example of nitrogen-containing koninginin-type natural product.Moreover,koningipyridine B was the first member in the koninginin family sharing a unique 6/6/5 dihydropyridine skeleton,and it was suggested to be the critical biosynthetic precursor of koningipyridine A.The structures of 1 and 2 were elucidated by the interpretation of 1D and 2D NMR spectroscopy,HRESIMS data,as well as theoretical calculations of 13C NMR and electronic circular dichroism(ECD).Moreover,all isolates were screened for antimicrobial activities against Staphylococcus aureus,MRSA,and Escherichia coli as well as the cytotoxic effects against three cancer cell lines(A549,Hela,and HepG2).展开更多
Objective:The study reviews status,main time nodes and hospital discharge services for family caregivers of children with Kawasaki disease complicated by coronary artery aneurysm to provide references for the developm...Objective:The study reviews status,main time nodes and hospital discharge services for family caregivers of children with Kawasaki disease complicated by coronary artery aneurysm to provide references for the development of hospital discharge preparation services for medical personnel and patients.Background:CAL of Kawasaki disease is the main cause of acquired heart disease in children,but there is not enough research on the readiness for hospital discharge.Design:Systematic review of observational and interventional studies.展开更多
The physical,emotional,and caregiving quality of caregivers for children with malignant solid tumors is significantly influenced by mental toughness.The definition of mental toughness,study methods,primary influencing...The physical,emotional,and caregiving quality of caregivers for children with malignant solid tumors is significantly influenced by mental toughness.The definition of mental toughness,study methods,primary influencing factors,and intervention strategies for the mental toughness of caregivers of children with malignant solid tumors will be examined in this paper.To improve the mental toughness of caregivers of children with malignant solid tumors,it is recommended that future studies enhance the number of intervention research methods and establish particular evaluation tools.展开更多
Colorectal cancer(CRC), one of the leading causes of cancer-related mortality globally, urgently requires complementary and alternative therapies. Ferroptosis, an iron-dependent form of regulated cell death driven by ...Colorectal cancer(CRC), one of the leading causes of cancer-related mortality globally, urgently requires complementary and alternative therapies. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising anticancer strategy. Dendrobium officinale(D. officinale), a renowned traditional Chinese medicinal herb, is widely used in several Asian countries for its nutritional and therapeutic benefits.Although D. officinale has demonstrated anti-tumor effects, the molecular mechanisms underlying its action against CRC remain incompletely characterized. This study aimed to elucidate the role of D. officinale in suppressing CRC through the induction of ferroptosis and its regulatory effects on glutathione peroxidase 4(GPX4), a key suppressor of ferroptosis. In vitro assays were conducted using HCT116 and SW480 CRC cell lines, and in vivo efficacy was evaluated in BALB/c nude mice bearing CRC xenografts. D. officinale significantly reduced CRC cell viability and proliferation in vitro and suppressed tumor growth in vivo. Induction of ferroptosis was evidenced by elevated levels of Fe^(2+), malondialdehyde(MDA), and lipid peroxidation, along with a depleted glutathione/oxidized glutathione disulfide(GSH/GSSG) ratio. Notably, these effects were reversed by ferroptosis inhibitors, including ferrostatin-1(Fer-1) and deferoxamine. Consistently, D. officinale markedly downregulated GPX4 expression. Overexpression of GPX4 rescued D. officinale-induced ferroptosis, whereas GPX4 silencing exacerbated this effect. D. officinale suppresses CRC by triggering GPX4-dependent ferroptosis,providing a novel, naturally derived therapeutic approach. These findings bridge traditional medicine and modern oncology, establishing a foundation for developing targeted CRC treatments.展开更多
Designing adhesive hydrogels with optimal properties for the treatment of injured tissues is challenging due to the tradeoff between material stiffness and toughness while maintaining adherence to wet tissue surfaces....Designing adhesive hydrogels with optimal properties for the treatment of injured tissues is challenging due to the tradeoff between material stiffness and toughness while maintaining adherence to wet tissue surfaces. In most cases, bioadhesives with improved mechanical strength often lack an appropriate elastic compliance, hindering their application for sealing soft, elastic, and dynamic tissues. Here, we present a novel strategy for engineering tissue adhesives in which molecular building blocks are manipulated to allow for precise control and optimization of the various aforementioned properties without any tradeoffs. To introduce tunable mechanical properties and robust tissue adhesion, the hydrogel network presents different modes of covalent and noncovalent interactions using N-hydroxysuccinimide ester (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), and Fe^(3+) ions. Through combining and tuning different molecular interactions and a variety of crosslinking mechanisms, we were able to design an extremely elastic (924%) and tough (4697 kJ/m3) multifunctional hydrogel that could quickly adhere to wet tissue surfaces within 5 s of gentle pressing and deform to support physiological tissue function over time under wet conditions. While Alg-NHS provides covalent bonding with the tissue surfaces, the catechol moieties of TA molecules synergistically adopt a mussel-inspired adhesive mechanism to establish robust adherence to the wet tissue. The strong adhesion of the engineered bioadhesive patch is showcased by its application to rabbit conjunctiva and porcine cornea. Meanwhile, the engineered bioadhesive demonstrated painless detachable characteristics and in vitro biocompatibility. Additionally, due to the molecular interactions between TA and Fe3+, antioxidant and antibacterial properties required to support the wound healing pathways were also highlighted. Overall, by tuning various molecular interactions, we were able to develop a single-hydrogel platform with an “all-in-one” multifunctionality that can address current challenges of engineering hydrogel-based bioadhesives for tissue repair and sealing.展开更多
Chemical vapor deposited(CVD)diamond as a burgeoning multifunctional material with tailored quality and characteristics can be artificially synthesized and controlled for various applications.Correspondingly,the appli...Chemical vapor deposited(CVD)diamond as a burgeoning multifunctional material with tailored quality and characteristics can be artificially synthesized and controlled for various applications.Correspondingly,the application-related“grade”concept associated with materials choice and design was gradually formulated,of which the availability and the performance are optimally suited.In this review,the explicit diversity of CVD diamond and the clarification of typical grades for applications,i.e.,from resplendent gem-grade to promising quantum-grade,were systematically summarized and discussed,according to the crystal quality and main consideration of ubiquitous nitrogen impurity content as well as major applications.Realizations of those,from quantum-grade with near-ideal crystal to electronic-grade having extremely low imperfections and then to optical,thermal as well as mechanical-grade needing controlled flaws and allowable impurities,would competently fulfill the multi-field application prospects with appropriate choice in terms of cost and quality.Exceptionally,wide range defects and impurities in the gem-grade diamond(only indicating single crystal),which are detrimental for technology applications,endows CVD crystals with fancy colors to challenge their natural counterparts.展开更多
Worldwide,cancer is a growing epidemic that results in large social and economic burdens.Despite advances in current diagnosis and treatment,most of the prognosis in cancer patients remains poor.It is urgent to find a...Worldwide,cancer is a growing epidemic that results in large social and economic burdens.Despite advances in current diagnosis and treatment,most of the prognosis in cancer patients remains poor.It is urgent to find alternative therapies with effective cancer prevention and treatment.Chinese herbal medicines(CHMs)have been increasingly used worldwide for cancer prevention and treatment due to their privileged properties.CHMs are useful in the suppression of various types of cancers through different mechanisms of action.Non-coding RNAs(ncRNAs),including microRNAs,long non-coding RNAs and circular RNAs,are closely involved in the cancer progression and development.Regulation of ncRNAs in tumor cells may be a useful pharmacological strategy for the cancer prevention and treatment.Substantial evidence exists that various phytochemicals from CHMs exert potent anticarcinogenic effects by regulating ncRNAs-related targets and signaling pathways.Herein,the purpose of this paper is to conclude the current understanding of phytochemicals from CHMs in ncRNAs-mediated cancer suppression and the molecular mechanisms.This review will help to provide beneficial clues related to the clinical use of CHMs in the cancer prevention and treatment and further promote new drug discovery against cancer.展开更多
基金sponsored by National Key Research and Development Program of China(No.2019YFE03100200)National Natural Science Foundation of China(No.5210020483)+1 种基金Postdoc Research Foundation of Shunde Graduate School of University of Science and Technology Beijing(No.2020BH015)Fundamental Research Funds for the Central Universities(No.FRF-MP-20-48)。
文摘In this study,uniform diamond films with a diameter of 100 mm were deposited in a 15 kW/2.45 GHz ellipsoidal microwave plasma chemical vapour deposition system.A phenomenological model previously developed by our group was used to simulate the distribution of the electric strength and electron density of plasma.Results indicate that the electric field in the cavity includes multiple modes,i.e.TM_(02) and TM_(03).When the gas pressure exceeds 10 kPa,the electron density of plasma increases and plasma volume decreases.A T-shaped substrate was developed to achieve uniform temperature,and the substrate was suspended in air fromφ70 to 100 mm,thus eliminating vertical heat dissipation.An edge electric field was added to the system after the introduction of the T-shaped substrate.Moreover,the plasma volume in this case was greater than that in the central electric field but smaller than that in the periphery electric field of the TM_(02) mode.This indicates that the electric field above and below the edge benefits the plasma volume rather than the periphery electric field of the TM_(02) mode.The quality,uniformity and surface morphology of the deposited diamond films were primarily investigated to maintain substrate temperature uniformity.When employing the improved substrate,the thickness unevenness of theφ100 mm diamond film decreased from 22%to 7%.
基金the National Key Research and Development Program of China(No.2016YFE0133200)National Natural Science Foundation of China(No.52172037)+4 种基金European Union’s Horizon 2020 Research and Innovation Staff Exchange Scheme(No.734578)Post-doctor Research Foundation of Shunde Graduate School of University of Science and Technology Beijing(No.2021 BH006)Beijing Municipal Natural Science Foundation(Nos.2212036 and 4192038)Science and Technology Innovation Special Project of Foshan Government(Nos.BK20BE021 and BK21BE004)Special thanks to the nation-al high-level-university sponsored graduate program of China Scholarship Council(CSC),USTB-Monte Biance Joint R&D Center and joint-postdoc research program of Shunde Graduate School of USTB.
文摘Current electronic technology based on silicon is approaching its physical and scientific limits. Carbon-based devices have numer- ous advantages for next generation electronics (e.g., fast speed, low power consumption and simple process), that when combined with the unique nature of the versatile allotropes of carbon elements, are creating an electronics revolution. Carbon electronics are greatly advancing with new preparations and sophisticated designs. In this perspective, representatives with various dimensions, e.g., carbon nanotubes, graphene, bulk diamond, and their extraordinary performance, are reviewed. The associated state-of-the-art devices and composite hybrid all-carbon structures are also emphasized to reveal their potential in the electronics field. Advances in commercial production have improved the cost effi-ciency, material quality, and device design, accelerating the promise of carbon materials.
基金supported in part by Zhejiang Provincial Natural Science Foundation of China under Grant LY21E070002 and LY17E070002。
文摘Electrically-excited flux-switching machines are advantageous in simple and reliable structure,good speed control performance,low cost,etc.,so they have arouse wide concerns from new energy field.However,they have much lower torque density/thrust density compared with the same type PM machines.To overcome this challenge,electromagnetic-thermal coupled analysis is carried out with respect to water-cooled electrically-excited flux-switching linear machines(EEFSLM).The simulation results indicate that the conventional fixed copper loss method(FCLM)is no longer suitable for high thrust density design,since it is unable to consider the strong coupling between the electromagnetic and thermal performance.Hence,a multi-step electromagnetic-thermal joint optimisation method is proposed,which first ensures the consistency between the electromagnetic and thermal modelling and then considers the effect of different field/armature coil sizes.By using the proposed joint optimisation method,it is found that the combination of relatively large size of field coil and relatively low field copper loss is favourable for achieving high thrust force for the current EEFSLM design.Moreover,the thrust force is raised by 13-15%compared with using the FCLM.The electromagnetic and thermal performance of the EEFSLM is validated by the prototype test.
基金Financial support for this research was provided by the National Natural Science Foundation of China(Nos.82173711 and 82003929)Youth Innovation Promotion Association of CAS(2020342)+2 种基金Natural Science Foundation of Hunan Province(Nos.2021JJ30917 and 2021JJ40993)Key Research and Development Project of Hainan Province(No.ZDYF2022SHFZ048)the Central South University postgraduate independent exploration and innovation project(No.2022zzts0899).
文摘Two novel koninginin derivatives,koningipyridines A and B(1 and 2),along with four known compounds(3-6)were isolated from the EtOAc extract of the endophytic fungus Trichoderma koningiopsis SC-5.Among them,koningipyridine A featured an unprecedented pentacyclic ketal skeleton with the formation of a fascinating 6/6/5/6/5 fused ring system and shared a characteristic pyridine core,which represents the first example of nitrogen-containing koninginin-type natural product.Moreover,koningipyridine B was the first member in the koninginin family sharing a unique 6/6/5 dihydropyridine skeleton,and it was suggested to be the critical biosynthetic precursor of koningipyridine A.The structures of 1 and 2 were elucidated by the interpretation of 1D and 2D NMR spectroscopy,HRESIMS data,as well as theoretical calculations of 13C NMR and electronic circular dichroism(ECD).Moreover,all isolates were screened for antimicrobial activities against Staphylococcus aureus,MRSA,and Escherichia coli as well as the cytotoxic effects against three cancer cell lines(A549,Hela,and HepG2).
文摘Objective:The study reviews status,main time nodes and hospital discharge services for family caregivers of children with Kawasaki disease complicated by coronary artery aneurysm to provide references for the development of hospital discharge preparation services for medical personnel and patients.Background:CAL of Kawasaki disease is the main cause of acquired heart disease in children,but there is not enough research on the readiness for hospital discharge.Design:Systematic review of observational and interventional studies.
文摘The physical,emotional,and caregiving quality of caregivers for children with malignant solid tumors is significantly influenced by mental toughness.The definition of mental toughness,study methods,primary influencing factors,and intervention strategies for the mental toughness of caregivers of children with malignant solid tumors will be examined in this paper.To improve the mental toughness of caregivers of children with malignant solid tumors,it is recommended that future studies enhance the number of intervention research methods and establish particular evaluation tools.
基金supported by the Department of Education of Guangdong Province (No.2023KTSCX024)the Project of Traditional Chinese Medicine Bureau of Guangdong Province(No.20251091)+3 种基金the Joint Funds of the National Natural Science Foundation of China (No.U22A20368)the Key-Area Research and Development Program of Guangdong Province (No.2020B1111100004)Guangdong Basic and Applied Basic Research Foundation (No.2020B1515130005)Shenzhen Baoan District Science and Technology Innovation Bureau Project(Nos.2022JD226 and 2023JD252)。
文摘Colorectal cancer(CRC), one of the leading causes of cancer-related mortality globally, urgently requires complementary and alternative therapies. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising anticancer strategy. Dendrobium officinale(D. officinale), a renowned traditional Chinese medicinal herb, is widely used in several Asian countries for its nutritional and therapeutic benefits.Although D. officinale has demonstrated anti-tumor effects, the molecular mechanisms underlying its action against CRC remain incompletely characterized. This study aimed to elucidate the role of D. officinale in suppressing CRC through the induction of ferroptosis and its regulatory effects on glutathione peroxidase 4(GPX4), a key suppressor of ferroptosis. In vitro assays were conducted using HCT116 and SW480 CRC cell lines, and in vivo efficacy was evaluated in BALB/c nude mice bearing CRC xenografts. D. officinale significantly reduced CRC cell viability and proliferation in vitro and suppressed tumor growth in vivo. Induction of ferroptosis was evidenced by elevated levels of Fe^(2+), malondialdehyde(MDA), and lipid peroxidation, along with a depleted glutathione/oxidized glutathione disulfide(GSH/GSSG) ratio. Notably, these effects were reversed by ferroptosis inhibitors, including ferrostatin-1(Fer-1) and deferoxamine. Consistently, D. officinale markedly downregulated GPX4 expression. Overexpression of GPX4 rescued D. officinale-induced ferroptosis, whereas GPX4 silencing exacerbated this effect. D. officinale suppresses CRC by triggering GPX4-dependent ferroptosis,providing a novel, naturally derived therapeutic approach. These findings bridge traditional medicine and modern oncology, establishing a foundation for developing targeted CRC treatments.
基金the National Institutes of Health(R01-EB023052R01HL140618).
文摘Designing adhesive hydrogels with optimal properties for the treatment of injured tissues is challenging due to the tradeoff between material stiffness and toughness while maintaining adherence to wet tissue surfaces. In most cases, bioadhesives with improved mechanical strength often lack an appropriate elastic compliance, hindering their application for sealing soft, elastic, and dynamic tissues. Here, we present a novel strategy for engineering tissue adhesives in which molecular building blocks are manipulated to allow for precise control and optimization of the various aforementioned properties without any tradeoffs. To introduce tunable mechanical properties and robust tissue adhesion, the hydrogel network presents different modes of covalent and noncovalent interactions using N-hydroxysuccinimide ester (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), and Fe^(3+) ions. Through combining and tuning different molecular interactions and a variety of crosslinking mechanisms, we were able to design an extremely elastic (924%) and tough (4697 kJ/m3) multifunctional hydrogel that could quickly adhere to wet tissue surfaces within 5 s of gentle pressing and deform to support physiological tissue function over time under wet conditions. While Alg-NHS provides covalent bonding with the tissue surfaces, the catechol moieties of TA molecules synergistically adopt a mussel-inspired adhesive mechanism to establish robust adherence to the wet tissue. The strong adhesion of the engineered bioadhesive patch is showcased by its application to rabbit conjunctiva and porcine cornea. Meanwhile, the engineered bioadhesive demonstrated painless detachable characteristics and in vitro biocompatibility. Additionally, due to the molecular interactions between TA and Fe3+, antioxidant and antibacterial properties required to support the wound healing pathways were also highlighted. Overall, by tuning various molecular interactions, we were able to develop a single-hydrogel platform with an “all-in-one” multifunctionality that can address current challenges of engineering hydrogel-based bioadhesives for tissue repair and sealing.
基金This work was supported by the National Key Research and Development Program of China(Grant No.2016YFE0133200)the European Union’s Horizon 2020 Research and Innovation Staff Exchange Scheme(Grant No.734578)+6 种基金the Post-doctor Research Foundation of Shunde Graduate School of University of Science and Technology Beijing(Grant No.2021BH006)the National Natural Science Foundation of China(Grant No.52172037)the Beijing Municipal Natural Science Foundation(Grant Nos.2212036 and 4192038)the Fundamental Research Funds for the Central Universities(FRF-MP-20-49Z)the Science and Technology Innovation Special Project of Foshan Government(Grant Nos.BK20BE021 and BK21BE004)Special thanks to the Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515110631)the national high-level-university sponsored graduate program of China Scholarship Council(CSC No.201806460089),USTB-Monte Biance Joint R&D Center.
文摘Chemical vapor deposited(CVD)diamond as a burgeoning multifunctional material with tailored quality and characteristics can be artificially synthesized and controlled for various applications.Correspondingly,the application-related“grade”concept associated with materials choice and design was gradually formulated,of which the availability and the performance are optimally suited.In this review,the explicit diversity of CVD diamond and the clarification of typical grades for applications,i.e.,from resplendent gem-grade to promising quantum-grade,were systematically summarized and discussed,according to the crystal quality and main consideration of ubiquitous nitrogen impurity content as well as major applications.Realizations of those,from quantum-grade with near-ideal crystal to electronic-grade having extremely low imperfections and then to optical,thermal as well as mechanical-grade needing controlled flaws and allowable impurities,would competently fulfill the multi-field application prospects with appropriate choice in terms of cost and quality.Exceptionally,wide range defects and impurities in the gem-grade diamond(only indicating single crystal),which are detrimental for technology applications,endows CVD crystals with fancy colors to challenge their natural counterparts.
基金the grants of National Natural Science Foundation of China(81720108033,81930114)Science and Technology Projects in Guangzhou(202201011393,202102021196)+2 种基金Project of Traditional Chinese Medicine Bureau of Guangdong Province(20211111,20231234)Key-Area Research and Development Program of Guangdong Province(2020B1111100004)Guangdong Basic and Applied Basic Reuter Foundation(2020B1515130005).
文摘Worldwide,cancer is a growing epidemic that results in large social and economic burdens.Despite advances in current diagnosis and treatment,most of the prognosis in cancer patients remains poor.It is urgent to find alternative therapies with effective cancer prevention and treatment.Chinese herbal medicines(CHMs)have been increasingly used worldwide for cancer prevention and treatment due to their privileged properties.CHMs are useful in the suppression of various types of cancers through different mechanisms of action.Non-coding RNAs(ncRNAs),including microRNAs,long non-coding RNAs and circular RNAs,are closely involved in the cancer progression and development.Regulation of ncRNAs in tumor cells may be a useful pharmacological strategy for the cancer prevention and treatment.Substantial evidence exists that various phytochemicals from CHMs exert potent anticarcinogenic effects by regulating ncRNAs-related targets and signaling pathways.Herein,the purpose of this paper is to conclude the current understanding of phytochemicals from CHMs in ncRNAs-mediated cancer suppression and the molecular mechanisms.This review will help to provide beneficial clues related to the clinical use of CHMs in the cancer prevention and treatment and further promote new drug discovery against cancer.
