Si-based materials have shown great potential as lithium-ion batteries(LIBs)anodes due to their natural reserves and high theoretical capacity.However,the large volume changes during cycles and poor conductivity of Si...Si-based materials have shown great potential as lithium-ion batteries(LIBs)anodes due to their natural reserves and high theoretical capacity.However,the large volume changes during cycles and poor conductivity of Si lead to rapid capacity decay and poor cycling stability,ultimately limiting their commercial applications.Herein,we have skillfully utilized the microporous MCM-22 zeolite as the unique silicon source to produce porous Si(pSi)sheets by a simple magnesiothermic reduction,followed by a carbon coating and further Ti_(3)C_(2)T_(x)MXene assembly,obtaining the ternary pSi@NC@TNSs composite.In the design,porous Si sheets provide more active sites and shorten Li-ion transport paths for electrochemical reactions.The N-doped carbon(NC)layer serves as a bonding layer to couple pSi and Ti_(3)C_(2)T_(x).The conductive network formed by 2D Ti_(3)C_(2)T_(x)and medium NC layer effectively enhances the overall charge transport of the electrode material,and helps to stabilize the electrode structure.Therefore,the as-made pSi@NC@TNSs anode delivers an improved lithium storage performance,exhibiting a high reversible capacity of 925 mAh/g at 0.5 A/g after 100 cycles.This present strategy provides an effective way towards high-performance Si-based anodes for LIBs.展开更多
Objective: The present study aimed to investigate circular RNA(circRNA) expression in uveal melanoma(UM).Methods: First,we used microarray to compare the expression profiles of circRNA in five UM samples and five norm...Objective: The present study aimed to investigate circular RNA(circRNA) expression in uveal melanoma(UM).Methods: First,we used microarray to compare the expression profiles of circRNA in five UM samples and five normal uvea tissues.Next,bioinformatics analyses,including gene ontology(GO) analysis and pathway analysis,were applied to study these differentially expressed circRNAs to predict pathogenic pathways that may be involved.Quantitative real-time polymerase chain reaction(qRT-PCR) in 20 UM samples and 20 normal uvea samples was used to confirm the circRNA expression profiles obtained from the microarray data.Finally,we analyzed the interaction between validated circRNAs and their potential cancer-associated miRNA targets.Results: In total,50,579 circRNAs [fold change(FC) ≥2.0; P<0.05],including 20,654 up-regulated and 29,925 down-regulated circRNAs,were identified as differentially expressed between UM tissues and normal uvea tissues.We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data,including hsacirc0119873,hsacirc0128533,hsacirc0047924,hsacirc0103232,hsa-circRNA10628-6,hsacirc0032148 and hsacirc0133460,which may be promising candidates to study future molecular mechanisms.Conclusions: This study explored,for the first time,the abnormal expression of circRNAs in UM and described the expression profile of circRNAs,providing a new potential target for the mechanism of UM and future treatment of UM.展开更多
In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generat...In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.展开更多
4D printing polymeric biomaterials can change their morphology or performance in response to stimuli from the external environment,compensating for the shortcomings of traditional 3D-printed static structures.This pap...4D printing polymeric biomaterials can change their morphology or performance in response to stimuli from the external environment,compensating for the shortcomings of traditional 3D-printed static structures.This paper provides a systematic overview of 4D printing polymeric biomaterials for tissue regeneration and provides an indepth discussion of the principles of these materials,including various smart properties,unique deformation mechanisms under stimulation conditions,and so on.A series of typical polymeric biomaterials and their composites are introduced from structural design and preparation methods,and their applications in tissue regeneration are discussed.Finally,the development prospect of 4D printing polymeric biomaterials is envi-sioned,aiming to provide innovative ideas and new perspectives for their more efficient and convenient application in tissue regeneration.展开更多
Purpose To investigate the impact of iris nevus on the incidence and prognosis of uveal melanoma(UM).Methods A retrospective cohort study was conducted involving 1128 UM cases and 4356 healthy controls.Partici-pants w...Purpose To investigate the impact of iris nevus on the incidence and prognosis of uveal melanoma(UM).Methods A retrospective cohort study was conducted involving 1128 UM cases and 4356 healthy controls.Partici-pants were categorized based on iris nevus presence and grade:grade 0(no iris nevus),grade 1(single iris nevus),grade 2(multiple iris nevi),and grade 3(partial or complete darkening of the iris).Propensity matching score method was employed to control for age and sex differences,while theχ2 test was used to compare the existence rate and grade of iris nevus between groups.Univariate ANOVA evaluated differences among various iris nevus grades,the Kaplan–Meier method analyzed the prognosis of patients with different iris nevus grades,and multivariate Cox proportional risk regression analysis was conducted to evaluate the relationship between clinical data and prognosis.Results A total of 5484 subjects were analyzed.UM patients exhibited a higher prevalence and grade of iris nevus(all P<0.001)after propensity matching.Patients with iris nevus in the affected eye did not show a worse prognosis(P=0.414).However,those with partial or complete iris darkening or multiple nevi had a poorer prognosis compared to those with a single or no iris nevus(all P<0.05).Iris nevus presence and grade in the healthy eye had no prognos-tic impact(P=0.726 and P=0.825,respectively).The multivariate COX proportional risk model showed that tumor diameter(P<0.001),age(P=0.020),and grade of iris nevus in the affected eye(P=0.009)were independent risk fac-tors for a worse prognosis.LSD analysis revealed that patients with partial or complete darkening of the iris had larger tumor diameters than those without iris nevus(P=0.013),single nevus(P=0.015),and multiple nevus(P=0.023).Discussion Our findings indicate a higher proportion and grade of iris nevus in UM patients compared to controls,and a worse prognosis for UM patients with higher-grade iris nevi in the affected eye.展开更多
A systematic wear model of the cylindrical grinding process with an alumina abrasive belt from the perspective of single grain sliding wear was established in this study.The model consists of three parts:a single cutt...A systematic wear model of the cylindrical grinding process with an alumina abrasive belt from the perspective of single grain sliding wear was established in this study.The model consists of three parts:a single cutting force model derived by applying a stress integration method,a single grain wear height analysis based on the wear rate of alumina,and a grinding mileage prediction of multiple grains with Gaussian distributed protrusion heights.Cutting force,single grain wear height and full‐size grinding mileage verification experiments were conducted.The results indicated that the established model was in reasonable agreement with the experimental outcomes,which suggests that this model could be useful in the industry to predict the wear process of abrasive belts.展开更多
Due to the weak information about cultural targets in the complex marine environment,an omission problem exists in large-scale mariculture extraction using single-view and single-source images.To overcome this problem...Due to the weak information about cultural targets in the complex marine environment,an omission problem exists in large-scale mariculture extraction using single-view and single-source images.To overcome this problem,we developed a mariculture extraction method that combines dense time-series Sentinel-2 and Sentinel-1 data.A high-precision Chinese mariculture distribution map for 2020 was produced with an overall accuracy of 94.00%and a kappa coefficient of 0.91.The results show that(1)the total area of mariculture was 1173249.22 ha on the national scale,which was significantly larger than the previous studies(459595.70 and 205920.28 ha,respectively),with Shandong Province(39.09%)having the largest proportion;(2)China’s mariculture presented a spatial distribution characteristic of‘Denser North and Sparser South’,and mariculture was centralized in the coastal zones of the northern provinces(60.76%)rather than the southern provinces;(3)the official production statistics and remote sensing-derived mariculture area revealed a highly corresponding trend at the provincial level,with an R2 reaching 0.78,which is much higher than the 0.07 and 0.41 values of the comparison data.The results directly provide data reference for mariculture production estimation and site selection or ideas for mariculture extraction in other regions and globally.展开更多
基金financially supported by the Natural Science Foundation of Shanghai(No.23ZR1423800)Shuguang Program from Shanghai Education Development Foundation and Shanghai Municipal Education Commission(No.18SG35)Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education),Nankai University.
文摘Si-based materials have shown great potential as lithium-ion batteries(LIBs)anodes due to their natural reserves and high theoretical capacity.However,the large volume changes during cycles and poor conductivity of Si lead to rapid capacity decay and poor cycling stability,ultimately limiting their commercial applications.Herein,we have skillfully utilized the microporous MCM-22 zeolite as the unique silicon source to produce porous Si(pSi)sheets by a simple magnesiothermic reduction,followed by a carbon coating and further Ti_(3)C_(2)T_(x)MXene assembly,obtaining the ternary pSi@NC@TNSs composite.In the design,porous Si sheets provide more active sites and shorten Li-ion transport paths for electrochemical reactions.The N-doped carbon(NC)layer serves as a bonding layer to couple pSi and Ti_(3)C_(2)T_(x).The conductive network formed by 2D Ti_(3)C_(2)T_(x)and medium NC layer effectively enhances the overall charge transport of the electrode material,and helps to stabilize the electrode structure.Therefore,the as-made pSi@NC@TNSs anode delivers an improved lithium storage performance,exhibiting a high reversible capacity of 925 mAh/g at 0.5 A/g after 100 cycles.This present strategy provides an effective way towards high-performance Si-based anodes for LIBs.
基金supported by Beijing Municipal Administration of Hospitals’ Ascent Plan(No.DFL20150201)the National Natural Science Foundation of China(No.81570891)+2 种基金Beijing Natural Science Foundation(No.7151003)Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau(No.2014-2-003)The Capital Health Research and Development of Special(No.2016-1-2051)
文摘Objective: The present study aimed to investigate circular RNA(circRNA) expression in uveal melanoma(UM).Methods: First,we used microarray to compare the expression profiles of circRNA in five UM samples and five normal uvea tissues.Next,bioinformatics analyses,including gene ontology(GO) analysis and pathway analysis,were applied to study these differentially expressed circRNAs to predict pathogenic pathways that may be involved.Quantitative real-time polymerase chain reaction(qRT-PCR) in 20 UM samples and 20 normal uvea samples was used to confirm the circRNA expression profiles obtained from the microarray data.Finally,we analyzed the interaction between validated circRNAs and their potential cancer-associated miRNA targets.Results: In total,50,579 circRNAs [fold change(FC) ≥2.0; P<0.05],including 20,654 up-regulated and 29,925 down-regulated circRNAs,were identified as differentially expressed between UM tissues and normal uvea tissues.We used qRT-PCR to verify seven dysregulated circRNAs indicated by the microarray data,including hsacirc0119873,hsacirc0128533,hsacirc0047924,hsacirc0103232,hsa-circRNA10628-6,hsacirc0032148 and hsacirc0133460,which may be promising candidates to study future molecular mechanisms.Conclusions: This study explored,for the first time,the abnormal expression of circRNAs in UM and described the expression profile of circRNAs,providing a new potential target for the mechanism of UM and future treatment of UM.
文摘In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.
基金supported by the National Key R&D Program(Grant No.2022YFB3804403)the National Natural Science Foundation of China(Grant Nos.92468106 and 82402533)+3 种基金the Natural Science Foundation of Guangdong Province in China(Grant No.2024B1515040018)the Shenzhen Fundamental Research Foundation(Grant Nos.JCYJ20220818101613028,and JSGGKQTD20210831174330015)the Shenzhen Medical Research Fund(Grant No.B2402016)the Shenzhen Science and Technology Program(JCYJ20240813153012017).
文摘4D printing polymeric biomaterials can change their morphology or performance in response to stimuli from the external environment,compensating for the shortcomings of traditional 3D-printed static structures.This paper provides a systematic overview of 4D printing polymeric biomaterials for tissue regeneration and provides an indepth discussion of the principles of these materials,including various smart properties,unique deformation mechanisms under stimulation conditions,and so on.A series of typical polymeric biomaterials and their composites are introduced from structural design and preparation methods,and their applications in tissue regeneration are discussed.Finally,the development prospect of 4D printing polymeric biomaterials is envi-sioned,aiming to provide innovative ideas and new perspectives for their more efficient and convenient application in tissue regeneration.
基金supported by Supported by National Natural Science Foundation of China(82141128)National Natural Science Foundation of China(82101180)+4 种基金The Capital Health Research and Development of Special(2020–1-2052)Beijing Natural Science Foundation(7204245)Science&Technology Project of Beijing Municipal Science&Technology Commission(Z201100005520045,Z181100001818003)Scientific Research Common Program of Beijing Municipal Commission of Education(KM202010025018)Beijing Municipal Administration of Hospitals’Youth Programme(QMS20190203),Beijing Dongcheng District Outstanding Talents Cultivating Plan(2018).
文摘Purpose To investigate the impact of iris nevus on the incidence and prognosis of uveal melanoma(UM).Methods A retrospective cohort study was conducted involving 1128 UM cases and 4356 healthy controls.Partici-pants were categorized based on iris nevus presence and grade:grade 0(no iris nevus),grade 1(single iris nevus),grade 2(multiple iris nevi),and grade 3(partial or complete darkening of the iris).Propensity matching score method was employed to control for age and sex differences,while theχ2 test was used to compare the existence rate and grade of iris nevus between groups.Univariate ANOVA evaluated differences among various iris nevus grades,the Kaplan–Meier method analyzed the prognosis of patients with different iris nevus grades,and multivariate Cox proportional risk regression analysis was conducted to evaluate the relationship between clinical data and prognosis.Results A total of 5484 subjects were analyzed.UM patients exhibited a higher prevalence and grade of iris nevus(all P<0.001)after propensity matching.Patients with iris nevus in the affected eye did not show a worse prognosis(P=0.414).However,those with partial or complete iris darkening or multiple nevi had a poorer prognosis compared to those with a single or no iris nevus(all P<0.05).Iris nevus presence and grade in the healthy eye had no prognos-tic impact(P=0.726 and P=0.825,respectively).The multivariate COX proportional risk model showed that tumor diameter(P<0.001),age(P=0.020),and grade of iris nevus in the affected eye(P=0.009)were independent risk fac-tors for a worse prognosis.LSD analysis revealed that patients with partial or complete darkening of the iris had larger tumor diameters than those without iris nevus(P=0.013),single nevus(P=0.015),and multiple nevus(P=0.023).Discussion Our findings indicate a higher proportion and grade of iris nevus in UM patients compared to controls,and a worse prognosis for UM patients with higher-grade iris nevi in the affected eye.
基金financial support from “China Scholarship Council(201707090012)” which helped his stay in Japan for this joint international researchsupported by “the Fundamental Research Funds for the Central Universities”(2018JBZ105)Natural Science Foundation of Tianjin(No.15JCQNJC04800)
文摘A systematic wear model of the cylindrical grinding process with an alumina abrasive belt from the perspective of single grain sliding wear was established in this study.The model consists of three parts:a single cutting force model derived by applying a stress integration method,a single grain wear height analysis based on the wear rate of alumina,and a grinding mileage prediction of multiple grains with Gaussian distributed protrusion heights.Cutting force,single grain wear height and full‐size grinding mileage verification experiments were conducted.The results indicated that the established model was in reasonable agreement with the experimental outcomes,which suggests that this model could be useful in the industry to predict the wear process of abrasive belts.
基金supported by the National Key Research and Development Program of China[grant number 2021YFB3900501]the National Natural Science Foundation of China[grant number 41671436,41901354,41890854]the Innovation Project of LREIS[grant number O88RAA01YA].
文摘Due to the weak information about cultural targets in the complex marine environment,an omission problem exists in large-scale mariculture extraction using single-view and single-source images.To overcome this problem,we developed a mariculture extraction method that combines dense time-series Sentinel-2 and Sentinel-1 data.A high-precision Chinese mariculture distribution map for 2020 was produced with an overall accuracy of 94.00%and a kappa coefficient of 0.91.The results show that(1)the total area of mariculture was 1173249.22 ha on the national scale,which was significantly larger than the previous studies(459595.70 and 205920.28 ha,respectively),with Shandong Province(39.09%)having the largest proportion;(2)China’s mariculture presented a spatial distribution characteristic of‘Denser North and Sparser South’,and mariculture was centralized in the coastal zones of the northern provinces(60.76%)rather than the southern provinces;(3)the official production statistics and remote sensing-derived mariculture area revealed a highly corresponding trend at the provincial level,with an R2 reaching 0.78,which is much higher than the 0.07 and 0.41 values of the comparison data.The results directly provide data reference for mariculture production estimation and site selection or ideas for mariculture extraction in other regions and globally.
