Background:As a rare disease,male breast cancer(MBC)is of increasing concern in China.Whether health inequalities of disease burden and healthcare utilization exist by ethnicity in male breast cancer remains unclear.W...Background:As a rare disease,male breast cancer(MBC)is of increasing concern in China.Whether health inequalities of disease burden and healthcare utilization exist by ethnicity in male breast cancer remains unclear.We aim to measure disease burden and healthcare utilization by ethnicity among male breast cancer patients in China.Methods:A retrospective cohort study was established during 2012-2021 based on the Inner Mongolia Regional Health Information Platform.Disease burden,including incidence,5-year prevalence,mortality,survival rate,and medical cost were analyzed.Results:Among 630 participants(mean[SD]age,59.4[13.1]years),age-standardized rates of incidence were 1.2(95%CI:0.4-2.1)per 100,000.All-cause mortality was 50.8 per 1000 person-years(95%CI:42.4-60.4).Regarding ethnicity,Mongolian had a higher age-standardized 5-year prevalence rate than Han(3.2[95%CI:2.5-4.0]vs 2.3[95%CI:1.7-3.0],P=0.016),but no significant differences existed in incidence rates,survival rates,and risk of all-cause and breast cancer-specific mortality.Meanwhile,few significant disparities in healthcare utilization between Han and Mongolian were observed.Conclusions:This study revealed a moderate disease burden and relatively lower healthcare utilization for male breast cancer in Inner Mongolia,China.No significant ethnic disparities existed in disease burden and healthcare utilization.However,increased attention to male breast cancer is warranted due to the crucial influence of economic factors on potential ethnic disparities.展开更多
Background:It is still uncertain how multimorbidity patterns affect transitions between fall states among middle-aged and older Chinese.Methods:Data were obtained from China Health and Retirement Longitudinal Study(CH...Background:It is still uncertain how multimorbidity patterns affect transitions between fall states among middle-aged and older Chinese.Methods:Data were obtained from China Health and Retirement Longitudinal Study(CHARLS)2011–2018.We utilized latent class analysis to categorize baseline multimorbidity patterns,Markov multi-state model to explore the impact of multimorbidity characterized by condition counts and multimorbidity patterns on subsequent fall transitions,and Cox proportional hazard models to assess hazard ratios of each transition.Results:A total of 14,244 participants aged 45 years and older were enrolled at baseline.Among these participants,11,956(83.9%)did not have a fall history in the last 2 years,1,054(7.4%)had mild falls,and 1,234(8.7%)had severe falls.Using a multi-state model,10,967 transitions were observed during a total follow-up of 57,094 person-times,6,527 of which had worsening transitions and 4,440 had improving transitions.Among 6,711 multimorbid participants,osteocardiovascular(20.5%),pulmonary-digestive-rheumatic(30.5%),metabolic-cardiovascular(22.9%),and neuropsychiatric-sensory(26.1%)patterns were classified.Multimorbid participants had significantly higher risks of transitions compared with other participants.Among 4 multimorbidity patterns,osteocardiovascular pattern had higher transition risks than other 3 patterns.Conclusions:Multimorbidity,especially the“osteo-cardiovascular pattern”identified in this study,was associated with higher risks of fall transitions among middle-aged and older Chinese.Generally,the effect of multimorbidity is more significant in older adults than in middle-aged adults.Findings from this study provide facts and evidence for fall prevention,and offer implications for clinicians to target on vulnerable population,and for public health policymakers to allocate healthcare resources.展开更多
基金supported by the Natural Science Foundation of China(grant numbers:82173616,72342015).
文摘Background:As a rare disease,male breast cancer(MBC)is of increasing concern in China.Whether health inequalities of disease burden and healthcare utilization exist by ethnicity in male breast cancer remains unclear.We aim to measure disease burden and healthcare utilization by ethnicity among male breast cancer patients in China.Methods:A retrospective cohort study was established during 2012-2021 based on the Inner Mongolia Regional Health Information Platform.Disease burden,including incidence,5-year prevalence,mortality,survival rate,and medical cost were analyzed.Results:Among 630 participants(mean[SD]age,59.4[13.1]years),age-standardized rates of incidence were 1.2(95%CI:0.4-2.1)per 100,000.All-cause mortality was 50.8 per 1000 person-years(95%CI:42.4-60.4).Regarding ethnicity,Mongolian had a higher age-standardized 5-year prevalence rate than Han(3.2[95%CI:2.5-4.0]vs 2.3[95%CI:1.7-3.0],P=0.016),but no significant differences existed in incidence rates,survival rates,and risk of all-cause and breast cancer-specific mortality.Meanwhile,few significant disparities in healthcare utilization between Han and Mongolian were observed.Conclusions:This study revealed a moderate disease burden and relatively lower healthcare utilization for male breast cancer in Inner Mongolia,China.No significant ethnic disparities existed in disease burden and healthcare utilization.However,increased attention to male breast cancer is warranted due to the crucial influence of economic factors on potential ethnic disparities.
基金funded by the National Key R&D Program of China(2023YFB4603200 and 2023YFC3606400)National Natural Science Foundation of China(72374013)Capital’s Funds for Health Improvement and Research(CFH 2024-1G-3014).
文摘Background:It is still uncertain how multimorbidity patterns affect transitions between fall states among middle-aged and older Chinese.Methods:Data were obtained from China Health and Retirement Longitudinal Study(CHARLS)2011–2018.We utilized latent class analysis to categorize baseline multimorbidity patterns,Markov multi-state model to explore the impact of multimorbidity characterized by condition counts and multimorbidity patterns on subsequent fall transitions,and Cox proportional hazard models to assess hazard ratios of each transition.Results:A total of 14,244 participants aged 45 years and older were enrolled at baseline.Among these participants,11,956(83.9%)did not have a fall history in the last 2 years,1,054(7.4%)had mild falls,and 1,234(8.7%)had severe falls.Using a multi-state model,10,967 transitions were observed during a total follow-up of 57,094 person-times,6,527 of which had worsening transitions and 4,440 had improving transitions.Among 6,711 multimorbid participants,osteocardiovascular(20.5%),pulmonary-digestive-rheumatic(30.5%),metabolic-cardiovascular(22.9%),and neuropsychiatric-sensory(26.1%)patterns were classified.Multimorbid participants had significantly higher risks of transitions compared with other participants.Among 4 multimorbidity patterns,osteocardiovascular pattern had higher transition risks than other 3 patterns.Conclusions:Multimorbidity,especially the“osteo-cardiovascular pattern”identified in this study,was associated with higher risks of fall transitions among middle-aged and older Chinese.Generally,the effect of multimorbidity is more significant in older adults than in middle-aged adults.Findings from this study provide facts and evidence for fall prevention,and offer implications for clinicians to target on vulnerable population,and for public health policymakers to allocate healthcare resources.
