As the scale of the networks continually expands,the detection of distributed denial of service(DDoS)attacks has become increasingly vital.We propose an intelligent detection model named IGED by using improved general...As the scale of the networks continually expands,the detection of distributed denial of service(DDoS)attacks has become increasingly vital.We propose an intelligent detection model named IGED by using improved generalized entropy and deep neural network(DNN).The initial detection is based on improved generalized entropy to filter out as much normal traffic as possible,thereby reducing data volume.Then the fine detection is based on DNN to perform precise DDoS detection on the filtered suspicious traffic,enhancing the neural network’s generalization capabilities.Experimental results show that the proposed method can efficiently distinguish normal traffic from DDoS traffic.Compared with the benchmark methods,our method reaches 99.9%on low-rate DDoS(LDDoS),flooded DDoS and CICDDoS2019 datasets in terms of both accuracy and efficiency in identifying attack flows while reducing the time by 17%,31%and 8%.展开更多
In line with the worldwide trend in population aging,China has stepped into an aging society since 2000.The outstanding features of aging,including a large proportion of the older population,rapid growth,dramatic expa...In line with the worldwide trend in population aging,China has stepped into an aging society since 2000.The outstanding features of aging,including a large proportion of the older population,rapid growth,dramatic expansion of the oldest-old,and uneven aging distribution,have put China in a unique position.Besides,older population is expanding in parallel with the escalating burden of disease,high prevalence of disability,and low social involvement.However,China is not prepared to solve these problems in terms of the economy,awareness,geriatric care system,geriatric team,social security,or age-friendly environment.From the perspective of public health,we summarized the major challenges and proposed the following policy recommendations:(1)strengthening the top-level design and building a"government-leading,multi-sectoral-cooperating,and society-participating"pattern;(2)enhancing health services by implementing the"comprehensive health"strategy;(3)developing home and community care,coordinately enhance institutional care,promote integration of medical and care systems,and establish a multidimensional tailored care system;(4)optimizing geriatric the supporting system,included the construction of geriatric team and the long-term care insurance system;and(5)establishing a physical and socially age-friendly environment.展开更多
EFL preservice teachers ’ research efficacy, as perceived competence to perform tasks in research, is crucial to their research engagement. This autobiographical narrative inquiry investigates the contribution of sca...EFL preservice teachers ’ research efficacy, as perceived competence to perform tasks in research, is crucial to their research engagement. This autobiographical narrative inquiry investigates the contribution of scaffolded research practice to a female EFL preservice teacher ’s research efficacy.The data were collected through conversations, notes, journals, and portfolios. The findings suggest that teacher research efficacy was pliable through scaffolded research practice. It emerged gradually over time, in different places with social and personal interaction. The factors contributing to the emerging research efficacy were: teacher educators ’ support, peers ’ support,and research participation. The study sheds light on teacher educators and EFL preservice teachers,with the intention of establishing an inquiry-based pedagogy for M.Ed. programs.展开更多
This study compared the effects on bone metabolism and morphology of pathological obesity induced by excessive fat intake in a non-hibernator(mice)versus healthy obesity due to pre-hibernation fattening in a hibernato...This study compared the effects on bone metabolism and morphology of pathological obesity induced by excessive fat intake in a non-hibernator(mice)versus healthy obesity due to pre-hibernation fattening in a hibernator(ground squirrels).Kunming mice were fed a high-fat diet to provide a model of pathological obesity(OB group).Daurian ground squirrels fattened naturally in their pre-hibernation season(PRE group)were used as a healthy obesity model.Micro-computed tomography(micro-CT)and three-point bending tests were used to determine the microstructure and mechanical properties of bone.Western blots were used to analyze protein expression levels related to bone metabolism(Runt-related transcription factor 2(RunX2),osteocalcin(OCN),alkaline phosphatase(ALP),osteoprotegerin(OPG),receptor activator of nuclear factor-κB ligand(RANKL),cathepsin K,matrix metallopeptidase 9(MMP9),patched protein homolog 1(Ptch1),phosphorylatedβ-catenin(P-β-catenin),and glycogen synthase kinase-3β(GSK-3β)).Compared with controls,there was no obvious bone loss in the OB mice,and the stiffness of the femur was increased significantly.Compared with summer active squirrels,bone formation was enhanced but the mechanical properties did not change in the PRE group squirrels.In OB mice,western blots showed significantly increased expression levels of all proteins except RunX2,OPG,and Ptch1.PRE ground squirrels showed significantly increased expression of most proteins except OCN and Ptch1,which decreased significantly,and P-β-catenin and OPG,which did not change.In conclusion,for non-hibernating mice,moderate obesity had a certain protective effect on bones,demonstrating two-way regulation,increasing both bone loss and bone formation.For pre-hibernating ground squirrels,the healthy obesity acquired before hibernation had a positive effect on the microstructure of bones,and also enhanced the expression levels of proteins related to bone formation,bone resorption,and Wnt signaling.展开更多
The full fluxes and associated air-sea variables based on three months of operational buoy observations in the East China Sea(ECS)in summer 2020 were analyzed for the first time.The surface net heat flux(Q_(net))was p...The full fluxes and associated air-sea variables based on three months of operational buoy observations in the East China Sea(ECS)in summer 2020 were analyzed for the first time.The surface net heat flux(Q_(net))was positive(139.7±77.7 W/m^(2))and was dominated by the combined eff ects of solar shortwave radiation(SW)and latent heat fluxes(LH).The mean heat flux components of 4 reanalysis datasets(NCEP2,MERRA-2,CFSR,and ERA5)and buoy data were compared to assess the mean ability of the modeling/reanalysis simulation.Among the four components of air-sea flux,SW was the best simulated,while LH was the worst simulated.The longwave radiation(LW)and LH values from reanalysis were higher than those from buoy data,especially LH.The high LH resulted in low Q_(net).Furthermore,the 4 reanalysis datasets were compared with the buoy dataset.Among all flux products,the difference in radiation flux was the smallest,while that in the turbulent flux was the greatest.The observed variables related to turbulent flux were analyzed to help determine the cause of the flux discrepancies.High wind speeds were the main cause of this difference.Using the variables provided by the reanalysis data and the same bulk formulas of the Coupled Ocean-Atmospheric Response Experiment(COARE 3.0),we found that the recalculated sensible heat flux(SH)and LH were closer to the observed heat fluxes than the direct model outputs.The signifi cant diff erences between these methods could account for the discrepancies among diff erent data.Among all air-sea flux products,the air-sea flux in ERA5 was closer to the in-situ observations than the other products.The comparison results of reanalysis data provide an important reference for more accurate studies of the summer heat flux in the ECS at the synoptic and climatic scales.展开更多
Polymer dielectrics are required to maintain high energy density at elevated temperatures for advanced power and electronic systems.Herein,we report a novel solution-processed core-shell structured poly-imide(PI)nanoc...Polymer dielectrics are required to maintain high energy density at elevated temperatures for advanced power and electronic systems.Herein,we report a novel solution-processed core-shell structured poly-imide(PI)nanocomposite with moderate dielectric constant HfO_(2)core and wide-bandgap Al_(2)O_(3)shell,ef-fectively addressing the typical trade-off between dielectric constant and breakdown strength in dielectric nanocomposites predominant at elevated temperatures.The formation of improved dielectrically match-ing interfaces by the rationally designed dielectric constant gradient from core-shell-matrix remarkably mitigates the distortion of the electric field around the interfaces,resulting in a high breakdown strength.Wide band gap Al_(2)O_(3)shell also introduces deeper traps to impede the conduction loss.The validity of Al_(2)O_(3)shell has been proved via experiments and simulations.Accordingly,HfO_(2)@Al_(2)O_(3)/PI nanocompos-ite exhibits an excellent charge-discharge efficiency of 91.7%at 300 MV/m and a maximum discharged energy density of 2.94 J/cm^(3)at 150℃,demonstrating its potential for high-temperature energy storage.展开更多
Protein liquid-liquid phase separation(LLPS),a pivotal phenomenon intricately linked to cellular processes,is regulated by various other proteins.However,there is still a lack of high-throughput methods for screening ...Protein liquid-liquid phase separation(LLPS),a pivotal phenomenon intricately linked to cellular processes,is regulated by various other proteins.However,there is still a lack of high-throughput methods for screening protein regulators of LLPS in target proteins.Here,we developed a CRISPR/Cas9-based screening method to identify protein phase separation regulators by integrating bimolecular fluorescence complementation(BiFC)and fluorescence-activated cell sorting(FACS).Using this newly developed method,we screened the RNA-binding proteins that regulate PABPN1 phase separation and identified the tumor suppressor QKI as a promoter of PABPN1 phase separation.Furthermore,QKI exhibits decreased expression levels and diminished nuclear localization in colorectal cancer cells,resulting in reduced PABPN1 phase separation,which,in turn,promotes alternative polyadenylation(APA),cell proliferation,and migration in colorectal cancer.展开更多
Background:Whether adherence to a healthy lifestyle is associated with a lower risk of developing pneumonia and a better long-term prognosis remains unclear.This study aimed to investigate associations of individual a...Background:Whether adherence to a healthy lifestyle is associated with a lower risk of developing pneumonia and a better long-term prognosis remains unclear.This study aimed to investigate associations of individual and combined lifestyle factors(LFs)with the incidence risk and long-term prognosis of pneumonia hospitalization.Methods:Using data from the China Kadoorie Biobank study,we used the multistate models to investigate the role of five high-risk LFs,including smoking,excessive alcohol drinking,unhealthy dietary habits,physical inactivity,and unhealthy body shape,alone or in combination in the transitions from a generally healthy state at baseline to pneumonia hospitalization or cardiovascular disease(CVD,regarded as a reference outcome),and subsequently to mortality.Results:Most of the five high-risk LFs were associated with increased risks of transitions from baseline to pneumonia and from pneumonia to death,but with different risk estimates.The greater the number of high-risk LFs,the higher the risk of developing pneumonia and long-term mortality risk after pneumonia,with the strength of associations comparable to that of LFs and CVD.Compared to participants with 0-1 high-risk LF,the adjusted hazard ratios(HRs)and 95%confidence intervals(CIs)for transitions from baseline to pneumonia and from pneumonia to death in those with five high-risk LFs were 1.43(1.28-1.60)and 1.98(1.61-2.42),respectively.Correspondingly,the respective HRs(95%CIs)for transitions from baseline to CVD and from CVD to death were 2.00(1.89-2.11)and 1.44(1.30-1.59),respectively.The risk estimates changed slightly when further adjusting for the presence of major chronic diseases.Conclusion:In this Chinese population,unhealthy LFs were associated with an increased incidence and long-term mortality risk of pneumonia.展开更多
Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well characterized.Here,with profiling of APA in colorectal cancer tissue...Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well characterized.Here,with profiling of APA in colorectal cancer tissues and poly(A)signal editing,we firstly identified that the shortened 3′UTR of CTNNIBP1 in colorectal cancer promotes cell proliferation and migration.We found that liquid-liquid phase separation(LLPS)of PABPN1 is reduced albeit with higher expression in cancer,and the reduction of LLPS leads to the shortened 3′UTR of CTNNBIP1and promotes cell proliferation and migration.Notably,the splicing factor SNRPD2 upregulated in colorectal cancer,can interact with glutamic-proline(EP)domain of PABPN1,and then disrupt LLPS of PABPN1,which attenuates the repression effect of PABPN1 on the proximal poly(A)sites.Our results firstly reveal a new regulation mechanism of APA by disruption of LLPS of PABPN1,suggesting that regulation of APA by interfering LLPS of 3′end processing factor may have the potential as a new way for the treatment of cancer.展开更多
Advancements in power electronics necessitate dielectric polymer films capable of operating at high temperatures and possessing high energy density.Although significant strides have been achieved by integrating inorga...Advancements in power electronics necessitate dielectric polymer films capable of operating at high temperatures and possessing high energy density.Although significant strides have been achieved by integrating inorganic fillers into high-temperature polymer matrices,the inherently low dielectric constants of these matrices have tempered the magnitude of success.In this work,we report an innovative nanocomposite based on sulfonylated polyimide(SPI),distinguished by the incorporation of sulfonyl groups within the SPI backbone and the inclusion of wide bandgap hafnium dioxide(HfO_(2))nanofillers.The nanocomposite has demonstrated notable enhancements in thermal stability,dielectric properties,and capacitive performance at elevated temperatures.Detailed simulations at both molecular and mesoscopic levels have elucidated the mechanisms behind these improvements,which could be attributed to confined segmental motion,an optimized electronic band structure,and a diminished incidence of dielectric breakdown ascribed to the presence of sulfonyl groups.Remarkably,the SPI-HfO_(2)nanocomposite demonstrates a high charge-discharge efficiency of 95.7%at an elevated temperature of 150℃and an applied electric field of 200 MV/m.Furthermore,it achieves a maximum discharged energy density of 2.71 J/cm^(3),signalling its substantial potential for energy storage applications under extreme conditions.展开更多
Future electronic devices toward high integration and miniaturization demand reliable operation of dielectric materials at high electric fields and elevated temperatures.However,the electrical deterioration caused by ...Future electronic devices toward high integration and miniaturization demand reliable operation of dielectric materials at high electric fields and elevated temperatures.However,the electrical deterioration caused by Joule heat generation remains a persistent challenge to overcome.Here,the solution-processed polyimide(PI)nanocomposites with unique two-dimensional(2D)alumina nanoplates are reported.Substantial improvements in the breakdown strength,charge–discharge efficiency and discharged energy density at elevated temperatures have been demonstrated in the composites,owing to simultaneously suppressed conduction loss and increased thermal conductivity upon the incorporation of 2D Al_(2)O_(3)nanofillers possessing excellent dielectric insulation and thermophysical properties.The predominance of Al_(2)O_(3)nanoplates in enhancing thermal stability and high-temperature capacitive performance over nanoparticles and nanowires is validated experimentally and is further rationalized via finite element simulations.Notably,the Al_(2)O_(3)nanoplates filled PI nanocomposite exhibits a hightemperature capability up to 200℃and remarkable efficiency(e.g.≥95%at 200 MV/m)over a wide temperature range,which outperforms commercial dielectric polymers and rivals the state-of-the-art polyimide nanocomposites.展开更多
基金This work is supported by the National Natural Science Foundation of China(Grant Nos.U22B2005,62072109)the Natural Science Foundation of Fujian Province(Grant No.2021J01625)the Major Science and Technology Project of Fuzhou(Grant No.2023-ZD-003).
文摘As the scale of the networks continually expands,the detection of distributed denial of service(DDoS)attacks has become increasingly vital.We propose an intelligent detection model named IGED by using improved generalized entropy and deep neural network(DNN).The initial detection is based on improved generalized entropy to filter out as much normal traffic as possible,thereby reducing data volume.Then the fine detection is based on DNN to perform precise DDoS detection on the filtered suspicious traffic,enhancing the neural network’s generalization capabilities.Experimental results show that the proposed method can efficiently distinguish normal traffic from DDoS traffic.Compared with the benchmark methods,our method reaches 99.9%on low-rate DDoS(LDDoS),flooded DDoS and CICDDoS2019 datasets in terms of both accuracy and efficiency in identifying attack flows while reducing the time by 17%,31%and 8%.
基金the National Natural Science Foundation of China(Grant No.81941018).
文摘In line with the worldwide trend in population aging,China has stepped into an aging society since 2000.The outstanding features of aging,including a large proportion of the older population,rapid growth,dramatic expansion of the oldest-old,and uneven aging distribution,have put China in a unique position.Besides,older population is expanding in parallel with the escalating burden of disease,high prevalence of disability,and low social involvement.However,China is not prepared to solve these problems in terms of the economy,awareness,geriatric care system,geriatric team,social security,or age-friendly environment.From the perspective of public health,we summarized the major challenges and proposed the following policy recommendations:(1)strengthening the top-level design and building a"government-leading,multi-sectoral-cooperating,and society-participating"pattern;(2)enhancing health services by implementing the"comprehensive health"strategy;(3)developing home and community care,coordinately enhance institutional care,promote integration of medical and care systems,and establish a multidimensional tailored care system;(4)optimizing geriatric the supporting system,included the construction of geriatric team and the long-term care insurance system;and(5)establishing a physical and socially age-friendly environment.
文摘EFL preservice teachers ’ research efficacy, as perceived competence to perform tasks in research, is crucial to their research engagement. This autobiographical narrative inquiry investigates the contribution of scaffolded research practice to a female EFL preservice teacher ’s research efficacy.The data were collected through conversations, notes, journals, and portfolios. The findings suggest that teacher research efficacy was pliable through scaffolded research practice. It emerged gradually over time, in different places with social and personal interaction. The factors contributing to the emerging research efficacy were: teacher educators ’ support, peers ’ support,and research participation. The study sheds light on teacher educators and EFL preservice teachers,with the intention of establishing an inquiry-based pedagogy for M.Ed. programs.
基金supported by the National Natural Science Foundation of China(Nos.31640072 and 31900338)the Natural Science Basic Research Program of Shaanxi(No.2020JM-428),China.
文摘This study compared the effects on bone metabolism and morphology of pathological obesity induced by excessive fat intake in a non-hibernator(mice)versus healthy obesity due to pre-hibernation fattening in a hibernator(ground squirrels).Kunming mice were fed a high-fat diet to provide a model of pathological obesity(OB group).Daurian ground squirrels fattened naturally in their pre-hibernation season(PRE group)were used as a healthy obesity model.Micro-computed tomography(micro-CT)and three-point bending tests were used to determine the microstructure and mechanical properties of bone.Western blots were used to analyze protein expression levels related to bone metabolism(Runt-related transcription factor 2(RunX2),osteocalcin(OCN),alkaline phosphatase(ALP),osteoprotegerin(OPG),receptor activator of nuclear factor-κB ligand(RANKL),cathepsin K,matrix metallopeptidase 9(MMP9),patched protein homolog 1(Ptch1),phosphorylatedβ-catenin(P-β-catenin),and glycogen synthase kinase-3β(GSK-3β)).Compared with controls,there was no obvious bone loss in the OB mice,and the stiffness of the femur was increased significantly.Compared with summer active squirrels,bone formation was enhanced but the mechanical properties did not change in the PRE group squirrels.In OB mice,western blots showed significantly increased expression levels of all proteins except RunX2,OPG,and Ptch1.PRE ground squirrels showed significantly increased expression of most proteins except OCN and Ptch1,which decreased significantly,and P-β-catenin and OPG,which did not change.In conclusion,for non-hibernating mice,moderate obesity had a certain protective effect on bones,demonstrating two-way regulation,increasing both bone loss and bone formation.For pre-hibernating ground squirrels,the healthy obesity acquired before hibernation had a positive effect on the microstructure of bones,and also enhanced the expression levels of proteins related to bone formation,bone resorption,and Wnt signaling.
基金Supported by the National Natural Science Foundation of China(Nos.42076016,41876224)。
文摘The full fluxes and associated air-sea variables based on three months of operational buoy observations in the East China Sea(ECS)in summer 2020 were analyzed for the first time.The surface net heat flux(Q_(net))was positive(139.7±77.7 W/m^(2))and was dominated by the combined eff ects of solar shortwave radiation(SW)and latent heat fluxes(LH).The mean heat flux components of 4 reanalysis datasets(NCEP2,MERRA-2,CFSR,and ERA5)and buoy data were compared to assess the mean ability of the modeling/reanalysis simulation.Among the four components of air-sea flux,SW was the best simulated,while LH was the worst simulated.The longwave radiation(LW)and LH values from reanalysis were higher than those from buoy data,especially LH.The high LH resulted in low Q_(net).Furthermore,the 4 reanalysis datasets were compared with the buoy dataset.Among all flux products,the difference in radiation flux was the smallest,while that in the turbulent flux was the greatest.The observed variables related to turbulent flux were analyzed to help determine the cause of the flux discrepancies.High wind speeds were the main cause of this difference.Using the variables provided by the reanalysis data and the same bulk formulas of the Coupled Ocean-Atmospheric Response Experiment(COARE 3.0),we found that the recalculated sensible heat flux(SH)and LH were closer to the observed heat fluxes than the direct model outputs.The signifi cant diff erences between these methods could account for the discrepancies among diff erent data.Among all air-sea flux products,the air-sea flux in ERA5 was closer to the in-situ observations than the other products.The comparison results of reanalysis data provide an important reference for more accurate studies of the summer heat flux in the ECS at the synoptic and climatic scales.
基金supported by the National Natu-ral Science Foundation of China(Nos.52107232 and 52377026)China Postdoctoral Science Foundation(No.2021M702563)+2 种基金State Key Laboratory of Electrical Insulation and Power Equipment(No.EIPE22312)Taishan Scholars and Young Experts Program of Shan-dong Province(No.tsqn202103057)the Qingchuang Talents Induction Program of Shandong Higher Education Institution(Research and Innovation Team of Structural-Functional Polymer Composites)and Fundamental Research Funds for the Central Universities(No.xzy012024004).
文摘Polymer dielectrics are required to maintain high energy density at elevated temperatures for advanced power and electronic systems.Herein,we report a novel solution-processed core-shell structured poly-imide(PI)nanocomposite with moderate dielectric constant HfO_(2)core and wide-bandgap Al_(2)O_(3)shell,ef-fectively addressing the typical trade-off between dielectric constant and breakdown strength in dielectric nanocomposites predominant at elevated temperatures.The formation of improved dielectrically match-ing interfaces by the rationally designed dielectric constant gradient from core-shell-matrix remarkably mitigates the distortion of the electric field around the interfaces,resulting in a high breakdown strength.Wide band gap Al_(2)O_(3)shell also introduces deeper traps to impede the conduction loss.The validity of Al_(2)O_(3)shell has been proved via experiments and simulations.Accordingly,HfO_(2)@Al_(2)O_(3)/PI nanocompos-ite exhibits an excellent charge-discharge efficiency of 91.7%at 300 MV/m and a maximum discharged energy density of 2.94 J/cm^(3)at 150℃,demonstrating its potential for high-temperature energy storage.
基金supported by the National Natural Science Foundation of China(Nos.32470586 and 31971332 to Y.F.,Nos.91942301 and 81430099 to A.X.)National Key Research and Development Program of China(No.2022YFA1103900 to Y.F.)Guangdong Science and Technology Department(No.2023B1212060028 to A.X.).
文摘Protein liquid-liquid phase separation(LLPS),a pivotal phenomenon intricately linked to cellular processes,is regulated by various other proteins.However,there is still a lack of high-throughput methods for screening protein regulators of LLPS in target proteins.Here,we developed a CRISPR/Cas9-based screening method to identify protein phase separation regulators by integrating bimolecular fluorescence complementation(BiFC)and fluorescence-activated cell sorting(FACS).Using this newly developed method,we screened the RNA-binding proteins that regulate PABPN1 phase separation and identified the tumor suppressor QKI as a promoter of PABPN1 phase separation.Furthermore,QKI exhibits decreased expression levels and diminished nuclear localization in colorectal cancer cells,resulting in reduced PABPN1 phase separation,which,in turn,promotes alternative polyadenylation(APA),cell proliferation,and migration in colorectal cancer.
基金This work was supported by grants from the National Natural Science Foundation of China(Nos.82388102,82192904,82404336,and 82192900)the Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2023ZD0510100)+4 种基金the Kadoorie Charitable Foundation in Hong Kong,the UK Wellcome Trust(Nos.212946/Z/18/Z,202922/Z/16/Z,104085/Z/14/Z,and 088158/Z/09/Z)the National Key R&D Program of China(No.2016YFC0900500)the National Natural Science Foundation of China(Nos.81390540,91846303,and 81941018)the Chinese Ministry of Science and Technology(No.2011BAI09B01)the High-Level Talents Research Start-Up Project of Fujian Medical University(No.XRCZX2023014).
文摘Background:Whether adherence to a healthy lifestyle is associated with a lower risk of developing pneumonia and a better long-term prognosis remains unclear.This study aimed to investigate associations of individual and combined lifestyle factors(LFs)with the incidence risk and long-term prognosis of pneumonia hospitalization.Methods:Using data from the China Kadoorie Biobank study,we used the multistate models to investigate the role of five high-risk LFs,including smoking,excessive alcohol drinking,unhealthy dietary habits,physical inactivity,and unhealthy body shape,alone or in combination in the transitions from a generally healthy state at baseline to pneumonia hospitalization or cardiovascular disease(CVD,regarded as a reference outcome),and subsequently to mortality.Results:Most of the five high-risk LFs were associated with increased risks of transitions from baseline to pneumonia and from pneumonia to death,but with different risk estimates.The greater the number of high-risk LFs,the higher the risk of developing pneumonia and long-term mortality risk after pneumonia,with the strength of associations comparable to that of LFs and CVD.Compared to participants with 0-1 high-risk LF,the adjusted hazard ratios(HRs)and 95%confidence intervals(CIs)for transitions from baseline to pneumonia and from pneumonia to death in those with five high-risk LFs were 1.43(1.28-1.60)and 1.98(1.61-2.42),respectively.Correspondingly,the respective HRs(95%CIs)for transitions from baseline to CVD and from CVD to death were 2.00(1.89-2.11)and 1.44(1.30-1.59),respectively.The risk estimates changed slightly when further adjusting for the presence of major chronic diseases.Conclusion:In this Chinese population,unhealthy LFs were associated with an increased incidence and long-term mortality risk of pneumonia.
基金supported by the National Key Research and Development Program of China(2022YFA1103900,2017YFC1308800)the National Natural Science Foundation of China(31971332,32000450,91942301,81430099)+5 种基金the National Basic Research Program of China(2013CB917801)the National High-tech Research and Development Program of China(863 Program)(2012AA02A520)Basic and Applied Basic Research Foundation of Guangdong Province(2020A1515010293)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(2021qntd26)the National Key Clinical Discipline([2012]649)the Program of Guangdong Provincial Clinical Research Center for Digestive Diseases(2020B1111170004)。
文摘Generally shortened 3′UTR due to alternative polyadenylation(APA)is widely observed in cancer,but its regulation mechanisms for cancer are not well characterized.Here,with profiling of APA in colorectal cancer tissues and poly(A)signal editing,we firstly identified that the shortened 3′UTR of CTNNIBP1 in colorectal cancer promotes cell proliferation and migration.We found that liquid-liquid phase separation(LLPS)of PABPN1 is reduced albeit with higher expression in cancer,and the reduction of LLPS leads to the shortened 3′UTR of CTNNBIP1and promotes cell proliferation and migration.Notably,the splicing factor SNRPD2 upregulated in colorectal cancer,can interact with glutamic-proline(EP)domain of PABPN1,and then disrupt LLPS of PABPN1,which attenuates the repression effect of PABPN1 on the proximal poly(A)sites.Our results firstly reveal a new regulation mechanism of APA by disruption of LLPS of PABPN1,suggesting that regulation of APA by interfering LLPS of 3′end processing factor may have the potential as a new way for the treatment of cancer.
基金supported by the National Natural Science Foundation of China(Nos.52107232,52377026 and 52301192)China Postdoctoral Science Foundation(No.2021M702563)+2 种基金State Key Laboratory of Electrical Insulation and Power Equipment(No.EIPE22312)Taishan Scholars and Young Experts Program of Shandong Province(No.tsqn202103057)the Qingchuang Talents Induction Program of Shandong Higher Education Institution(Research and Innovation Team of Structural-Functional Polymer Composites)and Fundamental Research Funds for the Central Universities(No.xzy012024004).
文摘Advancements in power electronics necessitate dielectric polymer films capable of operating at high temperatures and possessing high energy density.Although significant strides have been achieved by integrating inorganic fillers into high-temperature polymer matrices,the inherently low dielectric constants of these matrices have tempered the magnitude of success.In this work,we report an innovative nanocomposite based on sulfonylated polyimide(SPI),distinguished by the incorporation of sulfonyl groups within the SPI backbone and the inclusion of wide bandgap hafnium dioxide(HfO_(2))nanofillers.The nanocomposite has demonstrated notable enhancements in thermal stability,dielectric properties,and capacitive performance at elevated temperatures.Detailed simulations at both molecular and mesoscopic levels have elucidated the mechanisms behind these improvements,which could be attributed to confined segmental motion,an optimized electronic band structure,and a diminished incidence of dielectric breakdown ascribed to the presence of sulfonyl groups.Remarkably,the SPI-HfO_(2)nanocomposite demonstrates a high charge-discharge efficiency of 95.7%at an elevated temperature of 150℃and an applied electric field of 200 MV/m.Furthermore,it achieves a maximum discharged energy density of 2.71 J/cm^(3),signalling its substantial potential for energy storage applications under extreme conditions.
基金supported by National Natural Science Foundation of China(Nos.52107232 and 52377026)China Postdoctoral Science Foundation(No.2021M702563)+2 种基金State Key Laboratory of Electrical Insulation and Power Equipment(No.EIPE22312)Taishan Scholars and Young Experts Program of Shandong Province(No.tsqn202103057)the Qingchuang Talents Induction Program of Shandong Higher Education Institution(Research and Innovation Team of Structural-Functional Polymer Composites)and Fundamental Research Funds for the Central Universities(No.xzy012024004).
文摘Future electronic devices toward high integration and miniaturization demand reliable operation of dielectric materials at high electric fields and elevated temperatures.However,the electrical deterioration caused by Joule heat generation remains a persistent challenge to overcome.Here,the solution-processed polyimide(PI)nanocomposites with unique two-dimensional(2D)alumina nanoplates are reported.Substantial improvements in the breakdown strength,charge–discharge efficiency and discharged energy density at elevated temperatures have been demonstrated in the composites,owing to simultaneously suppressed conduction loss and increased thermal conductivity upon the incorporation of 2D Al_(2)O_(3)nanofillers possessing excellent dielectric insulation and thermophysical properties.The predominance of Al_(2)O_(3)nanoplates in enhancing thermal stability and high-temperature capacitive performance over nanoparticles and nanowires is validated experimentally and is further rationalized via finite element simulations.Notably,the Al_(2)O_(3)nanoplates filled PI nanocomposite exhibits a hightemperature capability up to 200℃and remarkable efficiency(e.g.≥95%at 200 MV/m)over a wide temperature range,which outperforms commercial dielectric polymers and rivals the state-of-the-art polyimide nanocomposites.
