In recent years,the mobile Internet has developed rapidly,and the network social platform has emerged as the times require,and more people make friends,chat and share dynamics through the network social platform.The n...In recent years,the mobile Internet has developed rapidly,and the network social platform has emerged as the times require,and more people make friends,chat and share dynamics through the network social platform.The network social platform is the virtual embodiment of the social network,each user represents a node in the directed graph of the social network.As the most popular online social platform in China,WeChat has developed rapidly in recent years.Large user groups,powerful mobile payment capabilities,and massive amounts of data have brought great influence to it.At present,the research on WeChat network at home and abroad mainly focuses on communication and sociology,but the research from the angle of influence is scarce.Therefore,based on the basic principle of PageRank,this paper proposes an influence evaluation model WURank algorithm suitable for WeChat network users.This algorithm takes into account the shortcomings of the traditional PageRank algorithm,and objectively evaluates the real-time influence of WeChat users from the perspective of WeChat user behavior(including:sharing,commenting,mentioning,collecting,likes)and time factors.展开更多
The publisher regrets that a technical error occurred,which led to the duplicate publication.We apologize to the authors and the readers for this unfortunate error and any inconvenience this may have caused.
The publisher regrets that a technical error occurred,which led to the duplicate publication.We apologize to the authors and the readers for this unfortunate error and any inconvenience this may have caused.
To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to co...To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the pandemic.Generally,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[2].展开更多
Activation-induced cytidine deaminase(AID)initiates class-switch recombination and somatic hypermutation(SHM)in antibody genes.Protein expression and activity are tightly controlled by various mechanisms.However,it re...Activation-induced cytidine deaminase(AID)initiates class-switch recombination and somatic hypermutation(SHM)in antibody genes.Protein expression and activity are tightly controlled by various mechanisms.However,it remains unknown whether a signal from the extracellular environment directly affects the AID activity in the nucleus where it works.Here,we demonstrated that a deubiquitinase USP10,which specifically stabilizes nuclear AID protein,can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain.Interestingly,the signals from BCR and TLR1/2 synergistically promoted this phosphorylation.The deficiency of USP10 in B cells significantly decreased AID protein levels,subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)or human immunodeficiency virus type 1(HIV-1)nanoparticle vaccines.Collectively,we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity.Its manipulation could be used for the development of vaccines and adjuvants.展开更多
基金This work was supported in part by the National Natural Science Foundation of China,Grant No.72073041Open Foundation for the University Innovation Platform in the Hunan Province,Grant No.18K103+3 种基金2011 Collaborative Innovation Center for Development and Utilization of Finance and Economics Big Data Property.Hunan Provincial Key Laboratory of Finance&Economics Big Data Science and Technology2020 Hunan Provincial Higher Education Teaching Reform Research Project under Grant HNJG-2020-1130,HNJG-2020-11242020 General Project of Hunan Social Science Fund under Grant 20B16.Scientific Research Project of Education Department of Hunan Province(Grand No.20K021)Social Science Foundation of Hunan Province(Grant No.17YBA049).
文摘In recent years,the mobile Internet has developed rapidly,and the network social platform has emerged as the times require,and more people make friends,chat and share dynamics through the network social platform.The network social platform is the virtual embodiment of the social network,each user represents a node in the directed graph of the social network.As the most popular online social platform in China,WeChat has developed rapidly in recent years.Large user groups,powerful mobile payment capabilities,and massive amounts of data have brought great influence to it.At present,the research on WeChat network at home and abroad mainly focuses on communication and sociology,but the research from the angle of influence is scarce.Therefore,based on the basic principle of PageRank,this paper proposes an influence evaluation model WURank algorithm suitable for WeChat network users.This algorithm takes into account the shortcomings of the traditional PageRank algorithm,and objectively evaluates the real-time influence of WeChat users from the perspective of WeChat user behavior(including:sharing,commenting,mentioning,collecting,likes)and time factors.
文摘The publisher regrets that a technical error occurred,which led to the duplicate publication.We apologize to the authors and the readers for this unfortunate error and any inconvenience this may have caused.
文摘The publisher regrets that a technical error occurred,which led to the duplicate publication.We apologize to the authors and the readers for this unfortunate error and any inconvenience this may have caused.
基金This work was supported by the National Special Research Program of China for Important Infectious Diseases(2017ZX10202102 and 2018ZX10302103)the Special 2019-nCoV Project of the National Key Research and Development Program of China(2020YFC0841400)+4 种基金the First Panel of 2021 Emergency Key Program of Guangzhou Laboratory(EKPG21-24)the Special 2019-nCoV Program of the Natural Science Foundation of China(NSFC)(82041002)the Special Research and Development Program of Guangzhou(202008070010)the Important Key Program of NSFC(81730060)the Joint-Innovation Program in Healthcare for Special Scientific Research Projects of Guangzhou(201803040002)to H.Z.
文摘To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the pandemic.Generally,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[2].
基金This work was supported by the National Special Research Program of China for Important Infectious Diseases(2017ZX10202102 and 2018ZX10302103)the Special 2019-nCoV Project of the National Key Research and Development Program of China(2020YFC0841400)the Special 2019-nCoV Program of the Natural Science Foundation of China(NSFC)(82041002),the Emergency Key Program of Guangzhou Laboratory(EKPG21-24),the Important Key Program of NSFC(81730060),and the Joint-Innovation Program in Healthcare for Special Scientific Research Projects of Guangzhou(201803040002)to Hui Zhang,the Postdoctoral Science Foundation of China(2019M663249,2020M683032)to Yuewen Luo and Jun Liu,the Guangdong Basic and Applied Basic Research Foundation(2020A1515110807)to Yuewen Luo and the Fundamental Research Funds for the Central Universities(20ykpy138)to Yuewen Luo.
文摘Activation-induced cytidine deaminase(AID)initiates class-switch recombination and somatic hypermutation(SHM)in antibody genes.Protein expression and activity are tightly controlled by various mechanisms.However,it remains unknown whether a signal from the extracellular environment directly affects the AID activity in the nucleus where it works.Here,we demonstrated that a deubiquitinase USP10,which specifically stabilizes nuclear AID protein,can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the NLS domain.Interestingly,the signals from BCR and TLR1/2 synergistically promoted this phosphorylation.The deficiency of USP10 in B cells significantly decreased AID protein levels,subsequently reducing neutralizing antibody production after immunization with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)or human immunodeficiency virus type 1(HIV-1)nanoparticle vaccines.Collectively,we demonstrated that USP10 functions as an integrator for both BCR and TLR signals and directly regulates nuclear AID activity.Its manipulation could be used for the development of vaccines and adjuvants.
