Immunogenic cell death(ICD)has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity.However,the trigger of ICD on the basis of chemotherapy and ph...Immunogenic cell death(ICD)has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity.However,the trigger of ICD on the basis of chemotherapy and phototherapy meets the obstacles of serious side effect and poor penetration ability,which seriously impedes the therapeutic effect.The development of sonodynamic immunotherapy with the evoking of ICD presents high promise for cancer treatment with high efficacy.Herein,high performance aggregation-induced emission(AIE)sonosensitizer is constructed on the basis of the engineering structure modulation for sonodynamic-augmented immunotherapy.By regulating the intermolecular interaction and pull-push electronic effect,sonosensitizer bearing AIE feature and amplified sono-sensitizing effect is developed.In addition,in vitro observation demonstrated that thiolate-substituted segment incorporation endows the molecules with enhanced cellular uptake efficiency and improved tumor cell eradication ability.More importantly,the developed sonosensitizer could efficiently evoke ICD upon the trigger of ultrasound,which allows for the efficient tumor eradication both at cellular level and in solid tumor.The inhibition of primary tumor and further boost systemic immunity response with the complete elimination toward the distant tumor is achieved.The investigation highlights the promise of utilizing AIE sonosensitizers in sonodynamic immunotherapy to conquer the current limitation of immunotherapy in solid tumor treatment.展开更多
基金financially supported by the Hunan Provincial Natural Science Foundation(Grants 2024RC3206,2022JJ40375,2021JJ304060,LINC00475,and 2023JJ40552)the Scientific Research Fund of Hunan Provincial Education Department(Grants 22A0287 and 22B0404)the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates,Guangzhou 510640,China(South China University of Technology)(Grant 2023B1212060003).
文摘Immunogenic cell death(ICD)has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity.However,the trigger of ICD on the basis of chemotherapy and phototherapy meets the obstacles of serious side effect and poor penetration ability,which seriously impedes the therapeutic effect.The development of sonodynamic immunotherapy with the evoking of ICD presents high promise for cancer treatment with high efficacy.Herein,high performance aggregation-induced emission(AIE)sonosensitizer is constructed on the basis of the engineering structure modulation for sonodynamic-augmented immunotherapy.By regulating the intermolecular interaction and pull-push electronic effect,sonosensitizer bearing AIE feature and amplified sono-sensitizing effect is developed.In addition,in vitro observation demonstrated that thiolate-substituted segment incorporation endows the molecules with enhanced cellular uptake efficiency and improved tumor cell eradication ability.More importantly,the developed sonosensitizer could efficiently evoke ICD upon the trigger of ultrasound,which allows for the efficient tumor eradication both at cellular level and in solid tumor.The inhibition of primary tumor and further boost systemic immunity response with the complete elimination toward the distant tumor is achieved.The investigation highlights the promise of utilizing AIE sonosensitizers in sonodynamic immunotherapy to conquer the current limitation of immunotherapy in solid tumor treatment.
