In this paper,a novel capacitor-inductor integrated structure was proposed.The dielectric material BaTiO3(BTO)and ferromagnetic material Ni0.5Zn0.5Fe2O4(NZFO)was prepared by sol-gel method.Phase composition and morpho...In this paper,a novel capacitor-inductor integrated structure was proposed.The dielectric material BaTiO3(BTO)and ferromagnetic material Ni0.5Zn0.5Fe2O4(NZFO)was prepared by sol-gel method.Phase composition and morphology of the thin films were characterized by XRD,SEM and AFM.The effect of annealing temperature on film crystallinity,surface morphology,dielectric properties and ferromagnetism was investigated.When the annealing temperature was 700°C,the BTO film and the NZFO film got the better dielectric properties and ferromagnetic properties.Then the BTO thin film was spin-coated on the substrate,and the NZFO thin film was in-situ sintered on the BTO thin film.The composite film possessed both ferromagnetism and dielectric properties.Finally,an inductive coil was fabricated on the BTO/NZFO composite film to produce a capacitance and inductance integrated device.展开更多
The release of emerging contaminants(ECs)into aquatic environments poses a significant risk to global water security.Advanced oxidation processes(AOPs),while effective in removing ECs,are often resource and energy-int...The release of emerging contaminants(ECs)into aquatic environments poses a significant risk to global water security.Advanced oxidation processes(AOPs),while effective in removing ECs,are often resource and energy-intensive.Here,we introduce a novel catalyst,CoFe quantum dots embedded in graphene nanowires(CoFeQds@GN-Nws),synthesized through anaerobic polymerization.It uniquely features electron-rich and electron-poor micro-regions on its surface,enabling a self-purification mechanism in wastewater.This is achieved by harnessing the internal energy of wastewater,particularly the bonding energy of pollutants and dissolved oxygen(DO).It demonstrates exceptional efficiency in removing ECs at ambient temperature and pressure without the need for external oxidants,achieving a removal rate of nearly 100.0%.The catalyst's structure-activity relationship reveals that CoFe quantum dots facilitate an unbalanced electron distribution,forming these micro-regions.This leads to a continuous electrondonation effect,where pollutants are effectively cleaved or oxidized.Concurrently,DO is activated into superoxide anions(O_(2)^(·-)),synergistically aiding in pollutant removal.This approach reduces resource and energy demands typically associated with AOPs,marking a sustainable advancement in wastewater treatment technologies.展开更多
Obesity is primarily caused by excessive intake as well as absorption of sugar and lipid.Postprandial surge in distention pressure and intestinal motility accelerates the absorption of nutrients.The response of intest...Obesity is primarily caused by excessive intake as well as absorption of sugar and lipid.Postprandial surge in distention pressure and intestinal motility accelerates the absorption of nutrients.The response of intestinal epithelial cells to mechanical stimulation is not fully understood.Piezo1,a mechanosensitive ion channel,is widely expressed throughout the digestive tract.However,its function in intestinal nutrient absorption is not yet clear.In our study,excessive lipid deposition was observed in the duodenum of obese patients,while duodenal Piezo1-CaMKK2-AMPKa was decreased when compared to normal-weight individuals.Under high-fat diet condition,the Piezo1iKO mice exhibited abnormally elevated sugar and lipid absorption as well as severe lipid deposition in the duodenum and liver.These phenotypes were mainly caused by the inhibition of duodenal CaMKK2-AMPKa and the upregulation of SGLT1 and DGAT2.In contrast,Yoda1,a Piezo1 agonist,was found to reduce intestinal lipid absorption in diet induced obese mice.Overexpression of Piezo1,stretch and Yoda1 inhibited lipid accumulation and the expression of DGAT2 and SGLT1,whereas knockdown of Piezo1 stimulated lipid accumulation and DGAT2 in Caco-2 cells.Our study reveals a previously unexplored mechanical regulation of nutrient absorption in intestinal epithelial cells,which may shed new light on the therapy of obesity.展开更多
Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate...Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical medicine.Traditional photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen content.Type I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic condition.Herein,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one” platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and PAT.The experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization reaction.Efficient intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,respectively.Impressively,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and outcome.As a result,superior anti-tumor performance was achieved in vitro and in vivo.This contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment.展开更多
Tightly integrating actuation,computation,and sensing in soft materials allows soft robots to respond autonomously to their environments.However,fusing these capabilities within a single soft module in an effi-cient,p...Tightly integrating actuation,computation,and sensing in soft materials allows soft robots to respond autonomously to their environments.However,fusing these capabilities within a single soft module in an effi-cient,programmable,and compatible way is still a significant challenge.Here,we introduce a strategy for integrating actuation,computation,and sensing capabilities in soft origami.Unified and plug-and-play soft origami modules can be reconfigured into diverse morphologies with specific functions or reprogrammed into a variety of soft logic circuits,similar to LEGO bricks.We built an untethered autonomous soft turtle that is able to sense stimuli,store data,process information,and perform swimming movements.The function multiplexing and signal compatibility of the origami minimize the number of soft devices,thereby reducing the complexity and redundancy of soft robots.Moreover,this origami also exhibits strong damage resistance and high durability.We envision that this work will offer an effective way to readily create on-demand soft robots that can operate in unknown environments.展开更多
Organic field-effect transistors(OFETs)are of the core units in organic electronic circuits,and the performance of OFETs replies critically on the properties of their dielectric layers.Owing to the intrinsic flexibili...Organic field-effect transistors(OFETs)are of the core units in organic electronic circuits,and the performance of OFETs replies critically on the properties of their dielectric layers.Owing to the intrinsic flexibility and natural compatibility with other organic components,organic polymers,such as poly(vinyl alcohol)(PVA),have emerged as highly interesting dielectric materials for OFETs.However,unsatisfactory issues,such as hysteresis,high subthreshold swing,and low effective carrier mobility,still considerably limit the practical applications of the polymer-dielectric OFETs for high-speed,low-voltage flexible organic circuits.This work develops a new approach of using supercritical CO_(2) fluid(SCCO_(2))treatment on PVA dielectrics to achieve remarkably high-performance polymer-dielectric OFETs.The SCCO_(2) treatment is able to completely eliminate the hysteresis in the transfer characteristics of OFETs,and it can also significantly reduce the device subthreshold slope to 0._(2)5 V/dec and enhance the saturation regime carrier mobility to 30.2 cm^(2) V^(-1) s^(-1),of which both the numbers are remarkable for flexible polymer-dielectric OFETs.It is further demonstrated that,coupling with an organic light-emitting diode(OLED),the SCCO_(2)-treated OFET is able to function very well under fast switching speed,which indicates that an excellent switching behavior of polymer-dielectric OFETs can be enabled by this SCCO_(2) approach.Considering the broad and essential applications of OFETs,we envision that this SCCO_(2) technology will have a very broad spectrum of applications for organic electronics,especially for high refresh rate and low-voltage flexible display devices.展开更多
文摘In this paper,a novel capacitor-inductor integrated structure was proposed.The dielectric material BaTiO3(BTO)and ferromagnetic material Ni0.5Zn0.5Fe2O4(NZFO)was prepared by sol-gel method.Phase composition and morphology of the thin films were characterized by XRD,SEM and AFM.The effect of annealing temperature on film crystallinity,surface morphology,dielectric properties and ferromagnetism was investigated.When the annealing temperature was 700°C,the BTO film and the NZFO film got the better dielectric properties and ferromagnetic properties.Then the BTO thin film was spin-coated on the substrate,and the NZFO thin film was in-situ sintered on the BTO thin film.The composite film possessed both ferromagnetism and dielectric properties.Finally,an inductive coil was fabricated on the BTO/NZFO composite film to produce a capacitance and inductance integrated device.
基金financially supported by the National Natural Science Foundation of China(52350005,52122009,52070046,and 51838005)the Introduced Innovative Research and Development Team Project under the“Pearl River Talent Recruitment Program”of Guangdong Province(2019ZT08L387)Basic and Applied Basic Research Project of Guangzhou(202201020163).
文摘The release of emerging contaminants(ECs)into aquatic environments poses a significant risk to global water security.Advanced oxidation processes(AOPs),while effective in removing ECs,are often resource and energy-intensive.Here,we introduce a novel catalyst,CoFe quantum dots embedded in graphene nanowires(CoFeQds@GN-Nws),synthesized through anaerobic polymerization.It uniquely features electron-rich and electron-poor micro-regions on its surface,enabling a self-purification mechanism in wastewater.This is achieved by harnessing the internal energy of wastewater,particularly the bonding energy of pollutants and dissolved oxygen(DO).It demonstrates exceptional efficiency in removing ECs at ambient temperature and pressure without the need for external oxidants,achieving a removal rate of nearly 100.0%.The catalyst's structure-activity relationship reveals that CoFe quantum dots facilitate an unbalanced electron distribution,forming these micro-regions.This leads to a continuous electrondonation effect,where pollutants are effectively cleaved or oxidized.Concurrently,DO is activated into superoxide anions(O_(2)^(·-)),synergistically aiding in pollutant removal.This approach reduces resource and energy demands typically associated with AOPs,marking a sustainable advancement in wastewater treatment technologies.
基金supported by grants from the National Natural Science Foundation of China(82170818,81770794)Guangdong Basic and Applied Basic Research Foundation(2024A1515010686,China)the Fundamental Research Funds for the Central Universities(21620423,China).
文摘Obesity is primarily caused by excessive intake as well as absorption of sugar and lipid.Postprandial surge in distention pressure and intestinal motility accelerates the absorption of nutrients.The response of intestinal epithelial cells to mechanical stimulation is not fully understood.Piezo1,a mechanosensitive ion channel,is widely expressed throughout the digestive tract.However,its function in intestinal nutrient absorption is not yet clear.In our study,excessive lipid deposition was observed in the duodenum of obese patients,while duodenal Piezo1-CaMKK2-AMPKa was decreased when compared to normal-weight individuals.Under high-fat diet condition,the Piezo1iKO mice exhibited abnormally elevated sugar and lipid absorption as well as severe lipid deposition in the duodenum and liver.These phenotypes were mainly caused by the inhibition of duodenal CaMKK2-AMPKa and the upregulation of SGLT1 and DGAT2.In contrast,Yoda1,a Piezo1 agonist,was found to reduce intestinal lipid absorption in diet induced obese mice.Overexpression of Piezo1,stretch and Yoda1 inhibited lipid accumulation and the expression of DGAT2 and SGLT1,whereas knockdown of Piezo1 stimulated lipid accumulation and DGAT2 in Caco-2 cells.Our study reveals a previously unexplored mechanical regulation of nutrient absorption in intestinal epithelial cells,which may shed new light on the therapy of obesity.
基金supported by the Beijing Natural Science Foundation(Z210017)the National Natural Science Foundation of China(21774130,51925306)+4 种基金the National Key R&D Program of China(2018FYA 0305800)the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDB-SSW-JSC046)the Strategic Priority Research ProgramChinese Academy of Sciences(XDB28000000)University of Chinese Academy of Sciences。
文摘Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and processes.Taking advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical medicine.Traditional photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen content.Type I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic condition.Herein,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one” platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and PAT.The experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization reaction.Efficient intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,respectively.Impressively,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and outcome.As a result,superior anti-tumor performance was achieved in vitro and in vivo.This contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment.
文摘Tightly integrating actuation,computation,and sensing in soft materials allows soft robots to respond autonomously to their environments.However,fusing these capabilities within a single soft module in an effi-cient,programmable,and compatible way is still a significant challenge.Here,we introduce a strategy for integrating actuation,computation,and sensing capabilities in soft origami.Unified and plug-and-play soft origami modules can be reconfigured into diverse morphologies with specific functions or reprogrammed into a variety of soft logic circuits,similar to LEGO bricks.We built an untethered autonomous soft turtle that is able to sense stimuli,store data,process information,and perform swimming movements.The function multiplexing and signal compatibility of the origami minimize the number of soft devices,thereby reducing the complexity and redundancy of soft robots.Moreover,this origami also exhibits strong damage resistance and high durability.We envision that this work will offer an effective way to readily create on-demand soft robots that can operate in unknown environments.
基金This work was financially supported by the Guangdong Natural Science Funds for Distinguished Young Scholar(2015A030306036)Shenzhen Science and Technology Research Grant(JCYJ20180302150354741)Key-Area Research and Development Program of Guangdong Province(2019B010924003).
文摘Organic field-effect transistors(OFETs)are of the core units in organic electronic circuits,and the performance of OFETs replies critically on the properties of their dielectric layers.Owing to the intrinsic flexibility and natural compatibility with other organic components,organic polymers,such as poly(vinyl alcohol)(PVA),have emerged as highly interesting dielectric materials for OFETs.However,unsatisfactory issues,such as hysteresis,high subthreshold swing,and low effective carrier mobility,still considerably limit the practical applications of the polymer-dielectric OFETs for high-speed,low-voltage flexible organic circuits.This work develops a new approach of using supercritical CO_(2) fluid(SCCO_(2))treatment on PVA dielectrics to achieve remarkably high-performance polymer-dielectric OFETs.The SCCO_(2) treatment is able to completely eliminate the hysteresis in the transfer characteristics of OFETs,and it can also significantly reduce the device subthreshold slope to 0._(2)5 V/dec and enhance the saturation regime carrier mobility to 30.2 cm^(2) V^(-1) s^(-1),of which both the numbers are remarkable for flexible polymer-dielectric OFETs.It is further demonstrated that,coupling with an organic light-emitting diode(OLED),the SCCO_(2)-treated OFET is able to function very well under fast switching speed,which indicates that an excellent switching behavior of polymer-dielectric OFETs can be enabled by this SCCO_(2) approach.Considering the broad and essential applications of OFETs,we envision that this SCCO_(2) technology will have a very broad spectrum of applications for organic electronics,especially for high refresh rate and low-voltage flexible display devices.
