Quantum sensing aims to detect signals with unparalleled sensitivity,potentially surpassing classical limitations.Solid-state spin defects,particularly nitrogen-vacancy centers in diamond,have emerged as promising pla...Quantum sensing aims to detect signals with unparalleled sensitivity,potentially surpassing classical limitations.Solid-state spin defects,particularly nitrogen-vacancy centers in diamond,have emerged as promising platforms due to their long coherence time,optical addressability,high field sensitivity,and spatial and spectral resolution,making them ideal for sensing and imaging applications.Their compact size and robust performance under room temperature and ambient conditions further enhance their suitability for real-world applications.We provide an overview of quantum sensing principles and explore efforts to improve sensor functionality,including advanced sensing protocols,spatial imaging techniques,and integration with optical systems to enhance detection efficiency.We also highlight recent progress in the applications of these sensors across various use cases,including biomedical diagnostics,semiconductor device inspection,and industrial and military applications.展开更多
Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery disease.Despite advancem...Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery disease.Despite advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention risks.Drugeluting balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion site.However,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a challenge.Herein,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional DEBs.Using the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH 4.0.Upon exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon surface.Combined with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the clinic.These results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.展开更多
基金the National Research Foundation of Korea(Grant No.NRF-2022M3K4A1094777)the Institute for Information&Communication Technology Planning&Evaluation(IITP)grant(Grant No.RS-2023-00230717)+5 种基金the Information Technology Research Center(ITRC)support program(Grant No.IITP-2024-2020-0-01606)the Creation of the Quantum Information Science R&D Ecosystem(Grant No.2022M3H3A106307411)through the National Research Foundation of Korea,funded by the Korean government(Ministry of Science and ICT)funded by the Korean government(MSIT)(Grant No.RS-2022-II220897,“Development of quantum imaging system for sub-shot-noise microscopy”)the National Research Foundation of Korea(Grant Nos.NRF-2022R1A2C2003176 and 2022M3H4A1A04096396)the ITRC support program(Grant Nos.IITP-2025-RS-2020-II201606 and RS-2023-00259676)the UNIST 2025 Research Fund(Grant No.1.250007.01).
文摘Quantum sensing aims to detect signals with unparalleled sensitivity,potentially surpassing classical limitations.Solid-state spin defects,particularly nitrogen-vacancy centers in diamond,have emerged as promising platforms due to their long coherence time,optical addressability,high field sensitivity,and spatial and spectral resolution,making them ideal for sensing and imaging applications.Their compact size and robust performance under room temperature and ambient conditions further enhance their suitability for real-world applications.We provide an overview of quantum sensing principles and explore efforts to improve sensor functionality,including advanced sensing protocols,spatial imaging techniques,and integration with optical systems to enhance detection efficiency.We also highlight recent progress in the applications of these sensors across various use cases,including biomedical diagnostics,semiconductor device inspection,and industrial and military applications.
基金supported by a grant from the Korea Health Technology R&D Project,Ministry of Health&Welfare(No.A111552),Republic of Korea.
文摘Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery disease.Despite advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention risks.Drugeluting balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion site.However,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a challenge.Herein,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional DEBs.Using the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH 4.0.Upon exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon surface.Combined with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the clinic.These results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.
