Psoriasis （Ps） and psoriatic arthritis （PsA） are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop （LC...Psoriasis （Ps） and psoriatic arthritis （PsA） are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop （LCE） gene cluster, especially the cluster 3 （LCE3） genes. It is noteworthy that the deletion of LCE3B and LCE3C （LCE3C_LCE3B-del） is significantly associated with these two diseases. Gene-gene interactions between LCE3 genes and other genes are associated with Ps and PsA. LCE3 genes also have pleiotropic effect on some autoimmune diseases, such as rheumatoid arthritis, atopic dermatitis and systemic lupus erythematosus. Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and PsA in the future.展开更多
Bimetallic nanocrystals have attracted considerable attention because of their complicated systems,which are far superior to those of their individual constituents.A TiO_(2)-confined PtMnP bimetallic catalyst(PtMnP@Ti...Bimetallic nanocrystals have attracted considerable attention because of their complicated systems,which are far superior to those of their individual constituents.A TiO_(2)-confined PtMnP bimetallic catalyst(PtMnP@TiO_(2)) was prepared using an ultrasonic-assisted coincident strategy,which demonstrated exceptional catalytic activity in the universal hydrogen evolution reaction (HER).Owing to the bimetallic synergistic effect and TiO_(2) confinement,PtMnP@TiO_(x)showed ultrasmall metal nanoparticles (NPs),a higher active Pt^(0) content,adequate activation at the porous surface,and abundant acid sites.Simulations were performed to visualize the strain properties of Mn and Pt during the bending process and demonstrate the high activity of Pt.The Pt-Mn bimetallic catalysts were enriched with Pt NPs,convoyed by electron transfer from Mn to Pt.Briefly,PtMnP@TiO_(2) showed robust evolution reaction activities (an overpotential of 220 mV at a current density of 10 mA cm^(-2) and a Tafel slope of 186 mV dec^(-1))and the ability to contrast stated catalysts without ultrasonication-plasma.This protocol revealed that the geometrical and electronic effects of Pt and P surrounding the Mn species in PtMnP@TiO_(2) were crucial for increasing the catalytic activity (99%) and durability (over 20 cycles),which were far superior to those of other reported catalysts.展开更多
In order to solve the problems including low fruit-bearing rate and low yield caused by blind plantation in production, the medium formula for pollen germination of Lonicera caerulea L. var. edulis Turcz. ex Herd., it...In order to solve the problems including low fruit-bearing rate and low yield caused by blind plantation in production, the medium formula for pollen germination of Lonicera caerulea L. var. edulis Turcz. ex Herd., its pollination habit, self-compatibility and open pollination compatibility between different superior individuals were investigated with superior individuals from superior wild individuals of L. caerulea in Changbai Mountains as experimental materials. Self-compatibility and open pollination compatibility among different fine plants provide theoretical basis for its further application and further selection of new varieties. The results showed the optimal medium for germination of L. caerulea pollen was 27.5% sucrose ＋ 100 PPM boric acid with a pH value of 6.0. On this medium, the superior individuals L1, L2 and L3 had the pollen germination rates of 53.4%, 50.9% and 51.6%, respectively. The three superior individuals had no significant differences in the quantity of germinated pollen tubes, which ranged from 1 to 4. The three excellent single plants were the most likely to germinate a single pollen tube, accounting for 83.3% of the pollen germinated and 89.6% of the pollen germinated. Therefore, in production, it is necessary to plant L1 with a certain amount of pollination trees or plant it together with multiple species, to improve its yield. On the contrary, L2 and L3 have no need for pollination trees theoretically, but whether the fruits obtained by self-pollination and outcrossing differ in quality still needs further study.展开更多
To the Editor:Atopic dermatitis(AD)is a chronic inflammatory skin condition marked by recurrent eczematous lesions and intense pruritus,affecting approximately 15–20%of children and up to 10%of adults worldwide.[1]Th...To the Editor:Atopic dermatitis(AD)is a chronic inflammatory skin condition marked by recurrent eczematous lesions and intense pruritus,affecting approximately 15–20%of children and up to 10%of adults worldwide.[1]The presence of AD significantly impairs patient quality of life and imposes substantial economic burdens on society.In recent years,the potential link between AD and lymphoma has attracted considerable attention from researchers and clinicians.Lymphoma,a malignancy of the lymphatic system,poses significant health risks due to its high mortality potential.[2]However,observational studies investigating the potential correlation between AD and lymphoma have yielded inconsistent results.Consequently,the association between AD and lymphoma remains controversial and warrants further investigation.展开更多
To the Editor:Psoriasis is a common,chronic papulosquamous skin disease occurring worldwide,presenting at any age,and leading to a substantial burden for individuals and society.Interleukin(IL)-17A is considered the k...To the Editor:Psoriasis is a common,chronic papulosquamous skin disease occurring worldwide,presenting at any age,and leading to a substantial burden for individuals and society.Interleukin(IL)-17A is considered the key effector cytokine inducing psoriatic inflammation and tissue damage.[1]Ixekizumab is a humanized monoclonal immunoglobulin G specifically binding to and inhibiting IL-17A.The efficacy and safety of ixekizumab in patients with psoriasis have been clearly demonstrated in several randomized clinical trials,namely UNCOVER-1,UNCOVER-2,UNCOVER-3,and UNCOVER-J.[2,3]However,the clinical research data on ixekizumab in Chinese psoriasis patients remain limited.展开更多
文摘Psoriasis （Ps） and psoriatic arthritis （PsA） are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop （LCE） gene cluster, especially the cluster 3 （LCE3） genes. It is noteworthy that the deletion of LCE3B and LCE3C （LCE3C_LCE3B-del） is significantly associated with these two diseases. Gene-gene interactions between LCE3 genes and other genes are associated with Ps and PsA. LCE3 genes also have pleiotropic effect on some autoimmune diseases, such as rheumatoid arthritis, atopic dermatitis and systemic lupus erythematosus. Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and PsA in the future.
基金supported by the National Research Foundation of Republic Korea (NRF-2022R1A2C1004392)。
文摘Bimetallic nanocrystals have attracted considerable attention because of their complicated systems,which are far superior to those of their individual constituents.A TiO_(2)-confined PtMnP bimetallic catalyst(PtMnP@TiO_(2)) was prepared using an ultrasonic-assisted coincident strategy,which demonstrated exceptional catalytic activity in the universal hydrogen evolution reaction (HER).Owing to the bimetallic synergistic effect and TiO_(2) confinement,PtMnP@TiO_(x)showed ultrasmall metal nanoparticles (NPs),a higher active Pt^(0) content,adequate activation at the porous surface,and abundant acid sites.Simulations were performed to visualize the strain properties of Mn and Pt during the bending process and demonstrate the high activity of Pt.The Pt-Mn bimetallic catalysts were enriched with Pt NPs,convoyed by electron transfer from Mn to Pt.Briefly,PtMnP@TiO_(2) showed robust evolution reaction activities (an overpotential of 220 mV at a current density of 10 mA cm^(-2) and a Tafel slope of 186 mV dec^(-1))and the ability to contrast stated catalysts without ultrasonication-plasma.This protocol revealed that the geometrical and electronic effects of Pt and P surrounding the Mn species in PtMnP@TiO_(2) were crucial for increasing the catalytic activity (99%) and durability (over 20 cycles),which were far superior to those of other reported catalysts.
基金Supported by the Cooperative Project between the Yanbian University,China and National Institute of Horticultural and Herbal Science of the Rural Development Administration(RDA)of the Republic of Korea
文摘In order to solve the problems including low fruit-bearing rate and low yield caused by blind plantation in production, the medium formula for pollen germination of Lonicera caerulea L. var. edulis Turcz. ex Herd., its pollination habit, self-compatibility and open pollination compatibility between different superior individuals were investigated with superior individuals from superior wild individuals of L. caerulea in Changbai Mountains as experimental materials. Self-compatibility and open pollination compatibility among different fine plants provide theoretical basis for its further application and further selection of new varieties. The results showed the optimal medium for germination of L. caerulea pollen was 27.5% sucrose ＋ 100 PPM boric acid with a pH value of 6.0. On this medium, the superior individuals L1, L2 and L3 had the pollen germination rates of 53.4%, 50.9% and 51.6%, respectively. The three superior individuals had no significant differences in the quantity of germinated pollen tubes, which ranged from 1 to 4. The three excellent single plants were the most likely to germinate a single pollen tube, accounting for 83.3% of the pollen germinated and 89.6% of the pollen germinated. Therefore, in production, it is necessary to plant L1 with a certain amount of pollination trees or plant it together with multiple species, to improve its yield. On the contrary, L2 and L3 have no need for pollination trees theoretically, but whether the fruits obtained by self-pollination and outcrossing differ in quality still needs further study.
基金supported by grants from the National Key R&D Program of China(Nos.2022YFC3602002 and 2024YFF0507404)National High Level Hospital Clinical Research Funding(Nos.2022-NHLHCRF-LX-02-03 and 2023-NHLHCRF-YXHZ-ZRZD-06).
文摘To the Editor:Atopic dermatitis(AD)is a chronic inflammatory skin condition marked by recurrent eczematous lesions and intense pruritus,affecting approximately 15–20%of children and up to 10%of adults worldwide.[1]The presence of AD significantly impairs patient quality of life and imposes substantial economic burdens on society.In recent years,the potential link between AD and lymphoma has attracted considerable attention from researchers and clinicians.Lymphoma,a malignancy of the lymphatic system,poses significant health risks due to its high mortality potential.[2]However,observational studies investigating the potential correlation between AD and lymphoma have yielded inconsistent results.Consequently,the association between AD and lymphoma remains controversial and warrants further investigation.
文摘To the Editor:Psoriasis is a common,chronic papulosquamous skin disease occurring worldwide,presenting at any age,and leading to a substantial burden for individuals and society.Interleukin(IL)-17A is considered the key effector cytokine inducing psoriatic inflammation and tissue damage.[1]Ixekizumab is a humanized monoclonal immunoglobulin G specifically binding to and inhibiting IL-17A.The efficacy and safety of ixekizumab in patients with psoriasis have been clearly demonstrated in several randomized clinical trials,namely UNCOVER-1,UNCOVER-2,UNCOVER-3,and UNCOVER-J.[2,3]However,the clinical research data on ixekizumab in Chinese psoriasis patients remain limited.
