AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±1...AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated.展开更多
Understanding the internal structure of Venus promotes the exploration of the evolutionary history of this planet.However,the existing research concerning the internal structure of Venus has not used any inversion met...Understanding the internal structure of Venus promotes the exploration of the evolutionary history of this planet.However,the existing research concerning the internal structure of Venus has not used any inversion methods.In this work we employed an inversion method to determine the internal structure of Venus using observational or hypothetical geodetic data;these data include mass,mean radius,mean moment of inertia and second degree tidal Love number k2.To determine the core state of Venus,we created two models of Venus,an isotropic 3-layer model with entire liquid core and an isotropic 4-layer model with liquid outer core and a solid inner core,assuming that the interior of Venus is spherically symmetric and in hydrostatic equilibrium.A series of the sensitivity analysis of interior structure parameters to the geodetic data considered in here shows that not all of the parameters can be constrained by the geodetic data from Venus.On this basis,a Markov Chain Monte Carlo algorithm was used to determine the posterior probability distribution and the optimal values of the internal structure parameters of Venus with the geodetic data.We found that the 3-layer model is more credible than the 4-layer model via currently geodetic data.For the assumption of the 3-layer model with the k2=0.295±0.066,I/MR^2=0.33±0.0165,andρ=5242.7±2.6 kg m^-3,the liquid iron-rich core of Venus has a radius of 3294+215-261km,which suggests a larger core than previous research has indicated.The average density of the mantle and liquid core of Venus are 4101+325-375and 11885+955-1242kg m~^-3,respectively.展开更多
基金Supported by(In part)Grant-in-Aid for Comprehensive Research from the Ministry of Education,Culture,Sports,Science and Technology of Japan
文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated.
基金the National Natural Science Foundation of China(U1831132,41874010)Innovation Group of Natural Fund of Hubei Province(2018CFA087)+1 种基金the Science and Technology Development Fund of Macao Special Administrative Region(FDCT 007/2016/A1,119/2017/A3,187/2017/A3)Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing(KF201813)。
文摘Understanding the internal structure of Venus promotes the exploration of the evolutionary history of this planet.However,the existing research concerning the internal structure of Venus has not used any inversion methods.In this work we employed an inversion method to determine the internal structure of Venus using observational or hypothetical geodetic data;these data include mass,mean radius,mean moment of inertia and second degree tidal Love number k2.To determine the core state of Venus,we created two models of Venus,an isotropic 3-layer model with entire liquid core and an isotropic 4-layer model with liquid outer core and a solid inner core,assuming that the interior of Venus is spherically symmetric and in hydrostatic equilibrium.A series of the sensitivity analysis of interior structure parameters to the geodetic data considered in here shows that not all of the parameters can be constrained by the geodetic data from Venus.On this basis,a Markov Chain Monte Carlo algorithm was used to determine the posterior probability distribution and the optimal values of the internal structure parameters of Venus with the geodetic data.We found that the 3-layer model is more credible than the 4-layer model via currently geodetic data.For the assumption of the 3-layer model with the k2=0.295±0.066,I/MR^2=0.33±0.0165,andρ=5242.7±2.6 kg m^-3,the liquid iron-rich core of Venus has a radius of 3294+215-261km,which suggests a larger core than previous research has indicated.The average density of the mantle and liquid core of Venus are 4101+325-375and 11885+955-1242kg m~^-3,respectively.
