Oxymatrine(OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties,including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is...Oxymatrine(OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties,including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is extensively employed to treat viral hepatitis; however, its effects on parvovirus infection have yet to be reported. In the present study, we investigated the effects of OMT on cell viability, virus DNA replication, viral gene expression, cell cycle, and apoptosis in Walter Reed canine cells/3873 D infected with minute virus of canines(MVC). OMT, at concentrations below 4 mmol/L(no cellular toxicity), was found to inhibit MVC DNA replication and reduce viral gene expression at both mRNA and protein levels, which was associated with the inhibition of cell cycle S-phase arrest in early-stage of MVC infection.Furthermore, OMT significantly increased cell viability, decreased MVC-infected cell apoptosis, and reduced the expression of activated caspase 3. Our results suggest that OMT has potential application in combating parvovirus infection.展开更多
In the original version of Fig.2,the marker line between column 2 and column 6 is redundant(Fig.2A),and MVC label and MVCIOMT label were accidentally swapped(Fig.2B).The correct Fig.2 is provided below.
Zinc-based flow batteries(ZFBs)have aroused great favor in large-scale energy storage due to the high security and low cost.However,the low areal capacity arising from the limited space for Zn plating hinders the furt...Zinc-based flow batteries(ZFBs)have aroused great favor in large-scale energy storage due to the high security and low cost.However,the low areal capacity arising from the limited space for Zn plating hinders the further development.Herein,a novel carbon felt-Sn-carbon felt sandwich host(CSCH)is designed and constructed.Benefiting from the strong chemical absorption and the dehydration effect on Zn(H_(2)O)_(6)^(2+),the Sn activation layer in the CSCH demonstrates the lowest comprehensive resistance for Zn deposition.Thus,Zn is induced to nucleate preferentially on the Sn activation layer,and grows towards the membrane,regulating the spatial distribution of Zn electrochemical deposits,which remarkably improves the areal capacity and cyclic stability of Zn anode.Consequently,the zinc-bromine flow batteries equipped with CSCH electrodes can achieve the ultra-high areal capacity of 120 mA h cm^(-2)at 80 mA cm^(-2),and run stably for 140 h with average energy efficiency of 80.3%in the extreme condition(80 mA cm^(-2),80 mA h cm^(-2)).This innovative work will inspire future advanced designs for high areal capacity electrodes in ZFBs.展开更多
Obesity and other metabolic syndromes such as hypertension,type 2 diabetes,and hyperlipidemia remain a major public health burden worldwide.Apart from higher incidence of cardiovascular diseases,obesity and other abno...Obesity and other metabolic syndromes such as hypertension,type 2 diabetes,and hyperlipidemia remain a major public health burden worldwide.Apart from higher incidence of cardiovascular diseases,obesity and other abnormal metabolic status also promote cancer development and poor prognosis of cancer patients(1-3).In addition to using different surgical modalities(4),weight management through lifestyle changes has proven to be a more economical and low-risk approach.For obese patients,whether daily caloric intake can be reasonably restricted is recognized as an important strategy for solving their problem.In the past few years,intermittent fasting(IF),especially time-restricted feeding(TRF),has shown good clinical weight loss effect(>5%loss from baseline)(5).Moreover,people who participate in IF or TRF can often show good compliance,because compared with traditional dieting,IF or TRF does not require participants to record the specific calories of each meal in detail,participants only need to eat within the specified time period and not have any caloric intake at any other time.展开更多
To analyse the vertical dynamic characteristics of the aircraft towing system under different constraints on the nose landing gear wheels of the aircraft during the towing slip-out mode,a dynamic model of the towing s...To analyse the vertical dynamic characteristics of the aircraft towing system under different constraints on the nose landing gear wheels of the aircraft during the towing slip-out mode,a dynamic model of the towing system considering the constraints between the clamping mechanism and the aircraft nose landing gear wheels was established based on the general towing system dynamic model.On this basis,an analysis was conducted to determine whether considering the aircraft wheel constraints affects the vertical vibration acceleration of the towing vehicle and the nose landing gear in low-speed(10 km/h)and high-speed(40 km/h)operating conditions.With the consideration of constraints at both ends of the aircraft wheels,the vertical acceleration of the towing vehicle’s centre of mass increased by 153%and 172%at low speed and high speed,respectively,compared to not considering the aircraft wheel constraints.Additionally,with the consideration of constraints at both ends of the aircraft wheels,the vertical acceleration of the nose landing gear’s centre of mass decreased to 20%and 57%at low speed and high speed,respectively,compared to not considering the aircraft wheel constraints.An analysis of the vertical vibration acceleration of the towing vehicle under different wheel constraint conditions found that the Root Mean Square(RMS)value of the vertical vibration acceleration of the towing vehicle’s centre of mass was minimized when the clamping angles of the clamping mechanism to the nose landing gear wheels were 63◦and 64◦,respectively.Under this clamping angle,the influence of the clamping forces at both ends of the clamping mechanism on the vertical vibration acceleration of the towing vehicle was minimal.The research results provide valuable reference for the direct constraints between the clamping mechanism and the nose landing gear wheels in the aircraft towing slip-out system.展开更多
基金funded by the Natural Sciences Foundation of China (31760041) to YSthe West China first-class Disciplines Basic Medical Sciences at Ningxia Medical University (No. NXYLXK2017B07)Innovative Training Program for College Students (201510752010) to NL
文摘Oxymatrine(OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties,including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is extensively employed to treat viral hepatitis; however, its effects on parvovirus infection have yet to be reported. In the present study, we investigated the effects of OMT on cell viability, virus DNA replication, viral gene expression, cell cycle, and apoptosis in Walter Reed canine cells/3873 D infected with minute virus of canines(MVC). OMT, at concentrations below 4 mmol/L(no cellular toxicity), was found to inhibit MVC DNA replication and reduce viral gene expression at both mRNA and protein levels, which was associated with the inhibition of cell cycle S-phase arrest in early-stage of MVC infection.Furthermore, OMT significantly increased cell viability, decreased MVC-infected cell apoptosis, and reduced the expression of activated caspase 3. Our results suggest that OMT has potential application in combating parvovirus infection.
文摘In the original version of Fig.2,the marker line between column 2 and column 6 is redundant(Fig.2A),and MVC label and MVCIOMT label were accidentally swapped(Fig.2B).The correct Fig.2 is provided below.
基金supported by the National Natural Science Foundation of China(22179019)the Natural Science Foundation of Hebei Province,China(B2020501003)the Fundamental Research Funds for the Central Universities(N2023030)。
文摘Zinc-based flow batteries(ZFBs)have aroused great favor in large-scale energy storage due to the high security and low cost.However,the low areal capacity arising from the limited space for Zn plating hinders the further development.Herein,a novel carbon felt-Sn-carbon felt sandwich host(CSCH)is designed and constructed.Benefiting from the strong chemical absorption and the dehydration effect on Zn(H_(2)O)_(6)^(2+),the Sn activation layer in the CSCH demonstrates the lowest comprehensive resistance for Zn deposition.Thus,Zn is induced to nucleate preferentially on the Sn activation layer,and grows towards the membrane,regulating the spatial distribution of Zn electrochemical deposits,which remarkably improves the areal capacity and cyclic stability of Zn anode.Consequently,the zinc-bromine flow batteries equipped with CSCH electrodes can achieve the ultra-high areal capacity of 120 mA h cm^(-2)at 80 mA cm^(-2),and run stably for 140 h with average energy efficiency of 80.3%in the extreme condition(80 mA cm^(-2),80 mA h cm^(-2)).This innovative work will inspire future advanced designs for high areal capacity electrodes in ZFBs.
文摘Obesity and other metabolic syndromes such as hypertension,type 2 diabetes,and hyperlipidemia remain a major public health burden worldwide.Apart from higher incidence of cardiovascular diseases,obesity and other abnormal metabolic status also promote cancer development and poor prognosis of cancer patients(1-3).In addition to using different surgical modalities(4),weight management through lifestyle changes has proven to be a more economical and low-risk approach.For obese patients,whether daily caloric intake can be reasonably restricted is recognized as an important strategy for solving their problem.In the past few years,intermittent fasting(IF),especially time-restricted feeding(TRF),has shown good clinical weight loss effect(>5%loss from baseline)(5).Moreover,people who participate in IF or TRF can often show good compliance,because compared with traditional dieting,IF or TRF does not require participants to record the specific calories of each meal in detail,participants only need to eat within the specified time period and not have any caloric intake at any other time.
基金supported by the the Fundamental Research Funds for the Central Universities,China(Grant No.3122022066)Postgraduate Research and Innovation Fund,China(Grant No.2022YJS056)National Natural Science Foundation of China(Grant No.U2033208).
文摘To analyse the vertical dynamic characteristics of the aircraft towing system under different constraints on the nose landing gear wheels of the aircraft during the towing slip-out mode,a dynamic model of the towing system considering the constraints between the clamping mechanism and the aircraft nose landing gear wheels was established based on the general towing system dynamic model.On this basis,an analysis was conducted to determine whether considering the aircraft wheel constraints affects the vertical vibration acceleration of the towing vehicle and the nose landing gear in low-speed(10 km/h)and high-speed(40 km/h)operating conditions.With the consideration of constraints at both ends of the aircraft wheels,the vertical acceleration of the towing vehicle’s centre of mass increased by 153%and 172%at low speed and high speed,respectively,compared to not considering the aircraft wheel constraints.Additionally,with the consideration of constraints at both ends of the aircraft wheels,the vertical acceleration of the nose landing gear’s centre of mass decreased to 20%and 57%at low speed and high speed,respectively,compared to not considering the aircraft wheel constraints.An analysis of the vertical vibration acceleration of the towing vehicle under different wheel constraint conditions found that the Root Mean Square(RMS)value of the vertical vibration acceleration of the towing vehicle’s centre of mass was minimized when the clamping angles of the clamping mechanism to the nose landing gear wheels were 63◦and 64◦,respectively.Under this clamping angle,the influence of the clamping forces at both ends of the clamping mechanism on the vertical vibration acceleration of the towing vehicle was minimal.The research results provide valuable reference for the direct constraints between the clamping mechanism and the nose landing gear wheels in the aircraft towing slip-out system.
