Objective:Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma(MCL)than those in Western.Given the success and tolerability of R-DA...Objective:Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma(MCL)than those in Western.Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas,we designed a prospective,phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL.The primary endpoint was the complete remission rate(CRR)at the end of induction(EOI).Methods:A total of 55 patients were enrolled.The CRR at the EOI was 89.1%[95%confidence interval(CI)78%±96%],and the overall response rate was 98.1%(95%CI 90%±100%).Most patients with bone marrow involvement quickly attained minimal residual disease(MRD)negative status,with a 95.7%rate at the EOI.Results:The 3-year progression-free survival(PFS)and overall survival rates were 66.3%and 83.2%,respectively.No patients discontinued treatment because of adverse events.Univariate analysis identified pathologic morphology and TP53 mutations as risk factors for PFS.However,high tumor proliferative activity and certain cytogenetic abnormalities showed no significant adverse prognostic significance.Conclusions:Intensive therapy based on a high cytarabine dose and continuously administered EDOCH achieved a high MRDnegative rate and provides an optional induction choice for young patients with MCL with high-risk factors.展开更多
The aim of the study is to determine the optimal structural parameters for a plastic centrifugal pump inducer within the framework of an orthogonal experimental method.For this purpose,a numerical study of the related...The aim of the study is to determine the optimal structural parameters for a plastic centrifugal pump inducer within the framework of an orthogonal experimental method.For this purpose,a numerical study of the related flow field is performed using CFX.The shaft power and the head of the pump are taken as the evaluation indicators.Accordingly,the examined variables are the thickness(S),the blade cascade degree(t),the blade rim angle(β1),the blade hub angle(β2)and the hub length(L).The impact of each structural parameter on each evaluation index is examined and special attention is paid to the following combinations:S2 mm,t 2,β1235°,β2360°and L 140 mm(corresponding to a maximum head of 98.15 m);S 5 mm,t 1.6,β1252°,β2350°and L 140 mm(corresponding to a minimum shaft power of 63.06 KW).Moreover,using least squares and fish swarm algorithms,the pump shaft power and head are further optimized,yielding the following optimal combination:S 5 mm,t 1.9,β1252°,β2360°and L 145 mm(corresponding to the maximum head of 91.90 m,and a minimum shaft power of 64.83 KW).展开更多
In order to determine the optimal structural parameters of a plastic centrifugal pump in the framework of an orthogonal-experiment approach,a numerical study of the related flow field has been performed using CFX.The ...In order to determine the optimal structural parameters of a plastic centrifugal pump in the framework of an orthogonal-experiment approach,a numerical study of the related flow field has been performed using CFX.The thickness S,outlet angleβ2,inlet angleβ1,wrap angle,and inlet diameter D1 of the splitter blades have been considered as the variable factors,using the shaft power and efficiency of the pump as evaluation indices.Through a parametric analysis,the relative importance of the influence of each structural parameter on each evaluation index has been obtained,leading to the following combinations:β119°,β235°,S 2 mm,wrap angle 154°,and D185 mm(corresponding to the maximum efficiency of 75.48%);β119°,β220°,S 6 mm,wrap angle 158°,and D181 mm(corresponding to the minimum shaft power of 75.48%).Moreover,the grey correlation method has been applied to re-optimize the shaft power and efficiency of the pump,leading to the following optimal combination:β119°,β215°,S 4 mm,D181 mm,and wrap angle 152°(corresponding to the maximum efficiency of 71.81%and minimum shaft power of 2.187 kW).展开更多
Large granular lymphocytic leukemia(LGLL)is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells.Standard first-line immunosuppressive treatments have limitations,achieving complete remissi...Large granular lymphocytic leukemia(LGLL)is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells.Standard first-line immunosuppressive treatments have limitations,achieving complete remission(CR)rates of up to 50%.Immune system dysregulation is implicated in LGLL.Promising results for thalidomide,an immunomodulatory drug,combined with prednisone and methotrexate(TPM),were observed in our pilot study.This multicenter study evaluated the effcacy and safety of a thalidomide,prednisone,and methotrexate(TPM)regimen in 52 symptomatic,methotrexate-and thalidomide-naive LGLL patients from June 2020 to August 2022.Thalidomide(100 mg daily for up to 24 months),prednisone(0.5-1.0 mg/kg every other day,tapered after 3 months),and methotrexate(10 mg/m^(2) weekly for up to 12 months)were administered.The primary objective was to determine the CR rate.The median follow-up duration was 29.0 months(range:4.0-42.0).Forty-seven patients(90.4%)achieved hematological and symptomatic responses.Thirty-nine patients(75.0%)achieved CR.The median time to response was 3.0 months(range:3.0-9.0).The median progression-free survival was 40.0 months(95%confidence interval(Cl):38.0-42.0),and the median duration of response was 39.0 months(95%Cl:36.1-41.9).The most common adverse event was peripheral neuropathy(24.1%),most of which(84.6%)were grades 1-2.Four patients experienced grade≥3 adverse events.In conclusion,the TPM regimen was an effective and safe treatment for symptomatic LGLL patients,with a particularly high CR rate.This trial was registered at www.clinicaltrials.gov(#NCT04453345).展开更多
Real-time thermal sensing through flexible temperature sensors in extreme environments is critically essential for precisely monitoring chemical reactions,propellant combustions,and metallurgy processes.However,despit...Real-time thermal sensing through flexible temperature sensors in extreme environments is critically essential for precisely monitoring chemical reactions,propellant combustions,and metallurgy processes.However,despite their low response speed,most existing thermal sensors and related sensing materials will degrade or even lose their sensing performances at either high or low temperatures.Achieving a microsecond response time over an ultrawide temperature range remains challenging.Here,we design a flexible temperature sensor that employs ultrathin and consecutive Mo_(1−x)W_(x)S_(2) alloy films constructed via inkjet printing and a thermal annealing strategy.The sensing elements exhibit a broad work range(20 to 823 K on polyimide and 1,073 K on flexible mica)and a record-low response time(about 30μs).These properties enable the sensors to detect instantaneous temperature variations induced by contact with liquid nitrogen,water droplets,and flames.Furthermore,a thermal sensing array offers the spatial mapping of arbitrary shapes,heat conduction,and cold traces even under bending deformation.This approach paves the way for designing unique sensitive materials and flexible sensors for transient sensing under harsh conditions.展开更多
Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-in...Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.展开更多
Rituximab maintenance(RM)prolongs the progression-free survival(PFS)of responding patients with follicular lymphoma(FL),but the maintenance efficacy in different Follicular Lymphoma International Prognostic Index(FLIP...Rituximab maintenance(RM)prolongs the progression-free survival(PFS)of responding patients with follicular lymphoma(FL),but the maintenance efficacy in different Follicular Lymphoma International Prognostic Index(FLIPI)risk group is still confusing.We performed a retrospective analysis of the effect of RM treatments in patients with FL responding to induction therapy based on their FLIPI risk assessment carried out prior to treatment.We identified 93 patients between 2013 and 2019 who received RM every 3 months for≥4 doses(RM group),and 60 patients who did not accept RM or received rituximab less than 4 doses(control group).After a median follow-up of 39 months,neither median overall survival(OS)nor PFS was reached for the entire population.The PFS was significantly prolonged in the RM group compared to the control group(median PFS NA vs 83.1 months,P=.00027).When the population was divided into the 3 FLIPI risk groups,the PFS differed significantly(4-year PFS rates,97.5%vs 88.8%vs 72.3%,P=.01)according to group.There was no significant difference in PFS for FLIPI low-risk patients with RM compared to the control group(4-year PFS rates,100%vs 93.8%,P=.23).However,the PFS of the RM group was significantly prolonged for FLIPI intermediate-risk(4-year PFS rates,100%vs 70.3%,P=.00077)and high-risk patients(4-year PFS rates,86.7%vs 57.1%,P=.023).These data suggest that standard RM significantly prolongs the PFS of patients assigned to intermediate-and high-risk FLIPI groups but not to low-risk FLIPI group,and pending larger-scale studies to validate.展开更多
In order to solve the problems of low sensitivity and complex sample pretreatment in traditional detection,a method was proposed in this study to detect daminozide using terahertz combined with a metamaterial sensor,w...In order to solve the problems of low sensitivity and complex sample pretreatment in traditional detection,a method was proposed in this study to detect daminozide using terahertz combined with a metamaterial sensor,which enables real-time and label-free molecular detection with high sensitivity.The correlation between the transmission frequency shift and absorbance of daminozide solution at different concentrations was analyzed.The simulation and experimental results showed that this metamaterial sensor could achieve highly sensitive sensing of daminozide solutions at 0.05 mg/L.The maximum quality factor(Q_(max))of the two peaks could reach 5.78 and 13.05,and the maximum figure of merit(FOM)of the two peaks can reach 0.82 and 1.72.The maximum sensitivity of two resonance peaks reached 38.148 GHz/(mg·L)and 133.516 GHz/(mg·L)when the concentration of daminozide in the solution was 2000 mg/L.There was an obvious positive correlation between the transmission and transmission,frequency shift and frequency shift,and absorbance and absorbance of the resonance peak of daminozide solutions.Therefore,this platform not only opens up new possibilities for the microanalysis of the chemical composition of substances in solutions but also provides a valuable reference for the design of other metamaterial-based sensors in the field of food safety.展开更多
The external pressure is one of the essential parameters for regulating the structure and energy con-version properties of antiferroelectric AgNbO_(3).For pure AgNbO_(3),however,there has been still a blank of its rea...The external pressure is one of the essential parameters for regulating the structure and energy con-version properties of antiferroelectric AgNbO_(3).For pure AgNbO_(3),however,there has been still a blank of its real lattice structure under the stress field.Here,high-pressure lattice structures and phase transitions of AgNbO_(3)have been explored by spectroscopic experiments and theoretical models.A successive phase transition process from Pbcm to C222_(1) to P2_(1) has been observed at the pressure range of 0-30 GPa,associated with displacive-type characterized by soft-mode kinetics.Note that the paraelectric phase cannot be achieved under high-pressure at room temperature.Significantly,the competition of long-range Coulomb force,short-range interatomic interaction,and covalent interaction in AgNbO_(3)lattice were demonstrated under the stress field.The present work can provide fundamental guidelines to reveal the high-pressure phase transitions of AgNbO_(3),which will open up possibilities for the designing device with functional properties at extremes.展开更多
Waldenstrom macroglobulinemia(WM)is a type of incurable,indolent B-cell lymphoma that is prone to relapse.Over time,treatment strategies have progressed from cytotoxic drugs to rituximab(R)-or bortezomib(V)-based regi...Waldenstrom macroglobulinemia(WM)is a type of incurable,indolent B-cell lymphoma that is prone to relapse.Over time,treatment strategies have progressed from cytotoxic drugs to rituximab(R)-or bortezomib(V)-based regimens,and have now entered into an era of Bruton tyrosine kinase inhibitor(BTKi)-based regimens.However,the optimal treatment for the relapsed patients is still unclear.Herein,we analyzed the outcomes of the first-and second-line therapies in 377 patients with WM to illustrate the optimal choices for second-line therapy.After a median follow-up of 45.4 months,89 patients received second-line therapy,and 53 patients were evaluated for response.The major response rates(MRR)of first-and second-line treatment were 65.1%and 67.9%(P=0.678).The median progression-free survival(PFS)for the second-line therapy(PFS2)was shorter than that for the first-line therapy(PFS1)(56.3 vs 40.7 months,P=0.03).However,PFS2 in targeted drugs group(R-/V-/BTKi-based regimens)was comparable to PFS1(60.7 months vs 44.7 months,respectively,P=0.21).Regarding second-line therapy,patients who underwent sequential treatment escalation—such as transitioning from cytotoxic drugs to R-/V-/BTKi-based regimens or from R-/V-based to BTKi-based regimens(escalation group)—had higher MRR(80.6%vs 47.1%,respectively,P=0.023)and longer PFS2(50.4 vs 23.5 months,respectively,P<0.001)compared to the non-escalation group.Patients in the escalation group also had longer post-relapse overall survival compared with the non-escalation group(median,not reached vs 50.7 months,respectively,P=0.039).Our findings indicate that sequential treatment escalation may improve the survival of patients with WM.展开更多
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82200215,82170193,and 82370197)the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(Grant No.2022-I2M-1-002)。
文摘Objective:Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma(MCL)than those in Western.Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas,we designed a prospective,phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL.The primary endpoint was the complete remission rate(CRR)at the end of induction(EOI).Methods:A total of 55 patients were enrolled.The CRR at the EOI was 89.1%[95%confidence interval(CI)78%±96%],and the overall response rate was 98.1%(95%CI 90%±100%).Most patients with bone marrow involvement quickly attained minimal residual disease(MRD)negative status,with a 95.7%rate at the EOI.Results:The 3-year progression-free survival(PFS)and overall survival rates were 66.3%and 83.2%,respectively.No patients discontinued treatment because of adverse events.Univariate analysis identified pathologic morphology and TP53 mutations as risk factors for PFS.However,high tumor proliferative activity and certain cytogenetic abnormalities showed no significant adverse prognostic significance.Conclusions:Intensive therapy based on a high cytarabine dose and continuously administered EDOCH achieved a high MRDnegative rate and provides an optional induction choice for young patients with MCL with high-risk factors.
基金project of the“The University Synergy Innovation Program of Anhui Province(GXXT-2019-004)”,“Natural Science Research Project of Anhui Universities(KJ2021ZD0144)”,“Wuhu Key R&D Project:Research and Industrialization of Intelligent Control Method of Engine Energy-Feeding Hydraulic Semi-Active Mount”.
文摘The aim of the study is to determine the optimal structural parameters for a plastic centrifugal pump inducer within the framework of an orthogonal experimental method.For this purpose,a numerical study of the related flow field is performed using CFX.The shaft power and the head of the pump are taken as the evaluation indicators.Accordingly,the examined variables are the thickness(S),the blade cascade degree(t),the blade rim angle(β1),the blade hub angle(β2)and the hub length(L).The impact of each structural parameter on each evaluation index is examined and special attention is paid to the following combinations:S2 mm,t 2,β1235°,β2360°and L 140 mm(corresponding to a maximum head of 98.15 m);S 5 mm,t 1.6,β1252°,β2350°and L 140 mm(corresponding to a minimum shaft power of 63.06 KW).Moreover,using least squares and fish swarm algorithms,the pump shaft power and head are further optimized,yielding the following optimal combination:S 5 mm,t 1.9,β1252°,β2360°and L 145 mm(corresponding to the maximum head of 91.90 m,and a minimum shaft power of 64.83 KW).
基金This article belongs to the project of the“The University Synergy Innovation Program of Anhui Province(GXXT-2019-004)”“Natural Science Research Project of Anhui Universities(KJ2021ZD0144)”“Wuhu Key R&D Project:Research and Industrialization of Intelligent Control Method of Engine Energy-feeding Hydraulic Semi-Active Mount”.
文摘In order to determine the optimal structural parameters of a plastic centrifugal pump in the framework of an orthogonal-experiment approach,a numerical study of the related flow field has been performed using CFX.The thickness S,outlet angleβ2,inlet angleβ1,wrap angle,and inlet diameter D1 of the splitter blades have been considered as the variable factors,using the shaft power and efficiency of the pump as evaluation indices.Through a parametric analysis,the relative importance of the influence of each structural parameter on each evaluation index has been obtained,leading to the following combinations:β119°,β235°,S 2 mm,wrap angle 154°,and D185 mm(corresponding to the maximum efficiency of 75.48%);β119°,β220°,S 6 mm,wrap angle 158°,and D181 mm(corresponding to the minimum shaft power of 75.48%).Moreover,the grey correlation method has been applied to re-optimize the shaft power and efficiency of the pump,leading to the following optimal combination:β119°,β215°,S 4 mm,D181 mm,and wrap angle 152°(corresponding to the maximum efficiency of 71.81%and minimum shaft power of 2.187 kW).
基金supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-12M-C&T-B-081 and 2022-I2M-1-022)the National Nature Science Foundation of China(82170193,82370197,82200215)+1 种基金the Tianjin Health Science and Technology Project(TJWJ2022XK021)the Tianjin Health Research Project(TJSQNYXXR-D2-152).
文摘Large granular lymphocytic leukemia(LGLL)is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells.Standard first-line immunosuppressive treatments have limitations,achieving complete remission(CR)rates of up to 50%.Immune system dysregulation is implicated in LGLL.Promising results for thalidomide,an immunomodulatory drug,combined with prednisone and methotrexate(TPM),were observed in our pilot study.This multicenter study evaluated the effcacy and safety of a thalidomide,prednisone,and methotrexate(TPM)regimen in 52 symptomatic,methotrexate-and thalidomide-naive LGLL patients from June 2020 to August 2022.Thalidomide(100 mg daily for up to 24 months),prednisone(0.5-1.0 mg/kg every other day,tapered after 3 months),and methotrexate(10 mg/m^(2) weekly for up to 12 months)were administered.The primary objective was to determine the CR rate.The median follow-up duration was 29.0 months(range:4.0-42.0).Forty-seven patients(90.4%)achieved hematological and symptomatic responses.Thirty-nine patients(75.0%)achieved CR.The median time to response was 3.0 months(range:3.0-9.0).The median progression-free survival was 40.0 months(95%confidence interval(Cl):38.0-42.0),and the median duration of response was 39.0 months(95%Cl:36.1-41.9).The most common adverse event was peripheral neuropathy(24.1%),most of which(84.6%)were grades 1-2.Four patients experienced grade≥3 adverse events.In conclusion,the TPM regimen was an effective and safe treatment for symptomatic LGLL patients,with a particularly high CR rate.This trial was registered at www.clinicaltrials.gov(#NCT04453345).
基金supported by the National Natural Science Foundation of China(62304182,62371397,and 62288102)the Natural Science Foundation of Shaanxi Province(2023-JC-YB-495)+1 种基金the Fundamental Research Funds for the Central Universitiesthe start-up funds from Northwestern Polytechnical University(G2022WD01001 and 23GH02021).
文摘Real-time thermal sensing through flexible temperature sensors in extreme environments is critically essential for precisely monitoring chemical reactions,propellant combustions,and metallurgy processes.However,despite their low response speed,most existing thermal sensors and related sensing materials will degrade or even lose their sensing performances at either high or low temperatures.Achieving a microsecond response time over an ultrawide temperature range remains challenging.Here,we design a flexible temperature sensor that employs ultrathin and consecutive Mo_(1−x)W_(x)S_(2) alloy films constructed via inkjet printing and a thermal annealing strategy.The sensing elements exhibit a broad work range(20 to 823 K on polyimide and 1,073 K on flexible mica)and a record-low response time(about 30μs).These properties enable the sensors to detect instantaneous temperature variations induced by contact with liquid nitrogen,water droplets,and flames.Furthermore,a thermal sensing array offers the spatial mapping of arbitrary shapes,heat conduction,and cold traces even under bending deformation.This approach paves the way for designing unique sensitive materials and flexible sensors for transient sensing under harsh conditions.
基金supported by the National Natural Science Foundation of China (52173152, 21805002)Guangdong Basic and Applied Basic Research Foundation (2020A1515110476)+7 种基金the Fund of the Rising Stars of Shaanxi Province (2021KJXX-48)the Shenzhen Science and Technology Program (KQTD20210811090115019)the Major Instrumentation Development Program of the Chinese Academy of Sciences(ZDKYYQ20220008)Shenzhen Basic Research (key project)(China)(JCYJ20210324120011030)the Scientific and Technological Innovation Team of Shaanxi Province (2022TD-36)the National Key R&D Programs(China)(2021YFA0910001)Shaanxi Fundamental Science Research Project for Chemistry&Biology (22JHQ078)the Scientific Research Program Funded by Shaanxi Provincial Education Department (22JK0247)。
文摘Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.
基金the National Natural Science Foundation of China(81970187,82170193,81920108006,and 81900203)Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-C&T-B-081).
文摘Rituximab maintenance(RM)prolongs the progression-free survival(PFS)of responding patients with follicular lymphoma(FL),but the maintenance efficacy in different Follicular Lymphoma International Prognostic Index(FLIPI)risk group is still confusing.We performed a retrospective analysis of the effect of RM treatments in patients with FL responding to induction therapy based on their FLIPI risk assessment carried out prior to treatment.We identified 93 patients between 2013 and 2019 who received RM every 3 months for≥4 doses(RM group),and 60 patients who did not accept RM or received rituximab less than 4 doses(control group).After a median follow-up of 39 months,neither median overall survival(OS)nor PFS was reached for the entire population.The PFS was significantly prolonged in the RM group compared to the control group(median PFS NA vs 83.1 months,P=.00027).When the population was divided into the 3 FLIPI risk groups,the PFS differed significantly(4-year PFS rates,97.5%vs 88.8%vs 72.3%,P=.01)according to group.There was no significant difference in PFS for FLIPI low-risk patients with RM compared to the control group(4-year PFS rates,100%vs 93.8%,P=.23).However,the PFS of the RM group was significantly prolonged for FLIPI intermediate-risk(4-year PFS rates,100%vs 70.3%,P=.00077)and high-risk patients(4-year PFS rates,86.7%vs 57.1%,P=.023).These data suggest that standard RM significantly prolongs the PFS of patients assigned to intermediate-and high-risk FLIPI groups but not to low-risk FLIPI group,and pending larger-scale studies to validate.
基金supported by the National Natural Science Foundation of China(Grant No.32071905,No.62101217,No.61771224)the Natural Science Foundation of Jiangsu Province(Grant No.BK20190858)+4 种基金the Project of Agricultural Equipment Department of Jiangsu University(Grant No.NZXB20210106)China Postdoctoral Science Foundation(Grant No.2019M661754)China Scholarship Council(Grant No.201908320223)Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX19_1619)Zhenjiang Science and Technology Innovation Fund(Grant No.SH2020051).
文摘In order to solve the problems of low sensitivity and complex sample pretreatment in traditional detection,a method was proposed in this study to detect daminozide using terahertz combined with a metamaterial sensor,which enables real-time and label-free molecular detection with high sensitivity.The correlation between the transmission frequency shift and absorbance of daminozide solution at different concentrations was analyzed.The simulation and experimental results showed that this metamaterial sensor could achieve highly sensitive sensing of daminozide solutions at 0.05 mg/L.The maximum quality factor(Q_(max))of the two peaks could reach 5.78 and 13.05,and the maximum figure of merit(FOM)of the two peaks can reach 0.82 and 1.72.The maximum sensitivity of two resonance peaks reached 38.148 GHz/(mg·L)and 133.516 GHz/(mg·L)when the concentration of daminozide in the solution was 2000 mg/L.There was an obvious positive correlation between the transmission and transmission,frequency shift and frequency shift,and absorbance and absorbance of the resonance peak of daminozide solutions.Therefore,this platform not only opens up new possibilities for the microanalysis of the chemical composition of substances in solutions but also provides a valuable reference for the design of other metamaterial-based sensors in the field of food safety.
基金supported by the National Natural Science Foundation of China(Grant Nos.62090013,61974043,12104156,62074058,61974044)the National Key Research and Development Program of China(Grants No.2019YFB2203403)+1 种基金Projects of Science and Technology Commission of Shanghai Municipality(Grant Nos.21JC1402100 and 23ZR1446400)Natural Science Foundation of Chongqing,China(CSTB2022NSCQ-MSX1367),the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning.
文摘The external pressure is one of the essential parameters for regulating the structure and energy con-version properties of antiferroelectric AgNbO_(3).For pure AgNbO_(3),however,there has been still a blank of its real lattice structure under the stress field.Here,high-pressure lattice structures and phase transitions of AgNbO_(3)have been explored by spectroscopic experiments and theoretical models.A successive phase transition process from Pbcm to C222_(1) to P2_(1) has been observed at the pressure range of 0-30 GPa,associated with displacive-type characterized by soft-mode kinetics.Note that the paraelectric phase cannot be achieved under high-pressure at room temperature.Significantly,the competition of long-range Coulomb force,short-range interatomic interaction,and covalent interaction in AgNbO_(3)lattice were demonstrated under the stress field.The present work can provide fundamental guidelines to reveal the high-pressure phase transitions of AgNbO_(3),which will open up possibilities for the designing device with functional properties at extremes.
基金supported by grants from the National Nature Science Foundation of China(81970187,82170193,81920108006,and 81900203)the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2022-I2M-1-022,2021-I2M-C,and T-B-081).
文摘Waldenstrom macroglobulinemia(WM)is a type of incurable,indolent B-cell lymphoma that is prone to relapse.Over time,treatment strategies have progressed from cytotoxic drugs to rituximab(R)-or bortezomib(V)-based regimens,and have now entered into an era of Bruton tyrosine kinase inhibitor(BTKi)-based regimens.However,the optimal treatment for the relapsed patients is still unclear.Herein,we analyzed the outcomes of the first-and second-line therapies in 377 patients with WM to illustrate the optimal choices for second-line therapy.After a median follow-up of 45.4 months,89 patients received second-line therapy,and 53 patients were evaluated for response.The major response rates(MRR)of first-and second-line treatment were 65.1%and 67.9%(P=0.678).The median progression-free survival(PFS)for the second-line therapy(PFS2)was shorter than that for the first-line therapy(PFS1)(56.3 vs 40.7 months,P=0.03).However,PFS2 in targeted drugs group(R-/V-/BTKi-based regimens)was comparable to PFS1(60.7 months vs 44.7 months,respectively,P=0.21).Regarding second-line therapy,patients who underwent sequential treatment escalation—such as transitioning from cytotoxic drugs to R-/V-/BTKi-based regimens or from R-/V-based to BTKi-based regimens(escalation group)—had higher MRR(80.6%vs 47.1%,respectively,P=0.023)and longer PFS2(50.4 vs 23.5 months,respectively,P<0.001)compared to the non-escalation group.Patients in the escalation group also had longer post-relapse overall survival compared with the non-escalation group(median,not reached vs 50.7 months,respectively,P=0.039).Our findings indicate that sequential treatment escalation may improve the survival of patients with WM.
