As a key component of tumor microenvironment,the microbiota has gradually played a key role in cancer research.Particularly in colorectal cancer,the specific population of microbiota within the tumor shows a strong as...As a key component of tumor microenvironment,the microbiota has gradually played a key role in cancer research.Particularly in colorectal cancer,the specific population of microbiota within the tumor shows a strong association with the tumor type.Although the existence and potential role of microbiota in tumors have been recognized,the specific associations between the microbiota and tumor tissue and the mechanism of action still need to be further explored.This paper reviews the discovery,origin,and emerging role of the intratumor microbiota in the immune microenvironment and systematically outlines the oncogenic and metastasis-promoting strategies of the intratumor microbiota.Moreover,it comprehensively and holistically evaluates therapeutic strategies and prognostic performance on the basis of the intratumor microbiota,with the goal of providing strong support for future research and clinical practice.展开更多
基金funded by the National Natural Science Foundation of China(No.82060453,82103645 and 82260596)the Natural Science Foundation of Jiangxi Province(No.20242BAB25506)the China Postdoctoral Science Foundation(No.2023M741523)。
文摘As a key component of tumor microenvironment,the microbiota has gradually played a key role in cancer research.Particularly in colorectal cancer,the specific population of microbiota within the tumor shows a strong association with the tumor type.Although the existence and potential role of microbiota in tumors have been recognized,the specific associations between the microbiota and tumor tissue and the mechanism of action still need to be further explored.This paper reviews the discovery,origin,and emerging role of the intratumor microbiota in the immune microenvironment and systematically outlines the oncogenic and metastasis-promoting strategies of the intratumor microbiota.Moreover,it comprehensively and holistically evaluates therapeutic strategies and prognostic performance on the basis of the intratumor microbiota,with the goal of providing strong support for future research and clinical practice.
