A solid-state powerful supercapacitor(SC) is fabricated with a substrate of Xerox paper. Its current collector based on a foldable electronic circuit is developed by simply pencil drawing. Thin graphite sheets on pape...A solid-state powerful supercapacitor(SC) is fabricated with a substrate of Xerox paper. Its current collector based on a foldable electronic circuit is developed by simply pencil drawing. Thin graphite sheets on paper provide effective channels for electron transmission with a low resistance of 95 X sq-1. The conductive organic material of polypyrrole coated on thin graphite sheets acts as the electrode material of the device. The as-fabricated SC exhibits a high specific capacitance of 52.9 F cm-3at a scan rate of 1 m V s-1. An energy storage unit fabricated by three full-charged series SCs can drive a commercial light-emitting diode robustly. This work demonstrated a simple, versatile and costeffective method for paper-based devices.展开更多
The bimetallic nanoparticles compositing of Ni-rich core and Cu-rich shell(Ni/Cu NPs)were successfully synthesized by a liquid-phase thermal decomposition method.The content of copper and nickel in Ni/Cu NPs was contr...The bimetallic nanoparticles compositing of Ni-rich core and Cu-rich shell(Ni/Cu NPs)were successfully synthesized by a liquid-phase thermal decomposition method.The content of copper and nickel in Ni/Cu NPs was controllable by adjusting the ratio of two metal precursors,copper formate(Cuf)and nickel acetate tetrahydrate(Ni(OAc)_(2)·4H_(2)O).Ni/Cu NPs were further anchored on graphene oxide(GO)to prepare a magnetic composite catalyst,called Ni/Cu-GO.The dispersibility of Ni/Cu NPs in solution was enhanced by GO anchoring to prevent the sintering and aggregation during the reaction process,thereby ensuring the catalytic and cycling performance of the catalyst.The catalytic transfer hydrogenation(CTH)reaction of nitroaromatics was investigated when ammonia borane was used as the hydrogen source.Cu dominated the main catalytic role in the reaction,while Ni played a synergistic role of catalysis and providing magnetic properties for separation.The Ni_(7)/Cu_(3)-GO catalyst exhibited the best catalytic performance with the conversion and yield of 99%and 96%,respectively,when 2-methyl-5-nitrophenol was used as the substrate.The Ni_(7)/Cu_(3)-GO catalyst also exhibited excellent cyclic catalytic performance with the 5-amino-2-methylphenol yield of above 90%after six cycles.In addition,the Ni_(7)/Cu_(3)-GO catalyst could be quickly recycled by magnetic separation.Moreover,the Ni_(7)/Cu_(3)-GO catalyst showed good catalytic performance for halogen-containing nitroaromatics without dehalogenation.展开更多
The skin is our outer permeability and immune defense barrier against myriad external assaults.Aryl hydrocarbon receptor(AhR)senses environmental factors and regulates barrier robustness and immune homeostasis.AhR ago...The skin is our outer permeability and immune defense barrier against myriad external assaults.Aryl hydrocarbon receptor(AhR)senses environmental factors and regulates barrier robustness and immune homeostasis.AhR agonists have been approved by the FDA for psoriasis treatment and are in clinical trials for the treatment of atopic dermatitis(AD),but the underlying mechanism of action remains poorly defined.Here,we report that OVOL1/Ovol1 is a conserved and direct transcriptional target of AhR in epidermal keratinocytes.We show that OVOL1/Ovol1 influences AhR-mediated regulation of keratinocyte gene expression and that OVOL1/Ovol1 ablation in keratinocytes impairs the barrier-promoting function of AhR,exacerbating AD-like inflammation.Mechanistically,we have identified Ovol1’s direct downstream targets genome-wide and provided in vivo evidence supporting the role of Id1 as a functional target in barrier maintenance,disease suppression,and neutrophil accumulation.Furthermore,our findings reveal that an IL-1/dermalγδT cell axis exacerbates type 2 and 3 immune responses downstream of barrier perturbation in Ovol1-deficient AD skin.Finally,we present data suggesting the clinical relevance of OVOL1 and ID1 functions in human AD skin.Our study highlights a keratinocyte-intrinsic AhR-Ovol1-Id1 regulatory axis that promotes both epidermal and immune homeostasis in the context of skin inflammation,identifying new therapeutic targets.展开更多
Background:Limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection on psoriasis patients.The objective of this study was to identify clinical factors ass...Background:Limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection on psoriasis patients.The objective of this study was to identify clinical factors associated with the prognosis of psoriasis following SARS-CoV-2 infection.Methods:A retrospective,multicenter study was conducted between March and May 2023.Univariable and multivariable logistic regression analyses were employed to identify factors associated with coronavirus disease 2019(COVID-19)-related psoriasis outcomes.The study included 2371 psoriasis patients from 12 clinical centers,with 2049 of them having been infected with SARS-CoV-2.Results:Among the infected groups,lower exacerbation rates were observed in individuals treated with biologics compared to those receiving traditional systemic or nonsystemic treatments(22.3%[236/1058]vs.39.8%[92/231]vs.37.5%[140/373],P<0.001).Psoriasis progression with lesions(adjusted odds ratio[OR]=8.197,95%confidence interval[95%CI]=5.685-11.820,compared to no lesions),hypertension(adjusted OR=1.582,95%CI=1.068-2.343),traditional systemic(adjusted OR=1.887,95%CI=1.263-2.818),and nonsystemic treatment(adjusted OR=1.602,95%CI=1.117-2.297)were found to be associated with exacerbation of psoriasis after SARS-CoV-2 infection,but not biologics(adjusted OR=0.931,95%CI=0.680-1.274,compared to no treatment),according to multivariable logistic regression analysis.Conclusions:A reduced risk of psoriasis exacerbation after SARS-CoV-2 infection was observed with biologics compared to traditional systemic and nonsystemic treatments.Significant risk factors for exacerbation after infection were identified as existing psoriatic lesions and hypertension.展开更多
Balanoposthitis(BP),a common male genitalia inflammation,is managed by clinicians from different specialties,including urology,pediatrics,dermatology,and venereology.Due to this diverse array of clinicians involved,th...Balanoposthitis(BP),a common male genitalia inflammation,is managed by clinicians from different specialties,including urology,pediatrics,dermatology,and venereology.Due to this diverse array of clinicians involved,there exists a lack of consistent,evidence-based recommendations for BP.The development of the consensus engaged 19 representative hospitals and it adhered to rigorous protocols,encompassing international registration(IPGRP-2021CN003)and the application of evidence grading criteria and recommendation standards[Appendix S1,Supplementary File,http://links.lww.com/CM9/C42].Over the period from December 2020 to October 2022,consensus on 12 clinical issues was reached through comprehensive evidence searches and two iterations of Delphi surveys[Supplementary File,http://links.lww.com/CM9/C42].展开更多
The collection of big data on skin and appendage phenotypes has revolutionized the field of personalized diagnosis and treatment by enabling the evaluation of individual characteristics and early detection of abnormal...The collection of big data on skin and appendage phenotypes has revolutionized the field of personalized diagnosis and treatment by enabling the evaluation of individual characteristics and early detection of abnormalities.To establish a standardized system for collecting and measuring big data on phenotypes,a systematic categorization of measurement entries has been undertaken,accompanied by recommendations on measurement entries,environmental equipment requirements,and collection processes,tailored to the needs of different usage scenarios.Specific collection sites have also been recommended based on different index characteristics.A multi-center,multi-regional collaboration has been initiated to collect big date on phenotypes of healthy and diseased skin in the Chinese population.This data will be correlated with patient disease information,exploring the factors influencing skin phenotype,analyzing the phenotypic data features that can predict prognosis,and ultimately promoting the exploration of the pathophysiology and pathogenesis of skin diseases and therapeutic approaches.Non-invasive skin measurement robots are also in development.This consensus aims to provide a reference for the study of phenomics and the standardization of phenotypic measurements of skin and appendages in China.展开更多
RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormalit...RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years.Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells,including development,differentiation,activation,migration,and polarization,thereby modulating the immune responses and are involved in some immune related diseases.In this review,we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications,including N6-methyladenosine(m^(6)A),5-methylcytosine(m^(5)C),N1-methyladenosine(m1 A),N7-methylguanosine(m^(7)G),N4-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,and adenosine-to-inosine(A-to-I)RNA editing,and summarize their critical roles in immune cell biology.Via regulating the biological processes of immune cells,RNA modifications can participate in the pathogenesis of immune related diseases,such as cancers,infection,inflammatory and autoimmune diseases.We further highlight the challenges and future directions based on the existing knowledge.All in all,this review will provide helpful knowledge as well as novel ideas for the researchers in this area.展开更多
基金supported by the National Basic Research Program(2011CB933300)of Chinathe National Natural Science Foundation of China(11204093,11374110)‘the Fundamental Research Funds for the Central Universities’,HUST:2012QN114,2013TS033
文摘A solid-state powerful supercapacitor(SC) is fabricated with a substrate of Xerox paper. Its current collector based on a foldable electronic circuit is developed by simply pencil drawing. Thin graphite sheets on paper provide effective channels for electron transmission with a low resistance of 95 X sq-1. The conductive organic material of polypyrrole coated on thin graphite sheets acts as the electrode material of the device. The as-fabricated SC exhibits a high specific capacitance of 52.9 F cm-3at a scan rate of 1 m V s-1. An energy storage unit fabricated by three full-charged series SCs can drive a commercial light-emitting diode robustly. This work demonstrated a simple, versatile and costeffective method for paper-based devices.
基金supported by the National Natural Science Foundation of China(Grant No.21776161)。
文摘The bimetallic nanoparticles compositing of Ni-rich core and Cu-rich shell(Ni/Cu NPs)were successfully synthesized by a liquid-phase thermal decomposition method.The content of copper and nickel in Ni/Cu NPs was controllable by adjusting the ratio of two metal precursors,copper formate(Cuf)and nickel acetate tetrahydrate(Ni(OAc)_(2)·4H_(2)O).Ni/Cu NPs were further anchored on graphene oxide(GO)to prepare a magnetic composite catalyst,called Ni/Cu-GO.The dispersibility of Ni/Cu NPs in solution was enhanced by GO anchoring to prevent the sintering and aggregation during the reaction process,thereby ensuring the catalytic and cycling performance of the catalyst.The catalytic transfer hydrogenation(CTH)reaction of nitroaromatics was investigated when ammonia borane was used as the hydrogen source.Cu dominated the main catalytic role in the reaction,while Ni played a synergistic role of catalysis and providing magnetic properties for separation.The Ni_(7)/Cu_(3)-GO catalyst exhibited the best catalytic performance with the conversion and yield of 99%and 96%,respectively,when 2-methyl-5-nitrophenol was used as the substrate.The Ni_(7)/Cu_(3)-GO catalyst also exhibited excellent cyclic catalytic performance with the 5-amino-2-methylphenol yield of above 90%after six cycles.In addition,the Ni_(7)/Cu_(3)-GO catalyst could be quickly recycled by magnetic separation.Moreover,the Ni_(7)/Cu_(3)-GO catalyst showed good catalytic performance for halogen-containing nitroaromatics without dehalogenation.
基金support from the China Scholarship Council(Grant No.201906260233)support from the National Science Foundation(NSF)-Simons Predoctoral Fellowship(NSF grant DMS1763272 and Simons Foundation grant 594598)+7 种基金supported by the NIH T32 Immunology Research Training Grant(Al 060573)supported by NSF predoctoral fellowship DGE-1839285supported by grants from the National Natural Science Foundation of China(No.81872522,82073429,and 82430101)the Innovation Program of the Shanghai Municipal Education Commission(No.2019-01-07-00-07-E00046)supported by National Institutes of Health Grants R01-AR068074,R35-GM145307,U01-AR073159,P30-AR075047NSF grant DMS1763272Simons Foundation grant 594598UC Irvine Office of Research.
文摘The skin is our outer permeability and immune defense barrier against myriad external assaults.Aryl hydrocarbon receptor(AhR)senses environmental factors and regulates barrier robustness and immune homeostasis.AhR agonists have been approved by the FDA for psoriasis treatment and are in clinical trials for the treatment of atopic dermatitis(AD),but the underlying mechanism of action remains poorly defined.Here,we report that OVOL1/Ovol1 is a conserved and direct transcriptional target of AhR in epidermal keratinocytes.We show that OVOL1/Ovol1 influences AhR-mediated regulation of keratinocyte gene expression and that OVOL1/Ovol1 ablation in keratinocytes impairs the barrier-promoting function of AhR,exacerbating AD-like inflammation.Mechanistically,we have identified Ovol1’s direct downstream targets genome-wide and provided in vivo evidence supporting the role of Id1 as a functional target in barrier maintenance,disease suppression,and neutrophil accumulation.Furthermore,our findings reveal that an IL-1/dermalγδT cell axis exacerbates type 2 and 3 immune responses downstream of barrier perturbation in Ovol1-deficient AD skin.Finally,we present data suggesting the clinical relevance of OVOL1 and ID1 functions in human AD skin.Our study highlights a keratinocyte-intrinsic AhR-Ovol1-Id1 regulatory axis that promotes both epidermal and immune homeostasis in the context of skin inflammation,identifying new therapeutic targets.
基金supported by a grant from the Clinical Research Project on COVID-19 infection at the Xijing Hospital(No.XJZT23XG29).
文摘Background:Limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection on psoriasis patients.The objective of this study was to identify clinical factors associated with the prognosis of psoriasis following SARS-CoV-2 infection.Methods:A retrospective,multicenter study was conducted between March and May 2023.Univariable and multivariable logistic regression analyses were employed to identify factors associated with coronavirus disease 2019(COVID-19)-related psoriasis outcomes.The study included 2371 psoriasis patients from 12 clinical centers,with 2049 of them having been infected with SARS-CoV-2.Results:Among the infected groups,lower exacerbation rates were observed in individuals treated with biologics compared to those receiving traditional systemic or nonsystemic treatments(22.3%[236/1058]vs.39.8%[92/231]vs.37.5%[140/373],P<0.001).Psoriasis progression with lesions(adjusted odds ratio[OR]=8.197,95%confidence interval[95%CI]=5.685-11.820,compared to no lesions),hypertension(adjusted OR=1.582,95%CI=1.068-2.343),traditional systemic(adjusted OR=1.887,95%CI=1.263-2.818),and nonsystemic treatment(adjusted OR=1.602,95%CI=1.117-2.297)were found to be associated with exacerbation of psoriasis after SARS-CoV-2 infection,but not biologics(adjusted OR=0.931,95%CI=0.680-1.274,compared to no treatment),according to multivariable logistic regression analysis.Conclusions:A reduced risk of psoriasis exacerbation after SARS-CoV-2 infection was observed with biologics compared to traditional systemic and nonsystemic treatments.Significant risk factors for exacerbation after infection were identified as existing psoriatic lesions and hypertension.
基金National Natural Science Foundation of China(No.82273538)Public Health Research and Development Program of the Shenyang Science and Technology Bureau(No.22-321-33-12)National Key R&D Program of China(No.2023YFC2508200)
文摘Balanoposthitis(BP),a common male genitalia inflammation,is managed by clinicians from different specialties,including urology,pediatrics,dermatology,and venereology.Due to this diverse array of clinicians involved,there exists a lack of consistent,evidence-based recommendations for BP.The development of the consensus engaged 19 representative hospitals and it adhered to rigorous protocols,encompassing international registration(IPGRP-2021CN003)and the application of evidence grading criteria and recommendation standards[Appendix S1,Supplementary File,http://links.lww.com/CM9/C42].Over the period from December 2020 to October 2022,consensus on 12 clinical issues was reached through comprehensive evidence searches and two iterations of Delphi surveys[Supplementary File,http://links.lww.com/CM9/C42].
基金sponsored by the Project of Intelligent Management Software for Multimodal Medical Big Data for New Generation Information Technology,Ministry of Industry and Information Technology of People’s Republic of China(TC210804V)the Research on the Precision Prevention and Treatment System for Skin Malignant Tumors,National Key Research and Development Program of China(2022YFC2504701,2022YFC2504705).
文摘The collection of big data on skin and appendage phenotypes has revolutionized the field of personalized diagnosis and treatment by enabling the evaluation of individual characteristics and early detection of abnormalities.To establish a standardized system for collecting and measuring big data on phenotypes,a systematic categorization of measurement entries has been undertaken,accompanied by recommendations on measurement entries,environmental equipment requirements,and collection processes,tailored to the needs of different usage scenarios.Specific collection sites have also been recommended based on different index characteristics.A multi-center,multi-regional collaboration has been initiated to collect big date on phenotypes of healthy and diseased skin in the Chinese population.This data will be correlated with patient disease information,exploring the factors influencing skin phenotype,analyzing the phenotypic data features that can predict prognosis,and ultimately promoting the exploration of the pathophysiology and pathogenesis of skin diseases and therapeutic approaches.Non-invasive skin measurement robots are also in development.This consensus aims to provide a reference for the study of phenomics and the standardization of phenotypic measurements of skin and appendages in China.
基金supported by grants from National Natural Science Foundation of China(No.81872522,82073429)Innovation Program of Shanghai Municipal Education Commission(No.2019-01-07-00-07-E00046)+1 种基金Clinical Research Plan of SHDC(No.SHDC2020CR1014B,SHDC12018X06)Program of Shanghai Academic Research Leader(No.20XD1403300).
文摘RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years.Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells,including development,differentiation,activation,migration,and polarization,thereby modulating the immune responses and are involved in some immune related diseases.In this review,we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications,including N6-methyladenosine(m^(6)A),5-methylcytosine(m^(5)C),N1-methyladenosine(m1 A),N7-methylguanosine(m^(7)G),N4-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,and adenosine-to-inosine(A-to-I)RNA editing,and summarize their critical roles in immune cell biology.Via regulating the biological processes of immune cells,RNA modifications can participate in the pathogenesis of immune related diseases,such as cancers,infection,inflammatory and autoimmune diseases.We further highlight the challenges and future directions based on the existing knowledge.All in all,this review will provide helpful knowledge as well as novel ideas for the researchers in this area.
