Purpose:To evaluate the clinical outcomes of tissue -engineered epithelium transplantation for severe ocular surface burns. Methods:This was a retrospective observational case series. From October 2005 to May 2011, 19...Purpose:To evaluate the clinical outcomes of tissue -engineered epithelium transplantation for severe ocular surface burns. Methods:This was a retrospective observational case series. From October 2005 to May 2011, 19 eyes of 19 patients with grade IV to VI ocular surface burns (Dua Classification) were treated by autologous transplantation of corneal stem cells cultivated on a fibrin gel membrane,with a mean follow-up of 16.2 months (range 12-36 months). Postoperative corneal surface stability, visual acuity (VA), corneal opacity, and neo- vascularization were evaluated. Results:No corneal perforations occurred and the entire corneal surface was free from epithelial defects in all eyes. At the final follow-up visit,VA in 17 eyes was improved after surgery,with 6 eyes achieving a VA of 20 / 100 or better. Corneal vascularization was significantly reduced in 17 (89.5% ).eyes.Corneal opacity was also improved in 12 (63.2%) eyes. All donor eyes remained healthy. Conclusion:Tissue-engineered epithelium transplantation can promote rapid reepithelialization of the ocular surface, inhibit corneal neovascularization,and improve vision for patients with severe ocular surface burns.(Eye Science 2013;.28:24- 29)展开更多
Purpose:To report an unusual case of retinal hernia in the central macula in an adult after iridocyclitis.Case report:.We report a case of a 46-year-old male who presented with blurred vision 2 weeks after complete re...Purpose:To report an unusual case of retinal hernia in the central macula in an adult after iridocyclitis.Case report:.We report a case of a 46-year-old male who presented with blurred vision 2 weeks after complete resolution of acute iridocyclitis. Anterior segment and vitreous body examinations were unremarkable. Yellowish spots in the macular area were observed. Spectral domain optical coherence tomography(SD-OCT) imaging of the macula showed loss of the inner segment / outer segment(IS / OS) photoreceptor junction,.with irregularity of the retinal pigment epithelium(RPE),.and a V-shaped hernia of the retina into the choroid.The macular lesions emerged as mild window defects on fluorescein angiography and were visualized as hypofluorescent patches on all-phase indocyanine green angiography. At a one month follow-up, the best-corrected visual acuity improved to20 / 20,.which was followed by partial restoration of the IS / OS line,.but a V-shaped hernia of the retina remained unchanged on SD-OCT.Conclusion:.Ophthalmologists should be alert to the changes in OCT of the macula in patients after iridocyclitis and further research on the cause and possible predisposing factors for retinal herniation is warranted.展开更多
Purpose: To evaluate the effect of tear malate dehydrogenase2 on monitoring ocular surface injury in mild dry eye(DE)disease.Methods: A total of 15 DE patients(30 eyes) with mild subjective symptoms but no ocular surf...Purpose: To evaluate the effect of tear malate dehydrogenase2 on monitoring ocular surface injury in mild dry eye(DE)disease.Methods: A total of 15 DE patients(30 eyes) with mild subjective symptoms but no ocular surface fluorescein staining signs were enrolled in this study.(DE group)..The control group was 15 healthy age- and sex-matched volunteers(30eyes)..All subjects were asked to fill out a DE symptoms questionnaire and take different tests including tear MDH and MDH2 activities evaluation,..tear breakup time.(TBUT),Schirmer I,.and slit-lamp examination of the ocular surface.We investigated different changes in tear MDH and MDH2 activities in the DE group and control group,.discussed the association between tear MDH2 activity and DE symptoms, and the relationship between tear MDH2 activity and diagnostic tests(Schirmer I and TBUT). We also analyzed the changes in tear MDH2 activities after the treatment with artificial tears.Results:.Tear MDH activities in the DE group and control group were 288 ±102 U / L and 259 ±112 U / L,.respectively,and this difference was not statistically significant(P >0.05).The tear MDH2 activities in DE group were significantly increased compared with control group. Tear MDH2 was significantly and negatively correlated with the Schirmer's value(r=-0.733,P<0.01) and the TBUT value(r=-0.841,P<0.01)..MDH2 also had a significant positive correlation with soreness symptoms(r=0.687, P < 0.01). Treatment with artificial tears relieved or eliminated all discomfort symptoms, together with a considerable decrease in MDH2 activities(P <0.01),.but no significant changes in the Schirmer and the TBUT tests were observed.Conclusion: Tear MDH2 activity can indicate ocular surfaceinjury in mild DE patients and may be used to monitor the response to therapy.展开更多
Purpose:.To assess the efficacy of vitrectomy combined with intravitreal injection in the treatment of endophthalmitis after phacoemulsification and IOL implantation. Methods:.Five patients.(5 eyes),.who had undergone...Purpose:.To assess the efficacy of vitrectomy combined with intravitreal injection in the treatment of endophthalmitis after phacoemulsification and IOL implantation. Methods:.Five patients.(5 eyes),.who had undergone conventional phacoemulsification combined with IOL implantation at another treatment facility,.presented with endophthalmitis. The subjects ranged in age from 41 to 79 years (65.8±0.5 years on average),.and three were male..All five cases received bacterial culture susceptibility testing..On the basis of the treatment of primary disease, 3 cases had anterior chamber irrigation,.and posterior vitrectomy followed by intravitreal injection of 1 mg vancomycin plus 2.25 mg ceftazidime. Results:.Four out of the five cases of endophthalmitis had a positive bacterial culture testing results.(two cases of staphylococcus epidermidis,.one case of enterococcus faecalis and one case of head-like staphylococcus),.and the remaining case had no bacterial growth..Four cases showed restored visual acuity,.clear vitreous cavity,.and no retinal detachment or other complications. Conclusion: Management of patients presenting with endophthalmitis subsequent to cataract surgery should include: prompt bacterial culture and drug sensitivity tests, and where appropriate, vitrectomy combined with intravitreal injection of vancomycin.展开更多
文摘Purpose:To evaluate the clinical outcomes of tissue -engineered epithelium transplantation for severe ocular surface burns. Methods:This was a retrospective observational case series. From October 2005 to May 2011, 19 eyes of 19 patients with grade IV to VI ocular surface burns (Dua Classification) were treated by autologous transplantation of corneal stem cells cultivated on a fibrin gel membrane,with a mean follow-up of 16.2 months (range 12-36 months). Postoperative corneal surface stability, visual acuity (VA), corneal opacity, and neo- vascularization were evaluated. Results:No corneal perforations occurred and the entire corneal surface was free from epithelial defects in all eyes. At the final follow-up visit,VA in 17 eyes was improved after surgery,with 6 eyes achieving a VA of 20 / 100 or better. Corneal vascularization was significantly reduced in 17 (89.5% ).eyes.Corneal opacity was also improved in 12 (63.2%) eyes. All donor eyes remained healthy. Conclusion:Tissue-engineered epithelium transplantation can promote rapid reepithelialization of the ocular surface, inhibit corneal neovascularization,and improve vision for patients with severe ocular surface burns.(Eye Science 2013;.28:24- 29)
文摘Purpose:To report an unusual case of retinal hernia in the central macula in an adult after iridocyclitis.Case report:.We report a case of a 46-year-old male who presented with blurred vision 2 weeks after complete resolution of acute iridocyclitis. Anterior segment and vitreous body examinations were unremarkable. Yellowish spots in the macular area were observed. Spectral domain optical coherence tomography(SD-OCT) imaging of the macula showed loss of the inner segment / outer segment(IS / OS) photoreceptor junction,.with irregularity of the retinal pigment epithelium(RPE),.and a V-shaped hernia of the retina into the choroid.The macular lesions emerged as mild window defects on fluorescein angiography and were visualized as hypofluorescent patches on all-phase indocyanine green angiography. At a one month follow-up, the best-corrected visual acuity improved to20 / 20,.which was followed by partial restoration of the IS / OS line,.but a V-shaped hernia of the retina remained unchanged on SD-OCT.Conclusion:.Ophthalmologists should be alert to the changes in OCT of the macula in patients after iridocyclitis and further research on the cause and possible predisposing factors for retinal herniation is warranted.
文摘Purpose: To evaluate the effect of tear malate dehydrogenase2 on monitoring ocular surface injury in mild dry eye(DE)disease.Methods: A total of 15 DE patients(30 eyes) with mild subjective symptoms but no ocular surface fluorescein staining signs were enrolled in this study.(DE group)..The control group was 15 healthy age- and sex-matched volunteers(30eyes)..All subjects were asked to fill out a DE symptoms questionnaire and take different tests including tear MDH and MDH2 activities evaluation,..tear breakup time.(TBUT),Schirmer I,.and slit-lamp examination of the ocular surface.We investigated different changes in tear MDH and MDH2 activities in the DE group and control group,.discussed the association between tear MDH2 activity and DE symptoms, and the relationship between tear MDH2 activity and diagnostic tests(Schirmer I and TBUT). We also analyzed the changes in tear MDH2 activities after the treatment with artificial tears.Results:.Tear MDH activities in the DE group and control group were 288 ±102 U / L and 259 ±112 U / L,.respectively,and this difference was not statistically significant(P >0.05).The tear MDH2 activities in DE group were significantly increased compared with control group. Tear MDH2 was significantly and negatively correlated with the Schirmer's value(r=-0.733,P<0.01) and the TBUT value(r=-0.841,P<0.01)..MDH2 also had a significant positive correlation with soreness symptoms(r=0.687, P < 0.01). Treatment with artificial tears relieved or eliminated all discomfort symptoms, together with a considerable decrease in MDH2 activities(P <0.01),.but no significant changes in the Schirmer and the TBUT tests were observed.Conclusion: Tear MDH2 activity can indicate ocular surfaceinjury in mild DE patients and may be used to monitor the response to therapy.
文摘Purpose:.To assess the efficacy of vitrectomy combined with intravitreal injection in the treatment of endophthalmitis after phacoemulsification and IOL implantation. Methods:.Five patients.(5 eyes),.who had undergone conventional phacoemulsification combined with IOL implantation at another treatment facility,.presented with endophthalmitis. The subjects ranged in age from 41 to 79 years (65.8±0.5 years on average),.and three were male..All five cases received bacterial culture susceptibility testing..On the basis of the treatment of primary disease, 3 cases had anterior chamber irrigation,.and posterior vitrectomy followed by intravitreal injection of 1 mg vancomycin plus 2.25 mg ceftazidime. Results:.Four out of the five cases of endophthalmitis had a positive bacterial culture testing results.(two cases of staphylococcus epidermidis,.one case of enterococcus faecalis and one case of head-like staphylococcus),.and the remaining case had no bacterial growth..Four cases showed restored visual acuity,.clear vitreous cavity,.and no retinal detachment or other complications. Conclusion: Management of patients presenting with endophthalmitis subsequent to cataract surgery should include: prompt bacterial culture and drug sensitivity tests, and where appropriate, vitrectomy combined with intravitreal injection of vancomycin.
