The ecological and climatic conditions in the main tea areas of western Guizhou were analyzed,and the comparison with Meitan,Duyun and Leishan tea areas in Guizhou Province was conducted. The results showed that sprin...The ecological and climatic conditions in the main tea areas of western Guizhou were analyzed,and the comparison with Meitan,Duyun and Leishan tea areas in Guizhou Province was conducted. The results showed that spring,summer and autumn tea can be picked in western Guizhou Province;spring tea can be picked for about 100 d,and summer and autumn tea can be picked for about 50 d. The average content of amino acids in tea from western Guizhou was 0.9%-2.9% higher than the national average,and the average content of polyphenols was 10.9% lower than the national average maximum,while the average content of caffeine was 1.4% lower than the national average maximum. In the first ten days of February,the temperature in the western tea area began to rise,which was earlier than Meitan,Duyun,Leishan tea areas and had a larger warming range,which was conducive to the germination of tea trees. The average temperature of ten days in the western tea area from middle May to early July was lower than that of Meitan,Duyun and Leishan tea areas,and the temperature rise was not violent,which was conducive to the growth of summer shoots and vigorous growth of tea buds. The ten-day average temperature of the western tea area from the first ten days of August to the last ten days of September was lower than Meitan,Duyun and Leishan tea areas,and its precipitation was more than Meitan,Duyun and Leishan tea areas,and the number of rainy and foggy days was more. The climate conditions are favorable for the formation of tea quality.展开更多
Lung cancer remains the leading cause of death among cancer patients,and the five-year survival rate is less than 25%.However,Methyl-CpG Binding Domain(MBD)4 polymorphism rs140693 predicts the prognosis of lung cancer...Lung cancer remains the leading cause of death among cancer patients,and the five-year survival rate is less than 25%.However,Methyl-CpG Binding Domain(MBD)4 polymorphism rs140693 predicts the prognosis of lung cancer patients still needs further verification.Primary lung cancer patients(n=839)were collected from two hospitals,genomic DNA was extracted from blood,and genotyping was performed using SNPcan technology.Kaplan-Meier technique and multivariate Cox proportional hazards model were used to analyze the prognosis association between MBD4 and clinical characteristics.Significantly conferred a poorer prognosis was associated with the CT genotype(CT vs.CC;adjusted hazard ratio[HR]=1.21,95%CI:1.03-1.43,p=0.023)and dominant CT+TT genotype(CT+TT vs.CC;HR=1.19,95%CI:1.02-1.39,p=0.029)of MBD4 polymorphism rs140693 for all lung cancer patients,compared with the CC genotype.Stratified analysis showed that polymorphism rs140693 CT and dominant CT+TT genotype conferred a significantly poorer prognosis in female and lung adenocarcinoma(ADC)cancer patients,compared with the CC genotype.Non-small cell lung cancer(NSCLC)patients with the CT genotype had a poorer prognosis than those with the CC genotype.Additionally,the allele T of small cell lung cancer(SCLC)patients compared with the allele C was associated with a poor prognosis,and the CT and recessive TT genotype of SCLC patients conferred a significantly poor prognosis.The MBD4 polymorphism rs140693 is a significant prognostic genetic marker for predicting the prognosis of lung cancer patients.展开更多
基金Supported by the Special Project for Building Science and Technology Cooperation and Innovation Capacity in Guizhou Province(52020-2015-01-02)。
文摘The ecological and climatic conditions in the main tea areas of western Guizhou were analyzed,and the comparison with Meitan,Duyun and Leishan tea areas in Guizhou Province was conducted. The results showed that spring,summer and autumn tea can be picked in western Guizhou Province;spring tea can be picked for about 100 d,and summer and autumn tea can be picked for about 50 d. The average content of amino acids in tea from western Guizhou was 0.9%-2.9% higher than the national average,and the average content of polyphenols was 10.9% lower than the national average maximum,while the average content of caffeine was 1.4% lower than the national average maximum. In the first ten days of February,the temperature in the western tea area began to rise,which was earlier than Meitan,Duyun,Leishan tea areas and had a larger warming range,which was conducive to the germination of tea trees. The average temperature of ten days in the western tea area from middle May to early July was lower than that of Meitan,Duyun and Leishan tea areas,and the temperature rise was not violent,which was conducive to the growth of summer shoots and vigorous growth of tea buds. The ten-day average temperature of the western tea area from the first ten days of August to the last ten days of September was lower than Meitan,Duyun and Leishan tea areas,and its precipitation was more than Meitan,Duyun and Leishan tea areas,and the number of rainy and foggy days was more. The climate conditions are favorable for the formation of tea quality.
基金currently receiving four grants from the National Natural Science Foundation of China(Grant NO.81372236,82272863 and 81972822)the Shanghai Postdoctoral Research Foundation in 2021(Class A Grant NO.12R21411500).
文摘Lung cancer remains the leading cause of death among cancer patients,and the five-year survival rate is less than 25%.However,Methyl-CpG Binding Domain(MBD)4 polymorphism rs140693 predicts the prognosis of lung cancer patients still needs further verification.Primary lung cancer patients(n=839)were collected from two hospitals,genomic DNA was extracted from blood,and genotyping was performed using SNPcan technology.Kaplan-Meier technique and multivariate Cox proportional hazards model were used to analyze the prognosis association between MBD4 and clinical characteristics.Significantly conferred a poorer prognosis was associated with the CT genotype(CT vs.CC;adjusted hazard ratio[HR]=1.21,95%CI:1.03-1.43,p=0.023)and dominant CT+TT genotype(CT+TT vs.CC;HR=1.19,95%CI:1.02-1.39,p=0.029)of MBD4 polymorphism rs140693 for all lung cancer patients,compared with the CC genotype.Stratified analysis showed that polymorphism rs140693 CT and dominant CT+TT genotype conferred a significantly poorer prognosis in female and lung adenocarcinoma(ADC)cancer patients,compared with the CC genotype.Non-small cell lung cancer(NSCLC)patients with the CT genotype had a poorer prognosis than those with the CC genotype.Additionally,the allele T of small cell lung cancer(SCLC)patients compared with the allele C was associated with a poor prognosis,and the CT and recessive TT genotype of SCLC patients conferred a significantly poor prognosis.The MBD4 polymorphism rs140693 is a significant prognostic genetic marker for predicting the prognosis of lung cancer patients.
