Challenges and opportunities in nerve regeneration： The central nervous system （CNS） has a limited ability to regen- erate. Subsequent to spinal injury, glial scar formation, creat- ed by fibroblasts, neuroglia, mo...Challenges and opportunities in nerve regeneration： The central nervous system （CNS） has a limited ability to regen- erate. Subsequent to spinal injury, glial scar formation, creat- ed by fibroblasts, neuroglia, monocytes, and endothelial cells, inhibits regeneration of the injured nerve. The peripheral nervous system （PNS） has a greater regeneration potential than the CNS; however, the current gold standard of treat- ment for a large nerve defect is still autologous nerve grafts, which require multiple surgeries. For this reason, researchers have been trying to regenerate nervous tissues, including brain, spinal cord. and PeriPheral nerves, for decades.展开更多
基金support from Pew Charitable Trusts and NSF CAREER Award (Grant No. DMR1452122)the fellowship from Keidanren Ishizaka Memorial Foundation
文摘Challenges and opportunities in nerve regeneration： The central nervous system （CNS） has a limited ability to regen- erate. Subsequent to spinal injury, glial scar formation, creat- ed by fibroblasts, neuroglia, monocytes, and endothelial cells, inhibits regeneration of the injured nerve. The peripheral nervous system （PNS） has a greater regeneration potential than the CNS; however, the current gold standard of treat- ment for a large nerve defect is still autologous nerve grafts, which require multiple surgeries. For this reason, researchers have been trying to regenerate nervous tissues, including brain, spinal cord. and PeriPheral nerves, for decades.
