The patient was found to have 4+urine sugar by physical examination 14 years ago and was treated with oral hypoglycemic drugs. Insulin was injected intramuscularly nine years ago. Two and a half years ago, it was foun...The patient was found to have 4+urine sugar by physical examination 14 years ago and was treated with oral hypoglycemic drugs. Insulin was injected intramuscularly nine years ago. Two and a half years ago, it was found that the color of the thumb, index and middle toe of the left foot became black. He went to a third-class hospital in Beijing and was diagnosed as “diabetes foot”. He was treated with “balloon dilation of lower limb blood vessels of diabetes foot”. Half a year ago, the third toe on the right side was broken and treated in the hospital again. “Popliteal artery stent implantation” was given for the diagnosis of “double kidney insufficiency, diabetes foot, left heart failure, combined heart valve disease”, “Hemofiltration therapy” and anti-inflammatory, amino acid supplementation, kidney function protection, anticoagulation, anemia correction and other treatments. Later, he went to our hospital and was diagnosed by the TCM diagnosis: category of consumptive disease, toe or finger gangrene (syndrome/pattern of qi and yin deficiency). Western medicine diagnosed: stage V of diabetes nephropathy, type II diabetes foot gangrene, combined with heart valve disease, hypoalbuminemia, double kidney cyst, moderate anemia, pleural effusion, hyperkalemia, pulmonary infection, and total heart failure. The patient was treated by the Qi-acupuncture therapy of TCM in combination with Chinese and Western medicine Medical treatment made the patient significantly better and discharged.展开更多
Luminescent nanoparticles(LNPs)have emerged as a promising approach for enhanced cell labelling and disease diagnosis by leveraging their unique photophysical and surface characteristics.Advanced generations of LNPs,s...Luminescent nanoparticles(LNPs)have emerged as a promising approach for enhanced cell labelling and disease diagnosis by leveraging their unique photophysical and surface characteristics.Advanced generations of LNPs,such as quantum dots,dye-loaded nanoparticles and up-converting nanoparticles,exhibit distinct properties and advantages tailored for specialised applications.Consequently,there is a growing focus and demand to develop organelle-specific LNPs to identify,treat and elucidate disease mechanisms.The endoplasmic reticulum(ER)represents one such organelle,playing crucial roles in protein synthesis and modification,calcium homeostasis,lipid trafficking,and regulation of cellular stress.The unfolded protein response,regulated by ER stress,is a clinically significant pathway within the ER,implicated in cellular dysfunction and disease.The growing understanding of ER stress and the unfolded protein response has led to a rapid emergence of endoplasmic reticulum-targeting LNPs(ERLNPs)for precise intracellular diagnosis and therapy.This review discusses current advances and design principles of ERLNPs,highlights current achievements and applications,and discusses the challenges and interdisciplinarity needed for future development.展开更多
The inadequate quantity of hydrogen peroxide(H_(2)O_(2))in cancer cells promptly results in the constrained success of chemodynamic therapy(CDT).Significant efforts made throughout the years;nevertheless,researchers a...The inadequate quantity of hydrogen peroxide(H_(2)O_(2))in cancer cells promptly results in the constrained success of chemodynamic therapy(CDT).Significant efforts made throughout the years;nevertheless,researchers are still facing the great challenge of designing a CDT agent and securing H_(2)O_(2) supply within the tumor cell.In this study,taking advantage of H_(2)O_(2) level maintenance mechanism in cancer cells,a nanozyme-based bimetallic metal-organic frameworks(MOFs)tandem reactor is fabricated to elevate intracellular H_(2)O_(2) levels,thereby enhancing CDT.In addition,under nearinfrared excitation,the upconversion nanoparticles(UCNPs)loaded into the MOFs can perform photocatalysis and generate hydrogen,which increases cellular susceptibility to radicals induced from H_(2)O_(2),inhibits cancer cell energy,causes DNA damages and induces tumor cell apoptosis,thus improving CDT therapeutic efficacy synergistically.The proposed nanozyme-based bimetallic MOFs-mediated CDT and UCNPs-mediated hydrogen therapy act as combined therapy with high efficacy and low toxicity.展开更多
This study introduces a pioneering design concept termed the“dual-feedback healing mechanism”,which investigates the relationship between oxidation products and protective coatings.Specifically,it focuses on channel...This study introduces a pioneering design concept termed the“dual-feedback healing mechanism”,which investigates the relationship between oxidation products and protective coatings.Specifically,it focuses on channeling oxidation products generated at exposed cracks in the substrate to interact with the antioxidant coatings,enabling a self-repair mechanism for cracks.BNf/SiBN was chosen as the ceramic matrix,while the Si-O-Al system served as the antioxidant coating.The dynamic process of obtaining Si-O-Al(SOAC)coating involving the pyrolysis of organic precursors and the dual-feedback healing mechanism were systematically investigated.These findings indicate that when the temperature surpasses 1150℃,the exposed BN fibers at the cracks are oxidized,transforming into B_(2)O_(3)(g).Subsequently,B_(2)O_(3)(g)reacts with SiO_(2),forming a SiBO mixture.The mixture effectively diminishes the viscosity of the coating,enabling it to flow and form a fresh protective layer that effectively blocks O_(2) infiltration.Consequently,after oxidation at 1500℃,the coated samples experience a mere 3%weight loss.This technology emphasizes the interconnectivity during material transformation,utilizing matrix oxidation products as a driving force for self-healing of the coating.This approach achieves intelligent-like,targeted closure of oxygen pathways,thereby pioneering a novel concept and direction for the advancement of antioxidant coatings.Consequently,this approach not only enhances our understanding of the fundamental nature of“self-healing”but also holds significant potential in the development of reparable antioxidant coatings.展开更多
Photochromic glass shows great promise for 3D optical information encryption and storage applications.The formation of Ag nanoclusters by light irradiation has been a significant development in the field of photochrom...Photochromic glass shows great promise for 3D optical information encryption and storage applications.The formation of Ag nanoclusters by light irradiation has been a significant development in the field of photochromic glass research.However,extending this approach to other metal nanoclusters remains a challenge.In this study,we present a pioneering method for crafting photochromic glass with reliably adjustable dual-mode luminescence in both the NIR and visible spectra.This was achieved by leveraging bimetallic clusters of bismuth,resulting in a distinct and novel photochromic glass.When rare-earth-doped,bismuth-based glass is irradiated with a 473 nm laser,and it undergoes a color transformation from yellow to red,accompanied by visible and broad NIR luminescence.This phenomenon is attributed to the formation of laserinduced(Bi^(+),Bi^(0))nanoclusters.We achieved reversible manipulation of the NIR luminescence of these nanoclusters and visible rare-earth luminescence by alternating exposure to a 473 nm laser and thermal stimulation.Information patterns can be inscribed and erased on a glass surface or in 3D space,and the readout is enabled by modulating visible and NIR luminescence.This study introduces a pioneering strategy for designing photochromic glasses with extensive NIR luminescence and significant potential for applications in highcapacity information encryption,optical data storage,optical communication,and NIR imaging.The exploration of bimetallic cluster formation in Bi represents a vital contribution to the advancement of multifunctional glass systems with augmented optical functionalities and versatile applications.展开更多
文摘The patient was found to have 4+urine sugar by physical examination 14 years ago and was treated with oral hypoglycemic drugs. Insulin was injected intramuscularly nine years ago. Two and a half years ago, it was found that the color of the thumb, index and middle toe of the left foot became black. He went to a third-class hospital in Beijing and was diagnosed as “diabetes foot”. He was treated with “balloon dilation of lower limb blood vessels of diabetes foot”. Half a year ago, the third toe on the right side was broken and treated in the hospital again. “Popliteal artery stent implantation” was given for the diagnosis of “double kidney insufficiency, diabetes foot, left heart failure, combined heart valve disease”, “Hemofiltration therapy” and anti-inflammatory, amino acid supplementation, kidney function protection, anticoagulation, anemia correction and other treatments. Later, he went to our hospital and was diagnosed by the TCM diagnosis: category of consumptive disease, toe or finger gangrene (syndrome/pattern of qi and yin deficiency). Western medicine diagnosed: stage V of diabetes nephropathy, type II diabetes foot gangrene, combined with heart valve disease, hypoalbuminemia, double kidney cyst, moderate anemia, pleural effusion, hyperkalemia, pulmonary infection, and total heart failure. The patient was treated by the Qi-acupuncture therapy of TCM in combination with Chinese and Western medicine Medical treatment made the patient significantly better and discharged.
基金supported by UTS Science Seed Funding,UTS Chancellor’s Research Fellowship Program(No.PRO22-15457)the National Health and Medical Research Council(No.2025442).
文摘Luminescent nanoparticles(LNPs)have emerged as a promising approach for enhanced cell labelling and disease diagnosis by leveraging their unique photophysical and surface characteristics.Advanced generations of LNPs,such as quantum dots,dye-loaded nanoparticles and up-converting nanoparticles,exhibit distinct properties and advantages tailored for specialised applications.Consequently,there is a growing focus and demand to develop organelle-specific LNPs to identify,treat and elucidate disease mechanisms.The endoplasmic reticulum(ER)represents one such organelle,playing crucial roles in protein synthesis and modification,calcium homeostasis,lipid trafficking,and regulation of cellular stress.The unfolded protein response,regulated by ER stress,is a clinically significant pathway within the ER,implicated in cellular dysfunction and disease.The growing understanding of ER stress and the unfolded protein response has led to a rapid emergence of endoplasmic reticulum-targeting LNPs(ERLNPs)for precise intracellular diagnosis and therapy.This review discusses current advances and design principles of ERLNPs,highlights current achievements and applications,and discusses the challenges and interdisciplinarity needed for future development.
基金funded by the National Natural Science Foundation of China(NSFC 81971734,32071323,32271410)the Science and Technology Projects in Fujian Province(2022FX1,2023Y4008)the Open Research Fund of Academy of Advanced Carbon Conversion Technology,Huaqiao University(AACCT0004).
文摘The inadequate quantity of hydrogen peroxide(H_(2)O_(2))in cancer cells promptly results in the constrained success of chemodynamic therapy(CDT).Significant efforts made throughout the years;nevertheless,researchers are still facing the great challenge of designing a CDT agent and securing H_(2)O_(2) supply within the tumor cell.In this study,taking advantage of H_(2)O_(2) level maintenance mechanism in cancer cells,a nanozyme-based bimetallic metal-organic frameworks(MOFs)tandem reactor is fabricated to elevate intracellular H_(2)O_(2) levels,thereby enhancing CDT.In addition,under nearinfrared excitation,the upconversion nanoparticles(UCNPs)loaded into the MOFs can perform photocatalysis and generate hydrogen,which increases cellular susceptibility to radicals induced from H_(2)O_(2),inhibits cancer cell energy,causes DNA damages and induces tumor cell apoptosis,thus improving CDT therapeutic efficacy synergistically.The proposed nanozyme-based bimetallic MOFs-mediated CDT and UCNPs-mediated hydrogen therapy act as combined therapy with high efficacy and low toxicity.
基金support from the National Natural Science Foundation of China(No.51972078)the Heilongjiang Touyan Team Program,the Fundamental Research Funds for the Central Universities(No.HIT.OCEF.2021003)the Key Laboratory of Advanced Structural-Functional Integration Materials&Green Manufacturing Technology.
文摘This study introduces a pioneering design concept termed the“dual-feedback healing mechanism”,which investigates the relationship between oxidation products and protective coatings.Specifically,it focuses on channeling oxidation products generated at exposed cracks in the substrate to interact with the antioxidant coatings,enabling a self-repair mechanism for cracks.BNf/SiBN was chosen as the ceramic matrix,while the Si-O-Al system served as the antioxidant coating.The dynamic process of obtaining Si-O-Al(SOAC)coating involving the pyrolysis of organic precursors and the dual-feedback healing mechanism were systematically investigated.These findings indicate that when the temperature surpasses 1150℃,the exposed BN fibers at the cracks are oxidized,transforming into B_(2)O_(3)(g).Subsequently,B_(2)O_(3)(g)reacts with SiO_(2),forming a SiBO mixture.The mixture effectively diminishes the viscosity of the coating,enabling it to flow and form a fresh protective layer that effectively blocks O_(2) infiltration.Consequently,after oxidation at 1500℃,the coated samples experience a mere 3%weight loss.This technology emphasizes the interconnectivity during material transformation,utilizing matrix oxidation products as a driving force for self-healing of the coating.This approach achieves intelligent-like,targeted closure of oxygen pathways,thereby pioneering a novel concept and direction for the advancement of antioxidant coatings.Consequently,this approach not only enhances our understanding of the fundamental nature of“self-healing”but also holds significant potential in the development of reparable antioxidant coatings.
基金Key Project of the National Natural Science Foundation of China-Yunnan Joint Fund,Grant/Award Number:U2102215National Natural Science Foundation of High End Foreign Expert Introduction Plan,Grant/Award Number:G2022039008L+1 种基金Academician Workstation of Cherkasova Tatiana in Yunnan Province,Grant/Award Number:202305 AF150099Yunnan Province Major Science and Technology Special Plan,Grant/Award Number:202302AB080005。
文摘Photochromic glass shows great promise for 3D optical information encryption and storage applications.The formation of Ag nanoclusters by light irradiation has been a significant development in the field of photochromic glass research.However,extending this approach to other metal nanoclusters remains a challenge.In this study,we present a pioneering method for crafting photochromic glass with reliably adjustable dual-mode luminescence in both the NIR and visible spectra.This was achieved by leveraging bimetallic clusters of bismuth,resulting in a distinct and novel photochromic glass.When rare-earth-doped,bismuth-based glass is irradiated with a 473 nm laser,and it undergoes a color transformation from yellow to red,accompanied by visible and broad NIR luminescence.This phenomenon is attributed to the formation of laserinduced(Bi^(+),Bi^(0))nanoclusters.We achieved reversible manipulation of the NIR luminescence of these nanoclusters and visible rare-earth luminescence by alternating exposure to a 473 nm laser and thermal stimulation.Information patterns can be inscribed and erased on a glass surface or in 3D space,and the readout is enabled by modulating visible and NIR luminescence.This study introduces a pioneering strategy for designing photochromic glasses with extensive NIR luminescence and significant potential for applications in highcapacity information encryption,optical data storage,optical communication,and NIR imaging.The exploration of bimetallic cluster formation in Bi represents a vital contribution to the advancement of multifunctional glass systems with augmented optical functionalities and versatile applications.
