BACKGROUND Duodenal mucosal ablation(DMA)using irreversible electroporation(IRE)with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver d...BACKGROUND Duodenal mucosal ablation(DMA)using irreversible electroporation(IRE)with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver disease(NAFLD).However,the specific metabolic contributions of DMA using IRE in NAFLD remain unclear.AIM To assess the feasibility and effectiveness of DMA using IRE in NAFLD rat models.METHODS Seven-week-old male Sprague-Dawley rats underwent DMA using IRE after 8 weeks on a high-fat diet.Two weeks post-treatment,duodenal and liver tissues and blood samples were collected.We evaluated differences in the duodenal wall structure,liver lipid deposition,enteroendocrine,claudin,and zonula ocludens-1 in the duodenal mucosa.RESULTS DMA using IRE could be safely performed in rats with NAFLD without duodenal bleeding,perforation,or stenosis.The duodenum healed well 2 weeks after DMA and was characterized by slimmer villi,narrower and shallower crypts,and thicker myenterons compared with the sham-control setting.Liver lipid deposition was reduced and serum lipid index parameters were considerably improved in the DMA setting.However,these improvements were independent of food intake and weight loss.In addition,enteroendocrine parameters,such as claudin,and zonula ocludens-1 levels in the duodenal mucosa,differed between the different settings in the DMA group.CONCLUSION By altering enteroendocrine and duodenal permeability,simple DMA using IRE ameliorated liver lipid deposition and improved serum lipid parameters in NAFLD rats.展开更多
Background:Electroacupuncture(EA)may affect the severity of hot flashes(HFs)associated with natural menopause and provide additional benefits for postmenopausal women.However,the evidence for its effectiveness in the ...Background:Electroacupuncture(EA)may affect the severity of hot flashes(HFs)associated with natural menopause and provide additional benefits for postmenopausal women.However,the evidence for its effectiveness in the management of early postmenopausal HFs remains inadequately understood.Objective:We designed this trial to assess the efficacy and safety of EA for relieving early postmenopausal HFs.Design,setting,participants and interventions:This randomized sham-controlled trial involved 72 women with HFs.The participants were divided equally into the intervention and control groups.The intervention group was treated with EA,while the control group was treated with sham acupuncture.The main acupoints used were Hegu(LI4),Guanyuan(RN4),Sanyinjiao(SP6),Taixi(KI3),Fuliu(KI7)and Shenshu(BL23).All participants received 18 treatment sessions,distributed across a 6-week period.The treatment was administered on three occasions per week,adhering to a fixed weekday schedule(Monday,Wednesday,Friday or Tuesday,Thursday,Saturday)with a minimum interval of one day between sessions.Each patient received a 12-week follow-up.Main outcome measures:The HF score was the primary outcome.Participants documented the frequency and severity of HFs in a 7-day symptom diary,which provided data for calculating the HF score.Secondary outcomes were the Menopause Rating Scale(MRS),Menopause-Specific Quality of Life Questionnaire(MENQOL),Pittsburgh Sleep Quality Index(PSQI)and Traditional Chinese Medicine Syndrome Score Scale(TCMSSS),as well as estradiol(E2),luteinizing hormone(LH)and folliclestimulating hormone(FSH)levels.Results:Both groups demonstrated significant reductions in HF scores after the treatment and during the follow-up(P<0.001).Immediately after completion of the 6-week treatment cycle and at 12 weeks postintervention,the HF scores were similar in both groups.At week 6,the intervention group showed significantly greater improvements in MRS,MENQOL(vasomotor,psychosocial,and physical),PSQI and TCMSSS scores(P<0.05).The improvements in the MENQOL(vasomotor,and psychosocial)and PSQI total scores persisted through the follow-up(P<0.05).However,the results showed no significant inter-or intragroup differences in sexual scores on the MENQOL(P>0.05).EA did not significantly decrease E2,LH or FSH levels compared to placebo.The incidence of adverse events was similar in both groups.Conclusion:EA does not significantly improve HFs in early postmenopausal patients.However,it enhances the quality of sleep and decreases menopausal symptoms across vasomotor,psychosocial and physical domains.Trial registration:Chinese Clinical Trial Registry(http://www.chictr.org.cn);Trial ID:Chi CTR2300072002.Please cite this article as:Wang HX,Yu XT,Hu J,Chen JJ,Mei YT,Chen YF.Electroacupuncture for hot flashes in early menopause:A randomized sham-controlled trial.J Integr Med.2025;23(5):519-527.?2025 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.Published by Elsevier B.V.All rights are reserved,including those for text and data mining,AI training,and similar technologies.展开更多
目的:探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与2型糖尿病视网膜病变(DR)的相关性。方法:选择2型糖尿病(DM)患者200例,按眼底检查结果分为眼底正常组( n =100)、非增殖期视网膜病变组(NPDR, n =62)和增殖期视网...目的:探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与2型糖尿病视网膜病变(DR)的相关性。方法:选择2型糖尿病(DM)患者200例,按眼底检查结果分为眼底正常组( n =100)、非增殖期视网膜病变组(NPDR, n =62)和增殖期视网膜病变组(PDR, n =38)。同时选取100例健康体检者作为正常对照( n =100)组;测定中性粒细胞、淋巴细胞及血小板计数等相关指标。结果: PDR组患者NLR值(2.54)高于对照组(1.81)、DM组(1.76)及NPDR组(1.85),差异有统计学意义( P <0.05),PDR组患者PLR值(126.18)高于DM组(111.64),差异有统计学意义( P <0.05)。Logistic回归分析显示,年龄(β=-0.047)是糖尿病视网膜病变的保护因素( P <0.05),病程(β=0.071)和收缩压(β=0.024)是危险因素( P <0.05),而NLR、PLR在回归分析中无统计学意义。结论:NLR、PLR值在PDR组升高,但并非糖尿病视网膜病变发生的独立危险因素。展开更多
目的评价参苓白术散治疗老年男性肌少症的成本-效用。方法280例老年男性肌少症患者随机分为干预组和对照组各140例,两组患者均给予营养运动治疗,干预组在营养运动治疗基础上加用参苓白术散,两组患者均随访24周。从卫生体系角度出发,利用...目的评价参苓白术散治疗老年男性肌少症的成本-效用。方法280例老年男性肌少症患者随机分为干预组和对照组各140例,两组患者均给予营养运动治疗,干预组在营养运动治疗基础上加用参苓白术散,两组患者均随访24周。从卫生体系角度出发,利用TreeAge Pro 2011软件建立决策树模型,对两种治疗方案进行成本-效用分析,并采用敏感性分析对结果的不确定性进行评价。结果与对照组相比,干预组方案成本(5019.46元vs.4864.57元)、效用[0.90357质量调整生命年(QALYs)vs.0.89430 QALYs]均较高,增量成本-效用比为16712.05元/QALY,低于意愿支付阈值。敏感性分析结果与成本-效用分析结果一致。结论与单独应用营养运动治疗相比,老年男性肌少症患者应用参苓白术散联合营养运动治疗更具有成本-效用。展开更多
Many DNA?based devices need to build stable and controllable DNA films on surfaces. However, the most com?monly used method of film characterization, namely, the probe?like microscopes which may destroy the sample and...Many DNA?based devices need to build stable and controllable DNA films on surfaces. However, the most com?monly used method of film characterization, namely, the probe?like microscopes which may destroy the sample and substrate. Surface Forces Apparatus(SFA) technique, specializing in surface interaction studies, is introduced to investigate the e ects of DNA concentration on the formation of single?stranded DNA(ss?DNA) film. The result demonstrates that 50 ng/μL is the lowest concentration that ss?DNA construct a dense layer on mica. Besides, it is also indicated that at di erent DNA concentrations, ss?DNA exhibit diverse morphology: lying flat on surface at 50 ng/μL while forming bilayer or cross?link at 100 ng/μL, and these ss?DNA structures are stable enough due to the repeatabil?ity even under the load of 15 mN/m. At the same time, an obvious adhesion force is measured:/m at 100 ng/μL, respectively, which is attributed to the ion?correlation e ect. M-6.5 mN/m at 50 ng/μL and-5.3 mNoreover, the atomic force microscopy(AFM) images reveal the entire surface is covered with wormlike ss?DNA and the measured surface roughness(1.8±0.2 nm) also matches well with the film thickness by SFA. The desorption behaviors of ss?DNA layer from mica surface occur by adding sodium salt into gap bu er, which is mainly ascribed to the decreased ion?ion cor?relation force. This paper employing SFA and AFM techniques to characterize the DNA film with flexibility and stable mechanical ability achieved by ion bridging method, is helpful to fabricate the DNA?based devices in nanoscale.展开更多
In this paper, a kind of elastic characteristic extraction method of underwater targets based on adaptive filtering is introduced. The kernel of the method is the recursive least square （RLS） algorithm. Firstly, the...In this paper, a kind of elastic characteristic extraction method of underwater targets based on adaptive filtering is introduced. The kernel of the method is the recursive least square （RLS） algorithm. Firstly, the geometric scattering signal is fit by using the echo signal and the incident signal. Then, the frequency spectrum of the echo signal and the geometric scattering signal are calculated. At last, the frequency spectrum of the elastic scattering signal is obtained. The research of the simulation and lake experiment is carried on. As the results show, the formants of the elastic signal frequency spectrum can be precisely extracted by the algorithm, and the extraction algorithm can apply to extracting the elastic characteristic from the echo signal in a real underwater acoustics environment.展开更多
In bistaic acoustic testing, there will be strong direct blast interference. An algorithm based on signal phase-matching array processing that rejects direct blast interference in bistatic acoustic testing has been st...In bistaic acoustic testing, there will be strong direct blast interference. An algorithm based on signal phase-matching array processing that rejects direct blast interference in bistatic acoustic testing has been studied, through which the object scattering signal is accurately extracted. Characteristics of bistatic acoustic testing and signal phase matching processing principle are fully integrated in this algorithm. Firstly, the direct blast interference is calculated from the receiving signal based on three subarrays signal phase matching processing. Secondly, the direct blast is rejected by subtraction from the receiving signal. In this way the limitations of the high signal to noise ratio that signal phase matching processing required for direct calculating the object scattering signal can be avoided. Simulation and sea trial results show that, when the ratio of signal to interference is greater than -20 dB, this algorithm of direct blast interference rejection based phase matching signal processing can accurately extract the object scattering signal.展开更多
A patent foramen ovale(PFO)is a clinical condition linked to ischemic stroke,aura migraine,and other pathologies.Current medical consensus posits that PFO closure may mitigate the risk of recurrent strokes.This case r...A patent foramen ovale(PFO)is a clinical condition linked to ischemic stroke,aura migraine,and other pathologies.Current medical consensus posits that PFO closure may mitigate the risk of recurrent strokes.This case report details the management of a 61-year-old female diagnosed with colon cancer for one month.Preoperative transthoracic echocardiography indicated a potential left-to-right shunt through the foramen ovale and mild regurgitation of both the mitral and aortic valves.The patient’s history revealed previous left-sided migraines,and a review of her medical records disclosed multifocal cerebral infarctions identified by a head CT.A pulmonary artery computed tomography angiography suggested embolization in the anterior branch of the right upper pulmonary artery and several branches of the right lower lung’s posterior and lateral basilar artery,along with thickening of the trunk canals of the pulmonary arteries.After a thorough assessment and extensive consultation with the surgical team,the procedure was transitioned from a laparoscopic radical resection to an open total colectomy.Anesthesia induction required careful avoidance of hypoxia,breath-holding,and coughing.Vigilant management of respiratory and circulatory functions was crucial during periods prone to intraoperative embolism formation.Postoperatively,attention was given to the stabilization of respiratory and circulatory functions during extubation,ensuring adequate sputum suction to prevent choking and close monitoring of breathing to avert airway obstruction post-extubation.Additionally,the patient was closely monitored for postoperative nausea and vomiting,a high-risk condition for this patient cohort.Strategies were implemented to minimize the risk of right-to-left shunting,ensuring the patient’s vital signs remained stable throughout the perioperative period.The patient was discharged safely after a 10-day recovery.For patients with cancer and PFO,comprehensive risk assessment and meticulous safety management are paramount.This case confirms the patient’s history of patent foramen ovale through the association between some atypical symptoms such as migraine,pulmonary embolism and cerebral infarction,which provides guidance for the management of anesthesia in the perioperative period,offering significant clinical implications.展开更多
This paper investigates the secrecy performance of maximal ratio combining （MRC） and selection combining （SC） with imperfect channel state information （CSI） in the physical layer. In a single-input multiple- out...This paper investigates the secrecy performance of maximal ratio combining （MRC） and selection combining （SC） with imperfect channel state information （CSI） in the physical layer. In a single-input multiple- output （SIMO） wiretap channel, a source transmits confidential messages to the destination equipped with M antennas using the MRC/SC scheme to process the received multiple signals. An eavesdropper equipped with N antennas also adopts the MRC/SC scheme to promote successful eavesdropping. We derive the exact and asymptotic closed-form expressions for the ergodic secrecy capacity （ESC） in two cases： （1） MRC with weighting errors, and （2） SC with outdated CSI. Moreover, two important indicators, namely high signal-to-noise ratio （SNR） slope and high SNR power offset, which govern ESC at the high SNR region, are derived. Finally, simulations are conducted to validate the accuracy of our proposed analytical models. Results indicate that ESC rises with the increase of the number of antennas and the received SNR at the destination, and fades with the increase of those at the eavesdropper. Another finding is that the high SNR slope is constant, while the high SNR power offset is correlated with the number of antennas at both the destination and the eavesdropper.展开更多
We investigate the secrecy outage performance of maximal ratio combining(MRC) in cognitive radio networks over Rayleigh fading channels. In a single-input multiple-output wiretap system, we consider a secondary user(S...We investigate the secrecy outage performance of maximal ratio combining(MRC) in cognitive radio networks over Rayleigh fading channels. In a single-input multiple-output wiretap system, we consider a secondary user(SU-TX) that transmits confidential messages to another secondary user(SU-RX) equipped with M(M ≥ 1)antennas where the MRC technique is adopted to improve its received signal-to-noise ratio. Meanwhile, an eavesdropper equipped with N(N ≥ 1) antennas adopts the MRC scheme to overhear the information between SU-TX and SU-RX. SU-TX adopts the underlay strategy to guarantee the service quality of the primary user without spectrum sensing. We derive the closed-form expressions for an exact and asymptotic secrecy outage probability.展开更多
基金Supported by the National Key Research and Development Program,No.2023YFF0713700 and No.2023YFF0713705Common Technology R&D Platform of Shaanxi Province,No.2023GXJS-01-1-2the Cyrus Tang Foundation Chung Ying Young Scholars Program.
文摘BACKGROUND Duodenal mucosal ablation(DMA)using irreversible electroporation(IRE)with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty liver disease(NAFLD).However,the specific metabolic contributions of DMA using IRE in NAFLD remain unclear.AIM To assess the feasibility and effectiveness of DMA using IRE in NAFLD rat models.METHODS Seven-week-old male Sprague-Dawley rats underwent DMA using IRE after 8 weeks on a high-fat diet.Two weeks post-treatment,duodenal and liver tissues and blood samples were collected.We evaluated differences in the duodenal wall structure,liver lipid deposition,enteroendocrine,claudin,and zonula ocludens-1 in the duodenal mucosa.RESULTS DMA using IRE could be safely performed in rats with NAFLD without duodenal bleeding,perforation,or stenosis.The duodenum healed well 2 weeks after DMA and was characterized by slimmer villi,narrower and shallower crypts,and thicker myenterons compared with the sham-control setting.Liver lipid deposition was reduced and serum lipid index parameters were considerably improved in the DMA setting.However,these improvements were independent of food intake and weight loss.In addition,enteroendocrine parameters,such as claudin,and zonula ocludens-1 levels in the duodenal mucosa,differed between the different settings in the DMA group.CONCLUSION By altering enteroendocrine and duodenal permeability,simple DMA using IRE ameliorated liver lipid deposition and improved serum lipid parameters in NAFLD rats.
基金supported by Shanghai Clinical Research Center for Acupuncture and Moxibustion(No.20MC1920500)National Administration of Traditional Chinese Medicine High-Level Disciplines Construction Project(No.ZYYZDXK-2023068)Three Year Action Plan for Shanghai to Further Accelerate the Inheritance,Innovation and Development of Traditional Chinese Medicine(2025-2027)(No.1-1-2)。
文摘Background:Electroacupuncture(EA)may affect the severity of hot flashes(HFs)associated with natural menopause and provide additional benefits for postmenopausal women.However,the evidence for its effectiveness in the management of early postmenopausal HFs remains inadequately understood.Objective:We designed this trial to assess the efficacy and safety of EA for relieving early postmenopausal HFs.Design,setting,participants and interventions:This randomized sham-controlled trial involved 72 women with HFs.The participants were divided equally into the intervention and control groups.The intervention group was treated with EA,while the control group was treated with sham acupuncture.The main acupoints used were Hegu(LI4),Guanyuan(RN4),Sanyinjiao(SP6),Taixi(KI3),Fuliu(KI7)and Shenshu(BL23).All participants received 18 treatment sessions,distributed across a 6-week period.The treatment was administered on three occasions per week,adhering to a fixed weekday schedule(Monday,Wednesday,Friday or Tuesday,Thursday,Saturday)with a minimum interval of one day between sessions.Each patient received a 12-week follow-up.Main outcome measures:The HF score was the primary outcome.Participants documented the frequency and severity of HFs in a 7-day symptom diary,which provided data for calculating the HF score.Secondary outcomes were the Menopause Rating Scale(MRS),Menopause-Specific Quality of Life Questionnaire(MENQOL),Pittsburgh Sleep Quality Index(PSQI)and Traditional Chinese Medicine Syndrome Score Scale(TCMSSS),as well as estradiol(E2),luteinizing hormone(LH)and folliclestimulating hormone(FSH)levels.Results:Both groups demonstrated significant reductions in HF scores after the treatment and during the follow-up(P<0.001).Immediately after completion of the 6-week treatment cycle and at 12 weeks postintervention,the HF scores were similar in both groups.At week 6,the intervention group showed significantly greater improvements in MRS,MENQOL(vasomotor,psychosocial,and physical),PSQI and TCMSSS scores(P<0.05).The improvements in the MENQOL(vasomotor,and psychosocial)and PSQI total scores persisted through the follow-up(P<0.05).However,the results showed no significant inter-or intragroup differences in sexual scores on the MENQOL(P>0.05).EA did not significantly decrease E2,LH or FSH levels compared to placebo.The incidence of adverse events was similar in both groups.Conclusion:EA does not significantly improve HFs in early postmenopausal patients.However,it enhances the quality of sleep and decreases menopausal symptoms across vasomotor,psychosocial and physical domains.Trial registration:Chinese Clinical Trial Registry(http://www.chictr.org.cn);Trial ID:Chi CTR2300072002.Please cite this article as:Wang HX,Yu XT,Hu J,Chen JJ,Mei YT,Chen YF.Electroacupuncture for hot flashes in early menopause:A randomized sham-controlled trial.J Integr Med.2025;23(5):519-527.?2025 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.Published by Elsevier B.V.All rights are reserved,including those for text and data mining,AI training,and similar technologies.
文摘目的:探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与2型糖尿病视网膜病变(DR)的相关性。方法:选择2型糖尿病(DM)患者200例,按眼底检查结果分为眼底正常组( n =100)、非增殖期视网膜病变组(NPDR, n =62)和增殖期视网膜病变组(PDR, n =38)。同时选取100例健康体检者作为正常对照( n =100)组;测定中性粒细胞、淋巴细胞及血小板计数等相关指标。结果: PDR组患者NLR值(2.54)高于对照组(1.81)、DM组(1.76)及NPDR组(1.85),差异有统计学意义( P <0.05),PDR组患者PLR值(126.18)高于DM组(111.64),差异有统计学意义( P <0.05)。Logistic回归分析显示,年龄(β=-0.047)是糖尿病视网膜病变的保护因素( P <0.05),病程(β=0.071)和收缩压(β=0.024)是危险因素( P <0.05),而NLR、PLR在回归分析中无统计学意义。结论:NLR、PLR值在PDR组升高,但并非糖尿病视网膜病变发生的独立危险因素。
文摘目的评价参苓白术散治疗老年男性肌少症的成本-效用。方法280例老年男性肌少症患者随机分为干预组和对照组各140例,两组患者均给予营养运动治疗,干预组在营养运动治疗基础上加用参苓白术散,两组患者均随访24周。从卫生体系角度出发,利用TreeAge Pro 2011软件建立决策树模型,对两种治疗方案进行成本-效用分析,并采用敏感性分析对结果的不确定性进行评价。结果与对照组相比,干预组方案成本(5019.46元vs.4864.57元)、效用[0.90357质量调整生命年(QALYs)vs.0.89430 QALYs]均较高,增量成本-效用比为16712.05元/QALY,低于意愿支付阈值。敏感性分析结果与成本-效用分析结果一致。结论与单独应用营养运动治疗相比,老年男性肌少症患者应用参苓白术散联合营养运动治疗更具有成本-效用。
基金National Natural Science Foundation of China(Grant No.51435003)Jiangsu Provincial Natural Science Foundation of China(Grant No.BK20160670)
文摘Many DNA?based devices need to build stable and controllable DNA films on surfaces. However, the most com?monly used method of film characterization, namely, the probe?like microscopes which may destroy the sample and substrate. Surface Forces Apparatus(SFA) technique, specializing in surface interaction studies, is introduced to investigate the e ects of DNA concentration on the formation of single?stranded DNA(ss?DNA) film. The result demonstrates that 50 ng/μL is the lowest concentration that ss?DNA construct a dense layer on mica. Besides, it is also indicated that at di erent DNA concentrations, ss?DNA exhibit diverse morphology: lying flat on surface at 50 ng/μL while forming bilayer or cross?link at 100 ng/μL, and these ss?DNA structures are stable enough due to the repeatabil?ity even under the load of 15 mN/m. At the same time, an obvious adhesion force is measured:/m at 100 ng/μL, respectively, which is attributed to the ion?correlation e ect. M-6.5 mN/m at 50 ng/μL and-5.3 mNoreover, the atomic force microscopy(AFM) images reveal the entire surface is covered with wormlike ss?DNA and the measured surface roughness(1.8±0.2 nm) also matches well with the film thickness by SFA. The desorption behaviors of ss?DNA layer from mica surface occur by adding sodium salt into gap bu er, which is mainly ascribed to the decreased ion?ion cor?relation force. This paper employing SFA and AFM techniques to characterize the DNA film with flexibility and stable mechanical ability achieved by ion bridging method, is helpful to fabricate the DNA?based devices in nanoscale.
基金supported by the Foundation of Key Laboratory for Underwater Test&Control Technology under Grant No.9140C260201110C26
文摘In this paper, a kind of elastic characteristic extraction method of underwater targets based on adaptive filtering is introduced. The kernel of the method is the recursive least square （RLS） algorithm. Firstly, the geometric scattering signal is fit by using the echo signal and the incident signal. Then, the frequency spectrum of the echo signal and the geometric scattering signal are calculated. At last, the frequency spectrum of the elastic scattering signal is obtained. The research of the simulation and lake experiment is carried on. As the results show, the formants of the elastic signal frequency spectrum can be precisely extracted by the algorithm, and the extraction algorithm can apply to extracting the elastic characteristic from the echo signal in a real underwater acoustics environment.
基金supported by the Foundation of Key Laboratory for Underwater Test & Control Technology under Grant No.9140C260201110C26
文摘In bistaic acoustic testing, there will be strong direct blast interference. An algorithm based on signal phase-matching array processing that rejects direct blast interference in bistatic acoustic testing has been studied, through which the object scattering signal is accurately extracted. Characteristics of bistatic acoustic testing and signal phase matching processing principle are fully integrated in this algorithm. Firstly, the direct blast interference is calculated from the receiving signal based on three subarrays signal phase matching processing. Secondly, the direct blast is rejected by subtraction from the receiving signal. In this way the limitations of the high signal to noise ratio that signal phase matching processing required for direct calculating the object scattering signal can be avoided. Simulation and sea trial results show that, when the ratio of signal to interference is greater than -20 dB, this algorithm of direct blast interference rejection based phase matching signal processing can accurately extract the object scattering signal.
基金supported by grants from the Anhui Provincial Natural Science Foundation(Grant No.2208085Y32 to Chaoliang Tang)the Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei Province(Grant No.CXPJJH12000005-07-115 to Chaoliang Tang).
文摘A patent foramen ovale(PFO)is a clinical condition linked to ischemic stroke,aura migraine,and other pathologies.Current medical consensus posits that PFO closure may mitigate the risk of recurrent strokes.This case report details the management of a 61-year-old female diagnosed with colon cancer for one month.Preoperative transthoracic echocardiography indicated a potential left-to-right shunt through the foramen ovale and mild regurgitation of both the mitral and aortic valves.The patient’s history revealed previous left-sided migraines,and a review of her medical records disclosed multifocal cerebral infarctions identified by a head CT.A pulmonary artery computed tomography angiography suggested embolization in the anterior branch of the right upper pulmonary artery and several branches of the right lower lung’s posterior and lateral basilar artery,along with thickening of the trunk canals of the pulmonary arteries.After a thorough assessment and extensive consultation with the surgical team,the procedure was transitioned from a laparoscopic radical resection to an open total colectomy.Anesthesia induction required careful avoidance of hypoxia,breath-holding,and coughing.Vigilant management of respiratory and circulatory functions was crucial during periods prone to intraoperative embolism formation.Postoperatively,attention was given to the stabilization of respiratory and circulatory functions during extubation,ensuring adequate sputum suction to prevent choking and close monitoring of breathing to avert airway obstruction post-extubation.Additionally,the patient was closely monitored for postoperative nausea and vomiting,a high-risk condition for this patient cohort.Strategies were implemented to minimize the risk of right-to-left shunting,ensuring the patient’s vital signs remained stable throughout the perioperative period.The patient was discharged safely after a 10-day recovery.For patients with cancer and PFO,comprehensive risk assessment and meticulous safety management are paramount.This case confirms the patient’s history of patent foramen ovale through the association between some atypical symptoms such as migraine,pulmonary embolism and cerebral infarction,which provides guidance for the management of anesthesia in the perioperative period,offering significant clinical implications.
基金Project supported by the National Natural Science Foundation of China （No. 61401372） and the Fundamental Research Funds for the Central Universities, China （Nos. XDJK2015B023 and XDJK2016A011）
文摘This paper investigates the secrecy performance of maximal ratio combining （MRC） and selection combining （SC） with imperfect channel state information （CSI） in the physical layer. In a single-input multiple- output （SIMO） wiretap channel, a source transmits confidential messages to the destination equipped with M antennas using the MRC/SC scheme to process the received multiple signals. An eavesdropper equipped with N antennas also adopts the MRC/SC scheme to promote successful eavesdropping. We derive the exact and asymptotic closed-form expressions for the ergodic secrecy capacity （ESC） in two cases： （1） MRC with weighting errors, and （2） SC with outdated CSI. Moreover, two important indicators, namely high signal-to-noise ratio （SNR） slope and high SNR power offset, which govern ESC at the high SNR region, are derived. Finally, simulations are conducted to validate the accuracy of our proposed analytical models. Results indicate that ESC rises with the increase of the number of antennas and the received SNR at the destination, and fades with the increase of those at the eavesdropper. Another finding is that the high SNR slope is constant, while the high SNR power offset is correlated with the number of antennas at both the destination and the eavesdropper.
基金Project supported in part by the National Natural Science Foundation of China(Nos.61401372 and 61531016)the Research Fund for the Doctoral Program of Higher Education of China(No.20130182120017)+1 种基金the Natural Science Foundation of CQ CSTC(No.cstc2013jcyj A40040)the Fundamental Research Funds for the Central Universities,China(No.XDJK2015B023)
文摘We investigate the secrecy outage performance of maximal ratio combining(MRC) in cognitive radio networks over Rayleigh fading channels. In a single-input multiple-output wiretap system, we consider a secondary user(SU-TX) that transmits confidential messages to another secondary user(SU-RX) equipped with M(M ≥ 1)antennas where the MRC technique is adopted to improve its received signal-to-noise ratio. Meanwhile, an eavesdropper equipped with N(N ≥ 1) antennas adopts the MRC scheme to overhear the information between SU-TX and SU-RX. SU-TX adopts the underlay strategy to guarantee the service quality of the primary user without spectrum sensing. We derive the closed-form expressions for an exact and asymptotic secrecy outage probability.
