The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accum...The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accumulated lactate served a vital role in the inefficacy of antitumor immune responses,the aggressiveness of tumor cells,and immunotherapy.1 Furthermore,lactate generated from the tumor microenvironment can be used as fuel for the proliferation and infiltration of immunosuppressive cells.2 Previous studies regarding the taxonomies of HCC,solely from the perspective of lactate3 or tumor immune microenvironment4 may introduce the potential for bias in the comprehension of HCC heterogeneity.Thus,deciphering the crosstalk properties between lactate and immune is imperative.展开更多
Human microbiota constitute a complex and dynamic community that interacts with the innate immunity of the host at various anatomical sites,influencing both physiological and pathological states.In individuals with a ...Human microbiota constitute a complex and dynamic community that interacts with the innate immunity of the host at various anatomical sites,influencing both physiological and pathological states.In individuals with a genetic predisposition,disruptions to the“innate immunity‒microbiota”axis appear to rewire immune responses within the tumor microenvironment(TME),thereby driving cancer pathogenesis.This review summarizes the intricate crosstalk between the microbiota and innate immunity in both healthy and cancerous states,focusing on the modulation of immune recognition and polarization during tumor progression,including immune escape,barrier disruption,chronic inflammatory transformation,and angiogenesis in the initiation phase,as well as the regulation of local invasion,vascular invasion,and pre-metastatic ecological niche formation involved in the metastatic phase.This review also highlights recent advances and challenges in leveraging microbiota for cancer immunotherapy,covering innovations in bacteriophages,genetically engineered probiotics,and bioinformatic applications.Moreover,this review proposes potential approaches to enhance therapeutic efficacy by targeting innate immunity‒microbiota interactions.Further mechanistic insights into these interactions may pave the way for developing innovative microbiota-based cancer immunotherapies.展开更多
Copper,one of the essential nutrients for the human body,acts as an electron relay in multiple pathways due to its redox properties.Both deficiencies and excesses of copper lead to cellular fragility.Therefore,it can ...Copper,one of the essential nutrients for the human body,acts as an electron relay in multiple pathways due to its redox properties.Both deficiencies and excesses of copper lead to cellular fragility.Therefore,it can manifest pro-and anti-cancer properties in tumors.Therefore,it is crucial to clarify the copper activity within the cell.We have thoughtfully summarized the metabolic activi-ties of copper from a macro and micro perspective.Cuproptosis,as well as other forms of cell death,is directly or indirectly interfered with by Cu2+,causing cancer cell death.Meanwhile,we did pan-cancer analysis of cuproptosis-related genes to further clarify the roles of these genes.In addition,copper has been found to be involved in multiple pathways within the metastasis of cancer cells.Given the complexity of copper’s role,we are compelled to ask:is copper a friend or a foe?Up to now,copper has been used in various clinical applications,including protocols for measurement of copper concentration and bioimaging of radioactive 64Cu.But therapeutically it is still a continuation of the old medicine,and new possibilities need to be explored,such as the use of nanomaterials.Some studies have also shown that copper has considerable interventional power in metabolic cancers,which provides the great applications potential of copper therapy in specific cancer types.This paper reviews the dual roles played by cuproptosis in cancer from the new perspectives of oxidative stress,cell death,and tumor metastasis,and points out the value of its application in specific can-cer types,summarizes the value of its testing and imaging from the perspective of clinical application as well as the current feasible options for the new use of the old drugs,and emphasizes the prospects for the application of nano-copper.展开更多
The cascade of metastasis in tumor cells,exhibiting organ-specific tendencies,may occur at numerous phases of the disease and progress under intense evolutionary pressures.Organ-specific metastasis relies on the forma...The cascade of metastasis in tumor cells,exhibiting organ-specific tendencies,may occur at numerous phases of the disease and progress under intense evolutionary pressures.Organ-specific metastasis relies on the formation of pre-metastatic niche(PMN),with diverse cell types and complex cell interactions contributing to this concept,adding a new dimension to the traditional metastasis cascade.Prior to metastatic dissemination,as orchestrators of PMN formation,primary tumor-derived extracellular vesicles prepare a fertile microenvironment for the settlement and colonization of circulating tumor cells at distant secondary sites,significantly impacting cancer progression and outcomes.Obviously,solely intervening in cancer metastatic sites passively after macrometastasis is often insufficient.Early prediction of metastasis and holistic,macro-level control represent the future directions in cancer therapy.This review emphasizes the dynamic and intricate systematic alterations that occur as cancer progresses,illustrates the immunological landscape of organ-specific PMN creation,and deepens understanding of treatment modalities pertinent to metastasis,thereby identifying some prognostic and predictive biomarkers favorable to early predict the occurrence of metastasis and design appropriate treatment combinations.展开更多
Gastric cancer(GC)ranks fifth for cancer incidence and fourth for mortality globally.1 Clinical outcomes have varied among patients receiving similar treatments at the same stage,suggesting the current prognostic tool...Gastric cancer(GC)ranks fifth for cancer incidence and fourth for mortality globally.1 Clinical outcomes have varied among patients receiving similar treatments at the same stage,suggesting the current prognostic tools remain somewhat flawed.2,3 single-cell analysis of GC data allowed us to dissect transcriptional programs underlying lymphocyte residency and exhaustion.展开更多
基金supported by the Major Science and Technology projects of Henan Province,China(No.221100310100).
文摘The interaction of lactate metabolism with immunity plays a crucial role in the remodeling of the immune microenvironment and even in the heterogeneous progression of hepatocellular carcinoma(HCC).The intratumor-accumulated lactate served a vital role in the inefficacy of antitumor immune responses,the aggressiveness of tumor cells,and immunotherapy.1 Furthermore,lactate generated from the tumor microenvironment can be used as fuel for the proliferation and infiltration of immunosuppressive cells.2 Previous studies regarding the taxonomies of HCC,solely from the perspective of lactate3 or tumor immune microenvironment4 may introduce the potential for bias in the comprehension of HCC heterogeneity.Thus,deciphering the crosstalk properties between lactate and immune is imperative.
基金supported by the Henan Provincial Science and Technology Research Project(grant number 221100310100 to Z.L.and X.H.).
文摘Human microbiota constitute a complex and dynamic community that interacts with the innate immunity of the host at various anatomical sites,influencing both physiological and pathological states.In individuals with a genetic predisposition,disruptions to the“innate immunity‒microbiota”axis appear to rewire immune responses within the tumor microenvironment(TME),thereby driving cancer pathogenesis.This review summarizes the intricate crosstalk between the microbiota and innate immunity in both healthy and cancerous states,focusing on the modulation of immune recognition and polarization during tumor progression,including immune escape,barrier disruption,chronic inflammatory transformation,and angiogenesis in the initiation phase,as well as the regulation of local invasion,vascular invasion,and pre-metastatic ecological niche formation involved in the metastatic phase.This review also highlights recent advances and challenges in leveraging microbiota for cancer immunotherapy,covering innovations in bacteriophages,genetically engineered probiotics,and bioinformatic applications.Moreover,this review proposes potential approaches to enhance therapeutic efficacy by targeting innate immunity‒microbiota interactions.Further mechanistic insights into these interactions may pave the way for developing innovative microbiota-based cancer immunotherapies.
基金Major Science and Technology projects of Henan Province,Grant/Award Number:221100310100。
文摘Copper,one of the essential nutrients for the human body,acts as an electron relay in multiple pathways due to its redox properties.Both deficiencies and excesses of copper lead to cellular fragility.Therefore,it can manifest pro-and anti-cancer properties in tumors.Therefore,it is crucial to clarify the copper activity within the cell.We have thoughtfully summarized the metabolic activi-ties of copper from a macro and micro perspective.Cuproptosis,as well as other forms of cell death,is directly or indirectly interfered with by Cu2+,causing cancer cell death.Meanwhile,we did pan-cancer analysis of cuproptosis-related genes to further clarify the roles of these genes.In addition,copper has been found to be involved in multiple pathways within the metastasis of cancer cells.Given the complexity of copper’s role,we are compelled to ask:is copper a friend or a foe?Up to now,copper has been used in various clinical applications,including protocols for measurement of copper concentration and bioimaging of radioactive 64Cu.But therapeutically it is still a continuation of the old medicine,and new possibilities need to be explored,such as the use of nanomaterials.Some studies have also shown that copper has considerable interventional power in metabolic cancers,which provides the great applications potential of copper therapy in specific cancer types.This paper reviews the dual roles played by cuproptosis in cancer from the new perspectives of oxidative stress,cell death,and tumor metastasis,and points out the value of its application in specific can-cer types,summarizes the value of its testing and imaging from the perspective of clinical application as well as the current feasible options for the new use of the old drugs,and emphasizes the prospects for the application of nano-copper.
基金supported by the Major Science and Technology projects of Henan Province(Grant no.221100310100).
文摘The cascade of metastasis in tumor cells,exhibiting organ-specific tendencies,may occur at numerous phases of the disease and progress under intense evolutionary pressures.Organ-specific metastasis relies on the formation of pre-metastatic niche(PMN),with diverse cell types and complex cell interactions contributing to this concept,adding a new dimension to the traditional metastasis cascade.Prior to metastatic dissemination,as orchestrators of PMN formation,primary tumor-derived extracellular vesicles prepare a fertile microenvironment for the settlement and colonization of circulating tumor cells at distant secondary sites,significantly impacting cancer progression and outcomes.Obviously,solely intervening in cancer metastatic sites passively after macrometastasis is often insufficient.Early prediction of metastasis and holistic,macro-level control represent the future directions in cancer therapy.This review emphasizes the dynamic and intricate systematic alterations that occur as cancer progresses,illustrates the immunological landscape of organ-specific PMN creation,and deepens understanding of treatment modalities pertinent to metastasis,thereby identifying some prognostic and predictive biomarkers favorable to early predict the occurrence of metastasis and design appropriate treatment combinations.
基金supported by the Major Science and Technologyprojectsof Henan Province,China(No.221100310100).
文摘Gastric cancer(GC)ranks fifth for cancer incidence and fourth for mortality globally.1 Clinical outcomes have varied among patients receiving similar treatments at the same stage,suggesting the current prognostic tools remain somewhat flawed.2,3 single-cell analysis of GC data allowed us to dissect transcriptional programs underlying lymphocyte residency and exhaustion.
