Circular RNAs (circ RNAs) are covalently closed,singlestranded non-coding RNAs generated through pre-m RNA back-splicing [1,2],exhibiting broad biological functions across cells and organisms [3,4].Recent advances in ...Circular RNAs (circ RNAs) are covalently closed,singlestranded non-coding RNAs generated through pre-m RNA back-splicing [1,2],exhibiting broad biological functions across cells and organisms [3,4].Recent advances in developing circular RNA (circ RNA)-based therapeutics and vaccines underscore their clinical utility [1,5–10].Nevertheless,circ RNA-based therapeutics face critical technical hurdles,including optimization of efficient circularization sequences,translation enhancement,and improved in vivo delivery [10].展开更多
基金supported by the National Key Research and Development Program of China (2022YFC3401402)the National Natural Science Foundation of China (T2188102,82272406,22574161)+3 种基金the Zhejiang Provincial Natural Science Foundation of China (QKHM25C0805,LDQ23B050001)the support from the Hangzhou Institute of Medicine (HIM)(2024ZZBS02)the Chinese Academy of Sciencesthe Joint Research Program of Eye Research Center (ERC202408)。
文摘Circular RNAs (circ RNAs) are covalently closed,singlestranded non-coding RNAs generated through pre-m RNA back-splicing [1,2],exhibiting broad biological functions across cells and organisms [3,4].Recent advances in developing circular RNA (circ RNA)-based therapeutics and vaccines underscore their clinical utility [1,5–10].Nevertheless,circ RNA-based therapeutics face critical technical hurdles,including optimization of efficient circularization sequences,translation enhancement,and improved in vivo delivery [10].
