Background A considerable proportion of elderly patients with symptomatic severe heart valve disease are treated conservatively de- spite clear indications for surgical intervention. However, little is known about how...Background A considerable proportion of elderly patients with symptomatic severe heart valve disease are treated conservatively de- spite clear indications for surgical intervention. However, little is known about how advanced age and comorbidities affect treatment deci-sion-making and therapeutic outcomes. Methods Patients （n = 234, mean age： 78.5 ± 3.7 years） with symptomatic severe heart valve dis- ease hospitalized in our center were included. One hundred and fifty-one patients （65%） were treated surgically （surgical group） and 83 （35%） were treated conservatively （conservative group）. Factors that affected therapeutic decision-making and treatment outcomes were investi- gated and long-term survival was explored. Results Isolated aortic valve disease, female sex, chronic renal insufficiency, aged _〉 80 years, pneumonia, and emergent status were independent factors associated with therapeutic decision-making. In-hospital mortality for the surgical group was 5.3% （8/151）. Three patients （3.6%） in the conservative group died during initial hospitalization. Low cardiac output syndrome and chronic renal insufficiency were identified as predictors of in-hospital mortality in the surgical group. Conservative treatment was identi- fied as the single risk factor for late death in the entire study population. The surgical group had better 5-year （77.2% vs. 45.4%, P 〈 0.0001） and 10-year （34.5% vs. 8.9%, P 〈 0.0001） survival rates than the conservative group, even when adjusted by propensity score-matched analysis. Conclusions Advanced age and geriatric comorbidities profoundly affect treatment decision-making for severe heart valve disease. Valve surgery in the elderly was not only safe but was also associated with good long-term survival while conservative treatment was unfavorable for patients with symptomatic severe valve disease.展开更多
Single crystals of K3Y3（BO3）4 were grown using the KBO2, LiF, and Li2CO3 as the fluxes by the top-seed solution method. The K3Y3（BO3）4 can be an excellent host for doping of Yb3＋, because there are six low-symmet...Single crystals of K3Y3（BO3）4 were grown using the KBO2, LiF, and Li2CO3 as the fluxes by the top-seed solution method. The K3Y3（BO3）4 can be an excellent host for doping of Yb3＋, because there are six low-symmetric yttrium atoms in one unit-cell of K3Y3（B 03）4. The growth of K3Y3（BO3）4 was studied in detail, and a good crystal with sizes of 24 mm × 15 mm× 8 mm was grown successfully below 900 ℃. Some characteristics, such as the X-ray dif- fraction, infrared spectroscopy, and thermal analysis, were also performed.展开更多
Dear Editor,Avian Influenza virus(AIV)H9N2 subtype viruses circulate widely in domestic fowl,and usually cause mild clinical signs in poultry(Li et al.,2005).Occasionally,avian H9N2 can infect humans and cause mild cl...Dear Editor,Avian Influenza virus(AIV)H9N2 subtype viruses circulate widely in domestic fowl,and usually cause mild clinical signs in poultry(Li et al.,2005).Occasionally,avian H9N2 can infect humans and cause mild clinical symptoms(Peiris et al.,1999;Lin et al.,2000).Genetic analysis indicates that the H9N2 genotype viruses exist in major poultry species(such as duck and chicken)and in minor poultry species(such as quail,partridge,chukar,pheasant,and guinea fowl)(Guan et al.,2000;Li et al.,2005).Meanwhile,frequent reassortment events展开更多
Objective:To mainly explore the effect of thalidomide combined with CHOP chemotherapy regimen on immunoglobulin,VEGF,lactate dehydrogenase,inflammatory factors and other related factors in patients with diffuse large ...Objective:To mainly explore the effect of thalidomide combined with CHOP chemotherapy regimen on immunoglobulin,VEGF,lactate dehydrogenase,inflammatory factors and other related factors in patients with diffuse large B-cell lymphoma.Methods:A total of 83 patients with diffuse large B-cell lymphoma admitted to the Department of Hematology and Oncology in our hospital from December 2012 to December 2018 were collected.CHOP chemotherapy was given to 40 patients in the chemotherapy group.And 43 patients in the thalidomide group were treated with thalidomide combined with CHOP chemotherapy.Immunoglobulin IgG,IgA,IgM,vascular endothelial growth factor(VEGF),tumor necrosis factor(TNF-α),lactate dehydrogenase(LDH),β2 microglobulin(β2-MG),Th17 cell ratio and natural killer cell(NK)ratio were measured before and after treatment.Results:There were no significant differences in immunoglobulin,inflammatory cytokines and other related factors between the two groups before treatment(P>0.05).After 6 cycles of treatment,the levels of immunoglobulin IgG,IgA,IgM,VEGF,LDH,β2-MG and the ratio of NK cells in the chemotherapy group were significantly lower than those before treatment(P<0.05);TNF-αand the ratio of Th17 cells were significantly higher than that those before treatment.The levels of IgG,IgA,IgM,VEGF,LDH andβ2-MG in the thalidomide group were significantly lower than those before treatment(P<0.05).The levels of TNF-α,Th17 cells and NK cell rates were significantly higher than those before treatment(P<0.05).In addition,the levels of IgG,IgA,IgM,VEGF,LDH andβ2-MG in the thalidomide group were significantly lower than those in the chemotherapy group(P<0.05),and the level of TNF-α,the rates of Th17 cells and NK cells were significantly higher than those in the chemotherapy group(P<0.05).Conclusion:Thalidomide combined with CHOP chemotherapy has a significant therapeutic effect on diffuse large B-cell lymphoma.Thalidomide combined with CHOP chemotherapy can significantly reduce the levels of angiogenesis VEGF,lactate dehydrogenase andβ2-MG in patients,significantly regulate the immune function of patients,and improve the Th17 cell rate and natural killer cell rate and the level of TNF-αin the body.This article provides the basis for the treatment of clinical diffuse large B cell lymphoma.展开更多
The net distance between the Xuetangwan interchange and the Huangshi tunnel exit of the Kaiyun expressway(Jiangkou-Yunyang-Longgang section)is used as an example in this paper.This paper analyses the problems in the s...The net distance between the Xuetangwan interchange and the Huangshi tunnel exit of the Kaiyun expressway(Jiangkou-Yunyang-Longgang section)is used as an example in this paper.This paper analyses the problems in the safety distance between expressway tunnel and interchange under multi tunnel,and proposes safety distance measures between expressway tunnel and interchange under multi tunnel,based on the current safety distance standard between expressway tunnel and interchange under multi tunnel.展开更多
With the accelerating pace of urbanization,the development and application of urban underground space has attracted much attention.In the construction of urban underground space,geotechnical engineering safety is the ...With the accelerating pace of urbanization,the development and application of urban underground space has attracted much attention.In the construction of urban underground space,geotechnical engineering safety is the key point for construction.Based on this,this paper analyzes the application of geotechnical engineering safety technology in urban underground space construction,in hope that this analysis can provide a scientific reference for the rational application of geotechnical engineering safety technology as well as the construction and development of urban underground space.展开更多
This paper briefly introduces the safety performance of the highway interchange design.The factors that influence the safety of the highway interchange design,was discussed in the paper based on the parts,which are th...This paper briefly introduces the safety performance of the highway interchange design.The factors that influence the safety of the highway interchange design,was discussed in the paper based on the parts,which are the safety of the interchange location,the safety of interchange form,and the safety design of the main line in interchange.展开更多
Lithium metal batteries(LMBs)are regarded as highly promising high-energy-density battery technology,primarily due to the ultrahigh theoretical capacity(3860 mAh g-1)and low electrochemical redox potential(-3.04 V vs....Lithium metal batteries(LMBs)are regarded as highly promising high-energy-density battery technology,primarily due to the ultrahigh theoretical capacity(3860 mAh g-1)and low electrochemical redox potential(-3.04 V vs.SHE)of the lithium metal anode.Nevertheless,the inherent flammability of conventional electrolytes poses significant safety challenges,inevitably limiting the practical deployment of LMBs.Triethyl phosphate(TEP)-based electrolytes,which endow the merits of low cost,exceptional thermal stability,and intrinsic nonflammability,have attracted considerable attention.In this review,we first introduce the key challenges associated with TEP-based electrolytes in LMBs.We then provide a comprehensive overview of recent progress in the development of TEP-based electrolytes in LMBs.Furthermore,we discuss modification strategies and propose future research directions for optimizing TEP-based electrolytes in LMBs.This review aims to provide valuable insights and guidance for the design of advanced TEP-based electrolytes,thereby facilitating the development of stable and safe LMBs.展开更多
文摘Background A considerable proportion of elderly patients with symptomatic severe heart valve disease are treated conservatively de- spite clear indications for surgical intervention. However, little is known about how advanced age and comorbidities affect treatment deci-sion-making and therapeutic outcomes. Methods Patients （n = 234, mean age： 78.5 ± 3.7 years） with symptomatic severe heart valve dis- ease hospitalized in our center were included. One hundred and fifty-one patients （65%） were treated surgically （surgical group） and 83 （35%） were treated conservatively （conservative group）. Factors that affected therapeutic decision-making and treatment outcomes were investi- gated and long-term survival was explored. Results Isolated aortic valve disease, female sex, chronic renal insufficiency, aged _〉 80 years, pneumonia, and emergent status were independent factors associated with therapeutic decision-making. In-hospital mortality for the surgical group was 5.3% （8/151）. Three patients （3.6%） in the conservative group died during initial hospitalization. Low cardiac output syndrome and chronic renal insufficiency were identified as predictors of in-hospital mortality in the surgical group. Conservative treatment was identi- fied as the single risk factor for late death in the entire study population. The surgical group had better 5-year （77.2% vs. 45.4%, P 〈 0.0001） and 10-year （34.5% vs. 8.9%, P 〈 0.0001） survival rates than the conservative group, even when adjusted by propensity score-matched analysis. Conclusions Advanced age and geriatric comorbidities profoundly affect treatment decision-making for severe heart valve disease. Valve surgery in the elderly was not only safe but was also associated with good long-term survival while conservative treatment was unfavorable for patients with symptomatic severe valve disease.
基金financially supported by the National Natural Science Foundation of China(No.51002119)
文摘Single crystals of K3Y3（BO3）4 were grown using the KBO2, LiF, and Li2CO3 as the fluxes by the top-seed solution method. The K3Y3（BO3）4 can be an excellent host for doping of Yb3＋, because there are six low-symmetric yttrium atoms in one unit-cell of K3Y3（B 03）4. The growth of K3Y3（BO3）4 was studied in detail, and a good crystal with sizes of 24 mm × 15 mm× 8 mm was grown successfully below 900 ℃. Some characteristics, such as the X-ray dif- fraction, infrared spectroscopy, and thermal analysis, were also performed.
基金supported by the National Natural Science Foundation of China(Grant Nos.12002126,12222206,and 12072238)Shanghai Rising-Star Program(Grant No.22QA1409500)+4 种基金High-Tech Project Research in Shanghai(Grant No.20511104200)Foundation of Jiangxi Province of China Educational Committee(Grant No.GJJ2200649)the National Natural Science Foundation of Jiangxi Province(Grant Nos.20224BAB201016,20202ACBL214016)the Fundamental Research Foundation for the Central Universities(Grant No.22120210526)the Natural Science Youth Foundation of Jiangsu Province(Grant No.BK20220554).
基金financial support from the Youth Innovation Promotion Association of Chinese Academy of Sciences(2014309)
文摘Dear Editor,Avian Influenza virus(AIV)H9N2 subtype viruses circulate widely in domestic fowl,and usually cause mild clinical signs in poultry(Li et al.,2005).Occasionally,avian H9N2 can infect humans and cause mild clinical symptoms(Peiris et al.,1999;Lin et al.,2000).Genetic analysis indicates that the H9N2 genotype viruses exist in major poultry species(such as duck and chicken)and in minor poultry species(such as quail,partridge,chukar,pheasant,and guinea fowl)(Guan et al.,2000;Li et al.,2005).Meanwhile,frequent reassortment events
基金This study was supported by the China International Medical Exchange Foundation(Grant No.Z-2014-06-19405).
文摘Objective:To mainly explore the effect of thalidomide combined with CHOP chemotherapy regimen on immunoglobulin,VEGF,lactate dehydrogenase,inflammatory factors and other related factors in patients with diffuse large B-cell lymphoma.Methods:A total of 83 patients with diffuse large B-cell lymphoma admitted to the Department of Hematology and Oncology in our hospital from December 2012 to December 2018 were collected.CHOP chemotherapy was given to 40 patients in the chemotherapy group.And 43 patients in the thalidomide group were treated with thalidomide combined with CHOP chemotherapy.Immunoglobulin IgG,IgA,IgM,vascular endothelial growth factor(VEGF),tumor necrosis factor(TNF-α),lactate dehydrogenase(LDH),β2 microglobulin(β2-MG),Th17 cell ratio and natural killer cell(NK)ratio were measured before and after treatment.Results:There were no significant differences in immunoglobulin,inflammatory cytokines and other related factors between the two groups before treatment(P>0.05).After 6 cycles of treatment,the levels of immunoglobulin IgG,IgA,IgM,VEGF,LDH,β2-MG and the ratio of NK cells in the chemotherapy group were significantly lower than those before treatment(P<0.05);TNF-αand the ratio of Th17 cells were significantly higher than that those before treatment.The levels of IgG,IgA,IgM,VEGF,LDH andβ2-MG in the thalidomide group were significantly lower than those before treatment(P<0.05).The levels of TNF-α,Th17 cells and NK cell rates were significantly higher than those before treatment(P<0.05).In addition,the levels of IgG,IgA,IgM,VEGF,LDH andβ2-MG in the thalidomide group were significantly lower than those in the chemotherapy group(P<0.05),and the level of TNF-α,the rates of Th17 cells and NK cells were significantly higher than those in the chemotherapy group(P<0.05).Conclusion:Thalidomide combined with CHOP chemotherapy has a significant therapeutic effect on diffuse large B-cell lymphoma.Thalidomide combined with CHOP chemotherapy can significantly reduce the levels of angiogenesis VEGF,lactate dehydrogenase andβ2-MG in patients,significantly regulate the immune function of patients,and improve the Th17 cell rate and natural killer cell rate and the level of TNF-αin the body.This article provides the basis for the treatment of clinical diffuse large B cell lymphoma.
文摘The net distance between the Xuetangwan interchange and the Huangshi tunnel exit of the Kaiyun expressway(Jiangkou-Yunyang-Longgang section)is used as an example in this paper.This paper analyses the problems in the safety distance between expressway tunnel and interchange under multi tunnel,and proposes safety distance measures between expressway tunnel and interchange under multi tunnel,based on the current safety distance standard between expressway tunnel and interchange under multi tunnel.
文摘With the accelerating pace of urbanization,the development and application of urban underground space has attracted much attention.In the construction of urban underground space,geotechnical engineering safety is the key point for construction.Based on this,this paper analyzes the application of geotechnical engineering safety technology in urban underground space construction,in hope that this analysis can provide a scientific reference for the rational application of geotechnical engineering safety technology as well as the construction and development of urban underground space.
文摘This paper briefly introduces the safety performance of the highway interchange design.The factors that influence the safety of the highway interchange design,was discussed in the paper based on the parts,which are the safety of the interchange location,the safety of interchange form,and the safety design of the main line in interchange.
基金supported by the National Natural Science Foundation of China(52202286,22309002,52250710680,52171217)the Key Research and Development Program of Zhejiang Province(2023C01232,2024C01057)+3 种基金the Natural Science Foundation of Zhejiang Province(LY24B030006)the Science and Technology Plan Project of Wenzhou Municipality(ZG2024055,ZG2022032)the Wenzhou Association for Science and Technology Innovation Program(NLTS2024-013)the Basic Research Project of Wenzhou City(G20220016)。
文摘Lithium metal batteries(LMBs)are regarded as highly promising high-energy-density battery technology,primarily due to the ultrahigh theoretical capacity(3860 mAh g-1)and low electrochemical redox potential(-3.04 V vs.SHE)of the lithium metal anode.Nevertheless,the inherent flammability of conventional electrolytes poses significant safety challenges,inevitably limiting the practical deployment of LMBs.Triethyl phosphate(TEP)-based electrolytes,which endow the merits of low cost,exceptional thermal stability,and intrinsic nonflammability,have attracted considerable attention.In this review,we first introduce the key challenges associated with TEP-based electrolytes in LMBs.We then provide a comprehensive overview of recent progress in the development of TEP-based electrolytes in LMBs.Furthermore,we discuss modification strategies and propose future research directions for optimizing TEP-based electrolytes in LMBs.This review aims to provide valuable insights and guidance for the design of advanced TEP-based electrolytes,thereby facilitating the development of stable and safe LMBs.
