With the advancements in gene sequencing technologies,including genome-wide association studies,polygenetic risk scores,and high-throughput sequencing,there has been a tremendous advantage in mapping a detailed bluepr...With the advancements in gene sequencing technologies,including genome-wide association studies,polygenetic risk scores,and high-throughput sequencing,there has been a tremendous advantage in mapping a detailed blueprint for the genetic model of bipolar disorder(BD).To date,intriguing genetic clues have been identified to explain the development of BD,as well as the genetic association that might be applied for the development of susceptibility prediction and pharmacogenetic intervention.Risk genes of BD,such as CACNA1C,ANK3,TRANK1,and CLOCK,have been found to be involved in various pathophysiological processes correlated with BD.Although the specific roles of these genes have yet to be determined,genetic research on BD will help improve the prevention,therapeutics,and prognosis in clinical practice.The latest preclinical and clinical studies,and reviews of the genetics of BD,are analyzed in this review,aiming to summarize the progress in this intriguing field and to provide perspectives for individualized,precise,and effective clinical practice.展开更多
The influence of acceleration of electrons on relativistic nonlinear Thomson scattering in tightly focused linearly polarized laser pulses is investigated for the first time. In the framework of classical electrodynam...The influence of acceleration of electrons on relativistic nonlinear Thomson scattering in tightly focused linearly polarized laser pulses is investigated for the first time. In the framework of classical electrodynamics, it is deduced and found that the more severe the change in the electron transverse acceleration, the stronger the asymmetry of the radiation angle distribution, and the greater the transverse acceleration, the greater the radiation energy. Tightly focused, ultrashort,and high-intensity lasers lead to violent electron acceleration processes, resulting in a bifurcated radiation structure with asymmetry and higher energy. Additionally, a change in the initial phase of the laser brings about periodic change of the acceleration, which in turn makes the radiation change periodically with the initial phase. In other cases, the radiation is in a symmetrical double-peak structure. These phenomena will help us to modulate radiation with more energy collimation.展开更多
The electrical performance of two-dimensional transition metal dichalcogenides （TMDs） is strongly affected by the number of structural defects. In this work, we provide an optical spectroscopic characterization appr...The electrical performance of two-dimensional transition metal dichalcogenides （TMDs） is strongly affected by the number of structural defects. In this work, we provide an optical spectroscopic characterization approach to correlate the number of structural defects and the electrical performance of WSe2 devices. Low-temperature photoluminescence （PL） spectra of electron-beam-lithography- processed WSe2 exhibit a clear defect-induced PL emission due to excitons bound to defects, which would strongly degrade the electrical performance. By adopting an electron-beam-free transfer-electrode technique, we successfully prepared a backgated WSe2 device containing a limited amount of defects. A maximum hole mobility of approximately 200 cm2.V -1.s-1 was achieved because of the reduced scattering sources, which is the highest reported value for this type of device. This work provides not only a versatile and nondestructive method to monitor the defects in TMDs but also a new route to approach the room-temperature phonon-limited mobility in high-performance TMD devices.展开更多
Purpose:This study examines the impact of international academic mobility on knowledge exchange between China and the West,including its potential benefits and risks,specifically in the humanities and social sciences(...Purpose:This study examines the impact of international academic mobility on knowledge exchange between China and the West,including its potential benefits and risks,specifically in the humanities and social sciences(HSS)fields.Design/Approach/Methods:This study employed qualitative research methods;specifically,data were collected through interviews and analyzed using thematic analysis.Findings:With increasing knowledge flows in global academia,Chinese HsS scholars are bene-fiting from international academic mobility.They engage in various activities,such as international visits,conferences,and research collaborations,and praise the role of mobility in building an understanding of Western culture and knowledge,including research dynamics,embodied and encultured knowledge,and location-specific textual materials.However,international mobility has inadvertently exacerbated global knowledge asymmetries,with some Chinese scholars uncrit-ically adopting Western paradigms.Nonetheless,pioneering Chinese HSS scholars aim to promote a two-way knowledge exchange between China and the West by fostering cultural reflexivity and enhancing their global visibility.Originality/Value:Chinese HsS scholars serve as an illuminating example in the context of glo-bal knowledge asymmetries dominated by the Anglo-American West.These findings have theor-etical and practical implications for fostering equitable and inclusive knowledge exchange between Western and non-Western societies through international academic mobility.展开更多
基金supported by the Zhejiang Provincial Key Research and Development Program(2021C03107)the Leading Talent of Scientific and Technological Innovation“Ten Thousand Talents Program”of Zhejiang Province(2021R52016)+1 种基金the Innovation Team for Precision Diagnosis and Treatment of Major Brain Diseases(2020R01001)the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(JNL-2023001B).
文摘With the advancements in gene sequencing technologies,including genome-wide association studies,polygenetic risk scores,and high-throughput sequencing,there has been a tremendous advantage in mapping a detailed blueprint for the genetic model of bipolar disorder(BD).To date,intriguing genetic clues have been identified to explain the development of BD,as well as the genetic association that might be applied for the development of susceptibility prediction and pharmacogenetic intervention.Risk genes of BD,such as CACNA1C,ANK3,TRANK1,and CLOCK,have been found to be involved in various pathophysiological processes correlated with BD.Although the specific roles of these genes have yet to be determined,genetic research on BD will help improve the prevention,therapeutics,and prognosis in clinical practice.The latest preclinical and clinical studies,and reviews of the genetics of BD,are analyzed in this review,aiming to summarize the progress in this intriguing field and to provide perspectives for individualized,precise,and effective clinical practice.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.10947170/A05 and 11104291)Natural Science Fund for Colleges and Universities in Jiangsu Province(Grant No.10KJB140006)+2 种基金Natural Sciences Foundation of Shanghai(Grant No.11ZR1441300)Natural Science Foundation of Nanjing University of Posts and Telecommunications(Grant No.NY221098)sponsored by the Jiangsu Qing Lan Project and STITP Project(Grant No.XYB2013012)。
文摘The influence of acceleration of electrons on relativistic nonlinear Thomson scattering in tightly focused linearly polarized laser pulses is investigated for the first time. In the framework of classical electrodynamics, it is deduced and found that the more severe the change in the electron transverse acceleration, the stronger the asymmetry of the radiation angle distribution, and the greater the transverse acceleration, the greater the radiation energy. Tightly focused, ultrashort,and high-intensity lasers lead to violent electron acceleration processes, resulting in a bifurcated radiation structure with asymmetry and higher energy. Additionally, a change in the initial phase of the laser brings about periodic change of the acceleration, which in turn makes the radiation change periodically with the initial phase. In other cases, the radiation is in a symmetrical double-peak structure. These phenomena will help us to modulate radiation with more energy collimation.
基金This work was supported by National Natural Science Foundation of China （Nos. 61422503, 21541013 and 61376104）, Natural Science Foundation of Jiangsu Province （No. BK20150596）, Jiangsu key laboratory for advanced metallic materials （No. BM2007204）, the open research funds of Key Laboratory of MEMS of Ministry of Education （SEU, China）, and the Funda- mental Research Funds for the Central Universities. The authors would like to thank Prof. Zhenhua Qiao from USTC, China for helpful discussions.
文摘The electrical performance of two-dimensional transition metal dichalcogenides （TMDs） is strongly affected by the number of structural defects. In this work, we provide an optical spectroscopic characterization approach to correlate the number of structural defects and the electrical performance of WSe2 devices. Low-temperature photoluminescence （PL） spectra of electron-beam-lithography- processed WSe2 exhibit a clear defect-induced PL emission due to excitons bound to defects, which would strongly degrade the electrical performance. By adopting an electron-beam-free transfer-electrode technique, we successfully prepared a backgated WSe2 device containing a limited amount of defects. A maximum hole mobility of approximately 200 cm2.V -1.s-1 was achieved because of the reduced scattering sources, which is the highest reported value for this type of device. This work provides not only a versatile and nondestructive method to monitor the defects in TMDs but also a new route to approach the room-temperature phonon-limited mobility in high-performance TMD devices.
基金financially supported by the National Natural Science Foundation of China (31770501)Graduate Research and Practice Projects of Minzu University of China (NO.BZKY2022046).
文摘Purpose:This study examines the impact of international academic mobility on knowledge exchange between China and the West,including its potential benefits and risks,specifically in the humanities and social sciences(HSS)fields.Design/Approach/Methods:This study employed qualitative research methods;specifically,data were collected through interviews and analyzed using thematic analysis.Findings:With increasing knowledge flows in global academia,Chinese HsS scholars are bene-fiting from international academic mobility.They engage in various activities,such as international visits,conferences,and research collaborations,and praise the role of mobility in building an understanding of Western culture and knowledge,including research dynamics,embodied and encultured knowledge,and location-specific textual materials.However,international mobility has inadvertently exacerbated global knowledge asymmetries,with some Chinese scholars uncrit-ically adopting Western paradigms.Nonetheless,pioneering Chinese HSS scholars aim to promote a two-way knowledge exchange between China and the West by fostering cultural reflexivity and enhancing their global visibility.Originality/Value:Chinese HsS scholars serve as an illuminating example in the context of glo-bal knowledge asymmetries dominated by the Anglo-American West.These findings have theor-etical and practical implications for fostering equitable and inclusive knowledge exchange between Western and non-Western societies through international academic mobility.
