[ Objective] This study aimed to explore the effect of C/N ratio on DHA production by Schizochytrium sp. , and the results were verified by pilot-scale fermentation. [ Method] Effect of C/N ratio on DHA production by ...[ Objective] This study aimed to explore the effect of C/N ratio on DHA production by Schizochytrium sp. , and the results were verified by pilot-scale fermentation. [ Method] Effect of C/N ratio on DHA production by Schizochytrium sp. JN-3 was explored. The industrial fermentation potential of Schizochytrium sp. JN-3 was investigated by pilot-scale fermentation in a 200 L fermentation tank. [ Result] Results of fermentation in a 7 L fermentation tank showed that the maximum biomass and total lipid content were 34.3 and 20.1 g/L, respectively, when C/N ratio was 10 ; the maximum DHA yield was 46.9% when C/N ratio was 20. When pilot-scale fermentation was conducted in a 200 L fermentation tank, the biomass was 30. 2 g/L, total lipid content was 18.4 g/L, accounting for 63.2% of the dry weight of cells; DHA content was 7.4 g/L, accounting for 40. 2% of the total lipid content. [ Condasion ] Schizochytrlum sp. JN-3 has good industrial fermentation notential.展开更多
We discuss the landscape of flavor physics at the Circular Electron-Positron Collider(CEPC),based on the nominal luminosity outlined in its Technical Design Report.The CEPC is designed to operate in multiple modes to ...We discuss the landscape of flavor physics at the Circular Electron-Positron Collider(CEPC),based on the nominal luminosity outlined in its Technical Design Report.The CEPC is designed to operate in multiple modes to address a variety of tasks.At the Z pole,the expected production of 4 Tera Z bosons will provide unique and highly precise measurements of Z boson couplings,while the substantial number of boosted heavy-flavored quarks and leptons produced in clean Z decays will facilitate investigations into their flavor physics with unprecedented precision.We investigate the prospects of measuring various physics benchmarks and discuss their implications for particle theories and phenomenological models.Our studies indicate that,with its highlighted advantages and anticipated excellent detector performance,the CEPC can explore beauty andτphysics in ways that are superior to or complementary with the Belle II and Large-Hadron-Collider-beauty experiments,potentially enabling the detection of new physics at energy scales of 10 TeV and above.This potential also extends to the observation of yet-to-be-discovered rare and exotic processes,as well as testing fundamental principles such as lepton flavor universality,lepton and baryon number conservation,etc.,making the CEPC a vibrant platform for flavor physics research.The WW threshold scan,Higgs-factory operation and top-pair productions of the CEPC further enhance its merits in this regard,especially for measuring the Cabibbo-Kobayashi-Maskawa matrix elements,and Flavor-Changing-NeutralCurrent physics of Higgs boson and top quarks.We outline the requirements for detector performance and considerations for future development to achieve the anticipated scientific goals.The role of machine learning for innovative detector design and advanced reconstruction algorithms is also stressed.The CEPC flavor physics program not only develops new capabilities for exploring flavor physics beyond existing projects but also enriches the physics opportunities of this machine.It should be remarked that,given the richness of the CEPC flavor physics,this manuscript is not meant to be a comprehensive survey,but rather an investigation of representative cases.Uncovering the full potential of flavor physics at the CEPC will require further dedicated explorations in the future.展开更多
基金Supported by Research Fund for the Doctoral Program of Ministry of Education(20100093120002)Open Project of the Key Laboratory of Industrial Biotechnology under Ministry of Education(KLIB-KF200906,KLIB-KF201005)
文摘[ Objective] This study aimed to explore the effect of C/N ratio on DHA production by Schizochytrium sp. , and the results were verified by pilot-scale fermentation. [ Method] Effect of C/N ratio on DHA production by Schizochytrium sp. JN-3 was explored. The industrial fermentation potential of Schizochytrium sp. JN-3 was investigated by pilot-scale fermentation in a 200 L fermentation tank. [ Result] Results of fermentation in a 7 L fermentation tank showed that the maximum biomass and total lipid content were 34.3 and 20.1 g/L, respectively, when C/N ratio was 10 ; the maximum DHA yield was 46.9% when C/N ratio was 20. When pilot-scale fermentation was conducted in a 200 L fermentation tank, the biomass was 30. 2 g/L, total lipid content was 18.4 g/L, accounting for 63.2% of the dry weight of cells; DHA content was 7.4 g/L, accounting for 40. 2% of the total lipid content. [ Condasion ] Schizochytrlum sp. JN-3 has good industrial fermentation notential.
基金financial support from the National Natural Science Foundation of China(NSFC)(12125507,12047503,12035008,2211530479,12475094,12135006,12075097,12375086,2022YFA1601903,12061141007,12375091,12342502,12235018,12335003,12105100,12475106,11961141015,12188102,12175245,12205171,12321005,tsqn202312052,2024HWYQ-005,12405121,12447167,12061141006,12405102,12125503,12305115,12075213,12335005,12235008)the Chinese Academy of Sciences(YSBR-101,XDB34030000)+11 种基金the National Key R&D Program of China(2022YFE0116900,2023YFA1606703,2022YFA1601901)the National Key Research and Development Program of China(2023YFA1606300)the Excellent Postdoctoral Program of Jiangsu Province(2023ZB891)the Shenzhen Science and Technology Program(202206193000001,20220816094256002)the Natural Science Foundation for Distinguished Young Scholars of Henan Province(242300421046)the Beijing Municipal Natural Science Foundation(JQ22002)the Area of Excellence(AoE/P-404/18-3)the General Research Fund(16304321)(both grants are issued by the Research Grants Council of Hong Kong S.A.R)the MOST National Key R&D Program(2023YFA1606303)the Shanghai Key Laboratory for Particle Physics and CosmologyKey Laboratory for Particle Astrophysics and Cosmology(Ministry of Education)Shanghai Jiao Tong University。
文摘We discuss the landscape of flavor physics at the Circular Electron-Positron Collider(CEPC),based on the nominal luminosity outlined in its Technical Design Report.The CEPC is designed to operate in multiple modes to address a variety of tasks.At the Z pole,the expected production of 4 Tera Z bosons will provide unique and highly precise measurements of Z boson couplings,while the substantial number of boosted heavy-flavored quarks and leptons produced in clean Z decays will facilitate investigations into their flavor physics with unprecedented precision.We investigate the prospects of measuring various physics benchmarks and discuss their implications for particle theories and phenomenological models.Our studies indicate that,with its highlighted advantages and anticipated excellent detector performance,the CEPC can explore beauty andτphysics in ways that are superior to or complementary with the Belle II and Large-Hadron-Collider-beauty experiments,potentially enabling the detection of new physics at energy scales of 10 TeV and above.This potential also extends to the observation of yet-to-be-discovered rare and exotic processes,as well as testing fundamental principles such as lepton flavor universality,lepton and baryon number conservation,etc.,making the CEPC a vibrant platform for flavor physics research.The WW threshold scan,Higgs-factory operation and top-pair productions of the CEPC further enhance its merits in this regard,especially for measuring the Cabibbo-Kobayashi-Maskawa matrix elements,and Flavor-Changing-NeutralCurrent physics of Higgs boson and top quarks.We outline the requirements for detector performance and considerations for future development to achieve the anticipated scientific goals.The role of machine learning for innovative detector design and advanced reconstruction algorithms is also stressed.The CEPC flavor physics program not only develops new capabilities for exploring flavor physics beyond existing projects but also enriches the physics opportunities of this machine.It should be remarked that,given the richness of the CEPC flavor physics,this manuscript is not meant to be a comprehensive survey,but rather an investigation of representative cases.Uncovering the full potential of flavor physics at the CEPC will require further dedicated explorations in the future.
