This study presents a theoretical and experimental analysis of laminar flow behavior of high-viscous non-Newtonian power-law and Bingham fluids in multiple structural bifurcation channel distributors.Theoretical model...This study presents a theoretical and experimental analysis of laminar flow behavior of high-viscous non-Newtonian power-law and Bingham fluids in multiple structural bifurcation channel distributors.Theoretical models are derived to describe velocity profiles,shear rate distribution,and pressure drop across specific channels.Modified pressure drop models are proposed based on experiments on 6 kinds of non-Newtonian fluids and 3 types of bifurcation channel distributors with different transition areas.Specifically,the deviations between the theoretical models and the experimental results are systematically analyzed,and models were modified with correction coefficients based on Reynolds number and dimensionless shape factor.The theoretical results,modified results and experimental data are compared and discussed to ensure the accuracy of the modified models,demonstrating a significant improvement in the prediction of pressure drops for high-viscous non-Newtonian fluids in certain types of bifurcation channels.Additional experiments and analyses were carried out to validate the modified models and the results suggest that the models offer a certain degree of universal applicability in bifurcation channel designs.It implies that for other types of bifurcation channel distributors,similar correction methods based on Reynolds number and shape factor may also be applicable even with different coefficients.展开更多
Visible light communication(VLC)based on laser diodes demonstrates great potential for high data rate maritime,terrestrial,and aerial wireless data links.Here,we design and fabricate high-speed blue laser diodes(LDs)g...Visible light communication(VLC)based on laser diodes demonstrates great potential for high data rate maritime,terrestrial,and aerial wireless data links.Here,we design and fabricate high-speed blue laser diodes(LDs)grown on c-plane gallium nitride(GaN)substrate.This was achieved through active region design and miniaturization toward a narrow ridge waveguide,short cavity length,and single longitudinal mode Fabry–Perot laser diode.The fabricated mini-LD has a low threshold current of 31 mA and slope efficiency of 1.02 W/A.A record modulation bandwidth of 5.9 GHz(−3dB)was measured from the mini-LD.Using the developed mini-LD as a transmitter,the VLC link exhibits a high data transmission rate of 20.06 Gbps adopting the bit and power loading discrete multitone(DMT)modulation technique.The corresponding bit error rate is 0.003,satisfying the forward error correction standard.The demonstrated GaN-based mini-LD has significantly enhanced data transmission rates,paving the path for energy-efficient VLC systems and integrated photonics in the visible regime.展开更多
Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues,resulting in tooth loss.Poor eradication of pathogenic microorganisms,persistent malignant inflammation and impa...Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues,resulting in tooth loss.Poor eradication of pathogenic microorganisms,persistent malignant inflammation and impaired osteo-/angiogenesis are currently the primary challenges to control disease progression and rebuild damaged alveolar bone.However,existing treatments for periodontitis fail to comprehensively address these issues.Herein,an injectable composite hydrogel(SFD/CS/ZIF-8@QCT)encapsulating quercetin-modified zeolitic imidazolate framework-8(ZIF-8@QCT)is developed.This hydrogel possesses thermo-sensitive and adhesive properties,which can provide excellent flowability and post-injection stability,resist oral fluid washout as well as achieve effective tissue adhesion.Inspirationally,it is observed that SFD/CS/ZIF-8@QCT exhibits a rapid localized hemostatic effect following implantation,and then by virtue of the sustained release of zinc ions and quercetin exerts excellent collective functions including antibacterial,immunomodulation,pro-osteo-/angiogenesis and pro-recruitment,ultimately facilitating excellent alveolar bone regeneration.Notably,our study also demonstrates that the inhibition of osteo-/angiogenesis of PDLSCs under the periodontitis is due to the strong inhibition of energy metabolism as well as the powerful activation of oxidative stress and autophagy,whereas the synergistic effects of quercetin and zinc ions released by SFD/CS/ZIF-8@QCT are effective in reversing these biological processes.Overall,our study presents innovative insights into the advancement of biomaterials to regenerate alveolar bone in periodontitis.展开更多
基金the financial support from the National Science and Technology Major Project of China(2024XXXXX2700)the National Natural Science Foundation of China (22408099)+1 种基金the Key Research and Development Program of Xinjiang Uygur Autonomous Region (2022B01032)the National Ten Thousand Talents Program。
文摘This study presents a theoretical and experimental analysis of laminar flow behavior of high-viscous non-Newtonian power-law and Bingham fluids in multiple structural bifurcation channel distributors.Theoretical models are derived to describe velocity profiles,shear rate distribution,and pressure drop across specific channels.Modified pressure drop models are proposed based on experiments on 6 kinds of non-Newtonian fluids and 3 types of bifurcation channel distributors with different transition areas.Specifically,the deviations between the theoretical models and the experimental results are systematically analyzed,and models were modified with correction coefficients based on Reynolds number and dimensionless shape factor.The theoretical results,modified results and experimental data are compared and discussed to ensure the accuracy of the modified models,demonstrating a significant improvement in the prediction of pressure drops for high-viscous non-Newtonian fluids in certain types of bifurcation channels.Additional experiments and analyses were carried out to validate the modified models and the results suggest that the models offer a certain degree of universal applicability in bifurcation channel designs.It implies that for other types of bifurcation channel distributors,similar correction methods based on Reynolds number and shape factor may also be applicable even with different coefficients.
基金National Key Research and Development Program of China(2022YFB2802803)National Natural Science Foundation of China(61925104,62031011,62274042)+2 种基金Natural Science Foundation of Shanghai Municipality(21ZR1406200)China Mobile Research Institute X-NETJiangsu Provincial Key Research and Development Program(BE2021008-5).
文摘Visible light communication(VLC)based on laser diodes demonstrates great potential for high data rate maritime,terrestrial,and aerial wireless data links.Here,we design and fabricate high-speed blue laser diodes(LDs)grown on c-plane gallium nitride(GaN)substrate.This was achieved through active region design and miniaturization toward a narrow ridge waveguide,short cavity length,and single longitudinal mode Fabry–Perot laser diode.The fabricated mini-LD has a low threshold current of 31 mA and slope efficiency of 1.02 W/A.A record modulation bandwidth of 5.9 GHz(−3dB)was measured from the mini-LD.Using the developed mini-LD as a transmitter,the VLC link exhibits a high data transmission rate of 20.06 Gbps adopting the bit and power loading discrete multitone(DMT)modulation technique.The corresponding bit error rate is 0.003,satisfying the forward error correction standard.The demonstrated GaN-based mini-LD has significantly enhanced data transmission rates,paving the path for energy-efficient VLC systems and integrated photonics in the visible regime.
基金National Natural Science Foundation of China(82370921,82071082)Program of Shanghai Technology Research Leader(23XD1430800)Fund of Department of Oral and Maxillofacial Surgery(Department 2023-01).
文摘Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues,resulting in tooth loss.Poor eradication of pathogenic microorganisms,persistent malignant inflammation and impaired osteo-/angiogenesis are currently the primary challenges to control disease progression and rebuild damaged alveolar bone.However,existing treatments for periodontitis fail to comprehensively address these issues.Herein,an injectable composite hydrogel(SFD/CS/ZIF-8@QCT)encapsulating quercetin-modified zeolitic imidazolate framework-8(ZIF-8@QCT)is developed.This hydrogel possesses thermo-sensitive and adhesive properties,which can provide excellent flowability and post-injection stability,resist oral fluid washout as well as achieve effective tissue adhesion.Inspirationally,it is observed that SFD/CS/ZIF-8@QCT exhibits a rapid localized hemostatic effect following implantation,and then by virtue of the sustained release of zinc ions and quercetin exerts excellent collective functions including antibacterial,immunomodulation,pro-osteo-/angiogenesis and pro-recruitment,ultimately facilitating excellent alveolar bone regeneration.Notably,our study also demonstrates that the inhibition of osteo-/angiogenesis of PDLSCs under the periodontitis is due to the strong inhibition of energy metabolism as well as the powerful activation of oxidative stress and autophagy,whereas the synergistic effects of quercetin and zinc ions released by SFD/CS/ZIF-8@QCT are effective in reversing these biological processes.Overall,our study presents innovative insights into the advancement of biomaterials to regenerate alveolar bone in periodontitis.
