Although there has been a notable decrease in cancer mortality rates for many common cancers over the last decades,there remains a concerning lack of progress in understanding and treating rare tumors[1].Rare tumors a...Although there has been a notable decrease in cancer mortality rates for many common cancers over the last decades,there remains a concerning lack of progress in understanding and treating rare tumors[1].Rare tumors are types of tumors that are rare in clinical practice,which are the subclass of rare diseases.The classification of rare tumors varies internationally,with the US Food and Drug Administration and National Cancer Institute defining them as tumors with an incidence rate of less than 15 per 100,000 individuals annually,while the European Medicines Agency set the threshold at 6 per 100,000.According to the results from the National Cancer Center PLATFORM study in China,rare tumors are defined as an annual incidence rate of 2.5/100,000 or less.Although the incidence of each rare tumor is low,the total number of rare tumors is not low.The total number of rare tumor incidence in China is about 560,000 per year,accounting for 14.2%of all cancer patients[2].More than half of the rare tumors lack clinical treatment guidelines,or there is no standard treatment in clinical practice,suggesting there is a huge unmet medical need for effective treatments for rare tumors.展开更多
Rare tumors,also known as rare cancers,are characterized by ex-tremely low incidence rates,which comprise a group of about 200 can-cers.1 In the United States(US),rare tumors are defined as those occur-ring in less th...Rare tumors,also known as rare cancers,are characterized by ex-tremely low incidence rates,which comprise a group of about 200 can-cers.1 In the United States(US),rare tumors are defined as those occur-ring in less than 15 cases per 100,000 individuals,2 while in Europe,the prevalence is even lower,with approximately 6 cases per 100,000 peo-ple.展开更多
In conventional corrosion-resistant alloys,precipitation usually reduces corrosion resistance severely by weakening passive films locally.In this work,we found that the aging-treated AlCoCrFeNi_(2.1)sam-ples,which hav...In conventional corrosion-resistant alloys,precipitation usually reduces corrosion resistance severely by weakening passive films locally.In this work,we found that the aging-treated AlCoCrFeNi_(2.1)sam-ples,which have abundant nanosized L 12 and body-centered cubic(BCC)precipitates in the lamellar face-centered cubic(FCC)and B2 phases,displayed better corrosion resistance than solution-treated AlCoCrFeNi_(2.1)samples without precipitates.In the AlCoCrFeNi_(2.1)alloy,the FCC phase with L1_(2)precipi-tates and the B2 phase with BCC precipitates were protected by passive films enriched with Cr and Al elements,respectively.Moreover,the Al-rich passive film of the B2 phase was less stable than the Cr-rich passive film of the FCC phase,so B2 phase dissolved preferentially.The Cr-rich passive film of the FCC phase remained stable with the formation of Al-rich L1_(2)precipitates inside the phase because those precipitates with the size of∼5 nm were too small to affect the composition of the Cr-rich passive film.The formation of Cr-rich BCC precipitates within the B2 phase increased the content of the Al element inside the phase,improving the stability of Al-rich passive film on the B2 phase.Furthermore,BCC precip-itates with the size of∼30 nm were protected by Cr-rich passive film,which could inhibit the expansion of corrosion pits.Thus,the corrosion resistance of eutectic high-entropy alloy AlCoCrFeN 2.1 was unprece-dentedly enhanced by the precipitation of BCC precipitates.Our study could provide an attractive strategy for designing high-entropy alloys with excellent corrosion resistance and high strength.展开更多
This paper aims to understand the current situation of heavy metal pollution in paddy soil in West Guangxi,to provide a reference for heavy metal pollution control. The content of Cd,Pb and As of 50 soil samples of cu...This paper aims to understand the current situation of heavy metal pollution in paddy soil in West Guangxi,to provide a reference for heavy metal pollution control. The content of Cd,Pb and As of 50 soil samples of cultivation layer( 0- 20 cm),taken from main rice producing areas in West Guangxi,is determined. The environment quality of soil is assessed with the single factor index and the potential ecological risk of paddy soil is evaluated with the potential ecological risk index of Hakanson. The results show that the mean content of Cd,Pb,and As in paddy soil samples is 0. 941,26. 46 and 10. 16 mg / kg,respectively. The Cd content of 54. 0% soil samples and the As content of 2. 0% soil samples are higher than the standard II National Soil Environment Quality,and Cd in paddy soil has high potential ecological risk. Heavy metal pollution in paddy soil in West Guangxi is mainly Cd pollution.展开更多
This study was intended to estimate production of major livestock and poultry manure and contaminant content,and find out current situation of manure pollution,so as to provide reference for pollution control of lives...This study was intended to estimate production of major livestock and poultry manure and contaminant content,and find out current situation of manure pollution,so as to provide reference for pollution control of livestock and poultry breeding industry in Guangxi.Based on the related statistic data in 2010 and the excretion coefficient of different livestock and poultry,the manure and its contaminant production amount of main livestock and poultry in Guangxi were estimated.Then the annual livestock and poultry manure load of farmland and the loss of contaminant were also calculated to analyze the ecological pressure resulted from livestock and poultry breeding in Guangxi.Following results were obtained:in 2010,the production amount of the livestock and poultry manure in Guangxi was 9141.30×104tons,including nutrient TN42.07×104tons and TP 13.62×104tons;the annual livestock and poultry manure and N,P pure nutrient load of farmland was 21t/hm2,98kg/hm2,and 32 kg/hm2respectively;the production amount of manure contaminants was BOD5383.43×104tons,COD Cr435.42×104tons,and NH3-N 42.08×104tons;according to 30%loss rate,the loss amount of COD Cr and NH3-N was higher than the sum of industrial and life waste water.It was concluded that the livestock and poultry breeding industry had little impact on soil environment,but posed a grave threat to water environment.展开更多
Rare diseases continue to pose a formidable public health challenge with lack or absence of effective treatments,demonstrating an immense need for rare disease drugs.However,the development of rare disease drugs remai...Rare diseases continue to pose a formidable public health challenge with lack or absence of effective treatments,demonstrating an immense need for rare disease drugs.However,the development of rare disease drugs remains uneven globally due to disparities in resource allocation,policy support,and medical infrastructure[1].Compared with other regions such as the USA and the EU,China exhibits distinct needs related to its particular disease spectrum,incidence,prevalence,genetic backgrounds,aetiology,and clinical practices[2].展开更多
Excessive accumulation of disulfide molecules,like cystine,can induce disulfide stress and high toxicity in cells,but the reduced form of nicotinamide adenine dinucleotide phosphate can reverse this process and mitiga...Excessive accumulation of disulfide molecules,like cystine,can induce disulfide stress and high toxicity in cells,but the reduced form of nicotinamide adenine dinucleotide phosphate can reverse this process and mitigate disulfide stress.展开更多
Background:Stroke is the leading cause of death in China,and predicting the stroke burden could provide essential information guiding the setting of medium-and long-term health policies and priorities.The study aimed ...Background:Stroke is the leading cause of death in China,and predicting the stroke burden could provide essential information guiding the setting of medium-and long-term health policies and priorities.The study aimed to project trends associated with stroke burden in China through 2050,not only in terms of incidence and mortality but also for prevalence and disability-adjusted life years(DALYs).Methods:Data on stroke rates in incidence,prevalence,deaths,and DALYs in China between 1990 and 2019 were obtained from a recent Global Burden of Disease study.Demographic-specific trends in rates over time were estimated using three models:the loglinear model,the Lee-Carter model,and a functional time series model.The mean absolute percentage error and the root mean squared error were used for model selection.Projections up to 2050 were estimated using the best fitting model.United Nations population data were used to project the absolute numbers through 2050.Results:From 2019 to 2050,the crude rates for all measures of the stroke burden are projected to increase continuously among both men and women.We project that compared with those in 2019,the incidence,prevalence,deaths,and DALYs because of stroke in China in 2050 will increase by 55.58%,119.16%,72.15%,and 20.04%,respectively;the corresponding increases in number were 2.19,34.27,1.58,and 9.21 million.The age-standardized rate is projected to substantially decline for incidence(8.94%),death(40.37%),and DALYs(43.47%),but the age-standardized prevalence rate is predicted to increase by 10.82%.By 2050,the burden of stroke among the population aged≥65 years will increase significantly:by 104.70%for incidence,by 218.48%for prevalence,by 100.00%for death,and by 58.93%for DALYs.Conclusions:With the aging population in China increasing over the next three decades,the burden of stroke will be markedly increased.Continuous efforts are needed to improve stroke health care and secondary prevention,especially for older adults.展开更多
Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible ...Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible number,the practice of precision medicine and development of novel therapies are largely hampered by many obstacles.Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping.Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines,insufficient biomarkers for prognosis/efficacy,and inability to identify potential novel therapies in clinical trials.Herein,by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas,we proposed a definition of rare tumor in China,including 515 tumor types with incidences of less than 2.5/100000 per year.We also summarized the current diagnosis process,treatment recommendations,and global developmental progress of targeted drugs and immunotherapy agents on the status quo.Lastly,we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN.With this informative report,we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients.展开更多
Background The trochanter of the femur is a common site for bone tumors.However,locating the specificboundary of bone tumor infiltration and determining the surgical method can be challenging.The objective of thisstud...Background The trochanter of the femur is a common site for bone tumors.However,locating the specificboundary of bone tumor infiltration and determining the surgical method can be challenging.The objective of thisstudy was to review the diagnosis,treatment,and surgical outcomes of patients with tumors or tumor-like changesin the femoral trochanter after computer-assisted precise tumor resection and hip-preserving reconstruction ofthe trochanter.Methods From January 2005 to September 2020,11 patients with trochanteric tumors(aged:18–53 years;sixmales and five females)were treated in Guangzhou First People’s Hospital.The cases included aneurysmal bonecyst(n=1),giant cell tumor of bone(n=2),fibrous histiocytoma of bone(n=1),endochondroma(n=1),andfibrous dysplasia of bone(n=6).For patients with trochanteric tumors,computed tomography and magnetic resonance imaging scanning were performed before operation to obtain two-dimensional image data of the lesion.Athree-dimensional digital model of bilateral lower limbs was reconstructed by computer technology,the boundary of tumor growth was determined by computer simulation,the process of tumor resection and reconstructionwas simulated,and the personalized guide template was designed.During the operation,the personalized guideplate guided the precise resection of the tumor,and the allogeneic bone was trimmed to match the shape of thebone defect.Results All 11 patients underwent accurate resection of the tumor or tumor-like lesion and reconstruction ofthe hip.In eight cases,the lesion was confined to the trochanter,which was fixed with large segment allogeneicbone,autologous iliac bone,and proximal femoral anatomic plate.In three cases,allogeneic bone,autologousiliac bone,and femoral reconstruction nail were used to fix the tumor under the trochanter.Postoperative Xray examination showed that the repair and reconstruction of the bone defect was effective,and callus bridgingbetween the allogenic bone and autogenous bone was observed 6 months after operation.All patients recoveredtheir walking function 3–6 months after operation.The duration of the follow-up period ranged from 6 monthsto 6 years.A patient experienced recurrence of endochondroma;pathological examination revealed chondrocyticsarcoma.The remaining 10 patients were treated with segmental resection and reconstruction.The operationtime ranged 2.5–4.5 h(average:3.2 h).Intraoperative blood loss ranged from 300 to 500 ml(average:368 ml).The local recurrence rate was 9.1%,and the overall survival rate was 100%.The average Musculoskeletal TumorSociety score was 27(excellent and good for eight and three patients,respectively).Conclusions Three-dimensional computer skeleton modeling and simulation-assisted resection and reconstruction of femoral trochanteric tumor is a new surgical technique,which might markedly improve the surgical effect,shorten the surgical time,increase the overall survival rate of patients with tumors,reduce the local recurrencerate,assist in the digitization and programming of femoral trochanteric tumor surgery,and improve surgicalaccuracy.展开更多
基金supported by the grant:The National Key Research and Development Program of China(Grant No.2023YFC2508500)Beijing Municipal Health Commission(Beijing Demonstration Research Ward BCRW20200303)+1 种基金National Natural Science Foundation of China(82272951,82272953)Chinese Academy of Medical Sciences(2022-I2M-C&T-B-070).
文摘Although there has been a notable decrease in cancer mortality rates for many common cancers over the last decades,there remains a concerning lack of progress in understanding and treating rare tumors[1].Rare tumors are types of tumors that are rare in clinical practice,which are the subclass of rare diseases.The classification of rare tumors varies internationally,with the US Food and Drug Administration and National Cancer Institute defining them as tumors with an incidence rate of less than 15 per 100,000 individuals annually,while the European Medicines Agency set the threshold at 6 per 100,000.According to the results from the National Cancer Center PLATFORM study in China,rare tumors are defined as an annual incidence rate of 2.5/100,000 or less.Although the incidence of each rare tumor is low,the total number of rare tumors is not low.The total number of rare tumor incidence in China is about 560,000 per year,accounting for 14.2%of all cancer patients[2].More than half of the rare tumors lack clinical treatment guidelines,or there is no standard treatment in clinical practice,suggesting there is a huge unmet medical need for effective treatments for rare tumors.
基金supported by Beijing Municipal Health Commission(grant number:BCRW20200303)National Natural Science Foundation of China(grant number:82272951,82272953)Chinese Academy of Medical Sciences(grant number:2022-I2M-C&T-B-070).
文摘Rare tumors,also known as rare cancers,are characterized by ex-tremely low incidence rates,which comprise a group of about 200 can-cers.1 In the United States(US),rare tumors are defined as those occur-ring in less than 15 cases per 100,000 individuals,2 while in Europe,the prevalence is even lower,with approximately 6 cases per 100,000 peo-ple.
基金This work was financially supported by the Natural Science Foundation of Hebei Province(No.E2020202009)the Tianjin Science and Technology Plan Project(No.20JCQNJC00900)+3 种基金the Science and Technology Project of Hebei Education Department(No.QN2020150)the National Natural Science Foundation of China(No.52101011)the Central Funds Guiding the Local Science and Technology Development of Hebei Province(No.226Z1001G)the Central Funds Guiding the Local Science and Technology Development of Hebei Province(No.226Z1012G).
文摘In conventional corrosion-resistant alloys,precipitation usually reduces corrosion resistance severely by weakening passive films locally.In this work,we found that the aging-treated AlCoCrFeNi_(2.1)sam-ples,which have abundant nanosized L 12 and body-centered cubic(BCC)precipitates in the lamellar face-centered cubic(FCC)and B2 phases,displayed better corrosion resistance than solution-treated AlCoCrFeNi_(2.1)samples without precipitates.In the AlCoCrFeNi_(2.1)alloy,the FCC phase with L1_(2)precipi-tates and the B2 phase with BCC precipitates were protected by passive films enriched with Cr and Al elements,respectively.Moreover,the Al-rich passive film of the B2 phase was less stable than the Cr-rich passive film of the FCC phase,so B2 phase dissolved preferentially.The Cr-rich passive film of the FCC phase remained stable with the formation of Al-rich L1_(2)precipitates inside the phase because those precipitates with the size of∼5 nm were too small to affect the composition of the Cr-rich passive film.The formation of Cr-rich BCC precipitates within the B2 phase increased the content of the Al element inside the phase,improving the stability of Al-rich passive film on the B2 phase.Furthermore,BCC precip-itates with the size of∼30 nm were protected by Cr-rich passive film,which could inhibit the expansion of corrosion pits.Thus,the corrosion resistance of eutectic high-entropy alloy AlCoCrFeN 2.1 was unprece-dentedly enhanced by the precipitation of BCC precipitates.Our study could provide an attractive strategy for designing high-entropy alloys with excellent corrosion resistance and high strength.
基金Supported by Guangxi Scientific Research and Technological Development Planning Project(1123001-9B)Special Research Project of Guangxi Academy of Agricultural Sciences(2013YZ192015YT32)
文摘This paper aims to understand the current situation of heavy metal pollution in paddy soil in West Guangxi,to provide a reference for heavy metal pollution control. The content of Cd,Pb and As of 50 soil samples of cultivation layer( 0- 20 cm),taken from main rice producing areas in West Guangxi,is determined. The environment quality of soil is assessed with the single factor index and the potential ecological risk of paddy soil is evaluated with the potential ecological risk index of Hakanson. The results show that the mean content of Cd,Pb,and As in paddy soil samples is 0. 941,26. 46 and 10. 16 mg / kg,respectively. The Cd content of 54. 0% soil samples and the As content of 2. 0% soil samples are higher than the standard II National Soil Environment Quality,and Cd in paddy soil has high potential ecological risk. Heavy metal pollution in paddy soil in West Guangxi is mainly Cd pollution.
基金Supported by Special Basic Scientific Research Project of Guangxi Academy of Agricultural Sciences[201020(Basic)]Scientific Development Fund Project of Guangxi Academy of Agricultural Sciences(GXAAS 2012JM10)
文摘This study was intended to estimate production of major livestock and poultry manure and contaminant content,and find out current situation of manure pollution,so as to provide reference for pollution control of livestock and poultry breeding industry in Guangxi.Based on the related statistic data in 2010 and the excretion coefficient of different livestock and poultry,the manure and its contaminant production amount of main livestock and poultry in Guangxi were estimated.Then the annual livestock and poultry manure load of farmland and the loss of contaminant were also calculated to analyze the ecological pressure resulted from livestock and poultry breeding in Guangxi.Following results were obtained:in 2010,the production amount of the livestock and poultry manure in Guangxi was 9141.30×104tons,including nutrient TN42.07×104tons and TP 13.62×104tons;the annual livestock and poultry manure and N,P pure nutrient load of farmland was 21t/hm2,98kg/hm2,and 32 kg/hm2respectively;the production amount of manure contaminants was BOD5383.43×104tons,COD Cr435.42×104tons,and NH3-N 42.08×104tons;according to 30%loss rate,the loss amount of COD Cr and NH3-N was higher than the sum of industrial and life waste water.It was concluded that the livestock and poultry breeding industry had little impact on soil environment,but posed a grave threat to water environment.
基金supported by the National Key Research and Development Program of China(2023YFC2508500)Beijing Municipal Health Commission(Beijing Demonstration Research Ward BCRW20200303)+1 种基金the National Natural Science Foundation of China(82272951 and 82272953)the Chinese Academy of Medical Sciences(2022-I2M-C&T-B-070).
文摘Rare diseases continue to pose a formidable public health challenge with lack or absence of effective treatments,demonstrating an immense need for rare disease drugs.However,the development of rare disease drugs remains uneven globally due to disparities in resource allocation,policy support,and medical infrastructure[1].Compared with other regions such as the USA and the EU,China exhibits distinct needs related to its particular disease spectrum,incidence,prevalence,genetic backgrounds,aetiology,and clinical practices[2].
基金supported by the National Natural Science Foundation of China(No.82272951,82272953)Beijing Municipal Health Commission(Beijing Demonstration Research Ward BCRW20200303)Chinese Academy of Medical Sciences(No.2022-I2M-C&T-B-070).
文摘Excessive accumulation of disulfide molecules,like cystine,can induce disulfide stress and high toxicity in cells,but the reduced form of nicotinamide adenine dinucleotide phosphate can reverse this process and mitigate disulfide stress.
基金National Key R&D Program of China(Nos.2019YFC1709804 and 2017YFC1700406)National Natural Science Foundation of China(Grant No.72004149)+2 种基金China Medical Board(Grant No.CMB19-324)Sichuan Youth Science and Technology Innovation Research Team(No.2020JDTD0015)1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYYC08003)
文摘Background:Stroke is the leading cause of death in China,and predicting the stroke burden could provide essential information guiding the setting of medium-and long-term health policies and priorities.The study aimed to project trends associated with stroke burden in China through 2050,not only in terms of incidence and mortality but also for prevalence and disability-adjusted life years(DALYs).Methods:Data on stroke rates in incidence,prevalence,deaths,and DALYs in China between 1990 and 2019 were obtained from a recent Global Burden of Disease study.Demographic-specific trends in rates over time were estimated using three models:the loglinear model,the Lee-Carter model,and a functional time series model.The mean absolute percentage error and the root mean squared error were used for model selection.Projections up to 2050 were estimated using the best fitting model.United Nations population data were used to project the absolute numbers through 2050.Results:From 2019 to 2050,the crude rates for all measures of the stroke burden are projected to increase continuously among both men and women.We project that compared with those in 2019,the incidence,prevalence,deaths,and DALYs because of stroke in China in 2050 will increase by 55.58%,119.16%,72.15%,and 20.04%,respectively;the corresponding increases in number were 2.19,34.27,1.58,and 9.21 million.The age-standardized rate is projected to substantially decline for incidence(8.94%),death(40.37%),and DALYs(43.47%),but the age-standardized prevalence rate is predicted to increase by 10.82%.By 2050,the burden of stroke among the population aged≥65 years will increase significantly:by 104.70%for incidence,by 218.48%for prevalence,by 100.00%for death,and by 58.93%for DALYs.Conclusions:With the aging population in China increasing over the next three decades,the burden of stroke will be markedly increased.Continuous efforts are needed to improve stroke health care and secondary prevention,especially for older adults.
基金supported by the Chinese Academy of Medical Sciences(No.2019XK320068)Chinese Academy of Medical Sciences(No.2020-I2M-2-007)+3 种基金Chinese Academy of Medical SciencesInnovation Fund for Medical Sciences(Construction and Application of Clinical Trial and Institution Evaluation System 2021-I2M-1-045)Beijing Municipal Commission of HealthBeijing Demonstration Research Ward BCRW20200303.
文摘Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible number,the practice of precision medicine and development of novel therapies are largely hampered by many obstacles.Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping.Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines,insufficient biomarkers for prognosis/efficacy,and inability to identify potential novel therapies in clinical trials.Herein,by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas,we proposed a definition of rare tumor in China,including 515 tumor types with incidences of less than 2.5/100000 per year.We also summarized the current diagnosis process,treatment recommendations,and global developmental progress of targeted drugs and immunotherapy agents on the status quo.Lastly,we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN.With this informative report,we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients.
文摘Background The trochanter of the femur is a common site for bone tumors.However,locating the specificboundary of bone tumor infiltration and determining the surgical method can be challenging.The objective of thisstudy was to review the diagnosis,treatment,and surgical outcomes of patients with tumors or tumor-like changesin the femoral trochanter after computer-assisted precise tumor resection and hip-preserving reconstruction ofthe trochanter.Methods From January 2005 to September 2020,11 patients with trochanteric tumors(aged:18–53 years;sixmales and five females)were treated in Guangzhou First People’s Hospital.The cases included aneurysmal bonecyst(n=1),giant cell tumor of bone(n=2),fibrous histiocytoma of bone(n=1),endochondroma(n=1),andfibrous dysplasia of bone(n=6).For patients with trochanteric tumors,computed tomography and magnetic resonance imaging scanning were performed before operation to obtain two-dimensional image data of the lesion.Athree-dimensional digital model of bilateral lower limbs was reconstructed by computer technology,the boundary of tumor growth was determined by computer simulation,the process of tumor resection and reconstructionwas simulated,and the personalized guide template was designed.During the operation,the personalized guideplate guided the precise resection of the tumor,and the allogeneic bone was trimmed to match the shape of thebone defect.Results All 11 patients underwent accurate resection of the tumor or tumor-like lesion and reconstruction ofthe hip.In eight cases,the lesion was confined to the trochanter,which was fixed with large segment allogeneicbone,autologous iliac bone,and proximal femoral anatomic plate.In three cases,allogeneic bone,autologousiliac bone,and femoral reconstruction nail were used to fix the tumor under the trochanter.Postoperative Xray examination showed that the repair and reconstruction of the bone defect was effective,and callus bridgingbetween the allogenic bone and autogenous bone was observed 6 months after operation.All patients recoveredtheir walking function 3–6 months after operation.The duration of the follow-up period ranged from 6 monthsto 6 years.A patient experienced recurrence of endochondroma;pathological examination revealed chondrocyticsarcoma.The remaining 10 patients were treated with segmental resection and reconstruction.The operationtime ranged 2.5–4.5 h(average:3.2 h).Intraoperative blood loss ranged from 300 to 500 ml(average:368 ml).The local recurrence rate was 9.1%,and the overall survival rate was 100%.The average Musculoskeletal TumorSociety score was 27(excellent and good for eight and three patients,respectively).Conclusions Three-dimensional computer skeleton modeling and simulation-assisted resection and reconstruction of femoral trochanteric tumor is a new surgical technique,which might markedly improve the surgical effect,shorten the surgical time,increase the overall survival rate of patients with tumors,reduce the local recurrencerate,assist in the digitization and programming of femoral trochanteric tumor surgery,and improve surgicalaccuracy.
